Trefoil Factor Peptides and Gastrointestinal Function, Annu. Rev. Physiol, vol.79, pp.357-380, 2017. ,
Upper airway mucin gene expression: a review, The Laryngoscope, vol.117, pp.932-938, 2007. ,
Function of the CysD domain of the gel-forming MUC2 mucin, Biochem. J, vol.436, pp.61-70, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00591704
Large Scale Identification of Proteins, Mucins, and Their O-Glycosylation in the Endocervical Mucus during the Menstrual Cycle, Mol. Cell. Proteomics, vol.6, pp.708-716, 2007. ,
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation, Nature, vol.504, pp.451-455, 2013. ,
Dimerization of the Human MUC2 Mucin in the Endoplasmic Reticulum Is Followed by a N-Glycosylationdependent Transfer of the Mono-and Dimers to the Golgi Apparatus, J. Biol. Chem, vol.273, pp.18857-18863, 1998. ,
Mucin mRNA expression in normal and vasomotor inferior turbinates, Am. J. Rhinol, vol.11, pp.293-302, 1997. ,
,
The biology of mucus: Composition, synthesis and organization, Adv. Drug Deliv. Rev, vol.124, pp.3-15, 2018. ,
Mucin structure, aggregation, physiological functions and biomedical applications, Curr. Opin. Colloid Interface Sci, vol.11, pp.164-170, 2006. ,
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses, J. Clin. Invest, vol.98, pp.1010-1020, 1996. ,
Olfactory changes among patients receiving chemotherapy, Eur. J. Oncol. Nurs. Off. J. Eur. Oncol. Nurs. Soc, vol.13, pp.9-15, 2009. ,
Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy, Bone Marrow Transplant, vol.34, pp.193-196, 2004. ,
Globular structure of human ovulatory cervical mucus, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.21, pp.3872-3876, 2007. ,
Developmental Mucin Gene Expression in the Human Respiratory Tract, Am. J. Respir. Cell Mol. Biol, vol.20, pp.209-218, 1999. ,
,
Mapping the Protein Domain Structures of the Respiratory Mucins: A Mucin Proteome Coverage Study, J. Proteome Res, vol.11, pp.4013-4023, 2012. ,
pH-Dependent Conformational Change of Gastric Mucin Leads to Sol-Gel Transition, Biophys. J, vol.76, pp.1250-1258, 1999. ,
Characterization of glycoconjugates in developing rat respiratory system by means of conventional and lectin histochemistry, Histochemistry, vol.95, pp.419-426, 1991. ,
Role of mucins in the skin during benign and malignant conditions, Cancer Lett, vol.301, pp.127-141, 2011. ,
Anatomy and cellular constituents of the human olfactory mucosa: a review, J. Neurol. Surg. Part B Skull Base, vol.75, pp.293-300, 2014. ,
Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice, Am. J. Respir. Cell Mol. Biol, vol.59, pp.383-396, 2018. ,
In vivo structure-function studies of 110 human hepatic lipase: the catalytic function rescues the lean phenotype of HLdeficient (hl-/-) mice, 2015. ,
Genome-Wide Search and Identification of a Novel Gel-Forming Mucin MUC19/Muc19 in Glandular Tissues, Am. J. Respir. Cell Mol. Biol, vol.30, pp.155-165, 2004. ,
Roles for transforming growth factoralpha in the stomach, J. Clin. Gastroenterol, vol.21, issue.1, pp.36-39, 1995. ,
Mucins: A biologically relevant glycan barrier in mucosal protection, Biochim. Biophys. Acta BBA -Gen. Subj, vol.1850, pp.236-252, 2015. ,
Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans, Gastroenterology, vol.119, pp.1496-1505, 2000. ,
Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction, Clin. Nutr. Edinb. Scotl, vol.27, pp.328-339, 2008. ,
salivary mucin 19 glycoproteins innate immune functions in streptococcus mutans-induced caries in mice and evidence for expression in human saliva, j. biol. chem, vol.290, pp.2993-3008, 2015. ,
Methotrexate-induced mucositis in mucin 2-deficient mice, J. Cell. Physiol, vol.210, pp.144-152, 2007. ,
Gel-forming mucin interactome drives mucus viscoelasticity, Adv. Colloid Interface Sci, vol.252, pp.69-82, 2018. ,
Mucin CYS domains are ancient and highly conserved modules that evolved in concert, Mol. Phylogenet. Evol, vol.52, pp.284-292, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02177076
