, retinal pigment epithelium, PLoS One, vol.8, p.54552, 2013.
Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFb and Wnt signaling, Development, vol.142, pp.3294-3306, 2015. ,
, Differ-Methods, vol.19, pp.755-764, 2013.
Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc Natl Acad Sci, vol.103, pp.12769-12774, 2006. ,
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa, Elife, vol.2, p.824, 2013. ,
Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells, STEM CELLS, vol.30, pp.673-686, 2012. ,
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment, STEM CELLS, vol.29, pp.1206-1218, 2011. ,
Selfformation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785, 2012. ,
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat Commun, vol.5, p.4047, 2014. ,
, CELLS, vol.33, pp.2416-2430, 2015.
From confluent human iPS cells to selfforming neural retina and retinal pigmented epithelium, Proc Natl Acad Sci, vol.111, pp.8518-8523, 2014. ,
Characterization of three-dimensional retinal tissue derived from human embryonic stem cells in adherent monolayer cultures, Stem Cells Dev, vol.24, pp.2778-2795, 2015. ,
Chemically defined conditions for human iPSC derivation and culture, Nat Methods, vol.8, pp.424-429, 2011. ,
Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells, Mol Vis, vol.17, pp.558-575, 2011. ,
Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate, STEM CELLS TRANSL MED, vol.4, pp.165-177, 2015. ,
Xeno-free and defined human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate in a large-eyed preclinical model, Stem Cell Rep, vol.6, pp.1-9, 2015. ,
Subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium for the treatment of macular degeneration: An assessment at 4 years, Invest Ophthalmol Vis Sci, vol.57, pp.1-9, 2016. ,
Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation, STEM CELLS TRANSL MED, vol.2, pp.16-24, 2013. ,
Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells, STEM CELLS TRANSL MED, vol.2, pp.255-264, 2013. ,
Production of retinal cells from confluent human iPS cells, Methods Mol Biol, vol.1357, pp.339-351, 2016. ,
A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system, Cell Rep, vol.9, pp.1191-1201, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01944649
Eye morphogenesis and patterning of the optic vesicle, Curr Top Dev Biol, vol.93, pp.61-84, 2010. ,
Regulation of eye formation by the Rx and pax6 homeobox genes, Cell Mol Life Sci, vol.57, pp.186-194, 2000. ,
Retinal repair by transplantation of photoreceptor precursors, Nature, vol.444, pp.203-207, 2006. ,
Repair of the degenerate retina by photoreceptor transplantation, Proc Natl Acad Sci, vol.110, pp.354-359, 2013. ,
Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, STEM CELLS, vol.29, pp.1391-1404, 2011. ,
Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina, Invest Ophthalmol Vis Sci, vol.52, pp.6462-6471, 2011. ,
Daylight vision repair by cell transplantation, STEM CELLS, vol.1, pp.1-15, 2015. ,
Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization, Proc Natl Acad Sci, vol.94, pp.12932-12937, 1997. ,
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis, Proc Natl Acad Sci, vol.104, pp.12005-12010, 2007. ,
Human retinal development: Ultrastructure of the outer retina, Am J Anat, vol.137, pp.357-385, 1973. ,
CD73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells, Invest Ophthalmol Vis Sci, vol.50, pp.5411-5418, 2009. ,
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration, Proc Natl Acad Sci, vol.113, 2016. ,
Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application, Stem Cell Rep, vol.2, pp.205-218, 2014. ,
Synthesis generating an iPSC bank for HLAmatched tissue transplantation based on known donor and recipient HLA types, Cell Stem Cell, vol.11, pp.147-152, 2012. ,
Development of a global network of induced pluripotent stem cell haplobanks, Regen Med, vol.10, pp.235-238, 2015. ,
, See www.StemCells.com for supporting information available online
A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system, Cell Rep, vol.9, pp.1191-1201, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01944649
Let there be light: gene and cell therapy for blindness, Gene Ther, vol.27, pp.134-147, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01258538
Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells, Stem Cell Reports, vol.2, pp.853-865, 2014. ,
Cone genesis tracing by the Chrnb4-EGFP mouse line: evidences of cellular material fusion after cone precursor transplantation, Mol. Ther, vol.25, pp.634-653, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01466245
The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells, Invest. Opthalmol. Vis. Sci, vol.52, pp.1640-1647, 2002. ,
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina, Nat. Biotechnol, vol.31, pp.741-747, 2013. ,
Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors, Stem Cell Reports, vol.9, pp.820-837, 2017. ,
Isolation and transplantation of autologous peripheral CD34+ progenitor cells highly purified by magnetic-activated cell sorting, Bone Marrow Transplant, vol.21, pp.987-993, 1998. ,
Molecular anatomy of the developing human retina, Dev. Cell, vol.43, pp.763-779, 2017. ,
Cellular strategies for retinal repair by photoreceptor replacement, Prog. Retin. Eye Res, vol.46, pp.31-66, 2015. ,
Transcriptome dynamics of developing photoreceptors in three-dimensional retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks, Stem Cells, vol.33, pp.3504-3518, 2015. ,
Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, Stem Cells, vol.29, pp.1391-1404, 2011. ,
Transplantation of photoreceptor precursors isolated via a cell surface biomarker panel from embryonic stem cellderived self-forming retina, Stem Cells, vol.33, pp.2469-2482, 2015. ,
Isolation of human photoreceptor precursors via a cell surface marker panel from stem cell-derived retinal organoids and fetal retinae, Stem Cells, vol.36, pp.709-722, 2018. ,
Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc. Natl. Acad. Sci. USA, vol.103, pp.12769-12774, 2006. ,
Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice, Cell Stem Cell, vol.4, pp.73-79, 2009. ,
Structural divergence of essential triad ribbon synapse proteins among placental mammals -implications for preclinical trials in photoreceptor transplantation therapy, Exp. Eye Res, vol.159, pp.156-167, 2017. ,
, , 2017.
