, efficacité de ces agro-solvants à l'échelle pilote et d'évaluer leurs coûts d'utilisation à l'échelle industrielle, En perspectives nous envisagerons également

, L'évaluation de l'effet de combinaison des agro-solvants en mélanges binaires ou ternaires sur l'efficacité d'extraction des molécules d'intérêts

, La recherche de méthodes innovantes pour la séparation des métabolites d'intérêts outre la distillation et l'évaporation classique du solvant afin de contourner les problèmes de volatilité et de viscosité des agro-solvants

, L'évaluation d'autres activités biologiques (activité anti-cancéreuse, anti-tyrosinase, etc) des biomolécules isolées à partir des différentes parties de P. lentiscus

, La séparation et la purification des principes actifs (PA) à l'aide des techniques chromatographiques innovantes comme la Chromatographie de Partage Centrifuge

, Et la modélisation des relations PA-cibles afin d'une éventuelle utilisation dans la formulation de nouveaux produits pharmaceutiques

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R. Le-développement-de-la-chimie-verte, Cette démarche a conduit à la sélection de quatre solvants verts, le MetHF pour l'extraction des acides gras, l'EtOAc pour l'extraction des arômes, l'EtOH/H2O (70/30) pour l'extraction des polyphénols et des flavonoïdes et l'EtOH/H2O (80/20) pour l'extraction des anthocyanes. Par la suite, l'activité anti-inflammatoire de l'extrait lipidique obtenu par le MeTHF et l'activité antioxydante des extraits aromatiques et des extraits phénoliques de P. lentiscus ont été évaluées in vitro. Ces travaux ont montré que l'huile végétale a présenté une activité anti-inflammatoire potentielle, inhibant de 91,9% la libération d'oxyde nitrique (NO . ) dans les macrophages RAW 264,7. De plus, les résultats ont permis de mettre en évidence la richesse des fruits en antioxydants, l'épuisement des ressources pétrolières et la prise de conscience des risques liée à l'utilisation des solvants pétroliers ont conduit à la recherche de nouvelles alternatives pour réduire l'utilisation des solvants nocifs non renouvelables tels que l'hexane

, Mots clés : Pistacia lentiscus, solvants alternatifs, éco-extraction, COSMO-RS, huile végétale, arômes, antioxydants, activité anti-inflammatoire