L. Pasteur, Note sur la maladie nouvelle provoquee par la salive d'un enfant mort de la rage, pp.94-103, 1881.

B. Prescott and . Microbiologie, , 2010.

R. Austrian, Pneumococcus: the first one hundred years, Rev. Infect. Dis, vol.3, pp.183-189, 1981.

A. Kadioglu, J. N. Weiser, J. C. Paton, and P. W. Andrew, The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease, Nat. Rev. Microbiol, vol.6, pp.288-301, 2008.

E. Jauneikaite, Current methods for capsular typing of Streptococcus pneumoniae, J. Microbiol. Methods, vol.113, pp.41-49, 2015.

U. B. Sorensen, J. Blom, A. Birch-andersen, and J. Henrichsen, Ultrastructural localization of capsules, cell wall polysaccharide, cell wall proteins, and F antigen in pneumococci, Infect. Immun, vol.56, pp.1890-1896, 1988.

U. B. Sorensen, J. Henrichsen, H. C. Chen, and S. C. Szu, Covalent linkage between the capsular polysaccharide and the cell wall peptidoglycan of Streptococcus pneumoniae revealed by immunochemical methods, Microb. Pathog, vol.8, pp.325-334, 1990.

P. Jin, First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children, J. Infect. Dis, vol.200, pp.1375-1380, 2009.

M. B. Oliver, M. P. Van-der-linden, S. A. Kuntzel, J. S. Saad, and M. H. Nahm, Discovery of Streptococcus pneumoniae Serotype 6 Variants with Glycosyltransferases Synthesizing Two Differing Repeating Units, J. Biol. Chem, vol.288, pp.25976-25985, 2013.

J. J. Calix and M. H. Nahm, A New Pneumococcal Serotype, 11E, Has a Variably Inactivated wcjE Gene, J. Infect. Dis, vol.202, pp.29-38, 2010.

J. J. Calix, Biochemical, Genetic, and Serological Characterization of Two Capsule Subtypes among Streptococcus pneumoniae Serotype 20 Strains: DISCOVERY OF A NEW PNEUMOCOCCAL SEROTYPE, J. Biol. Chem, vol.287, pp.27885-27894, 2012.

R. Austrian, Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention, Rev. Infect. Dis, vol.3, pp.1-17, 1981.

M. Martin, An Outbreak of Conjunctivitis Due to Atypical Streptococcus pneumoniae, N. Engl. J. Med, vol.348, pp.1112-1121, 2003.

N. F. Crum, C. P. Barrozo, F. A. Chapman, M. A. Ryan, and K. L. Russell, An Outbreak of Conjunctivitis Due to a Novel Unencapsulated Streptococcus pneumoniae among Military Trainees, Clin. Infect. Dis, vol.39, pp.1148-1154, 2004.

C. Lee, S. D. Banks, J. P. Li, and . Virulence, Immunity, and Vaccine Related to Streptococcus pneumoniae, Crit. Rev. Microbiol, vol.18, pp.89-114, 1991.

M. Abeyta, G. G. Hardy, and J. Yother, Genetic alteration of capsule type but not PspA type affects accessibility of surface-bound complement and surface antigens of Streptococcus pneumoniae, Infect. Immun, vol.71, pp.218-225, 2003.

C. M. Macleod and M. R. Kraus, Relation of virulence of pneumococcal strains for mice to the quantity of capsular polysaccharide formed in vitro, J. Exp. Med, vol.92, pp.1-9, 1950.

M. K. Hostetter, Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production, J. Infect. Dis, vol.153, pp.682-693, 1986.

S. J. Tilley, E. V. Orlova, R. J. Gilbert, P. W. Andrew, and H. R. Saibil, Structural Basis of Pore Formation by the Bacterial Toxin Pneumolysin, Cell, vol.121, pp.247-256, 2005.

R. A. Hirst, A. Kadioglu, C. O'callaghan, and P. W. Andrew, The role of pneumolysin in pneumococcal pneumonia and meningitis, Clin. Exp. Immunol, vol.138, pp.195-201, 2004.

A. Kadioglu, W. Coward, M. J. Colston, C. R. Hewitt, and P. W. Andrew, CD4-Tlymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection, Infect. Immun, vol.72, pp.2689-2697, 2004.

T. J. Mitchell, P. W. Andrew, F. K. Saunders, A. N. Smith, and G. J. Boulnois, Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein, Mol. Microbiol, vol.5, pp.1883-1888, 1991.