Evolution of the Large Secreted Gel-Forming Mucins, Mol. Biol. Evol, vol.17, pp.1175-1184, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-02177653
Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse??Se-quence data from this article have been deposited with the GenBank Data Library M, Standaert, A., 2019. Contribution of the Gut Microbiota in P28GST-Mediated Anti, 2003. ,
Olfactory epithelium changes in germfree mice, Sci. Rep, vol.6, p.24687, 2016. ,
C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/?-catenin signaling in cells, FEBS Lett, vol.590, pp.2639-2649, 2016. ,
Protein C-mannosylation: facts and questions, Acta Biochim. Pol, vol.47, pp.781-789, 2000. ,
,
Studies on the selectivity of antitumor agents, Cancer Res, vol.27, pp.1309-1437, 1967. ,
Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system, Mucosal Immunol, vol.9, pp.1353-1359, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02459450
Distribution of mucins at the ocular surface, Exp. Eye Res, vol.78, pp.379-388, 2004. ,
Phospholipid composition and surface-active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary diseases, Pediatr. Pulmonol, vol.13, pp.22-27, 1992. ,
Role of the physiochemical properties of mucus in the protection of the respiratory epithelium, Eur. Respir. J, vol.5, pp.477-487, 1992. ,
The value of plasma citrulline to predict mucosal injury in intestinal allografts, Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg, vol.6, pp.2786-2790, 2006. ,
Better early outcome with enteral rather than parenteral nutrition in children undergoing MAC allo-SCT, Clin. Nutr. Edinb. Scotl, vol.37, pp.2113-2121, 2018. ,
Coordinate Regulation of the Gel-forming Mucin Genes at Chromosome 11p15.5, J. Biol. Chem, vol.288, pp.6717-6725, 2013. ,
Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier, Sci. Rep, vol.5, p.9577, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02380839
The Extraordinarily Complex but Highly Structured Organization of Intestinal Mucus-Gel Unveiled in Multicolor Images, PLOS ONE, vol.6, p.18761, 2011. ,
Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC, PloS One, vol.6, p.25452, 2011. ,
The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions, J. Exp. Med, vol.148, pp.1661-1677, 1978. ,
,
Human Trefoil Factor 2 Is a Lectin That Binds ?-GlcNAc-capped Mucin Glycans with Antibiotic Activity against Helicobacter pylori, J. Biol. Chem, vol.289, pp.27363-27375, 2014. ,
Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure, J. Biol. Chem, vol.272, pp.15232-15241, 1997. ,
The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium, Toxicol. Pathol, vol.34, pp.252-269, 2006. ,
Muc5ac: a critical component mediating the rejection of enteric nematodes, J. Exp. Med, vol.208, pp.893-900, 2011. ,
Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis, J. Crohns Colitis, vol.10, pp.1324-1335, 2016. ,
Odorant-binding proteins and xenobiotic metabolizing enzymes: implications in olfactory perireceptor events, Anat. Rec. Hoboken NJ, vol.296, pp.1333-1345, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00866526
The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins, Dig. Dis. Sci, vol.49, pp.1598-1606, 2004. ,
Tear film mucins: Front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins, Tears: A Unique Mucosal Surface Secretion, vol.117, pp.62-78, 2013. ,
The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia?, Trends Biochem. Sci, vol.18, pp.239-243, 1993. ,
Atomic Force Microscopy Reveals Aggregation of Gastric Mucin at Low pH, Biomacromolecules, vol.6, pp.3458-3466, 2005. ,
Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells, Biochem. J, vol.318, pp.319-324, 1996. ,
Citrulline and Monocyte-Derived Macrophage Reactivity before Conditioning Predict Acute Graft-versus-Host Disease, Biol. Blood Marrow Transplant. J. Am. Soc. Blood Marrow Transplant, vol.23, pp.913-921, 2017. ,
, Consequences of induction chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: a translational study, 2019.
