E. Adjadj, M. Schlumberger, and F. De-vathaire, Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer, The Lancet Oncology, vol.10, issue.2, pp.181-190, 2009.

N. M. Akulevich, Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma, Endocrine-related cancer, vol.16, issue.2, pp.491-503, 2009.

F. J. Anon, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser et al., Cancer Incidence and Mortality Worldwide: IARC CancerBase, issue.11, 2012.

F. Lyon, International Agency for Research on C, 2014.

B. Aschebrook-kilfoy, Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer, Endocrine-related cancer, vol.19, issue.3, pp.333-377, 2012.

M. Austen, B. Lüscher, and J. M. Lüscher-firzlaff, Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding protei, The Journal of biological chemistry, vol.272, issue.3, pp.1709-1726, 1997.

M. Avbelj, High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis, European journal of endocrinology / European Federation of Endocrine Societies, vol.156, issue.5, pp.511-520, 2007.

Y. P. Balhara and K. S. Deb, Impact of alcohol use on thyroid function, Indian journal of endocrinology and metabolism, vol.17, issue.4, pp.580-587, 2013.

H. N. Bastos, Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk, Thyroid : official journal of the American Thyroid Association, vol.19, issue.10, pp.1067-75, 2009.

R. M. Belin, Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Surve, The Journal of clinical endocrinology and metabolism, vol.89, issue.12, pp.6077-86, 2004.

G. R. Bignell, Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer, American journal of human genetics, vol.61, issue.5, pp.1123-1153, 1997.

F. Binder-foucard, Cancer incidence and mortality in France over the 1980-2012 period: Solid tumors. Revue d'Épidémiologie et de Santé Publique, vol.62, pp.95-108, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01915012

E. Bonora, The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma, International journal of cancer. Journal international du cancer, 2013.

A. P. Boyle, Annotation of functional variation in personal genomes using RegulomeDB, Genome research, vol.22, issue.9, pp.1790-1797, 2012.

A. Brenner, Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer, PloS one, vol.8, issue.3, p.57243, 2013.

P. Brindel, Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study, Cancer causes & control : CCC, vol.20, issue.5, pp.581-90, 2009.

P. Brindel, Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in native women in French Polynesia: a population-based case-control study, American journal of epidemiology, vol.167, issue.2, pp.219-248, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00274702

N. E. Bufalo, Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants, Endocrine-related cancer, vol.13, issue.4, pp.1185-93, 2006.

M. W. Butler, Glutathione S-transferase copy number variation alters lung gene expression, European Respiratory Journal, vol.38, issue.1, pp.15-28, 2011.

P. B??ková, T. Lumley, and K. Rice, Permutation and Parametric Bootstrap Tests for Gene-Gene and Gene-Environment Interactions, Annals of Human Genetics, vol.75, issue.1, pp.36-45, 2011.

S. Caini, Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies, Cancer Causes & Control, vol.26, issue.4, pp.511-518, 2015.

E. Canbay, Higher glutathione transferase GSTM1 0/0 genotype frequency in young thyroid carcinoma patients, Current medical research and opinion, vol.19, issue.2, pp.102-106, 2003.

L. Cancemi, Evidences that the polymorphism Pro-282-Ala within the tumor suppressor gene WWOX is a new risk factor for differentiated thyroid carcinoma, International Journal of Cancer, vol.129, issue.12, pp.2816-2824, 2011.

F. Canzian, A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. American journal of human genetics, vol.63, pp.1743-1751, 1998.

Y. Cao, Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis, BioMed research international, p.103515, 2015.

B. M. Cavaco, Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis, The Journal of clinical endocrinology and metabolism, vol.93, issue.11, pp.4426-4456, 2008.

X. Chen, Learning position weight matrices from sequence and expression data, Computational Systems Bioinformatics Conference, vol.6, pp.249-60, 2007.

F. Chiang, Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.14, issue.18, pp.5919-5943, 2008.

E. Chiefari, Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation, BMC cancer, vol.2, p.35, 2002.

Y. A. Cho and J. Kim, Thyroid cancer risk and smoking status: a meta-analysis, Cancer causes & control : CCC, vol.25, issue.9, pp.1187-95, 2014.

M. Cipollini, TPO genetic variants and risk of differentiated thyroid carcinoma in two European populations, International Journal of Cancer, vol.133, issue.12, pp.2843-2851, 2013.

E. Cléro, Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area, Thyroid : official journal of the American Thyroid Association, vol.20, issue.11, pp.1285-93, 2010.

I. Clinckspoor, Vitamin D in thyroid tumorigenesis and development, Progress in Histochemistry and Cytochemistry, vol.48, pp.65-98, 2013.

M. Colonna, Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France, Cancer epidemiology, vol.39, issue.4, pp.511-519, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01912611

G. Cruzan, Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors, Regulatory Toxicology and Pharmacology, vol.66, issue.1, pp.24-29, 2013.

K. Czene, P. Lichtenstein, and K. Hemminki, Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database, International journal of cancer. Journal international du cancer, vol.99, issue.2, pp.260-266, 2002.

M. Derwahl and D. Nicula, Estrogen and its role in thyroid cancer, Endocrine-related cancer, vol.21, issue.5, pp.273-83, 2014.

R. Dou, Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence, British Journal of Nutrition, vol.115, issue.9, pp.1643-1660, 2016.

Z. Fan, Association between the CYP11 family and six cancer types, Oncology Letters, vol.12, issue.1, pp.35-40, 2016.

M. D. Fesinmeyer, Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring, vol.21, pp.835-881, 2013.

G. Figlioli, A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma, Cancer Epidemiology Biomarkers & Prevention, vol.25, pp.1-24, 2016.

G. Figlioli, Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk, Scientific reports, vol.5, p.8922, 2015.

G. Figlioli, Novel genome-wide association study-based candidate loci for differentiated thyroid cancer risk, The Journal of clinical endocrinology and metabolism, 2014.

S. Franceschi, A pooled analysis of case-control studies of thyroid cancer. IV. Benign thyroid diseases, Cancer causes & control, vol.10, issue.6, pp.583-595, 1999.

J. Gaspar, Combined effects of glutathione S-transferase polymorphisms and thyroid cancer risk, Cancer genetics and cytogenetics, vol.151, issue.1, pp.60-67, 2004.

S. A. Geisler, GSTM1, GSTT1, and the Risk of Squamous Cell Carcinoma of the Head and Neck: A Mini-HuGE Review, American Journal of Epidemiology, vol.154, issue.2, pp.95-105, 2001.

F. Gemignani, Development of lung cancer before the age of 50: The role of xenobiotic metabolizing genes, Carcinogenesis, vol.28, issue.6, pp.1287-1293, 2007.

D. E. Goldgar, Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands, Journal of the National Cancer Institute, vol.86, issue.21, pp.1600-1608, 1994.

Y. Guan and M. Stephens, Practical issues in imputation-based association mapping, PLoS genetics, vol.4, issue.12, p.1000279, 2008.

J. Gudmundsson, Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations, Nature genetics, vol.41, issue.4, pp.460-464, 2009.

J. Gudmundsson, Discovery of common variants associated with low TSH levels and thyroid cancer risk, Nature genetics, vol.44, issue.3, pp.319-341, 2012.

R. Guignard, Alcohol drinking, tobacco smoking, and anthropometric characteristics as risk factors for thyroid cancer: a countrywide case-control study in New Caledonia, American journal of epidemiology, vol.166, issue.10, pp.1140-1149, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00176743

A. C. Guilhen, Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.15, issue.1, pp.406-418, 2009.

J. D. Hayes and R. C. Strange, Glutathione S-transferase polymorphisms and their biological consequences, Pharmacology, vol.61, issue.3, pp.154-66, 2000.

C. He, A large-scale candidate gene association study of age at menarche and age at natural menopause, Human Genetics, vol.128, issue.5, pp.515-527, 2010.

H. He, A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24, Cancer research, vol.69, issue.2, pp.625-631, 2009.

H. He, W. Li, S. Liyanarachchi, and J. Jendrzejewski, Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2, The Journal of clinical endocrinology and metabolism, vol.100, issue.1, pp.164-72, 2014.

H. He, W. Li, S. Liyanarachchi, and M. Srinivas, Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer, Proceedings of the National Academy of Sciences of the United States of America, vol.112, pp.6128-6161, 2015.

K. Hemminki, C. Eng, and B. Chen, Familial risks for nonmedullary thyroid cancer, The Journal of clinical endocrinology and metabolism, vol.90, issue.10, pp.5747-53, 2005.

K. Hemminki and P. Vaittinen, Familial cancers in a nationwide family cancer database: age distribution and prevalence, European Journal of Cancer, vol.35, issue.7, pp.1109-1126, 1999.

B. E. Henderson and H. S. Feigelson, Hormonal carcinogenesis, Carcinogenesis, vol.21, issue.3, pp.427-460, 2000.

D. Hermann, A. Heinz, and K. Mann, Dysregulation of the hypothalamic-pituitary-thyroid axis in alcoholism, Addiction, issue.11, pp.1369-1381, 2002.

A. Hernández, Glutathione S-transferase polymorphisms in thyroid cancer patients, Cancer Letters, vol.190, issue.1, pp.37-44, 2003.

A. Hirvonen, Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer, pp.37-47, 1999.

T. Ho, Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis, Thyroid : official journal of the American Thyroid Association, vol.19, issue.2, pp.129-164, 2009.

