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Réponses de peur et encodage du temps dans la formation des mémoires de peur chez le rat : du comportement aux réseaux neuronaux

Abstract : Fear conditioning is one of the most commonly used tasks to study the formation of emotional memories. In this thesis, we were interested in odor fear conditioning in which the arrival of an odor is followed after a fixed time interval by an aversive stimulus. The animal learns very quickly that the odor predicts the arrival of the aversive stimulus and develops a fear response to the odor characterized by different behaviors such as immobility of fear (freezing), the emission of ultrasonic vocalizations, or variations in respiratory rate. The first objective of this thesis was to characterize the impact of ultrasonic vocalization emission on the rat's brain activities. In this learning, the animal also learns the duration of the interval between the arrival of the odor and the aversive stimulus. The circuits underlying the encoding of durations in this learning have been very little studied. However, time encoding is involved in many behaviors, and would be a fundamental component of associative learning. The second objective of the thesis was thus to characterize the temporal course of fear responses during the odor- aversive stimulus interval, as well as that of brain activities. For these two objectives, we used a fine-grain behavioural approach coupled with electrophysiological recording of oscillatory activities in a network of structures including the prefrontal cortex, amygdala, dorsal striatum and olfactory cortex. We have shown that within this network, oscillatory activities are modulated by the duration of the interval, in relation to behavioural responses
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Submitted on : Thursday, March 26, 2020 - 4:24:43 PM
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Maryne Dupin. Réponses de peur et encodage du temps dans la formation des mémoires de peur chez le rat : du comportement aux réseaux neuronaux. Neurosciences. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1308⟩. ⟨tel-02520473v1⟩



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