S. D. Bentley, Genetic Analysis of the Capsular Biosynthetic Locus from All 90

, Pneumococcal Serotypes. PLoS Genet, vol.2, p.31, 2006.

S. Bergmann and S. Hammerschmidt, Versatility of pneumococcal surface proteins, Microbiol. Read. Engl, vol.152, pp.295-303, 2006.

K. Overweg, The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses, Infect. Immun, vol.68, pp.4180-4188, 2000.

S. Manco, Pneumococcal Neuraminidases A and B Both Have Essential Roles during Infection of the Respiratory Tract and Sepsis, Infect. Immun, vol.74, pp.4014-4020, 2006.

E. Varon and C. Janoir, , 2016.

B. M. Gray and H. C. Dillon, Epidemiological studies of Streptococcus pneumoniae in infants: antibody to types 3, 6, 14, and 23 in the first two years of life, J. Infect. Dis, vol.158, pp.948-955, 1988.

P. Chavanet, Portage nasopharyngé, sensibilités et sérotypes de Streptococcus pneumoniae et Haemophilus influenzae chez les enfants de crèches, Médecine Mal. Infect, vol.41, pp.307-317, 2011.

J. F. Brundage, Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness, Lancet Infect. Dis, vol.6, pp.303-312, 2006.

D. Bogaert, Pneumococcal carriage in children in The Netherlands: a molecular epidemiological study, J. Clin. Microbiol, vol.39, pp.3316-3320, 2001.

B. B. Mook-kanamori, M. Geldhoff, T. Van-der-poll, and D. Van-de-beek, Pathogenesis and Pathophysiology of Pneumococcal Meningitis, Clin. Microbiol. Rev, vol.24, pp.557-591, 2011.

B. Dunais, C. Laurans, P. Bruno, H. Carsenti-dellamonica, and M. Roussel-delvallez, Portage de pneumocoques dans les établissements d'accueil du jeune enfant des Alpes-Maritimes et du Nord, Médecine Mal. Infect, vol.38, pp.30-34, 2008.

A. L. Nelson, Capsule enhances pneumococcal colonization by limiting mucusmediated clearance, Infect. Immun, vol.75, pp.83-90, 2007.

A. M. Burnaugh, L. J. Frantz, and S. J. King, Growth of Streptococcus pneumoniae on Human Glycoconjugates Is Dependent upon the Sequential Activity of Bacterial Exoglycosidases, J. Bacteriol, vol.190, pp.221-230, 2008.

S. J. King, K. R. Hippe, and J. N. Weiser, Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae, Mol. Microbiol, vol.59, pp.961-974, 2006.

K. M. Davis, H. T. Akinbi, A. J. Standish, and J. N. Weiser, Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae, PLoS Pathog, vol.4, p.1000241, 2008.

M. I. Crisostomo, Attenuation of penicillin resistance in a peptidoglycan Oacetyl transferase mutant of Streptococcus pneumoniae, Mol. Microbiol, vol.61, pp.1497-1509, 2006.

W. Vollmer and A. Tomasz, Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae, Infect. Immun, vol.70, pp.7176-7178, 2002.

M. Shaper, S. K. Hollingshead, W. H. Benjamin, and D. E. Briles, PspA Protects Streptococcus pneumoniae from Killing by Apolactoferrin, and Antibody to PspA Enhances Killing of Pneumococci by Apolactoferrin, Infect. Immun, vol.72, pp.5031-5040, 2004.

D. Bogaert, C. M. Thompson, K. Trzcinski, R. Malley, and M. Lipsitch, The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model, Vaccine, vol.28, pp.681-685, 2010.

C. Picard, A. Puel, J. Bustamante, C. Ku, and J. Casanova, Primary immunodeficiencies associated with pneumococcal disease, Curr. Opin. Allergy Clin. Immunol, vol.3, pp.451-459, 2003.

C. S. Kaetzel, Polymeric Ig receptor: defender of the fort or Trojan horse?, Curr. Biol. CB, vol.11, pp.35-38, 2001.

Y. Kurono, H. Shigemi, K. Shimamura, and G. Mogi, Inhibition of Bacterial Adherence by Nasopharyngeal Secretions, Ann. Otol. Rhinol. Laryngol, vol.100, pp.455-458, 1991.