T. Ho, Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis. Archives of otolaryngology--head & neck surgery, vol.132, pp.756-61, 2006.

S. Hong, S. Myung, and H. Kim, Alcohol Intake and Risk of Thyroid Cancer: A Meta-analysis of Observational Studies. Cancer Research and Treatment, 2016.

P. L. Horn-ross, Hormonal factors and the risk of papillary thyroid cancer in the California Teachers Study cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.20, issue.8, pp.1751-1760, 2011.

P. L. Horn-ross, Iodine and thyroid cancer risk among women in a multiethnic population: the Bay Area Thyroid Cancer Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.10, issue.9, pp.979-85, 2001.

B. Howie, J. Marchini, and M. Stephens, Genotype imputation with thousands of genomes, vol.3, pp.457-70, 2011.

B. N. Howie, P. Donnelly, and J. Marchini, A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies, PLoS Genetics, vol.5, issue.6, p.1000529, 2009.

R. S. Huang, Population-specific GSTM1 copy number variation, Human molecular genetics, vol.18, issue.2, pp.366-72, 2009.

I. Ionita-laza, Sequence kernel association tests for the combined effect of rare and common variants, American journal of human genetics, vol.92, issue.6, pp.841-53, 2013.

J. Jendrzejewski, The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type, Proceedings of the National Academy of Sciences of the United States of America, vol.109, pp.8646-51, 2012.

A. M. Jones, Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24, Journal of medical genetics, vol.49, issue.3, pp.158-63, 2012.

G. C. Kabat, Smoking and alcohol consumption in relation to risk of thyroid cancer in postmenopausal women, Cancer epidemiology, vol.36, issue.4, pp.335-375, 2012.

R. Kallel, Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: New insight on the role of FOXE1 in thyroid carcinoma, Cancer Biomarkers, vol.8, issue.1, pp.43-51, 2010.

B. A. Kilfoy, International patterns and trends in thyroid cancer incidence, Cancer Causes and Control, vol.20, issue.5, pp.525-531, 1973.

C. M. Kitahara, Childhood height and body mass index were associated with risk of adult thyroid cancer in a large cohort study, Cancer research, vol.74, issue.1, pp.235-277, 2014.

C. M. Kitahara and M. S. Linet, Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States, Cancer causes & control : CCC, vol.23, issue.10, pp.1615-1639, 2012.

C. M. Kitahara and G. Neta, Common obesity-related genetic variants and papillary thyroid cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.21, issue.12, pp.2268-71, 2012.

C. M. Kitahara, Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.20, issue.3, pp.464-72, 2011.

C. M. Kitahara and J. A. Sosa, The changing incidence of thyroid cancer, Nature reviews. Endocrinology, vol.12, issue.11, pp.646-653, 2016.

A. Klimkiewicz, COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients, Journal of Addiction Medicine, p.1, 2016.

J. Klug and M. Beato, Binding of YY1 to a site overlapping a weak TATA box is essential for transcription from the uteroglobin promoter in endometrial cells, Molecular and cellular biology, vol.16, issue.11, pp.6398-407, 1996.

A. Köhler, Genome-wide association study on differentiated thyroid cancer, The Journal of clinical endocrinology and metabolism, vol.98, issue.10, pp.1674-81, 2013.

L. N. Kolonel, An epidemiologic study of thyroid cancer in Hawaii, Cancer causes & control : CCC, vol.1, issue.3, pp.223-257, 1990.

N. Kreiger and R. Parkes, Cigarette smoking and the risk of thyroid cancer, European Journal of Cancer, vol.36, issue.15, pp.1969-1973, 2000.

V. N. Kristensen and A. L. Børresen-dale, Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism, Mutation Research/Reviews in Mutation Research, vol.462, issue.2-3, pp.323-333, 2000.

S. Kweon, Polymorphisms of methylenetetrahydrofolate reductase and glutathione Stransferase are not associated with the risk of papillary thyroid cancer in Korean population, Molecular biology reports, vol.41, issue.6, pp.3793-3802, 2014.

I. Landa, The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors, PLoS genetics, vol.5, issue.9, p.1000637, 2009.

I. Landa and M. Robledo, Association studies in thyroid cancer susceptibility: are we on the right track, Journal of molecular endocrinology, issue.1, p.47, 2011.

X. Lao, Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis, Cancer cell international, vol.14, issue.1, p.127, 2014.

J. Leclerc, Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues, Biochimie, vol.93, issue.6, pp.1012-1027, 2011.

M. C. Lemos, Combined GSTM1 and GSTT1 null genotypes are associated with a lower risk of papillary thyroid cancer, Journal of endocrinological investigation, vol.31, issue.6, pp.542-547, 2008.

M. C. Lemos, Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer, Clinical Endocrinology, vol.67, issue.2, pp.180-183, 2007.

F. Lesueur, Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma, Journal of medical genetics, vol.39, issue.4, pp.260-265, 2002.

C. Leux and P. Guénel, Risk factors of thyroid tumors: role of environmental and occupational exposures to chemical pollutants. Revue d'épidémiologie et de santé publique, vol.58, pp.359-67, 2010.

J. Li, Glutathione S-transferase M1, T1, and P1 polymorphisms and thyroid cancer risk: a meta-analysis, Cancer epidemiology, vol.36, issue.6, pp.333-373, 2012.

M. Li, Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets, Human genetics, vol.131, issue.5, pp.747-56, 2012.

Y. Li, Genotype imputation. Annual review of genomics and human genetics, vol.10, pp.387-406, 2009.

S. Liyanarachchi, Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma, Thyroid : official journal of the American Thyroid Association, vol.23, issue.12, pp.1532-1572, 2013.

S. Lönn, Papillary thyroid cancer and polymorphic variants in TSHR-and RET-related genes: a nested case-control study within a cohort of U.S. radiologic technologists. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.16, issue.1, pp.174-181, 2007.

Y. L. Low, Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility, PLoS Genetics, vol.6, issue.7, pp.1-8, 2010.

M. J. Loza, Assembly of Inflammation-Related Genes for Pathway-Focused Genetic Analysis, PLoS ONE, vol.2, issue.10, p.1035, 2007.

J. Ma, Obesity and risk of thyroid cancer: evidence from a meta-analysis of 21 observational studies, vol.21, pp.283-91, 2015.

S. Maillard, Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population, PloS one, vol.10, issue.4, p.123700, 2015.

C. D. Malchoff, Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome, The Journal of clinical endocrinology and metabolism, vol.85, issue.5, pp.1758-64, 2000.

V. Mancikova, Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations, International journal of cancer. Journal international du cancer. Available at, 2015.

P. T. Männistö and S. Kaakkola, Catechol-O-methyltransferase, Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors, p.51, 1999.

T. A. Manolio, Finding the missing heritability of complex diseases, Nature, issue.7265, p.461, 2009.

A. A. Mansoori and S. K. Jain, Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis, Asian Pacific journal of cancer prevention, vol.16, issue.12, pp.4803-4815, 2015.

M. A. Marcello, Obesity and thyroid cancer, Endocrine-related cancer, vol.21, issue.5, pp.255-71, 2014.

J. Marchini and B. Howie, Genotype imputation for genome-wide association studies, Nature reviews. Genetics, vol.11, issue.7, pp.499-511, 2010.

J. D. Mckay, Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21, American journal of human genetics, vol.69, issue.2, pp.440-446, 2001.

R. A. Mclellan, Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity, Molecular pharmacology, vol.52, issue.6, pp.958-65, 1997.

C. L. Meinhold, Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health Study, British journal of cancer, vol.101, issue.9, pp.1630-1634, 2009.

C. L. Meinhold, Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study, American journal of epidemiology, vol.171, issue.2, pp.242-52, 2010.

A. Memon, Epidemiology of reproductive and hormonal factors in thyroid cancer: evidence from a case-control study in the Middle East, International journal of cancer, vol.97, issue.1, pp.82-91, 2002.

A. Memon, A. Varghese, and A. Suresh, Benign thyroid disease and dietary factors in thyroid cancer: a case-control study in Kuwait, British Journal of Cancer, vol.86, issue.11, pp.1745-1750, 2002.

K. Mitrunen and A. Hirvonen, Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism, Mutation research, vol.544, issue.1, pp.9-41, 2003.

E. Miyauchi, Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects, Molecular Pharmaceutics, vol.13, issue.8, pp.2631-2640, 2016.

M. A. Mooney and B. Wilmot, Gene set analysis: A step-by-step guide. American journal of medical genetics, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, vol.168, pp.517-544, 2015.

M. Moore, Cancer epidemiology in the pacific islands -past, present and future, Asian Pacific journal of cancer prevention, vol.11, issue.2, pp.99-106, 2010.

E. C. Morari, The null genotype of glutathione s-transferase M1 and T1 locus increases the risk for thyroid cancer, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol.11, pp.1485-1493, 2002.

L. Morey and K. Helin, Polycomb group protein-mediated repression of transcription, Trends in biochemical sciences, vol.35, issue.6, pp.323-355, 2010.

H. Moriya, Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects, Biomedical reports, vol.2, issue.2, pp.265-269, 2014.

P. Mota, Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility, Journal of cancer research and clinical oncology, vol.141, issue.5, pp.851-60, 2015.

