, Cancers lymphohématopoïétiques (N=28): Bas: RR=1,7

M. Andersson, M. Vyberg, J. Visfeldt, B. Carstensen, and H. H. Storm, Primary liver tumors among Danish patients exposed to Thorotrast, Radiation research, vol.137, issue.2, pp.262-73, 1994.

. Atsdr, Toxicological profile for uranium. Agency for Toxic Substances and Disease Registry, 2013.

T. V. Azizova, E. S. Grigoryeva, R. G. Haylock, M. V. Pikulina, and M. B. Moseeva, The British journal of radiology, vol.88, 1054.

T. Behrens, Shift work and the incidence of prostate cancer: a 10-year follow-up of a German population-based cohort study. Scandinavian journal of work, environment & health, vol.43, issue.6, pp.560-568, 2017.

E. Blanchardon, D. Bingham, R. Bull, C. De-vathaire, C. Cockerill et al., Dosimetric protocol (CURE internal deliverable D2. 2). DoReMi-Low Dose Research Towards Multidisciplinary Integration-task 58 'CURE project, 2014.

E. Blanchardon, A. Flüry-herard, and F. Paquet, , 2007.

A. Bleise, P. R. Danesi, and W. Burkart, Properties, use and health effects of depleted uranium (DU): a general overview, Journal of environmental radioactivity, vol.64, issue.2-3, pp.93-112, 2003.

J. D. Boice, S. S. Cohen, M. T. Mumma, B. Chadda, and W. J. Blot, Mortality among residents of, vol.27, pp.299-319, 2007.

J. D. Boice, S. S. Cohen, M. T. Mumma, B. Chadda, and W. J. Blot, A cohort study of uranium millers and miners of Grants, Journal of radiological protection : official journal of the Society for Radiological Protection, vol.28, issue.3, pp.303-328, 1979.

J. D. Boice, Updated mortality analysis of radiation workers at Rocketdyne (Atomics International, Radiation research, vol.176, issue.2, pp.244-258, 2011.

S. Bouet, E. Samson, I. Jovanovic, D. Laurier, and O. Laurent, First mortality analysis in the French cohort of uranium millers (F-Millers), period 1968-2013, 2017.

J. Bouyer and D. Hémon, Les matrices emplois-expositions. Revue d'epidemiologie et de sante publique, vol.42, pp.235-245, 1994.

N. E. Breslow and N. E. Day, Indirect standardization and multiplicative models for rates, with reference to the age adjustment of cancer incidence and relative frequency data, Journal of chronic diseases, vol.28, issue.5-6, pp.289-303, 1975.

I. G. Canu, E. D. Ellis, and M. Tirmarche, Cancer risk in nuclear workers occupationally exposed to uraniumemphasis on internal exposure, Health physics, vol.94, issue.1, pp.1-17, 2008.

C. Castellani, IDEAS Guidelines (Version 2) for the estimation of committed doses from incorporation monitoring data, EURADOS report, vol.1, pp.202013-202014, 2013.

C. Chan, Mortality patterns among Paducah Gaseous Diffusion Plant workers, American College of Occupational and Environmental Medicine, vol.52, issue.7, pp.725-757, 2010.

, Quatrième partie : Santé et sécurité au travail, Livre IV : Prévention de certains risques d'exposition, Titre V : Prévention des risques d'exposition aux rayonnements, Chapitre Ier : Prévention des risques d'exposition aux rayonnements ionisants, Code du travail (Version à venir au 1er juillet 2018) Article R4451-6 Code du travail. vol Partie réglementaire, vol.3

C. Biobayes, Initiation à la statistique bayésienne: Bases théoriques et applications en alimentation, environnement, épidémiologie et génétique, 2015.

J. B. Cologne, S. Tokuoka, G. W. Beebe, T. Fukuhara, and K. Mabuchi, , 1999.

J. Cuzick, Prevention and early detection of prostate cancer, The lancet oncology, vol.15, issue.11, pp.484-492, 2014.

E. Davesne, Rapport DRPH/SDI/2010-11,IRSN/IRSN-2010/135. Laboratoire d'Evaluation de la Dose Interne, IRSN/DRPH/SDI/LEDI, 2010.