E. N. Janoff, Killing of Streptococcus pneumoniae by capsular polysaccharidespecific polymeric IgA, complement, and phagocytes, J. Clin. Invest, vol.104, pp.1139-1147, 1999.

C. E. Fasching, Impact of the Molecular Form of Immunoglobulin A on Functional Activity in Defense against Streptococcus pneumoniae, Infect. Immun, vol.75, pp.1801-1810, 2007.

J. N. Weiser, Antibody-enhanced pneumococcal adherence requires IgA1 protease, Proc. Natl. Acad. Sci, vol.100, pp.4215-4220, 2003.

G. D. Raphael, Pathophysiology of rhinitis. Lactoferrin and lysozyme in nasal secretions, J. Clin. Invest, vol.84, pp.1528-1535, 1989.

O. Senkovich, Structure of a Complex of Human Lactoferrin N-lobe with

, Pneumococcal Surface Protein A Provides Insight into Microbial Defense Mechanism, J. Mol. Biol, vol.370, pp.701-713, 2007.

A. L. Esposito, C. A. Clark, and W. J. Poirier, An assessment of the factors contributing to the killing of type 3 Streptococcus pneumoniae by human polymorphonuclear leukocytes in vitro, APMIS Acta Pathol. Microbiol. Immunol. Scand, vol.98, pp.111-121, 1990.

. Janeway, Immunobiology: the immune system in health and disease,. in (Garland)

C. Picard, Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency: Medicine (Baltimore), vol.89, pp.403-425, 2010.

E. Tuomanen, B. Hengstler, O. Zak, and A. Tomasz, The role of complement in inflammation during experimental pneumococcal meningitis, Microb. Pathog, vol.1, pp.15-32, 1986.

M. M. Polfliet, Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis, J. Immunol. Baltim. Md, vol.167, pp.4644-4650, 1950.

H. Jarva, T. S. Jokiranta, R. Würzner, and S. Meri, Complement resistance mechanisms of streptococci, Mol. Immunol, vol.40, pp.95-107, 2003.

J. Li, D. T. Glover, A. J. Szalai, S. K. Hollingshead, and D. E. Briles, PspA and PspC Minimize Immune Adherence and Transfer of Pneumococci from Erythrocytes to Macrophages through Their Effects on Complement Activation, Infect. Immun, vol.75, pp.5877-5885, 2007.

C. Neeleman, Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H, Infect. Immun, vol.67, pp.4517-4524, 1999.

J. Hament, Pneumococcal immune adherence to human erythrocytes, Eur. J. Clin. Invest, vol.33, pp.169-175, 2003.

R. B. Alcantara, L. C. Preheim, and M. J. Gentry-nielsen, Pneumolysin-Induced Complement Depletion during Experimental Pneumococcal Bacteremia, Infect. Immun, vol.69, pp.3569-3575, 2001.

J. A. Aas, B. J. Paster, L. N. Stokes, I. Olsen, and F. E. Dewhirst, Defining the Normal Bacterial Flora of the Oral Cavity, J. Clin. Microbiol, vol.43, pp.5721-5732, 2005.

S. D. Brugger, L. J. Hathaway, and K. Muhlemann, Detection of Streptococcus pneumoniae Strain Cocolonization in the Nasopharynx, J. Clin. Microbiol, vol.47, pp.1750-1756, 2009.

B. Park, V. Nizet, and G. Y. Liu, Role of Staphylococcus aureus Catalase in Niche Competition against Streptococcus pneumoniae, J. Bacteriol, vol.190, pp.2275-2278, 2008.

S. Dawid, A. M. Roche, and J. N. Weiser, The blp Bacteriocins of Streptococcus pneumoniae Mediate Intraspecies Competition both In Vitro and In Vivo, Infect. Immun, vol.75, pp.443-451, 2007.

J. A. Mccullers, Insights into the Interaction between Influenza Virus and Pneumococcus, Clin. Microbiol. Rev, vol.19, pp.571-582, 2006.

D. M. Morens, J. K. Taubenberger, and A. S. Fauci, Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness, J. Infect. Dis, vol.198, pp.962-970, 2008.

Y. Chien, K. P. Klugman, and D. M. Morens, Bacterial Pathogens and Death during the 1918 Influenza Pandemic, N. Engl. J. Med, vol.361, pp.2582-2583, 2009.