J. Nagano, A case-control study in Hiroshima and Nagasaki examining non-radiation risk factors for thyroid cancer, Journal of epidemiology, vol.17, issue.3, pp.76-85, 2007.

E. Negri, A pooled analysis of case-control studies of thyroid cancer. II. Menstrual and reproductive factors, Cancer causes & control : CCC, vol.10, issue.2, pp.143-55, 1999.

G. Neta, Common genetic variants related to genomic integrity and risk of papillary thyroid cancer, Access, vol.32, issue.8, pp.1231-1237, 2011.

M. L. Neuhouser, A. R. Kristal, and D. F. Penson, Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: Review of epidemiologic literature, Urology, vol.64, issue.2, pp.201-211, 2004.

M. S. Nørskov, Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population, The pharmacogenomics journal, vol.11, issue.4, pp.292-301, 2011.

M. S. Nørskov, High-throughput genotyping of copy number variation in glutathione Stransferases M1 and T1 using real-time PCR in 20,687 individuals, Clinical biochemistry, vol.42, issue.3, pp.201-210, 2009.

J. L. Omdahl, H. A. Morris, B. K. May, . ;-h-ydroxylase-e-nzymes, and . The-v-itamin-d-p-athway, Expression, Function, and Regulation, Annual Review of Nutrition, vol.22, issue.1, pp.139-166, 2002.

M. Onda, Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers, Journal of human genetics, vol.49, issue.6, pp.312-320, 2004.

S. Park, Reproductive Factors, Glutathione S-Transferase M1 and T1 Genetic Polymorphism and Breast Cancer Risk, Breast Cancer Research and Treatment, vol.78, issue.1, pp.89-96, 2003.

K. Pazaitou-panayiotou, S. A. Polyzos, and C. S. Mantzoros, Obesity reviews : an official journal of the International Association for the Study of Obesity, vol.14, pp.1006-1028, 2013.

M. Penna-martinez, Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma, Thyroid : official journal of the American Thyroid Association, vol.22, issue.7, pp.709-725, 2012.

T. M. Penning, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones, The Biochemical journal, vol.351, pp.67-77, 2000.

T. M. Penning and M. C. Byrns, Steroid hormone transforming aldo-keto reductases and cancer, Annals of the New York Academy of Sciences, pp.33-42, 1155.

C. M. Pereda, Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population, BMC Genetics, vol.16, 2015.

C. Pilon, Mutations in CYP11B1 gene converting 11??-hydroxylase into an aldosteroneproducing enzyme are not present in aldosterone-producing adenomas, Journal of Clinical Endocrinology and Metabolism, vol.84, issue.11, pp.4228-4231, 1999.

R. L. Prentice, Radiation exposure and thyroid cancer incidence among Hiroshima and Nagasaki residents, vol.62, pp.207-219, 1982.

M. Rebaï, Association of polymorphisms in estrogen and thyroid hormone receptors with thyroid cancer risk, Journal of receptor and signal transduction research, vol.29, issue.2, pp.113-121, 2009.

T. R. Rebbeck, Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.6, issue.9, pp.733-776, 1997.

A. A. Reis, Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules, Genetics and molecular research : GMR, vol.9, issue.4, pp.2222-2231, 2010.

Y. Ren and J. J. Lence-anta, Foxe1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population, Thyroid, 2016.

Y. Ren and J. J. Lence-anta, Foxe1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population, Thyroid : official journal of the American Thyroid Association. Available at, 2016.

S. Rinaldi, Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study, International Journal of Cancer, vol.131, issue.6, pp.1004-1014, 2012.

E. Ron, Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies, Radiation research, vol.141, issue.3, pp.259-77, 1995.

M. J. Rose-zerilli, Copy-number variation genotyping of GSTT1 and GSTM1 gene deletions by real-time PCR, Clinical chemistry, vol.55, issue.9, pp.1680-1685, 2009.

M. A. Rossing, Risk of papillary thyroid cancer in women in relation to smoking and alcohol consumption, Epidemiology, vol.11, issue.1, pp.49-54, 2000.

M. Rotinen, Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta, The Journal of endocrinology, vol.200, issue.1, pp.85-92, 2009.

A. Rudolph, Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy, International journal of cancer. Journal international du cancer, vol.131, issue.5, pp.841-849, 2012.

M. Saitou and T. Ishida, Distributions of the GSTM1 and GSTT1 null genotypes worldwide are characterized by latitudinal clines, Asian Pacific journal of cancer prevention : APJCP, vol.16, issue.1, pp.355-61, 2015.

A. Schlattl, Relating CNVs to transcriptome data at fine resolution: assessment of the effect of variant size, type, and overlap with functional regions, Genome research, vol.21, issue.12, pp.2004-2017, 2011.

S. J. Schonfeld, Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk, Thyroid : official journal of the American Thyroid Association, vol.22, issue.2, pp.151-157, 2012.

S. J. Schonfeld, Polymorphisms in oxidative stress and inflammation pathway genes, lowdose ionizing radiation, and the risk of breast cancer among US radiologic technologists, Cancer causes & control : CCC, vol.21, issue.11, pp.1857-66, 2010.

B. L. Secretan, Spe ci a l R e p or t Body Fatness and Cancer -Viewpoint of the IARC Working Group, 2016.

A. Sen, Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study, British journal of cancer, vol.113, issue.5, pp.840-847, 2015.

J. Shi and S. Lee, A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis, vol.72, pp.945-954, 2016.

A. J. Sigurdson, Cancer incidence in the US radiologic technologists health study, Cancer, issue.12, pp.3080-3089, 1983.

A. J. Sigurdson, Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan, Radiation research, vol.171, issue.1, pp.77-88, 2009.

J. A. Simon and C. A. Lange, Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.647, pp.21-29, 2008.

S. Singer, Quality of Life in Patients with Thyroid Cancer Compared with the General Population, Thyroid, vol.22, issue.2, pp.117-124, 2012.

A. K. Siraj, Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population, BMC medical genetics, vol.9, issue.1, p.61, 2008.

O. P. Soldin, Thyroid hormone levels associated with active and passive cigarette smoking, Thyroid : official journal of the American Thyroid Association, vol.19, issue.8, pp.817-840, 2009.

R. Sprenger, Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotypephenotype correlation, Pharmacogenetics, vol.10, issue.6, pp.557-65, 2000.

K. Stankov, GSTT1 and M1 polymorphisms in Hürthle thyroid cancer patients, Cancer letters, vol.240, issue.1, pp.76-82, 2006.

S. H. Stewart, COMT Genotype Influences the Effect of Alcohol on Blood Pressure: Results From the COMBINE Study, American Journal of Hypertension, vol.22, issue.1, pp.87-91, 2009.

E. M. Sturgis, Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis, The Laryngoscope, vol.115, issue.6, pp.938-945, 2005.

T. Suzuki, Anthropometric factors at age 20 years and risk of thyroid cancer, Cancer causes & control : CCC, vol.19, issue.10, pp.1233-1275, 2008.

M. Takahashi, The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl, Human molecular genetics, vol.19, issue.12, pp.2516-2539, 2010.

C. Tian, P. K. Gregersen, and M. F. Seldin, Accounting for ancestry: Population substructure and genome-wide association studies, Human Molecular Genetics, vol.17, issue.R2, pp.143-150, 2008.

G. Tournel, CYP2F1 genetic polymorphism: Identification of interethnic variations, Xenobiotica, vol.37, issue.12, pp.1433-1438, 2007.

G. Tournel, Molecular analysis of the CYP2F1 gene: Identification of a frequent nonfunctional allelic variant. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, pp.79-89, 2007.

T. Truong, Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia, Cancer causes & control : CCC, vol.21, issue.8, pp.1183-92, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00471339

T. Truong, Role of goiter and of menstrual and reproductive factors in thyroid cancer: a population-based case-control study in New Caledonia (South Pacific), a very high incidence area, American journal of epidemiology, vol.161, issue.11, pp.1056-65, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00085408

T. Truong, Time trends and geographic variations for thyroid cancer in New Caledonia, a very high incidence area (1985-1999), vol.16, pp.62-70, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00138472

S. Vaccarella, The Impact of Diagnostic Changes on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Selected High-Resource Countries, Thyroid : official journal of the American Thyroid Association, vol.25, issue.10, pp.1127-1163, 2015.

P. Valeix, Effects of light to moderate alcohol consumption on thyroid volume and thyroid function, Clinical endocrinology, vol.68, issue.6, pp.988-95, 2008.

R. Vigneri, P. Malandrino, and P. Vigneri, The changing epidemiology of thyroid cancer: why is incidence increasing? Current opinion in oncology, 2014.

D. Vito and M. , Overexpression of estrogen receptor-? in human papillary thyroid carcinomas studied by laser-capture microdissection and molecular biology, Cancer science, vol.102, issue.10, pp.1921-1928, 2011.

K. Wang, M. Li, and M. Bucan, Pathway-based approaches for analysis of genomewide association studies, American journal of human genetics, vol.81, issue.6, pp.1278-83, 2007.

Y. Wang, Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population, Journal of medical genetics, vol.50, issue.10, pp.689-95, 2013.

L. D. Ward and M. Kellis, HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants, Nucleic acids research, vol.40, 2012.