E. Davesne and E. Blanchardon, Physico-chemical characteristics of uranium compounds: A review, International journal of radiation biology, vol.90, issue.11, pp.975-88, 2014.

E. Davesne, EURADOS Report: Uncertainties in internal dose assessment: Lifetime dose, 2017.

E. Davesne, O. Laurent, and M. A. Lopez, , 2018.

D. Drubay, S. Ancelet, A. Acker, M. Kreuzer, D. Laurier et al., Kidney cancer mortality and ionizing radiation among French and German uranium miners, Radiation and environmental biophysics, vol.53, issue.3, pp.505-518, 2014.

D. Drubay, S. Caer-lorho, P. Laroche, D. Laurier, and E. Rage, Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study, Radiation research, vol.183, issue.5, pp.550-62, 2015.

E. Dupree-ellis, J. Watkins, J. N. Ingle, and J. Phillips, External radiation exposure and mortality in a cohort of uranium processing workers, American journal of epidemiology, vol.152, issue.1, pp.91-95, 2000.

E. A. Dupree, J. P. Watkins, J. N. Ingle, P. W. Wallace, C. M. West et al., , 1995.

A. M. Dzhambov and D. D. Dimitrova, Occupational noise and ischemic heart disease: A systematic review, Noise & health, vol.18, issue.83, pp.167-77, 2016.

J. Feuardent, P. Scanff, D. Crescini, and A. Rannou, Occupational external exposure to ionising radiation in France, Radiation protection dosimetry, vol.157, pp.610-618, 2005.

D. Fisher, . Stoezel, and . Ga, Radiological health aspects of uranium milling Pacific, 1983.

E. S. Gilbert, Lung cancer risks from plutonium: an updated analysis of data from the Mayak worker cohort, Radiation research, vol.179, issue.3, pp.332-374, 2013.

M. Gillies, Mortality from Circulatory Diseases and other Non-Cancer Outcomes among Nuclear Workers in France, the United Kingdom and the United States (INWORKS), Radiation research, vol.188, issue.3, pp.276-290, 2017.

M. Goldberg, Job exposure matrices in industry, International journal of epidemiology, vol.22, issue.Supplement_2, pp.10-15, 1993.

E. J. Grant, Solid cancer incidence among the Life Span Study of atomic bomb survivors, Radiation research, vol.187, issue.5, pp.513-537, 2017.

J. Grellier, Risk of lung cancer mortality in nuclear workers from internal exposure to alpha particle-emitting radionuclides, Epidemiology, 2017.

G. Canu and I. , Does uranium induce circulatory diseases? First results from a French cohort of uranium workers, Occupational and environmental medicine, vol.69, issue.6, pp.404-413, 2012.

G. Canu, I. , J. , S. Cardis, and E. , Uranium carcinogenicity in humans might depend on the physical and chemical nature of uranium and its isotopic composition: results from pilot epidemiological study of French nuclear workers, Cancer Causes Control, vol.22, 1563.

G. Canu and I. , Effects of chronic uranium internal exposure on mortality: results of a pilot study among French nuclear workers, 2014.

, , vol.62, pp.339-50

J. H. Hendry, M. Akahoshi, L. S. Wang, S. E. Lipshultz, F. A. Stewart et al., Radiation-induced cardiovascular injury, Radiation and environmental biophysics, vol.47, issue.2, pp.189-193, 2008.

. Hleg, Expert Group (HLEG). Final report of High Level and, 2009.

S. Hoffmann, E. Rage, D. Laurier, P. Laroche, C. Guihenneuc et al., Accounting for Berkson and Classical Measurement Error in Radon Exposure Using a Bayesian Structural Approach in the Analysis of Lung Cancer Mortality in the French Cohort of Uranium Miners, Radiation research, vol.187, issue.2, pp.196-209, 2017.