Association Between Low Plasma Level of Citrulline Before Allogeneic Hematopoietic Cell Transplantation and Severe Gastrointestinal Graft vs Host Disease, Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc, vol.16, pp.908-917, 2018. ,
Successful Imatinib therapy as a bridge to transplant in an atypical myeloproliferative neoplasm, Curr. Res. Transl. Med. I, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02393679
Molecular mapping of statherin-and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system, J. Dent. Res, vol.79, pp.732-739, 2000. ,
Expression of mucin antigens and Lewis X-related antigens in carcinomas and dysplasia of the pharynx and larynx, Pathol. Int, vol.46, pp.646-655, 1996. ,
, J
New approaches to the treatments of short bowel syndrome-associated intestinal failure, Curr. Opin. Gastroenterol, vol.30, pp.182-188, 2014. ,
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of hostmicrobial interactions, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.4659-4665, 2011. ,
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.15064-15069, 2008. ,
Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice, Exp. Anim, vol.45, pp.155-160, 1996. ,
The role of the adaptive immune system in regulation of gut microbiota, Immunol. Rev, vol.260, pp.67-75, 2014. ,
Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy, Cancer Chemother. Pharmacol, vol.74, pp.675-680, 2014. ,
Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium, Chem. Senses, vol.44, pp.511-521, 2019. ,
Differential response of gel-forming mucins to pathogenic middle ear bacteria, Int. J. Pediatr. Otorhinolaryngol, vol.78, pp.1368-1373, 2014. ,
Intestinal goblet cells and mucins in health and disease: recent insights and progress, Curr. Gastroenterol. Rep, vol.12, pp.319-330, 2010. ,
Intestinal goblet cells and mucins in health and disease: recent insights and progress, Curr. Gastroenterol. Rep, vol.12, pp.319-330, 2010. ,
Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression, Cell Tissue Res, vol.335, pp.489-503, 2009. ,
Expression Analysis of Human Salivary Glands by Laser Microdissection: Differences Between Submandibular and Labial Glands, Cell. Physiol. Biochem, vol.26, pp.375-382, 2010. ,
Dietary Phosphatidylcholine Supplementation Attenuates Inflammatory Mucosal Damage in a Rat Model of Experimental Colitis, Shock, vol.38, pp.177-185, 2012. ,
Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp, Mol. Biol. Cell, vol.9, pp.301-309, 1998. ,
Gel-forming mucins appeared early in metazoan evolution, Proc. Natl. Acad. Sci, vol.104, pp.16209-16214, 2007. ,
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation, World J. Gastroenterol, vol.20, pp.3751-3761, 2014. ,
The hydrophobic barrier properties of gastrointestinal mucus, Annu. Rev. Physiol, vol.57, pp.565-583, 1995. ,
Transglutaminases: crosslinking enzymes with pleiotropic functions, Nat. Rev. Mol. Cell Biol, vol.4, pp.140-156, 2003. ,
Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis development, Inflamm. Bowel Dis, vol.17, pp.2047-2057, 2011. ,
Osmotic changes and ethanol modify TFF gene expression in gastrointestinal cell lines, FEBS Lett, vol.439, pp.180-184, 1998. ,
Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins, Gut, vol.46, pp.515-521, 2000. ,
Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests, Cancer, vol.103, pp.191-199, 2005. ,
,
Immunity, inflammation, and allergy in the gut, Science, vol.307, pp.1920-1925, 2005. ,
Tissue Localization of Human Trefoil Factors 1, 2, and 3, J. Histochem. Cytochem, vol.55, pp.505-513, 2007. ,
Defensins and mucosal protection, Novartis Found. Symp, vol.263, pp.211-218, 2004. ,