F. Weber and C. Eng, Editorial: Germline Variants within RET: Clinical Utility or Scientific Playtoy?, The Journal of Clinical Endocrinology & Metabolism, vol.90, issue.11, pp.6334-6336, 2005.

D. Williams, Cancer after nuclear fallout: lessons from the Chernobyl accident, Nature reviews. Cancer, vol.2, issue.7, pp.543-552, 2002.

J. A. Williams and D. H. Phillips, Mammary Expression of Xenobiotic Metabolizing Enzymes and Their Potential Role in Breast Cancer, Cancer Research, issue.17, p.60, 2000.

J. J. Wiltshire, Systematic Review of Trends in the Incidence Rates of Thyroid Cancer, 2016.

L. Wu and J. Zhu, Linear reduction in thyroid cancer risk by oral contraceptive use: a doseresponse meta-analysis of prospective cohort studies, Human reproduction, vol.30, issue.9, pp.2234-2274, 2015.

C. Xhaard, Anthropometric Risk Factors for Differentiated Thyroid Cancer in Young Men and Women From Eastern France: A Case-Control Study, American journal of epidemiology, vol.182, issue.3, pp.202-216, 2015.

C. Xhaard, Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: a population-based case-control study, American journal of epidemiology, vol.180, issue.10, pp.1007-1024, 2014.

S. Xu, Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?, The Journal of endocrinology, vol.218, issue.1, pp.125-158, 2013.

K. Yu, Pathway analysis by adaptive combination of P-values, Genetic epidemiology, vol.33, issue.8, pp.700-709, 2009.

L. B. Zablotska, A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine, American journal of epidemiology, vol.167, issue.3, pp.305-317, 1998.

G. Zai, A review of molecular genetic studies of neurocognitive deficits in schizophrenia, Neuroscience & Biobehavioral Reviews, vol.72, pp.50-67, 2017.

R. Zamora-ros, Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study, International journal of cancer, vol.136, issue.5, pp.1218-1245, 2015.

D. V. Zaykin, Truncated product method for combiningP-values, Genetic Epidemiology, vol.22, issue.2, pp.170-185, 2002.

W. Zhang, Meta-analysis in the association between obesity and risk of thyroid cancer, International journal of clinical and experimental medicine, vol.7, issue.12, pp.5268-74, 2014.

T. Zheng, Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk, British journal of cancer, vol.88, issue.1, pp.58-62, 2003.

Q. Zhou, Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR), Tumor Biology, vol.37, issue.3, pp.3105-3113, 2016.

J. Zhu, Parity and thyroid cancer risk: a meta-analysis of epidemiological studies, Cancer medicine, vol.5, issue.4, pp.739-52, 2016.

M. B. Zimmermann and V. Galetti, Iodine intake as a risk factor for thyroid cancer: a comprehensive review of animal and human studies, Thyroid research, vol.8, 2015.

, Jamais Non-nul, vol.63, issue.11, p.0

, 29) Déjà pris Non-nul 156, Jamais Nul, vol.75, issue.8, p.11

, Jamais Non-nul, vol.108, issue.23, p.0

, 29) 1,09 (0,43-2,75) Déjà pris Non-nul 270, Jamais Nul, vol.25, issue.5, pp.52-53

, Jamais Non-nul, vol.119, issue.19, p.0

, ,66) Déjà pris Non-nul 275, Journal: International Journal of Cancer Manuscript, vol.12, issue.2, p.359

W. Type, Research Article Date Submitted by the Author: 05, 2016.

F. Lesueur and . Institut,

M. Sanchez, U. Paris-saclay, . Paris-sud, . Uvsq, . Inserm et al., Anne-Valerie; centre Francois Baclesse, registre general des Tumeurs du calvados et Enquete parmantier Cancers; Inserm U1086, Cancers and prevention Mulot, Claire; Université Paris Descartes, INSERM UMR 5775 EPIGENETEC Laurent-Puig, Pierre; Université Paris Descartes, INSERM UMR 5775 EPIGENETEC Schartz, Claire; Institut de Cancerologie Jean Godinot

P. Guenel and . Paris-saclay,

. Moore-m-a, F. Baumann, S. Foliaki, M. T. Goodman, R. Haddock et al., Cancer epidemiology in the pacific islands -past, present and future, Asian Pac J Cancer Prev, vol.11, issue.2, pp.99-106, 2010.

J. Ferlay, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser et al., Cancer Incidence and Mortality Worldwide: IARC CancerBase, issue.11, 2012.

F. Lyon, International Agency for Research on C, 2014.

T. Truong, Y. Rougier, D. Dubourdieu, C. Guihenneuc-jouyaux, L. Orsi et al., Time trends and geographic variations for thyroid cancer in New Caledonia, a very high incidence area (1985-1999), Eur J Cancer Prev, vol.16, pp.62-70, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00138472

T. Truong, L. Orsi, D. Dubourdieu, Y. Rougier, D. Hémon et al., Role of goiter and of menstrual and reproductive factors in thyroid cancer: a population-based case-control study in New Caledonia (South Pacific), a very high incidence area, Am J Epidemiol, vol.161, pp.1056-65, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00085408

C. Leux and P. Guénel, Risk factors of thyroid tumors: role of environmental and occupational exposures to chemical pollutants, Rev Epidemiol Sante Publique, vol.58, pp.359-67, 2010.

E. Cléro, C. Leux, P. Brindel, T. Truong, A. Anger et al.,

F. Vathaire, Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area, Thyroid, vol.20, pp.1285-93, 2010.

D. E. Goldgar, D. F. Easton, L. A. Cannon-albright, and M. H. Skolnick, Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands, J Natl Cancer Inst, vol.86, pp.1600-1608, 1994.

K. Czene, P. Lichtenstein, and K. Hemminki, Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database, Int J Cancer, vol.99, pp.260-266, 2002.

K. Hemminki, C. Eng, and B. Chen, Familial risks for nonmedullary thyroid cancer, J Clin Endocrinol Metab, vol.90, pp.5747-53, 2005.

M. Robledo, Association studies in thyroid cancer susceptibility : are we on the right track ?, J Mol Endocrinol, vol.2, 2011.

F. Lesueur, M. Stark, T. Tocco, H. Ayadi, M. J. Delisle et al., Genetic heterogeneity in familial nonmedullary thyroid carcinoma: exclusion of linkage to RET, MNG1, and TCO in 56 families. NMTC Consortium, J Clin Endocrinol Metab, vol.84, pp.2157-62, 1999.

C. D. Malchoff, M. Sarfarazi, B. Tendler, F. Forouhar, G. Whalen et al., Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome, J Clin Endocrinol Metab, vol.85, pp.1758-64, 2000.

F. Granja, J. Morari, E. C. Morari, L. Correa, L. Assumpção et al., Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer, Cancer Lett, vol.210, pp.151-158, 2004.

J. Gudmundsson, P. Sulem, D. F. Gudbjartsson, J. G. Jonasson, A. Sigurdsson et al., Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations, Nat Genet, vol.41, pp.460-464, 2009.

M. Takahashi, V. A. Saenko, T. I. Rogounovitch, T. Kawaguchi, V. M. Drozd et al., The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl, Hum Mol Genet, vol.19, pp.2516-2539, 2010.

F. Damiola, G. Byrnes, M. Moissonnier, M. Pertesi, I. Deltour et al., Contribution of ATM and FOXE1 (TTF2) to risk of papillary thyroid carcinoma in Belarusian children exposed to radiation, Int J Cancer, vol.134, pp.1659-68, 2014.

J. Gudmundsson, P. Sulem, D. F. Gudbjartsson, J. G. Jonasson, G. Masson et al., Discovery of common variants associated with low TSH levels and thyroid cancer risk, Nat Genet, vol.44, pp.319-341, 2012.

V. Mancikova, R. Cruz, L. Inglada-pérez, C. Fernández-rozadilla, I. Landa et al., Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations, Int J Cancer, 2015.

I. Landa, S. Ruiz-llorente, C. Montero-conde, L. Inglada-pérez, F. Schiavi et al., The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors, PLoS Genet, vol.5, p.1000637, 2009.

M. Bullock, E. L. Duncan, O. Neill, C. Tacon, L. Sywak et al., Association of FOXE1 polyalanine repeat region with papillary thyroid cancer, J Clin Endocrinol Metab, vol.97, pp.1814-1823, 2012.

Y. Fan, Z. Ding, Z. Yang, X. Deng, J. Kang et al., Expression and clinical significance of FOXE1 in papillary thyroid carcinoma, Mol Med Rep, vol.8, pp.123-130, 2013.

E. Bonora, C. Rizzato, C. Diquigiovanni, T. Oudot-mellakh, D. Campa et al., The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma, Int J Cancer, 2013.

H. He, W. Li, S. Liyanarachchi, J. Jendrzejewski, M. Srinivas et al., Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR and a novel lincRNA gene, PTCSC2, J Clin Endocrinol Metab, 2014.

J. Jendrzejewski, H. He, H. S. Radomska, W. Li, J. Tomsic et al., The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24, J Med Genet, vol.49, pp.158-63, 2012.

D. Vito, M. , D. Santis, E. Perrone, G. A. et al., Overexpression of estrogen receptor-? in human papillary thyroid carcinomas studied by laser-capture microdissection and molecular biology, Cancer Sci, vol.102, pp.1921-1928, 2011.