A. M. Geddes, Influenza and bacterial pneumonia, Int. J. Antimicrob. Agents, vol.34, pp.293-294, 2009.

, Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) -United States, Centers for Disease Control and Prevention (CDC), vol.58, pp.1071-1074, 2009.

G. Regev-yochay, Association Between Carriage of Streptococcus pneumoniae and Staphylococcus aureus in Children, JAMA, vol.292, p.716, 2004.

D. Bogaert, Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children, The Lancet, vol.363, pp.1871-1872, 2004.

E. S. Lysenko, A. J. Ratner, A. L. Nelson, and J. N. Weiser, The Role of Innate Immune Responses in the Outcome of Interspecies Competition for Colonization of Mucosal Surfaces, PLoS Pathog, vol.1, p.1, 2005.

T. Lux, M. Nuhn, R. Hakenbeck, and P. Reichmann, Diversity of Bacteriocins and Activity Spectrum in Streptococcus pneumoniae, J. Bacteriol, vol.189, pp.7741-7751, 2007.

J. A. Preston and D. H. Dockrell, Virulence factors in pneumococcal respiratory pathogenesis, Future Microbiol, vol.3, pp.205-221, 2008.

H. Li-korotky, Interaction of pneumococcal phase variation and middle ear pressure/gas composition: An in vitro model of simulated otitis media, Microb. Pathog, vol.45, pp.201-206, 2008.

D. R. Cundell, J. N. Weiser, J. Shen, A. Young, and E. I. Tuomanen, Relationship between colonial morphology and adherence of Streptococcus pneumoniae, Infect. Immun, vol.63, pp.757-761, 1995.

J. N. Weiser, R. Austrian, P. K. Sreenivasan, and H. R. Masure, Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization, Infect. Immun, vol.62, pp.2582-2589, 1994.

J. O. Kim, Relationship between cell surface carbohydrates and intrastrain variation on opsonophagocytosis of Streptococcus pneumoniae, Infect. Immun, vol.67, pp.2327-2333, 1999.

C. Hyams, Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype, Infect. Immun, vol.78, pp.716-725, 2010.

D. R. Cundell, B. J. Pearce, J. Sandros, A. M. Naughton, and H. R. Masure, Peptide permeases from Streptococcus pneumoniae affect adherence to eucaryotic cells, Infect. Immun, vol.63, pp.2493-2498, 1995.

T. M. Wizemann, Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.7985-7990, 1996.

D. R. Cundell, N. P. Gerard, C. Gerard, I. Idanpaan-heikkila, and E. I. Tuomanen, Streptococcus pneumoniae anchor to activated human cells by the receptor for plateletactivating factor, Nature, vol.377, pp.435-438, 1995.

J. R. Zhang, The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells, Cell, vol.102, pp.827-837, 2000.

C. Janoir and E. Varon, Infections à pneumocoques, EMC -Mal. Infect, vol.11, pp.1-17, 2014.

B. Henriques-normark and E. I. Tuomanen, The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis. Cold Spring Harb, Perspect. Med, vol.3, pp.10215-010215, 2013.

A. Réseau, Rapport de l'enquete sur la surveillance de la consommation d'antibiotiques. resultats 2015, 2017.

N. R. Cooper and G. R. Nemerow, The role of antibody and complement in the control of viral infections, J. Invest. Dermatol, vol.83, pp.121-127, 1984.

K. Murphy, C. Weaver, and . Janeway's-immunobiology, , 2016.

F. Martin and J. Kearney, B1 cells: similarities and differences with other B cell subsets, Curr. Opin. Immunol, vol.13, pp.195-201, 2001.

K. R. Alugupalli, A distinct role for B1b lymphocytes in T cell-independent immunity, Curr. Top. Microbiol. Immunol, vol.319, pp.105-130, 2008.

J. Geginat, Plasticity of Human CD4 T Cell Subsets. Front. Immunol, vol.5, 2014.

Y. Lin, S. R. Slight, and S. A. Khader, Th17 cytokines and vaccine-induced immunity, Semin. Immunopathol, vol.32, pp.79-90, 2010.

P. Kumar, K. Chen, and J. K. Kolls, Th17 cell based vaccines in mucosal immunity, Curr. Opin. Immunol, vol.25, pp.373-380, 2013.