Mucin genes have different expression patterns in healthy and diseased upper airway mucosa, Clin. Exp. Allergy, vol.36, pp.448-457, 2006. ,
Intestinal effector T cells in health and disease, Immunity, vol.31, pp.389-400, 2009. ,
Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia, Trends Mol. Med, vol.21, pp.492-503, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01427451
Solution Structure of the Disulfide-Linked Dimer of Human Intestinal Trefoil Factor (TFF3): The Intermolecular Orientation and Interactions Are Markedly Different from Those of Other Dimeric Trefoil Proteins, Biochemistry, vol.42, pp.15139-15147, 2003. ,
Modulation of intestinal barrier by intestinal microbiota : pathological and therapeutic implications, Pharmacol. Res, vol.69, pp.42-51, 2013. ,
Modulation of intestinal barrier by intestinal microbiota : pathological and therapeutic implications, Pharmacol. Res, vol.69, pp.42-51, 2013. ,
Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution, Biochem. J, vol.364, pp.191-200, 2002. ,
Gel-forming mucins form distinct morphologic structures in airways, Proc. Natl. Acad. Sci. U. S. A, vol.114, pp.6842-6847, 2017. ,
Effect of a hydrophobic phospholipid lining of the gastric mucosa in bioadhesion, Pharm. Res, vol.25, pp.16-24, 2008. ,
Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function, Am. J. Pathol, vol.180, pp.626-635, 2012. ,
C-Mannosylation of MUC5AC and MUC5B Cys subdomains, Glycobiology, vol.14, pp.325-337, 2004. ,
Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of, Genes. Genomics, vol.38, pp.340-352, 1996. ,
Biomarkers of gut barrier failure in the ICU, Curr. Opin. Crit. Care, vol.22, pp.152-160, 2016. ,
, vivo imaging of the Muc5b gel-forming mucin. Sci. Rep. 7, p.44591, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02361416
Site-specific O-Glycosylation on the MUC2 Mucin, 2013. ,
, J. Biol. Chem, vol.288, pp.14636-14646
Do Lipids Retard the Evaporation of the Tear Fluid?, Invest. Ophthalmol. Vis. Sci, vol.53, pp.6442-6447, 2012. ,
The Reduction-insensitive Bonds of the MUC2, 2016. ,
, Mucin Are Isopeptide Bonds, J. Biol. Chem, vol.291, pp.13580-13590
Developmental expression of mucin genes in the human gastrointestinal system, Gut, vol.42, pp.220-226, 1998. ,
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas, J. Histochem. Cytochem. Off. J. Histochem. Soc, vol.48, pp.377-388, 2000. ,
Mucin-type O-glycosylation is controlled by short-and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family, Glycobiology, vol.26, pp.360-376, 2016. ,
Evidence of Regio-specific Glycosylation in Human Intestinal Mucins PRES-ENCE OF AN ACIDIC GRADIENT ALONG THE INTESTINAL TRACT, J. Biol. Chem, vol.278, pp.46337-46348, 2003. ,
Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori, Glycobiology, vol.22, pp.1193-1206, 2012. ,
Secretory IgA N-and O-glycans provide a link between the innate and adaptive immune systems, J. Biol. Chem, vol.278, pp.20140-20153, 2003. ,
The trefoil protein TFF1 is bound to MUC5AC in humangastric mucosa, Cell. Mol. Life Sci, vol.61, pp.1946-1954, 2004. ,
Mucin gene expression in human male urogenital tract epithelia, Hum. Reprod, vol.21, pp.2783-2793, 2006. ,
The intestinal barrier function and its involvement in digestive disease, 2015. ,
, Rev. Espanola Enfermedades Dig. Organo Of. Soc. Espanola Patol. Dig, vol.107, pp.686-696
Host-microbe interactions: the difficult yet peaceful coexistence of the microbiota and the intestinal mucosa, Br. J. Nutr, vol.109, issue.2, pp.12-20, 2013. ,
Intestinal inflammation and mucosal barrier function, Inflamm. Bowel Dis, vol.20, pp.2394-2404, 2014. ,