S. Xu, G. Chen, W. Peng, K. Renko, and M. Derwahl, Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?, J Endocrinol, 2013.

M. Onda, H. Nagai, A. Yoshida, S. Miyamoto, S. Asaka et al., Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers, J Hum Genet, vol.49, pp.312-320, 2004.

E. Chiefari, A. Brunetti, F. Arturi, J. Bidart, D. Russo et al., Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation? BMC Cancer, vol.2, p.35, 2002.

H. He, W. Li, S. Liyanarachchi, M. Srinivas, Y. Wang et al., Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer, Proc Natl Acad Sci, vol.112, pp.6128-6161, 2015.

L. Morey and K. Helin, Polycomb group protein-mediated repression of transcription, Trends Biochem Sci, vol.35, pp.323-355, 2010.

J. Klug and M. Beato, Binding of YY1 to a site overlapping a weak TATA box is essential for transcription from the uteroglobin promoter in endometrial cells, Mol Cell Biol, vol.16, pp.6398-407, 1996.

M. Austen, B. Lüscher, and J. M. Lüscher-firzlaff, Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive elementbinding protein (CPB)-binding protei, J Biol Chem, vol.272, pp.1709-1726, 1997.

C. M. Pereda, F. Lesueur, M. Pertesi, N. Robinot, J. J. Lence-anta et al., Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population

, BMC Genet, vol.16, 2015.

S. Maillard, F. Damiola, E. Clero, M. Pertesi, N. Robinot et al., Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population, PLoS One, vol.10, p.123700, 2015.

R. Guignard, T. Truong, Y. Rougier, D. Baron-dubourdieu, and P. Guénel, Alcohol drinking, tobacco smoking, and anthropometric characteristics as risk factors for thyroid cancer: a countrywide case-control study in New Caledonia, Am J Epidemiol, vol.166, pp.1140-1149, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00176743

T. Truong, D. Baron-dubourdieu, Y. Rougier, and P. Guénel, Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia. Cancer Causes Control, vol.21, pp.1183-92, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00471339

W. M. Wiersinga, Smoking and thyroid, Clin Endocrinol (Oxf), 2013.

, Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle, hormonal and reproductive characteristics: a study in Europeans and Melanesians from Metropolitan France

, Anne-Valérie Guizard, vol.3

:. Cesp--cancer and . Environment-team, 5: U1086 Inserm-UCNB, vol.2

. Moore, Approximately 90% of thyroid cancers are represented by differentiated thyroid carcinomas (DTC), which are subdivided into papillary or follicular carcinomas. The incidence of thyroid cancer is characterized by considerable ethnic and geographic variations, 2010.

. Moore, One of the highest incidence rates has been observed in Melanesian women of New Caledonia (71.4 per 100 000 person-years, 2010.

(. Vaccarella, , 2015.

&. Kitahara and . Sosa, , 2016.

. Truong, Overweight, iodine intake deficiency, reduced consumption of alcohol and tobacco, high parity and late age at menarche have also been associated with DTC risk, 2005.

&. Leux, . Guénel, and . Cléro, It was shown that thyroid cancer is one of the cancers with the highest familial risk (Hemminki & Vaittinen 1999), suggesting a role for genetic risk factors. However, only few variants have been identified so far, 2010.

S. Glutathione, GST) family, such as GSTM1 and GSTT1 that encode for phase II enzymes are involved in the detoxification and neutralization of environmental carcinogens, therapeutic drugs, or products of oxidative stress. The enzyme activity depends in a dosedependent manner on the number of copies of GSTM1 and GSTT1 (copy number variations, CNVs) in an individual's genome (McLellan et al. 1997; Sprenger et al. 2000) with complete gene deletion resulting in a loss of function. Thus, it is believed that gene deletion may confer a higher vulnerability to carcinogen exposure, 2011.

J. Li, In a recent meta-analysis of 12 epidemiological studies on the association between GSTM1 or GSTT1-null genotypes and DTC, no overall association was detected, 2012.

, age at menarche ? 13 years and menopause were associated with increased odds ratios at the limit of statistical significance. The odds ratio was below unity for alcohol drinkers and users of oral contraceptives as compared to non-users, and it was close to one for parous compared to non-parous women, whatever the number of children. Among Melanesians, the odds ratio clearly increased with BMI, but no statistically significant association was detected for other risk factors. Associations of DTC with lifestyle habits or hormonal and reproductive risk factors are described in more details somewhere else for the CATHY (Cordina-Duverger et al., submitted) and the NC (Guignard et al. 2007; Truong et al. 2005) studies. The proportion of GSTM1-null genotypes among controls was 51.2% in Europeans and 82.5% in Melanesians. The corresponding figures for the GSTT1-null genotype were 20.5% and 39.4%, respectively. The proportion of controls with the null genotype for both GSTM1 and GSTT1 was 10, Europeans, the odds ratios for DTC increased slightly in individuals with BMI ? 25 kg/m 2 . In women

, Odds ratios for BMI, alcohol drinking and tobacco smoking are shown separately for the null and the non-null genotypes in Table 3, both ethnic groups

, However, none of the p-values for interaction between BMI and genotypes was statistically significant. Among Europeans, the odd ratios for obesity increased with decreasing number of copies of GSTT1

, Odds ratios for alcohol drinking were below unity in both ethnic groups

, 95%CI: 0.07, 0.81) in Europeans and Melanesians, respectively (p for interaction not significant) (Table 3). For tobacco smoking

, GSTs genotypes are shown in Table 4. For GSTM1, no statistically significant interaction was detected in either ethnic group with age at menarche, parity, oral contraceptive, or menopausal status. For GSTT1 among Europeans, the odds ratios for age at menarche >13 years were 0.57 (95% CI) and 1.79 (95% CI) in women with GSTT1 null-and non-null genotype respectively (p for interaction 0.02); similarly, the odds ratios for parous vs, The odds ratios for hormonal and reproductive risk factors of DTC among women

E. Adjadj, M. Schlumberger, and F. De-vathaire, Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer, The Lancet Oncology, vol.10, issue.2, pp.181-190, 2009.

N. M. Akulevich, Polymorphisms of DNA damage response genes in radiationrelated and sporadic papillary thyroid carcinoma, Endocrine-related cancer, vol.16, issue.2, pp.491-503, 2009.

F. J. Anon, I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser et al., Cancer Incidence and Mortality Worldwide: IARC CancerBase, issue.11, 2012.

F. Lyon, International Agency for Research on C, 2014.

B. Aschebrook-kilfoy, Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer, Endocrine-related cancer, vol.19, issue.3, pp.333-377, 2012.

M. Austen, B. Lüscher, and J. M. Lüscher-firzlaff, Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding protei, The Journal of biological chemistry, vol.272, issue.3, pp.1709-1726, 1997.

M. Avbelj, High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis, European journal of endocrinology / European Federation of Endocrine Societies, vol.156, issue.5, pp.511-520, 2007.

Y. P. Balhara and K. S. Deb, Impact of alcohol use on thyroid function, Indian journal of endocrinology and metabolism, vol.17, issue.4, pp.580-587, 2013.

H. N. Bastos, Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk, Thyroid : official journal of the American Thyroid Association, vol.19, issue.10, pp.1067-75, 2009.

R. M. Belin, Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Surve, The Journal of clinical endocrinology and metabolism, vol.89, issue.12, pp.6077-86, 2004.

G. R. Bignell, Familial nontoxic multinodular thyroid goiter locus maps to 210 chromosome 14q but does not account for familial nonmedullary thyroid cancer, American journal of human genetics, vol.61, issue.5, pp.1123-1153, 1997.

F. Binder-foucard, Cancer incidence and mortality in France over the 1980-2012 period: Solid tumors. Revue d'Épidémiologie et de Santé Publique, vol.62, pp.95-108, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01915012

E. Bonora, The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma, International journal of cancer. Journal international du cancer, 2013.

A. P. Boyle, Annotation of functional variation in personal genomes using RegulomeDB, Genome research, vol.22, issue.9, pp.1790-1797, 2012.

A. Brenner, Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer, PloS one, vol.8, issue.3, p.57243, 2013.

P. Brindel, Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study, Cancer causes & control : CCC, vol.20, issue.5, pp.581-90, 2009.

P. Brindel, Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in native women in French Polynesia: a population-based casecontrol study, American journal of epidemiology, vol.167, issue.2, pp.219-248, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00274702

N. E. Bufalo, Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants, Endocrine-related cancer, vol.13, issue.4, pp.1185-93, 2006.

M. W. Butler, Glutathione S-transferase copy number variation alters lung gene expression, European Respiratory Journal, vol.38, issue.1, pp.15-28, 2011.

P. B??ková, T. Lumley, and K. Rice, Permutation and Parametric Bootstrap Tests for Gene-Gene and Gene-Environment Interactions, Annals of Human Genetics, vol.75, issue.1, pp.36-45, 2011.

S. Caini, Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies, Cancer Causes & Control, vol.26, issue.4, pp.511-518, 2015.

E. Canbay, Higher glutathione transferase GSTM1 0/0 genotype frequency in young thyroid carcinoma patients, Current medical research and opinion, vol.19, issue.2, pp.102-106, 2003.