W. Hsu, The incidence of leukemia, lymphoma and multiple myeloma among atomic bomb survivors, Radiation research, vol.179, issue.3, pp.361-382, 2013.

M. Chen and D. Sinha, Limits for intake of radionuclides by workers. ICRP Publication 30, Part 1. Annals of the ICRP 2., ICRP (1994) Human respiratory tract model for radiological protection. ICRP Publication 66, IARC (1988) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol.43, 1979.

, Individual monitoring for internal exposure of workers. ICRP Publication 78, Annals of the ICRP, 1997.

, The 2007 recommendations of the International Commission on Radiological Protection ICRP Publication 103, Annals of the ICRP, vol.36, issue.2-4, 2006.

, Nuclear Decay Data for Dosimetric Calculations. ICRP Publication 107, Annals of the ICRP, vol.38, issue.3, 2008.

, Occupational Intakes of Radionuclides: Part 1. ICRP Publication 130, Annals of the ICRP, vol.44, 2015.

. Irsn, Norme ISO 20553: Surveillance professionnelle des travailleurs exposés à un risque de contamination interne par des matérieux radioactifs, 2006.

L. M. Juliao, D. R. Melo, and S. Wdo, , 2007.

H. Kondo, M. Soda, M. Mine, and K. Yokota, Effects of radiation on the incidence of prostate cancer among Nagasaki atomic bomb survivors, Cancer science, vol.104, issue.10, pp.1368-71, 2013.

P. C. Konturek, T. Brzozowski, and S. J. Konturek, Gut clock: implication of circadian rhythms in the gastrointestinal tract, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, vol.62, issue.2, pp.139-50, 2011.

M. Kreuzer, Low-dose ionising radiation and cardiovascular diseases--Strategies for molecular epidemiological studies in Europe, Mutation research Reviews in mutation research, vol.764, pp.90-100, 2015.

M. Kreuzer, Mortality from internal and external radiation exposure in a cohort of male German uranium millers, International archives of occupational and environmental health, vol.88, issue.4, pp.431-472, 2015.

M. Kreuzer, Occupational dust and radiation exposure and mortality from stomach cancer among German uranium miners, Occupational and environmental medicine, pp.2011-100051, 1946.

O. Laurent, Concerted Uranium Research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure, J Radiol Prot, vol.36, issue.2, pp.319-364, 2016.

D. Laurier, Progress in understanding radon risk, pp.65-89, 2013.

K. Leuraud, L. Fournier, E. Samson, S. Caër-lorho, and D. Laurier, , 2017.

K. Leuraud, Ionising radiation and risk of death from leukaemia and lymphoma in radiationmonitored workers (INWORKS): an international cohort study, The Lancet Haematology, vol.2, issue.7, pp.276-81, 2015.

C. Y. Li and F. C. Sung, A review of the healthy worker effect in occupational epidemiology, Occup Med (Lond), vol.49, issue.4, pp.225-234, 1999.

L. F. Li, Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review), International journal of molecular medicine, vol.34, issue.2, pp.372-80, 2014.

M. P. Little, Radiation and circulatory disease, Mutation research, vol.770, pp.299-318, 2016.

M. P. Little, Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks, Environmental health perspectives, vol.120, issue.11, p.1503, 2012.

M. P. Little, Impact of uncertainties in exposure assessment on estimates of thyroid cancer risk among Ukrainian children and adolescents exposed from the Chernobyl accident, PloS one, vol.9, issue.1, p.85723, 2014.

J. H. Lubin, Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies, American journal of epidemiology, vol.170, issue.8, pp.937-984, 2009.

J. L. Marchand, Generating person-years and calculating SMR using SAS: a simple program for exact calculations, Revue d'epidemiologie et de sante publique, vol.58, pp.370-374, 2010.

J. L. Marchand, E. Imbernon, and M. Goldberg, Analyse de la mortalité générale et par cancer des travailleurs et ex-travailleurs d, 2005.