Fight them or feed them: how the intestinal mucus layer manages the gut microbiota, Gastroenterol. Rep, vol.7, pp.3-12, 2019. ,
Fcgbp -A Potential Viral Trap in RV144, Open AIDS J, vol.8, pp.21-24, 2014. ,
Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures, Am. J. Physiol.-Lung Cell. Mol. Physiol, vol.301, pp.181-186, 2011. ,
Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning, Transplantation, vol.82, pp.835-839, 2006. ,
Better outcome of patients undergoing enteral tube feeding after myeloablative conditioning for allogeneic stem cell transplantation, Transplantation, vol.94, pp.287-294, 2012. ,
Further evidence that the human MUC2 gene transcripts in the intestine and trachea are identical, Biochem. J, vol.306, pp.311-312, 1995. ,
Role of associated and covalently bound lipids in salivary mucin hydrophobicity: effect of proteolysis and disulfide bridge reduction, Biochem. Biophys. Res. Commun, vol.151, pp.1046-1053, 1988. ,
Aquaporin pathways and mucin secretion of Bowman's glands might protect the olfactory mucosa, Chem. Senses, vol.37, pp.35-46, 2012. ,
Phase II investigational oral drugs for the treatment of radio/chemotherapy induced oral mucositis, Expert Opin. Investig. Drugs, vol.27, pp.147-154, 2018. ,
Palifermin for oral mucositis after intensive therapy for hematologic cancers, N. Engl. J. Med, vol.351, pp.2590-2598, 2004. ,
, Essentials of Glycobiology, 2015.
Regulation of intestinal epithelial permeability by tight junctions, Cell. Mol. Life Sci. CMLS, vol.70, pp.631-659, 2013. ,
Pre-epithelial mucus layer in the colon of conventional and germ-free rats, Histochem. J, vol.22, pp.491-497, 1990. ,
Development of human minor salivary glands: expression of mucins according to stage of morphogenesis, J. Anat, vol.219, pp.410-417, 2011. ,
Trefoil" disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins), FEBS Lett, vol.250, pp.85-90, 1989. ,
Effect of trefoil factors on the viscoelastic properties of mucus gels, Eur. J. Clin. Invest, vol.32, pp.519-527, 2002. ,
Differential expression of tissue transglutaminase in human cells. An immunohistochemical study, Cell Tissue Res, vol.255, pp.215-224, 1989. ,
pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins, Gastroenterology, vol.118, pp.70-80, 2000. ,
Intestinal mucosal barrier function in health and disease, Nat. Rev. Immunol, vol.9, pp.799-809, 2009. ,
Differences in terminal carbohydrate structures of sialomucin in the murine nasal cavity, Eur. Arch. Oto-Rhino-Laryngol. Off, 1994. ,
, J. Eur. Fed. Oto-Rhino-Laryngol. Soc. EUFOS Affil. Ger. Soc. Oto-Rhino-Laryngol. -Head Neck Surg, vol.251, pp.119-122
Normal histology of the nasal cavity and application of special techniques, Environ. Health Perspect, vol.85, pp.187-208, 1990. ,
Improved procedure for the isolation of functionally active lymphoid cells from the murine intestine, J. Immunol. Methods, vol.103, pp.161-167, 1987. ,
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection, Gastroenterology, vol.131, pp.117-129, 2006. ,
Newly synthesized claudins but not occludin are added to the basal side of the tight junction, Mol. Biol. Cell, vol.30, pp.1406-1424, 2019. ,
Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract, Am. J. Physiol, vol.273, pp.296-302, 1997. ,
MUC5B is the prominent mucin in human gallbladder and is also expressed in a subset of colonic goblet cells, Am. J. Physiol, vol.274, pp.871-878, 1998. ,
Colorectal cancer in mice genetically deficient in the mucin Muc2, Science, vol.295, pp.1726-1729, 2002. ,
Supramolecular Dynamics of Mucus. Cold Spring Harb, Perspect. Med, vol.2, p.9597, 2012. ,
, Polymorphism of human mucin genes in chest disease: possible significance of MUC2, 2000.