L. Cancemi, Evidences that the polymorphism Pro-282-Ala within the tumor suppressor gene WWOX is a new risk factor for differentiated thyroid carcinoma, International Journal of Cancer, vol.129, issue.12, pp.2816-2824, 2011.

F. Canzian, A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. American journal of human genetics, vol.63, pp.1743-1751, 1998.

Y. Cao, Reproductive Factors but Not Hormonal Factors Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis, BioMed research international, p.103515, 2015.

B. M. Cavaco, Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis, The Journal of clinical endocrinology and metabolism, vol.93, issue.11, pp.4426-4456, 2008.

X. Chen, Learning position weight matrices from sequence and expression data, Computational Systems Bioinformatics Conference, vol.6, pp.249-60, 2007.

F. Chiang, Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.14, issue.18, pp.5919-5943, 2008.

E. Chiefari, Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation, BMC cancer, vol.2, p.35, 2002.

Y. A. Cho and J. Kim, Thyroid cancer risk and smoking status: a meta-analysis, Cancer causes & control : CCC, vol.25, issue.9, pp.1187-95, 2014.

M. Cipollini, TPO genetic variants and risk of differentiated thyroid carcinoma in two European populations, International Journal of Cancer, vol.133, issue.12, pp.2843-2851, 2013.

E. Cléro, Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area, Thyroid : official journal of the American Thyroid Association, vol.20, issue.11, pp.1285-93, 2010.

I. Clinckspoor, Vitamin D in thyroid tumorigenesis and development, Progress in Histochemistry and Cytochemistry, vol.48, pp.65-98, 2013.

M. Colonna, Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France, Cancer epidemiology, vol.39, issue.4, pp.511-519, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01912611

G. Cruzan, Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors, Regulatory Toxicology and Pharmacology, vol.66, issue.1, pp.24-29, 2013.

K. Czene, P. Lichtenstein, and K. Hemminki, Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database, International journal of cancer. Journal international du cancer, vol.99, issue.2, pp.260-266, 2002.

M. Derwahl and D. Nicula, Estrogen and its role in thyroid cancer, Endocrine-related cancer, vol.21, issue.5, pp.273-83, 2014.

R. Dou, Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence, British Journal of Nutrition, vol.115, issue.9, pp.1643-1660, 2016.

Z. Fan, Association between the CYP11 family and six cancer types, Oncology Letters, vol.12, issue.1, pp.35-40, 2016.

M. D. Fesinmeyer, Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring, vol.21, pp.835-881, 2013.

G. Figlioli, A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma, Cancer Epidemiology Biomarkers & Prevention, vol.25, pp.1-24, 2016.

G. Figlioli, Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk, Scientific reports, vol.5, p.8922, 2015.

G. Figlioli, Novel genome-wide association study-based candidate loci for differentiated thyroid cancer risk, The Journal of clinical endocrinology and metabolism, 2014.

S. Franceschi, A pooled analysis of case-control studies of thyroid cancer. IV. Benign thyroid diseases, Cancer causes & control, vol.10, issue.6, pp.583-595, 1999.

J. Gaspar, Combined effects of glutathione S-transferase polymorphisms and thyroid cancer risk, Cancer genetics and cytogenetics, vol.151, issue.1, pp.60-67, 2004.

S. A. Geisler, GSTM1, GSTT1, and the Risk of Squamous Cell Carcinoma of the Head and Neck: A Mini-HuGE Review, American Journal of Epidemiology, vol.154, issue.2, pp.95-105, 2001.

F. Gemignani, Development of lung cancer before the age of 50: The role of xenobiotic metabolizing genes, Carcinogenesis, vol.28, issue.6, pp.1287-1293, 2007.

D. E. Goldgar, Systematic population-based assessment of cancer risk in firstdegree relatives of cancer probands, Journal of the National Cancer Institute, vol.86, issue.21, pp.1600-1608, 1994.

Y. Guan and M. Stephens, Practical issues in imputation-based association mapping, PLoS genetics, vol.4, issue.12, p.1000279, 2008.

J. Gudmundsson, Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations, Nature genetics, vol.41, issue.4, pp.460-464, 2009.

J. Gudmundsson, Discovery of common variants associated with low TSH levels and thyroid cancer risk, Nature genetics, vol.44, issue.3, pp.319-341, 2012.

R. Guignard, Alcohol drinking, tobacco smoking, and anthropometric characteristics as risk factors for thyroid cancer: a countrywide case-control study in New Caledonia, American journal of epidemiology, vol.166, issue.10, pp.1140-1149, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00176743

A. C. Guilhen, Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility, Clinical cancer research : an official journal of the American Association for Cancer Research, vol.15, issue.1, pp.406-418, 2009.

J. D. Hayes and R. C. Strange, Glutathione S-transferase polymorphisms and their biological consequences, Pharmacology, vol.61, issue.3, pp.154-66, 2000.

C. He, A large-scale candidate gene association study of age at menarche and age at natural menopause, Human Genetics, vol.128, issue.5, pp.515-527, 2010.

H. He, A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24, Cancer research, vol.69, issue.2, pp.625-631, 2009.

H. He, W. Li, S. Liyanarachchi, and J. Jendrzejewski, Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2, The Journal of clinical endocrinology and metabolism, vol.100, issue.1, pp.164-72, 2014.

H. He, W. Li, S. Liyanarachchi, and M. Srinivas, Multiple functional variants in longrange enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer, Proceedings of the National Academy of Sciences of the United States of America, vol.112, pp.6128-6161, 2015.

K. Hemminki, C. Eng, and B. Chen, Familial risks for nonmedullary thyroid cancer, The Journal of clinical endocrinology and metabolism, vol.90, issue.10, pp.5747-53, 2005.

K. Hemminki and P. Vaittinen, Familial cancers in a nationwide family cancer database: age distribution and prevalence, European Journal of Cancer, vol.35, issue.7, pp.1109-1126, 1999.

B. E. Henderson and H. S. Feigelson, Hormonal carcinogenesis, Carcinogenesis, vol.21, issue.3, pp.427-460, 2000.

D. Hermann, A. Heinz, and K. Mann, Dysregulation of the hypothalamic-pituitarythyroid axis in alcoholism, Addiction, issue.11, pp.1369-1381, 2002.

A. Hernández, Glutathione S-transferase polymorphisms in thyroid cancer patients, Cancer Letters, vol.190, issue.1, pp.37-44, 2003.

A. Hirvonen, Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer, pp.37-47, 1999.

T. Ho, Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis, Thyroid : official journal of the American Thyroid Association, vol.19, issue.2, pp.129-164, 2009.

T. Ho, Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis. Archives of otolaryngology--head & neck surgery, vol.132, pp.756-61, 2006.

S. Hong, S. Myung, and H. Kim, Alcohol Intake and Risk of Thyroid Cancer: A Metaanalysis of Observational Studies. Cancer Research and Treatment, 2016.

P. L. Horn-ross, Hormonal factors and the risk of papillary thyroid cancer in the California Teachers Study cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.20, issue.8, pp.1751-1760, 2011.

P. L. Horn-ross, Iodine and thyroid cancer risk among women in a multiethnic population: the Bay Area Thyroid Cancer Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.10, issue.9, pp.979-85, 2001.

B. Howie, J. Marchini, and M. Stephens, Genotype imputation with thousands of genomes, vol.3, pp.457-70, 2011.

B. N. Howie, P. Donnelly, and J. Marchini, A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies, PLoS Genetics, vol.5, issue.6, p.1000529, 2009.

R. S. Huang, Population-specific GSTM1 copy number variation, Human molecular genetics, vol.18, issue.2, pp.366-72, 2009.

I. Ionita-laza, Sequence kernel association tests for the combined effect of rare and common variants, American journal of human genetics, vol.92, issue.6, pp.841-53, 2013.

J. Jendrzejewski, The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type, Proceedings of the National Academy of Sciences of the United States of America, vol.109, pp.8646-51, 2012.

A. M. Jones, Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24, Journal of medical genetics, vol.49, issue.3, pp.158-63, 2012.

G. C. Kabat, Smoking and alcohol consumption in relation to risk of thyroid cancer in postmenopausal women, Cancer epidemiology, vol.36, issue.4, pp.335-375, 2012.

R. Kallel, Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: New insight on the role of FOXE1 in thyroid carcinoma, Cancer Biomarkers, vol.8, issue.1, pp.43-51, 2010.

B. A. Kilfoy, International patterns and trends in thyroid cancer incidence, Cancer Causes and Control, vol.20, issue.5, pp.525-531, 1973.

C. M. Kitahara, Childhood height and body mass index were associated with risk of adult thyroid cancer in a large cohort study, Cancer research, vol.74, issue.1, pp.235-277, 2014.

C. M. Kitahara and M. S. Linet, Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States, Cancer causes & control : CCC, vol.23, issue.10, pp.1615-1639, 2012.

C. M. Kitahara and G. Neta, Common obesity-related genetic variants and papillary thyroid cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.21, issue.12, pp.2268-71, 2012.

C. M. Kitahara, Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.20, issue.3, pp.464-72, 2011.

C. M. Kitahara and J. A. Sosa, The changing incidence of thyroid cancer, Nature reviews. Endocrinology, vol.12, issue.11, pp.646-653, 2016.

A. Klimkiewicz, COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients, Journal of Addiction Medicine, p.1, 2016.

J. Klug and M. Beato, Binding of YY1 to a site overlapping a weak TATA box is essential for transcription from the uteroglobin promoter in endometrial cells, Molecular and cellular biology, vol.16, issue.11, pp.6398-407, 1996.