S. Crotty, A brief history of T cell help to B cells, Nat. Rev. Immunol, vol.15, pp.185-189, 2015.

S. Bentebibel, Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination, Sci. Transl. Med, vol.5, pp.176-208, 2013.

D. Tarlinton and K. Good-jacobson, Diversity Among Memory B Cells: Origin, Consequences, and Utility. Science, vol.341, pp.1205-1211, 2013.

C. C. Goodnow, C. G. Vinuesa, K. L. Randall, F. Mackay, and R. Brink, Control systems and decision making for antibody production, Nat. Immunol, vol.11, pp.681-688, 2010.

K. Reif, Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position, Nature, vol.416, pp.94-99, 2002.

I. C. Maclennan, Extrafollicular antibody responses, Immunol. Rev, vol.194, pp.8-18, 2003.

D. Silva, N. S. Klein, and U. , Dynamics of B cells in germinal centres, Nat. Rev. Immunol, vol.15, pp.137-148, 2015.

M. A. Linterman and C. G. Vinuesa, T Follicular Helper Cells During Immunity and Tolerance, Progress in Molecular Biology and Translational Science, vol.92, pp.207-248, 2010.

S. Crotty, Follicular Helper CD4 T Cells (T(FH) ), Annu. Rev. Immunol, vol.29, pp.621-663, 2011.

T. Kurosaki, K. Kometani, W. Ise, and . Memory-b-cells, Nat. Rev. Immunol, vol.15, pp.149-159, 2015.

K. L. Good-jacobson and M. J. Shlomchik, Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics, J. Immunol, vol.185, pp.3117-3125, 2010.

Z. Hao and K. Rajewsky, Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow, J. Exp. Med, vol.194, pp.1151-1164, 2001.

T. L. Carvalho, T. Mota-santos, A. Cumano, J. Demengeot, and P. Vieira, Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)-mice, J. Exp. Med, vol.194, pp.1141-1150, 2001.

S. Plotkin, W. Orenstein, and . Offit, P. Vaccines, 2008.

S. Merluzzi, Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells, Blood, vol.115, pp.2810-2817, 2010.

K. Chen, Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils, Nat. Immunol, vol.10, pp.889-898, 2009.

J. Gauchat, Induction of human IgE synthesis in B cells by mast cells and basophils, Nature, vol.365, pp.340-343, 1993.

C. Siegrist and R. Aspinall, B-cell responses to vaccination at the extremes of age, Nat. Rev. Immunol, vol.9, p.185, 2009.

A. M. Van-deursen, The impact of the 13-valent pneumococcal conjugate vaccine on pneumococcal carriage in the Community Acquired Pneumonia Immunization Trial in Adults (CAPiTA) Study, Clin. Infect. Dis, 2018.

, Avis relatif à la vaccination contre le pneumocoque par le vaccin Pneumo 23® chez l'adulte et l'enfant âgé de 5 ans et plus infectés par le VIH, 2009.

, Avis relatif au schéma vaccinal de la vaccination par le vaccin anti-pneumococcique congugué heptavalent, 2008.

, Haut Conseil de la Santé Publique. HCSP. Avis relatif à la vaccination par le vaccin pneumococcique conjugué 13-valent, 2009.

, Avis relatif aux recommandations de la vaccination pour les adultes et les enfants âgés de plus de 2 ans à risque d'infection invasive à pneumocoque, 2013.

, Haut Conseil de la Santé Publique. HCSP. Avis relatif aux recommendations vaccinales contre les infections à pneumocoque pour les adultes, 2017.

C. D. Barrett, Multiple antigen for immunization against poliomyelitis, diphtheria, pertussis, and tetanus. II. Response of infants and young children to primary immunization and eighteen-month booster, Am. J. Public Health Nations Health, vol.49, pp.644-655, 1959.

N. B. Halasa, A. Shea, J. R. Shi, B. J. Lafleur, and K. M. Edwards, Poor Immune Responses to a Birth Dose of Diphtheria, Tetanus, and Acellular Pertussis Vaccine, J. Pediatr, vol.153, 2008.

R. W. Provenzano, L. H. Wetterlow, and C. L. Sullivan, Immunization and Antibody Response in the Newborn Infant: Pertussis Inoculation within Twenty-Four Hours of Birth, N. Engl. J. Med, vol.273, pp.959-965, 1965.

L. D. Felton, G. Kauffmann, B. Prescott, and B. Ottinger, Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides, J. Immunol. Baltim. Md, vol.74, pp.17-26, 1950.