, Am. J. Respir. Cell Mol. Biol, vol.23, pp.678-686
Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects, Expert Rev. Gastroenterol. Hepatol, vol.7, pp.683-687, 2013. ,
Imaging of complications of oncological therapy in the gastrointestinal system, Cancer Imaging Off. Publ. Int. Cancer Imaging Soc, vol.12, pp.163-172, 2012. ,
Novel forms of protein glycosylation, Curr. Opin. Struct. Biol, vol.8, pp.565-571, 1998. ,
Novel forms of protein glycosylation, Curr. Opin. Struct. Biol, vol.8, pp.565-571, 1998. ,
T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis, Mucosal Immunol, vol.8, pp.1297-1312, 2015. ,
Post-translational Modification of Thrombospondin Type-1 Repeats in ADAMTS-like 1/Punctin-1 by C-Mannosylation of Tryptophan, J. Biol. Chem, vol.284, pp.30004-30015, 2009. ,
Boundary Lubrication by Associative Mucin, Langmuir, vol.31, pp.4733-4740, 2015. ,
Apoptosis and differentiation in the crypt-villus unit of the rat small intestine, J. Submicrosc. Cytol. Pathol, vol.31, pp.15-30, 1999. ,
Rôle of lipids in airway function, Eur. J. Respir. Dis. Suppl, vol.153, pp.197-204, 1987. ,
Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair, Am. J. Physiol, vol.277, pp.785-795, 1999. ,
Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/-mice, Am. J. Pathol, vol.166, pp.1239-1246, 2005. ,
Quantitative gas chromatography/mass spectrometry determination of C-mannosylation of tryptophan residues in glycoproteins, Anal. Biochem, vol.329, pp.199-206, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00021360
Sequence and structure relationships within von Willebrand factor, Blood, vol.120, pp.449-458, 2012. ,
, immunohistochemistry, primary polyclonal anti-Muc5b (CP1), monoclonal anti-MUC5AC (45M1, kindly given by J. Bara), and commercial rabbit polyclonal anti-GFP antibodies
which have been used successfully by hundreds of researchers (45M1 and anti-GFP), were used, 2008. ,
Because Muc5ac immunostaining requires a citrate pretreatment, dual Muc5b and Muc5ac immunostaining was performed only on Muc5b-GFP reporter and Muc5b ?/? mice using the anti-GFP antibody. FITC-conjugated anti-rabbit and tetramethylrhodamine (TRITC) anti-mouse secondary antibodies were used. TRITC-conjugated Maackia amurensis agglutinin (MAA) and TRITC-conjugated Ulex europaeus agglutinin I (UEA-1) lectins (EY Laboratories, Three to five noses from each genotype were analyzed. High-quality captures in bright field and fluorescence were performed, and images were digitized on an Axio Scan, 2011. ,
Results and discussion Mucin expression in the nasal airway Muc5b production has been reported recently in mouse BGs in one study using immunohistochemistry ,
, In this last work, Muc5ac staining was observed using a mouse monoclonal antibody (Clone SPM488). However, this antibody has not been validated in mouse and is directed against a nonglycosylated synthetic 20-mer peptide from the tandem repeat sequence of the human mucin, mouse BGs might produce Muc5b, but secrete mainly Muc5ac, vol.5
This was confirmed using the anti-Muc5b antibody in WT mice (Suppl. Figure 1) and in Muc5b-GFP reporter mice (data not shown), whereas Muc5ac but not Muc5b was found exclusively in the RE of T1 sections of Muc5b-GFP reporter mice (Fig. 2) and WT mice (Suppl. Figure 2). In the distal nasal airway (T3 sections), Muc5b but not Muc5ac is produced in the OE of reporter Muc5b-GFP mice (Fig. 3). This was further confirmed using the anti-Muc5b antibody in WT (Suppl. Figure 2) and Muc5b-GFP reporter mice (data not shown), and the other against the GFP-tag of the reporter Muc5b transgenic mouse. Additionally, we studied the expression of the other major respiratory GFM, Muc5ac, vol.117, pp.932-938, 2011. ,