A. Köhler, Genome-wide association study on differentiated thyroid cancer, The Journal of clinical endocrinology and metabolism, vol.98, issue.10, pp.1674-81, 2013.

L. N. Kolonel, An epidemiologic study of thyroid cancer in Hawaii, Cancer causes & control : CCC, vol.1, issue.3, pp.223-257, 1990.

N. Kreiger and R. Parkes, Cigarette smoking and the risk of thyroid cancer, European Journal of Cancer, vol.36, issue.15, pp.1969-1973, 2000.

V. N. Kristensen and A. L. Børresen-dale, Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism, Mutation Research/Reviews in Mutation Research, vol.462, issue.2-3, pp.323-333, 2000.

S. Kweon, Polymorphisms of methylenetetrahydrofolate reductase and glutathione S-transferase are not associated with the risk of papillary thyroid cancer in Korean population, Molecular biology reports, vol.41, issue.6, pp.3793-3802, 2014.

I. Landa, The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors, PLoS genetics, vol.5, issue.9, p.1000637, 2009.

I. Landa and M. Robledo, Association studies in thyroid cancer susceptibility: are we on the right track, Journal of molecular endocrinology, issue.1, p.47, 2011.

X. Lao, Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis, Cancer cell international, vol.14, issue.1, p.127, 2014.

J. Leclerc, Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues, Biochimie, vol.93, issue.6, pp.1012-1027, 2011.

M. C. Lemos, Combined GSTM1 and GSTT1 null genotypes are associated with a lower risk of papillary thyroid cancer, Journal of endocrinological investigation, vol.31, issue.6, pp.542-547, 2008.

M. C. Lemos, Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer, Clinical Endocrinology, vol.67, issue.2, pp.180-183, 2007.

F. Lesueur, Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma, Journal of medical genetics, vol.39, issue.4, pp.260-265, 2002.

C. Leux and P. Guénel, Risk factors of thyroid tumors: role of environmental and occupational exposures to chemical pollutants. Revue d'épidémiologie et de santé publique, vol.58, pp.359-67, 2010.

J. Li, Glutathione S-transferase M1, T1, and P1 polymorphisms and thyroid cancer risk: a meta-analysis, Cancer epidemiology, vol.36, issue.6, pp.333-373, 2012.

M. Li, Evaluating the effective numbers of independent tests and significant pvalue thresholds in commercial genotyping arrays and public imputation reference datasets, Human genetics, vol.131, issue.5, pp.747-56, 2012.

Y. Li, Genotype imputation. Annual review of genomics and human genetics, vol.10, pp.387-406, 2009.

S. Liyanarachchi, Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma, Thyroid : official journal of the American Thyroid Association, vol.23, issue.12, pp.1532-1572, 2013.

S. Lönn, Papillary thyroid cancer and polymorphic variants in TSHR-and RETrelated genes: a nested case-control study within a cohort of U.S. radiologic technologists. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.16, issue.1, pp.174-181, 2007.

Y. L. Low, Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility, PLoS Genetics, vol.6, issue.7, pp.1-8, 2010.

M. J. Loza, Assembly of Inflammation-Related Genes for Pathway-Focused Genetic Analysis, PLoS ONE, vol.2, issue.10, p.1035, 2007.

J. Ma, Obesity and risk of thyroid cancer: evidence from a meta-analysis of 21 observational studies, vol.21, pp.283-91, 2015.

S. Maillard, Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population, PloS one, vol.10, issue.4, p.123700, 2015.

C. D. Malchoff, Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome, The Journal of clinical endocrinology and metabolism, vol.85, issue.5, pp.1758-64, 2000.

V. Mancikova, Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations, International journal of cancer. Journal international du cancer. Available at, 2015.

P. T. Männistö and S. Kaakkola, Catechol-O-methyltransferase, Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors, p.51, 1999.

T. A. Manolio, Finding the missing heritability of complex diseases, Nature, issue.7265, p.461, 2009.

A. A. Mansoori and S. K. Jain, Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis, Asian Pacific journal of cancer prevention, vol.16, issue.12, pp.4803-4815, 2015.

M. A. Marcello, Obesity and thyroid cancer, Endocrine-related cancer, vol.21, issue.5, pp.255-71, 2014.

J. Marchini and B. Howie, Genotype imputation for genome-wide association studies, Nature reviews. Genetics, vol.11, issue.7, pp.499-511, 2010.

J. D. Mckay, Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21, American journal of human genetics, vol.69, issue.2, pp.440-446, 2001.

R. A. Mclellan, Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity, Molecular pharmacology, vol.52, issue.6, pp.958-65, 1997.

C. L. Meinhold, Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health Study, British journal of cancer, vol.101, issue.9, pp.1630-1634, 2009.

C. L. Meinhold, Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study, American journal of epidemiology, vol.171, issue.2, pp.242-52, 2010.

A. Memon, Epidemiology of reproductive and hormonal factors in thyroid cancer: evidence from a case-control study in the Middle East, International journal of cancer, vol.97, issue.1, pp.82-91, 2002.

A. Memon, A. Varghese, and A. Suresh, Benign thyroid disease and dietary factors in thyroid cancer: a case-control study in Kuwait, British Journal of Cancer, vol.86, issue.11, pp.1745-1750, 2002.

K. Mitrunen and A. Hirvonen, Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism, Mutation research, vol.544, issue.1, pp.9-41, 2003.

E. Miyauchi, Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects, Molecular Pharmaceutics, vol.13, issue.8, pp.2631-2640, 2016.

M. A. Mooney and B. Wilmot, Gene set analysis: A step-by-step guide. American journal of medical genetics, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, vol.168, pp.517-544, 2015.

M. Moore, Cancer epidemiology in the pacific islands -past, present and future, Asian Pacific journal of cancer prevention, vol.11, issue.2, pp.99-106, 2010.

E. C. Morari, The null genotype of glutathione s-transferase M1 and T1 locus increases the risk for thyroid cancer, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol.11, pp.1485-1493, 2002.

L. Morey and K. Helin, Polycomb group protein-mediated repression of transcription, Trends in biochemical sciences, vol.35, issue.6, pp.323-355, 2010.

H. Moriya, Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects, Biomedical reports, vol.2, issue.2, pp.265-269, 2014.

P. Mota, Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility, Journal of cancer research and clinical oncology, vol.141, issue.5, pp.851-60, 2015.

J. Nagano, A case-control study in Hiroshima and Nagasaki examining nonradiation risk factors for thyroid cancer, Journal of epidemiology, vol.17, issue.3, pp.76-85, 2007.

E. Negri, A pooled analysis of case-control studies of thyroid cancer. II. Menstrual and reproductive factors, Cancer causes & control : CCC, vol.10, issue.2, pp.143-55, 1999.

G. Neta, Common genetic variants related to genomic integrity and risk of papillary thyroid cancer, Access, vol.32, issue.8, pp.1231-1237, 2011.

M. L. Neuhouser, A. R. Kristal, and D. F. Penson, Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: Review of epidemiologic literature, Urology, vol.64, issue.2, pp.201-211, 2004.

M. S. Nørskov, Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population, The pharmacogenomics journal, vol.11, issue.4, pp.292-301, 2011.

M. S. Nørskov, High-throughput genotyping of copy number variation in glutathione S-transferases M1 and T1 using real-time PCR in 20,687 individuals, Clinical biochemistry, vol.42, issue.3, pp.201-210, 2009.

J. L. Omdahl, H. A. Morris, B. K. May, . ;-h-ydroxylase-e-nzymes, and . The-v-itamin-d-p-athway, Expression, Function, and Regulation, Annual Review of Nutrition, vol.22, issue.1, pp.139-166, 2002.

M. Onda, Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers, Journal of human genetics, vol.49, issue.6, pp.312-320, 2004.

S. Park, Reproductive Factors, Glutathione S-Transferase M1 and T1 Genetic Polymorphism and Breast Cancer Risk, Breast Cancer Research and Treatment, vol.78, issue.1, pp.89-96, 2003.

K. Pazaitou-panayiotou, S. A. Polyzos, and C. S. Mantzoros, Obesity reviews : an official journal of the International Association for the Study of Obesity, vol.14, pp.1006-1028, 2013.

M. Penna-martinez, Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma, Thyroid : official journal of the American Thyroid Association, vol.22, issue.7, pp.709-725, 2012.

T. M. Penning, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones, The Biochemical journal, vol.351, pp.67-77, 2000.

T. M. Penning and M. C. Byrns, Steroid hormone transforming aldo-keto reductases and cancer, Annals of the New York Academy of Sciences, pp.33-42, 1155.

C. M. Pereda, Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population, BMC Genetics, vol.16, 2015.

C. Pilon, Mutations in CYP11B1 gene converting 11??-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas, Journal of Clinical Endocrinology and Metabolism, vol.84, issue.11, pp.4228-4231, 1999.

R. L. Prentice, Radiation exposure and thyroid cancer incidence among Hiroshima and Nagasaki residents, vol.62, pp.207-219, 1982.

M. Rebaï, Association of polymorphisms in estrogen and thyroid hormone receptors with thyroid cancer risk, Journal of receptor and signal transduction research, vol.29, issue.2, pp.113-121, 2009.