H. Käyhty, V. Karanko, H. Peltola, and P. H. Mäkelä, Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory, Pediatrics, vol.74, pp.857-865, 1984.

D. M. Granoff, A. Chacko, K. R. Lottenbach, and K. E. Sheetz, Immunogenicity of Haemophilus influenzae type b polysaccharide-outer membrane protein conjugate vaccine in patients who acquired Haemophilus disease despite previous vaccination with type b polysaccharide vaccine, J. Pediatr, vol.114, pp.925-933, 1989.

S. J. Holmes and D. M. Granoff, The biology of Haemophilus influenzae type b vaccination failure, J. Infect. Dis, vol.165, issue.1, pp.121-128, 1992.

D. M. Granoff, R. K. Gupta, R. B. Belshe, and E. L. Anderson, Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination, J. Infect. Dis, vol.178, pp.870-874, 1998.

H. Jokhdar, Immunologic hyporesponsiveness to serogroup C but not serogroup A following repeated meningococcal A/C polysaccharide vaccination in Saudi Arabia, Clin. Diagn. Lab. Immunol, vol.11, pp.83-88, 2004.

N. E. Macdonald, Induction of immunologic memory by conjugated vs plain meningococcal C polysaccharide vaccine in toddlers: a randomized controlled trial, JAMA, vol.280, pp.1685-1689, 1998.

A. Leach, Induction of immunologic memory in Gambian children by vaccination in infancy with a group A plus group C meningococcal polysaccharide-protein conjugate vaccine, J. Infect. Dis, vol.175, pp.200-204, 1997.

J. Maclennan, Immunologic Memory 5 Years after Meningococcal A/C Conjugate Vaccination in Infancy, J. Infect. Dis, vol.183, pp.97-104, 2001.

R. Borrow, Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A/C polysaccharide vaccine and vaccine-naïve controls, Vaccine, vol.19, pp.3043-3050, 2001.

D. M. Vu, Priming for Immunologic Memory in Adults by Meningococcal Group C Conjugate Vaccination, Clin. Vaccine Immunol, vol.13, pp.605-610, 2006.

H. Keyserling, Safety, Immunogenicity, and Immune Memory of a Novel Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (MCV-4) in Healthy Adolescents, Arch. Pediatr. Adolesc. Med, vol.159, p.907, 2005.

N. E. Macdonald, S. A. Halperin, B. J. Law, L. E. Danzig, and D. M. Granoff, Can meningococcal C conjugate vaccine overcome immune hyporesponsiveness induced by previous administration of plain polysaccharide vaccine, JAMA, vol.283, pp.1826-1827, 2000.

Y. Al-mazrou, Serologic Responses to ACYW135 Polysaccharide Meningococcal Vaccine in Saudi Children under 5 Years of Age, Infect. Immun, vol.73, pp.2932-2939, 2005.

H. Käyhty, V. Karanko, H. Peltola, S. Sarna, and P. H. Mäkelä, Serum antibodies to capsular polysaccharide vaccine of group A Neissera meningitidis followed for three years in infants and children, J. Infect. Dis, vol.142, pp.861-868, 1980.

R. Borrow, Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults, Vaccine, vol.19, pp.1129-1132, 2000.

F. M. Russell, Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial, Vaccine, vol.28, pp.3341-3349, 2010.

S. T. Sigurdardottir, Decreased immune response to pneumococcal conjugate vaccine after 23-valent pneumococcal polysaccharide vaccine in children, Vaccine, vol.32, pp.417-424, 2014.

E. A. Clutterbuck, Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells, J. Infect. Dis, vol.205, pp.1408-1416, 2012.

D. M. Musher, A. M. Rueda, M. H. Nahm, E. A. Graviss, and M. C. Rodriguez-barradas, Initial and Subsequent Response to Pneumococcal Polysaccharide and Protein-Conjugate Vaccines Administered Sequentially to Adults Who Have Recovered from Pneumococcal Pneumonia, J. Infect. Dis, vol.198, pp.1019-1027, 2008.

A. De-roux, Comparison of Pneumococcal Conjugate Polysaccharide and Free Polysaccharide Vaccines in Elderly Adults: Conjugate Vaccine Elicits Improved Antibacterial Immune Responses and Immunological Memory, Clin. Infect. Dis, vol.46, pp.1015-1023, 2008.