J. W. Marsh, Dosimetric models used in the Alpha-Risk project to quantify exposure of uranium miners to radon gas and its progeny, Radiation protection dosimetry, vol.130, issue.1, pp.101-107, 2008.

J. W. Marsh, Dosimetric calculations for uranium miners for epidemiological studies, Radiation protection dosimetry, vol.149, issue.4, pp.371-83, 2012.

D. Mcgeoghegan and K. Binks, The mortality and cancer morbidity experience of workers at the Capenhurst uranium enrichment facility 1946-95, Journal of radiological protection : official journal of the Society for Radiological Protection, vol.20, issue.4, pp.381-401, 2000.

D. Mcgeoghegan and K. Binks, The mortality and cancer morbidity experience of workers at the Springfields uranium production facility, 1946-95, Journal of Radiological Protection, vol.20, issue.2, p.111, 2000.

S. A. Meo and F. Suraya, Effect of environmental air pollution on cardiovascular diseases, European review for medical and pharmacological sciences, vol.19, issue.24, pp.4890-4897, 2015.

M. M. Methner, H. A. Feng, and D. F. Utterback, , pp.1150-1157, 200116.

E. Michel, E. Jougla, F. Hatton, and L. Chérié-challine, Principaux indicateurs de mortalité, 1995.

M. Möhner, M. Lindtner, and H. Otten, , 2008.

M. Möhner, M. Lindtner, H. Otten, and H. G. Gille, Leukemia and exposure to ionizing radiation among German uranium miners, American journal of industrial medicine, vol.49, issue.4, pp.238-248, 2006.

T. Mori, Summary of entire Japanese thorotrast follow-up study: updated 1998, Radiation research, vol.152, issue.6, pp.84-91, 1999.

, Implications of Recent Epidemiological Studies for the Linear-Non Threshold Model and Radiation Protection, NCRP, 2018.

M. Neuilly, Limite de détection. Techniques de l'ingénieur Analyse et caractérisation, vol.1, 1998.

A. M. Nomura and L. N. Kolonel, Prostate cancer: a current perspective, Epidemiologic reviews, vol.13, pp.200-227, 1991.

, Committee on Health Risks of Exposure to Radon (BEIR VI). Health Effects of Exposure to Radon: BEIR VI NRC (2006) Health risks from exposure to low levels of ionizing radiation : BEIR VII, NRC, 1999.

D. C. Washington,

K. Ozasa, Studies of the mortality of atomic bomb survivors, Radiation research, vol.14, issue.3, pp.229-272, 2012.

D. A. Pierce, Y. Shimizu, D. L. Preston, M. Vaeth, and K. Mabuchi, Studies of the mortality of atomic bomb survivors, Radiation research, vol.146, issue.1, pp.1-27, 1996.

L. E. Pinkerton, T. F. Bloom, M. J. Hein, and E. M. Ward, Mortality among a cohort of uranium mill workers: an update, Occupational and environmental medicine, vol.61, issue.1, pp.57-64, 2004.

M. Puncher, A. Birchall, and R. K. Bull, An intake prior for the Bayesian analysis of plutonium and uranium exposures in an epidemiology study, Radiation protection dosimetry, vol.162, issue.3, pp.306-321, 2014.

S. D. Putnam, , 2000.

E. Rage, S. Caer-lorho, D. Drubay, S. Ancelet, P. Laroche et al., Mortality analyses in the updated French cohort of uranium miners (1946-2007), International archives of occupational and environmental health, vol.88, issue.6, pp.717-747, 2015.

E. Rage, S. Caer-lorho, and D. Laurier, Low radon exposure and mortality among Jouac uranium miners: an update of the French cohort (1946-2007), Journal of radiological protection : official journal of the Society for Radiological Protection, vol.38, issue.1, pp.92-108, 2018.

E. Rage, Risk of lung cancer mortality in relation to lung doses among French uranium miners: follow-up 1956-1999, Radiation research, vol.177, issue.3, pp.288-97, 2012.

V. Rapisarda, Hepatocellular carcinoma and the risk of occupational exposure, World journal of hepatology, vol.8, issue.13, pp.573-90, 2016.