Mucin mRNA expression in normal and vasomotor inferior turbinates, Am J Rhinol, vol.11, pp.293-302, 1997. ,
Characterization of glycoconjugates in developing rat respiratory system by means of conventional and lectin histochemistry, Histochemistry, vol.95, pp.419-426, 1991. ,
Anatomy and cellular constituents of the human olfactory mucosa: a review, J Neurol Surg B Skull Base, vol.75, pp.293-300, 2014. ,
In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl ?/? ) mice, Physiol Rep, vol.3, 2015. ,
Role of Spdef in the regulation of Muc5b expression in the airways of naive and mucoobstructed mice, Am J Respir Cell Mol Biol, vol.59, pp.383-396, 2018. ,
Eukaryotic protein glycosylation: a primer for histochemists and cell biologists, Histochem Cell Biol, vol.147, pp.119-147, 2017. ,
Transgenic mouse reporter to study Muc5b in vivo, Ann Am Thorac Soc, vol.15, pp.149-153, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02149469
The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin, Biochem Biophys Res Commun, vol.492, pp.331-337, 2017. ,
Olfactory epithelium changes in germfree mice, Sci Rep, vol.6, p.24687, 2016. ,
The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice, Histochem Cell Biol, vol.133, pp.517-525, 2010. ,
The extraordinarily complex but highly structured organization of intestinal mucus-gel unveiled in multicolor images, PLoS One, vol.6, p.61, 2011. ,
Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier, Sci Rep, vol.5, p.9577, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02380839
Comparative morphometry of the nasal cavity in rats and mice, J Anat, vol.135, pp.83-88, 1982. ,
The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium, Toxicol Pathol, vol.34, pp.252-269, 2006. ,
Odorant-binding proteins and xenobiotic metabolizing enzymes: implications in olfactory perireceptor events, Anat Rec, vol.296, pp.1333-1345, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00866526
Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression, Cell Tissue Res, vol.335, pp.489-503, 2009. ,
Histochemical study of the olfactory mucosae of the horse, Acta Histochem, vol.118, pp.361-368, 2016. ,
Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin, FEBS J, vol.275, pp.481-489, 2008. ,
Mucins in the mucosal barrier to infection, Mucosal Immunol, vol.1, pp.183-197, 2008. ,
Gelforming mucins form distinct morphologic structures in airways, 2017. ,
, Proc Natl Acad Sci, vol.114, pp.6842-6847
Cell and molecular biology of human lacrimal gland and nasolacrimal duct mucins, Int Rev Cytol, vol.249, issue.06, pp.49005-49012, 2006. ,
Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments, PLoS One, vol.12, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02381192
, vivo imaging of the Muc5b gel-forming mucin. Sci Rep, vol.7, p.44591, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02361416
The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome, Mucosal Immunol, vol.9, pp.1442-1454, 2016. ,
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas, J Histochem Cytochem, vol.48, p.307, 2000. ,
Aquaporin pathways and mucin secretion of Bowman's glands might protect the olfactory mucosa, Chem Senses, vol.37, pp.35-46, 2012. ,
Differences in terminal carbohydrate structures of sialomucin in the murine nasal cavity, Eur Arch Otorhinolaryngol, vol.251, pp.119-122, 1994. ,
Abnormal expression of Muc5b in Cftr-null mice and in mammary tumors of MMTV-ras mice, Histochem Cell Biol, vol.136, pp.699-708, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02176612
Sialoglycoproteins and penultimate sugar expression pattern in developing murine olfactory and respiratory mucosa, Yonsei Med J, vol.39, pp.20-26, 1998. ,