G. V. Orthopoulos, M. C. Theodoridou, V. A. Ladis, D. K. Tsousis, and V. I. Spoulou, The effect of 23-valent pneumococcal polysaccharide vaccine on immunological priming induced by 7-valent conjugate vaccine in asplenic subjects with ?-thalassemia, Vaccine, vol.27, pp.350-354, 2009.

M. T. Dransfield, Superior Immune Response to Protein-Conjugate versus Free Pneumococcal Polysaccharide Vaccine in Chronic Obstructive Pulmonary Disease, Am. J. Respir. Crit. Care Med, vol.180, pp.499-505, 2009.

I. Papadatou, Antigen-Specific B-Cell Response to 13-Valent Pneumococcal Conjugate Vaccine in Asplenic Individuals With -Thalassemia Previously Immunized With 23-Valent Pneumococcal Polysaccharide Vaccine, Clin. Infect. Dis, vol.59, pp.862-865, 2014.

R. Lazarus, A Randomized Study Comparing Combined Pneumococcal Conjugate and Polysaccharide Vaccination Schedules in Adults, Clin. Infect. Dis, vol.52, pp.736-742, 2011.

I. Papadatou and V. Spoulou, Pneumococcal Vaccination in High-Risk Individuals: Are We Doing It Right? Clin, Vaccine Immunol, vol.23, pp.388-395, 2016.

R. Borrow, Serotype-Specific Immune Unresponsiveness to Pneumococcal Conjugate Vaccine following Invasive Pneumococcal Disease, Infect. Immun, vol.76, pp.5305-5309, 2008.

R. Dagan, N. Givon-lavi, D. Greenberg, B. Fritzell, and C. Siegrist, Nasopharyngeal Carriage of Streptococcus pneumoniae Shortly before Vaccination with a Pneumococcal Conjugate Vaccine Causes Serotype-Specific Hyporesponsiveness in Early Infancy, J. Infect. Dis, vol.201, pp.1570-1579, 2010.

S. P. Bjarnarson, H. Benonisson, G. Del-giudice, and I. Jonsdottir, Pneumococcal Polysaccharide Abrogates Conjugate-Induced Germinal Center Reaction and Depletes Antibody Secreting Cell Pool, Causing Hyporesponsiveness, PLoS ONE, vol.8, p.72588, 2013.

S. Kanswal, Suppressive Effect of Bacterial Polysaccharides on BAFF System Is Responsible for Their Poor Immunogenicity, J. Immunol, vol.186, pp.2430-2443, 2011.

S. F. Brynjolfsson, Hyporesponsiveness Following Booster Immunization With Bacterial Polysaccharides Is Caused by Apoptosis of Memory B Cells, J. Infect. Dis, vol.205, pp.422-430, 2012.

P. Richmond, Meningococcal C Polysaccharide Vaccine Induces Immunologic Hyporesponsiveness in Adults That Is Overcome by Meningococcal C Conjugate Vaccine, J. Infect. Dis, vol.181, pp.761-764, 2000.

J. Sakai and M. Akkoyunlu, The Role of BAFF System Molecules in Host Response to Pathogens, Clin. Microbiol. Rev, vol.30, pp.991-1014, 2017.

L. G. Ng, BAFF costimulation of Toll-like receptor-activatedB-1 cells, Eur. J. Immunol, vol.36, pp.1837-1846, 2006.

R. Elgueta, V. C. De-vries, and R. J. Noelle, The immortality of humoral immunity: Long-lived humoral immunity, Immunol. Rev, vol.236, pp.139-150, 2010.

W. N. Khan, Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis, J. Immunol, vol.183, pp.3561-3567, 2009.

F. Mackay and P. Schneider, Cracking the BAFF code, Nat. Rev. Immunol, vol.9, pp.491-502, 2009.

G. S. Dickinson, M. Akkoyunlu, R. J. Bram, and K. R. Alugupalli, BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses: BAFFR and TACI in B-1b cell function, Ann. N. Y. Acad. Sci, vol.1362, pp.57-67, 2015.

Y. Sasaki, S. Casola, J. L. Kutok, K. Rajewsky, and M. Schmidt-supprian, TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology, J. Immunol. Baltim. Md, vol.173, pp.2245-2252, 1950.

S. Shulga-morskaya, B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation, J. Immunol. Baltim. Md, vol.173, pp.2331-2341, 1950.