V. Rapisarda, Cadmium exposure and prostate cancer: insights, mechanisms and perspectives, Front Biosci, vol.23, pp.1687-1700, 2018.

M. Reginatto, , 2006.

S. Rican, E. Jougla, and G. (. Salem, Inégalités socio-spatiales de mortalité en France. BEH, pp.30-31, 2003.

D. Richardson, Ionizing radiation and leukemia mortality among Japanese atomic bomb survivors, Radiation research, vol.172, issue.3, pp.368-382, 1950.

D. B. Richardson, Site-specific Solid Cancer Mortality After Exposure to Ionizing Radiation: A Cohort Study of Workers (INWORKS), Epidemiology, vol.29, issue.1, pp.31-40, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02457230

D. B. Richardson, Risk of cancer from occupational exposure to ionising radiation: retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS), BMJ, vol.351, p.5359, 2015.

D. B. Richardson and S. Wing, Lung cancer mortality among workers at a nuclear materials fabrication plant, American journal of industrial medicine, vol.49, issue.2, pp.102-113, 2006.

A. Rocco, D. Compare, D. Angrisani, S. Zamparelli, M. Nardone et al., Alcoholic disease: liver and beyond, World journal of gastroenterology, vol.20, issue.40, pp.14652-14661, 2014.

A. E. Sahmoun, L. D. Case, S. A. Jackson, and G. G. Schwartz, Cadmium and prostate cancer: a critical epidemiologic analysis, Cancer investigation, vol.23, issue.3, pp.256-263, 2005.

E. Samson, Etude de faisabilité: Reconstitution d'une cohorte des travailleurs des usines de traitement chimique du minerai d'uranium, 2014.

E. Samson, , 2018.

E. Samson, Cancer and non-cancer mortality among French uranium cycle workers: the TRACY cohort, BMJ open, vol.6, issue.4, p.10316, 2016.

D. W. Schafer and E. S. Gilbert, Some statistical implications of dose uncertainty in radiation dose-response analyses, Radiation research, vol.166, issue.1, pp.303-315, 2006.

. Sfmt, Bonnes pratiques professionnelles. Surveillance médico-professionnelle de l'exposition interne aux radionucléides en INB, 2011.

G. B. Sharp, The relationship between internally deposited alpha-particle radiation and subsite-specific liver cancer and liver cirrhosis: an analysis of published data, Journal of radiation research, vol.43, issue.4, pp.371-80, 2002.

Y. Shimizu, Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, BMJ, vol.340, p.5349, 2010.

S. R. Silver, Mortality and ionising radiation exposures among workers employed at the Fernald Feed Materials Production Center, Occupational and environmental medicine, vol.70, issue.7, pp.453-63, 2013.

S. L. Simon, F. O. Hoffman, and E. Hofer, The two-dimensional Monte Carlo: a new methodologic paradigm for dose reconstruction for epidemiological studies, Radiation research, vol.183, issue.1, pp.27-41, 2015.

M. Souidi, , 2009.

, Annales de biologie clinique, vol.67, issue.1, pp.23-38

L. Stammler, A. Uhl, B. Mayer, and F. Keller, Renal effects and carcinogenicity of occupational exposure to uranium: a meta-analysis, Nephron extra, vol.6, issue.1, pp.1-11, 2016.

L. Stayner, A Monte Carlo maximum likelihood method for estimating uncertainty arising from shared errors in exposures in epidemiological studies of nuclear workers, Radiation research, vol.168, issue.6, pp.757-63, 2007.

D. O. Stram, Shared dosimetry error in epidemiological dose-response analyses, PloS one, vol.10, issue.3, p.119418, 2015.

N. Taylor, , 1991.

M. J. Thun, D. B. Baker, K. Steenland, A. B. Smith, W. Halperin et al., Renal toxicity in uranium mill workers, Scandinavian journal of work, environment & health, vol.11, issue.2, pp.83-90, 1985.