T. R. Rebbeck, Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.6, issue.9, pp.733-776, 1997.

A. A. Reis, Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules, Genetics and molecular research : GMR, vol.9, issue.4, pp.2222-2231, 2010.

Y. Ren and J. J. Lence-anta, Foxe1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population, Thyroid, 2016.

Y. Ren and J. J. Lence-anta, Foxe1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population, Thyroid : official journal of the American Thyroid Association. Available at, 2016.

S. Rinaldi, Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study, International Journal of Cancer, vol.131, issue.6, pp.1004-1014, 2012.

E. Ron, Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies, Radiation research, vol.141, issue.3, pp.259-77, 1995.

M. J. Rose-zerilli, Copy-number variation genotyping of GSTT1 and GSTM1 gene deletions by real-time PCR, Clinical chemistry, vol.55, issue.9, pp.1680-1685, 2009.

M. A. Rossing, Risk of papillary thyroid cancer in women in relation to smoking and alcohol consumption, Epidemiology, vol.11, issue.1, pp.49-54, 2000.

M. Rotinen, Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta, The Journal of endocrinology, vol.200, issue.1, pp.85-92, 2009.

A. Rudolph, Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy, International journal of cancer. Journal international du cancer, vol.131, issue.5, pp.841-849, 2012.

M. Saitou and T. Ishida, Distributions of the GSTM1 and GSTT1 null genotypes worldwide are characterized by latitudinal clines, Asian Pacific journal of cancer prevention : APJCP, vol.16, issue.1, pp.355-61, 2015.

A. Schlattl, Relating CNVs to transcriptome data at fine resolution: assessment of the effect of variant size, type, and overlap with functional regions, Genome research, vol.21, issue.12, pp.2004-2017, 2011.

S. J. Schonfeld, Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk, Thyroid : official journal of the American Thyroid Association, vol.22, issue.2, pp.151-157, 2012.

S. J. Schonfeld, Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists, Cancer causes & control : CCC, vol.21, issue.11, pp.1857-66, 2010.

B. L. Secretan, Spe ci a l R e p or t Body Fatness and Cancer -Viewpoint of the IARC Working Group, 2016.

A. Sen, Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study, British journal of cancer, vol.113, issue.5, pp.840-847, 2015.

J. Shi and S. Lee, A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis, vol.72, pp.945-954, 2016.

A. J. Sigurdson, Cancer incidence in the US radiologic technologists health study, Cancer, issue.12, pp.3080-3089, 1983.

A. J. Sigurdson, Thyroid nodules, polymorphic variants in DNA repair and RETrelated genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan, Radiation research, vol.171, issue.1, pp.77-88, 2009.

J. A. Simon and C. A. Lange, Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.647, pp.21-29, 2008.

S. Singer, Quality of Life in Patients with Thyroid Cancer Compared with the General Population, Thyroid, vol.22, issue.2, pp.117-124, 2012.

A. K. Siraj, Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population, BMC medical genetics, vol.9, issue.1, p.61, 2008.

O. P. Soldin, Thyroid hormone levels associated with active and passive cigarette smoking, Thyroid : official journal of the American Thyroid Association, vol.19, issue.8, pp.817-840, 2009.

R. Sprenger, Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation, Pharmacogenetics, vol.10, issue.6, pp.557-65, 2000.

K. Stankov, GSTT1 and M1 polymorphisms in Hürthle thyroid cancer patients, Cancer letters, vol.240, issue.1, pp.76-82, 2006.

S. H. Stewart, COMT Genotype Influences the Effect of Alcohol on Blood Pressure: Results From the COMBINE Study, American Journal of Hypertension, vol.22, issue.1, pp.87-91, 2009.

E. M. Sturgis, Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis, The Laryngoscope, vol.115, issue.6, pp.938-945, 2005.

T. Suzuki, Anthropometric factors at age 20 years and risk of thyroid cancer, Cancer causes & control : CCC, vol.19, issue.10, pp.1233-1275, 2008.

M. Takahashi, The FOXE1 locus is a major genetic determinant for radiationrelated thyroid carcinoma in Chernobyl, Human molecular genetics, vol.19, issue.12, pp.2516-2539, 2010.

C. Tian, P. K. Gregersen, and M. F. Seldin, Accounting for ancestry: Population substructure and genome-wide association studies, Human Molecular Genetics, vol.17, issue.R2, pp.143-150, 2008.

G. Tournel, CYP2F1 genetic polymorphism: Identification of interethnic variations, Xenobiotica, vol.37, issue.12, pp.1433-1438, 2007.

G. Tournel, Molecular analysis of the CYP2F1 gene: Identification of a frequent non-functional allelic variant. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, pp.79-89, 2007.

T. Truong, Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia, Cancer causes & control : CCC, vol.21, issue.8, pp.1183-92, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00471339

T. Truong, Role of goiter and of menstrual and reproductive factors in thyroid cancer: a population-based case-control study in New Caledonia (South Pacific), a very high incidence area, American journal of epidemiology, vol.161, issue.11, pp.1056-65, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00085408

T. Truong, Time trends and geographic variations for thyroid cancer in New Caledonia, a very high incidence area (1985-1999), vol.16, pp.62-70, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00138472

S. Vaccarella, The Impact of Diagnostic Changes on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Selected High-Resource Countries, Thyroid : official journal of the American Thyroid Association, vol.25, issue.10, pp.1127-1163, 2015.

P. Valeix, Effects of light to moderate alcohol consumption on thyroid volume and thyroid function, Clinical endocrinology, vol.68, issue.6, pp.988-95, 2008.

R. Vigneri, P. Malandrino, and P. Vigneri, The changing epidemiology of thyroid cancer: why is incidence increasing? Current opinion in oncology, 2014.

D. Vito and M. , Overexpression of estrogen receptor-? in human papillary thyroid carcinomas studied by laser-capture microdissection and molecular biology, Cancer science, vol.102, issue.10, pp.1921-1928, 2011.

K. Wang, M. Li, and M. Bucan, Pathway-based approaches for analysis of genomewide association studies, American journal of human genetics, vol.81, issue.6, pp.1278-83, 2007.

Y. Wang, Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population, Journal of medical genetics, vol.50, issue.10, pp.689-95, 2013.

L. D. Ward and M. Kellis, HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants, Nucleic acids research, vol.40, 2012.

F. Weber and C. Eng, Editorial: Germline Variants within RET: Clinical Utility or Scientific Playtoy?, The Journal of Clinical Endocrinology & Metabolism, vol.90, issue.11, pp.6334-6336, 2005.

D. Williams, Cancer after nuclear fallout: lessons from the Chernobyl accident, Nature reviews. Cancer, vol.2, issue.7, pp.543-552, 2002.

J. A. Williams and D. H. Phillips, Mammary Expression of Xenobiotic Metabolizing Enzymes and Their Potential Role in Breast Cancer, Cancer Research, issue.17, p.60, 2000.

J. J. Wiltshire, Systematic Review of Trends in the Incidence Rates of Thyroid Cancer, Thyroid, 2016.

L. Wu and J. Zhu, Linear reduction in thyroid cancer risk by oral contraceptive use: a dose-response meta-analysis of prospective cohort studies, Human reproduction, vol.30, issue.9, pp.2234-2274, 2015.

C. Xhaard, Anthropometric Risk Factors for Differentiated Thyroid Cancer in Young Men and Women From Eastern France: A Case-Control Study, American journal of epidemiology, vol.182, issue.3, pp.202-216, 2015.

C. Xhaard, Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: a population-based case-control study, American journal of epidemiology, vol.180, issue.10, pp.1007-1024, 2014.

S. Xu, Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?, The Journal of endocrinology, vol.218, issue.1, pp.125-158, 2013.

K. Yu, Pathway analysis by adaptive combination of P-values, Genetic epidemiology, vol.33, issue.8, pp.700-709, 2009.

L. B. Zablotska, A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine, American journal of epidemiology, vol.167, issue.3, pp.305-317, 1998.

G. Zai, A review of molecular genetic studies of neurocognitive deficits in schizophrenia, Neuroscience & Biobehavioral Reviews, vol.72, pp.50-67, 2017.

R. Zamora-ros, Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study, International journal of cancer, vol.136, issue.5, pp.1218-1245, 2015.

D. V. Zaykin, Truncated product method for combiningP-values, Genetic Epidemiology, vol.22, issue.2, pp.170-185, 2002.

W. Zhang, Meta-analysis in the association between obesity and risk of thyroid cancer, International journal of clinical and experimental medicine, vol.7, issue.12, pp.5268-74, 2014.

T. Zheng, Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk, British journal of cancer, vol.88, issue.1, pp.58-62, 2003.

Q. Zhou, Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR), Tumor Biology, vol.37, issue.3, pp.3105-3113, 2016.

J. Zhu, Parity and thyroid cancer risk: a meta-analysis of epidemiological studies, Cancer medicine, vol.5, issue.4, pp.739-52, 2016.

M. B. Zimmermann and V. Galetti, Iodine intake as a risk factor for thyroid cancer: a comprehensive review of animal and human studies, Thyroid research, vol.8, 2015.

. Null, , vol.2, p.63

. Ic, All ORs are adjusted for age, sex and area of residence. Ca/Co: Cases/Controls. OR: Odd ratios, p.95