K. M. Haas, J. C. Poe, D. A. Steeber, and T. F. Tedder, B-1a and B-1b Cells Exhibit Distinct Developmental Requirements and Have Unique Functional Roles in Innate and Adaptive Immunity to S. pneumoniae, Immunity, vol.23, pp.7-18, 2005.

J. B. Foote and J. F. Kearney, Generation of B Cell Memory to the Bacterial Polysaccharide -1,3 Dextran, J. Immunol, vol.183, pp.6359-6368, 2009.

D. M. Musher, R. Sampath, and M. C. Rodriguez-barradas, The Potential Role for Protein-Conjugate Pneumococcal Vaccine in Adults: What Is the Supporting Evidence?, Clin. Infect. Dis, vol.52, pp.633-640, 2011.

R. Gold, M. L. Lepow, I. Goldschneider, T. L. Draper, and E. C. Gotschlich, Clinical evaluation of group A and group C meningococcal polysaccharide vaccines in infants, J. Clin. Invest, vol.56, pp.1536-1547, 1975.

M. Hinge, H. A. Ingels, H. Slotved, and I. Mølle, Serologic response to a 23-valent pneumococcal vaccine administered prior to autologous stem cell transplantation in patients with multiple myeloma, APMIS, vol.120, pp.935-940, 2012.

J. D. Robertson, Immunogenicity of vaccination against influenza, Streptococcus pneumoniae and Haemophilus influenzae type B in patients with multiple myeloma, Br. J. Cancer, vol.82, pp.1261-1265, 2000.

G. P. Schmid, R. P. Smith, A. L. Baltch, C. A. Hall, and G. Schiffman, Antibody response to pneumococcal vaccine in patients with multiple myeloma, J. Infect. Dis, vol.143, pp.590-597, 1981.

M. Sinisalo, Antibody response to 7-valent conjugated pneumococcal vaccine in patients with chronic lymphocytic leukaemia, Vaccine, vol.26, pp.82-87, 2007.

M. J. Bonten, Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults, N. Engl. J. Med, vol.372, pp.1114-1125, 2015.

A. M. Van-deursen, Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine in Older Adults With and Without Comorbidities in the Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA), Clin. Infect. Dis, vol.65, pp.787-795, 2017.

H. Lode, Dose-ranging study of a single injection of pneumococcal conjugate vaccine (1×, 2×, or 4×) in healthy subjects aged 70 years or older, Vaccine, vol.29, pp.4940-4946, 2011.

C. Y. Chan, Pneumococcal conjugate vaccine primes for antibody responses to polysaccharide pneumococcal vaccine after treatment of Hodgkin's disease, J. Infect. Dis, vol.173, pp.256-258, 1996.

C. Sadlier, Immunological efficacy of pneumococcal vaccine strategies in HIVinfected adults: a randomized clinical trial, Sci. Rep, vol.6, 2016.

P. Lesprit, Immunological efficacy of a prime-boost pneumococcal vaccination in HIV-infected adults, AIDS, vol.21, pp.2425-2434, 2007.

M. Peñaranda, A. Payeras, A. Cambra, J. Mila, and M. Riera, Conjugate and polysaccharide pneumococcal vaccines do not improve initial response of the polysaccharide vaccine in HIV-infected adults, AIDS, vol.24, pp.1226-1228, 2010.

I. Ridda, Immunological responses to pneumococcal vaccine in frail older people, Vaccine, vol.27, pp.1628-1636, 2009.

D. Goldblatt, The Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine versus 23-Valent Polysaccharide Vaccine in Adults Aged 50-80 Years, Clin. Infect. Dis, vol.49, pp.1318-1325, 2009.

J. Poolman and R. Borrow, Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines, Expert Rev. Vaccines, vol.10, pp.307-322, 2011.

L. A. Jackson, Immunogenicity of varying dosages of 7-valent pneumococcal polysaccharide-protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine, Vaccine, vol.25, pp.4029-4037, 2007.

L. A. Jackson, Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older, Vaccine, vol.31, pp.3594-3602, 2013.

R. N. Greenberg, Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naïve adults 60-64 years of age, Vaccine, vol.32, pp.2364-2374, 2014.

K. M. Miernyk, Immunogenicity and Reactogenicity of Pneumococcal Polysaccharide and Conjugate Vaccines in Alaska Native Adults 55-70 Years of Age, Clin. Infect. Dis, vol.49, pp.241-248, 2009.