M. Tirmarche, J. Harrison, D. Laurier, F. Paquet, E. Blanchardon et al., Lung cancer risk from radon and progeny and statement on radon, Annals of the ICRP, vol.40, issue.1, pp.1-64, 2010.

L. Tomasek and I. Malatova, Leukaemia and lymphoma among Czech uranium miners, Medical Radiology and Radiation Safety, vol.51, 2006.

, Sources and Effects of Ionizing Radiation, Report of the general Assembly with Scientifc Annexes, vol.I, 2000.

. Unscear, Summary of low-dose radiation effects on health, 2010.

, UNSCEAR (2012) UNSCEAR 2012 Report. Sources, effects and risks of ionizing radiation

, UNSCEAR (2016) Sources, effects and risks of Ionizing Radiation. Annex D. Biological effects of selected internal emitters -uranium

B. Vacquier, The influence of multiple types of occupational exposure to radon, gamma rays and long-lived radionuclides on mortality risk in the French "post-55" sub-cohort of uranium miners, Radiation research, vol.176, issue.6, pp.796-806, 2011.

D. Venzon and S. Moolgavkar, A method for computing profile-likelihood-based confidence intervals, pp.87-94, 1988.

M. V. Vyas, Shift work and vascular events: systematic review and meta-analysis, BMJ, vol.345, p.4800, 2012.

J. L. Anderson, S. J. Bertke, and D. J. Tollerud, Dose-response relationships between internally-deposited uranium and select health outcomes in gaseous diffusion plant workers, WHO (2014) WHO handbook on indoor radon, 1948.

J. H. Yiin, Mortality in a combined cohort of uranium enrichment workers, American journal of industrial medicine, vol.60, issue.1, pp.96-108, 2017.

J. H. Yiin, A nested case-control study of multiple myeloma risk and uranium exposure among workers at the Oak Ridge Gaseous Diffusion Plant, Radiation research, vol.171, issue.6, pp.637-645, 2009.

L. B. Zablotska, N. Fenske, M. Schnelzer, S. Zhivin, D. Laurier et al., Analysis of mortality in a pooled cohort of Canadian and German uranium processing workers with no mining experience, International archives of occupational and environmental health, vol.91, issue.1, pp.91-103, 2018.

L. B. Zablotska, R. S. Lane, and S. E. Frost, Mortality (1950-1999) and cancer incidence (1969-1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and gamma-ray doses, BMJ open, vol.3, issue.2, 2013.

S. Zhivin, Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case-control study, Occupational and environmental medicine, 2017.

S. Zhivin, Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case-control study, Occupational and environmental medicine, vol.75, issue.4, pp.270-276, 2018.

S. Zhivin, Mortality (1968-2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds, Occupational and environmental medicine, vol.73, issue.3, pp.167-74, 2016.

S. Zhivin and D. Laurier, Guseva Canu I (2014) Health effects of occupational exposure to uranium: do physicochemical properties matter?, International journal of radiation biology, vol.90, issue.11, pp.1104-1117

K. Zu and E. Giovannucci, Smoking and aggressive prostate cancer: a review of the epidemiologic evidence, Cancer causes & control, vol.20, issue.10, pp.1799-1810, 2009.

, Ajusté sur le sexe, l'âge, l'année de naissance, le statut socio-économique (SES)

, Ajusté sur le sexe, l'âge, l'année de naissance, le statut socio-économique (SES) et le statut tabagique

, Ajusté sur le sexe, l'âge, l'année de naissance, le statut socio-économique (SES) et l'indice de masse corporelle

, Ajusté sur le sexe, l'âge, l'année de naissance, le statut socio-économique (SES) et l'indice glycémique (IG)

, Ajusté sur le sexe, l'âge, l'année de naissance, le statut socio-économique (SES) et la pression artérielle (PA)

. Ajusté, L. De-naissance, (. Statut-socio-Économique, P. A. Ses), and . Imc, NE' indique que la borne inférieure de l'intervalle de confiance n'a pas pu être calculé car elle se trouve à la limite de l