IGF-1 signaling plays an important role in the formation of three-dimensional laminated neural retina and other ocular structures from human embryonic stem cells, Stem Cells, vol.33, pp.2416-2430, 2015. ,
Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report, Eur. Heart J, vol.36, pp.2011-2017, 2015. ,
, , 2009.
, Modeling early retinal development with human embryonic and induced pluripotent stem cells, Proc. Natl. Acad. Sci. USA, vol.106, pp.16698-16703
, , 2012.
, Self-formation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785
Genotypic and phenotypic characterization of P23H line 1 rat model, PLoS One, vol.10, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01228055
A reinterpretation of cell transplantation: GFP transfer from donor to host photoreceptors, Stem Cells, vol.35, pp.932-939, 2017. ,
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells, Nat. Biotechnol, vol.26, pp.215-224, 2008. ,
Restoration of vision after transplantation of photoreceptors, Nature, vol.485, pp.99-103, 2012. ,
Donor and host photoreceptors engage in material transfer following transplantation of postmitotic photoreceptor precursors, Nat. Commun, vol.7, p.13029, 2016. ,
, , 2017.
From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium, Proc. Natl. Acad. Sci. USA, vol.111, pp.8518-8523, 2014. ,
Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xenofree and feeder-free conditions, Stem Cells, vol.35, pp.1176-1188, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01480587
Daylight vision repair by cell transplantation, Stem Cells, vol.33, pp.79-90, 2015. ,
Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy, Invest. Ophthalmol. Vis. Sci, vol.57, pp.3509-3520, 2016. ,
Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange, Nat. Commun, vol.7, p.13028, 2016. ,
Rebuilding the missing part-a review on photoreceptor transplantation, Front. Syst. Neurosci, vol.10, pp.1-14, 2017. ,
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation, Proc. Natl. Acad. Sci. USA, vol.110, pp.1101-1106, 2013. ,
Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion, Stem Cell Reports, vol.10, pp.1-16, 2016. ,
Isolation and comparative transcriptome analysis of human fetal and iPSC-derived cone photoreceptor cells, Stem Cell Reports, vol.9, pp.1898-1915, 2017. ,
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness, Sci. Rep, vol.6, p.30742, 2016. ,
Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells, Development, vol.144, pp.1368-1381, 2017. ,
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat. Commun, vol.5, pp.1-14, 2014. ,
Immunosuppression via loss of IL2rg enhances long-term functional integration of hESC-derived photoreceptors in the mouse retina, Cell Stem Cell, vol.20, pp.374-384, 2017. ,
, Oriane Rabesandratana, José-Alain Sahel, Jens Duebel, Gael Orieux, Sacha Reichman
, , 2013.
, Multiplex Genome Engineering Using CRISPR/VCas Systems. Science (80-. ), vol.339, pp.819-823
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases, Nat. Biotechnol, vol.27, pp.851-857, 2009. ,
, Multiplex Cell and Lineage Tracking with Combinatorial Labels, vol.81, pp.505-520, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01086032
Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration, Sci. Transl. Med, vol.9, 2017. ,
Involvement of Bcl-2-Associated Transcription Factor 1 in the Differentiation of Early-Born Retinal Cells, J. Neurosci, vol.34, pp.1530-1541, 2014. ,
Genome engineering using the CRISPR-Cas9 system, Nat. Protoc, vol.8, pp.2281-2308, 2013. ,
Gene therapy restores vision in a canine model of childhood blindness, Nat. Genet, vol.28, pp.92-95, 2001. ,
Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies, Dev. Biol, vol.305, pp.1-13, 2007. ,
, , 2009.
, Growth kinetics and transplantation of human retinal progenitor cells, Exp. Eye Res, vol.89, pp.301-310
Identification of neural progenitors in the adult mammalian eye, Biochem. Biophys. Res. Commun, vol.270, pp.517-521, 2000. ,
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.3890-3895, 2006. ,
The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis, Neuron, vol.94, pp.550-568, 2017. ,
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy, Nat. Genet, vol.15, pp.236-246, 1997. ,
Differentiation of Human Embryonic Stem Cell-Derived Retinal Progenitors into Retinal Cells by Sonic Hedgehog and/or Retinal Pigmented Epithelium and Transplantation into the Subretinal Space of Sodium Iodate-Injected Rabbits, Stem Cells Dev, vol.21, pp.42-53, 2012. ,
The Murine Cone Photoreceptor, Neuron, vol.27, pp.513-523, 2000. ,
Retinal transplantation -Advantages of intact fetal sheets, Prog. Retin. Eye Res, 2002. ,
Successful cotransplantation of intact sheets of fetal retina with retinal pigment epithelium, Investig. Ophthalmol. Vis. Sci, 1999. ,
Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice, Stem Cell Reports, vol.2, pp.662-674, 2014. ,
Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patients, Investig. Ophthalmol. Vis. Sci, vol.51, pp.3687-3700, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00472460
Multipotent cell lineages in early mouse development depend on SOX2 function, Genes Dev, vol.17, pp.126-140, 2003. ,
Inherited Retinal Diseases: Vertebrate Animal Models, Encyclopedia of Life Sciences, 2006. ,
In vivo CRISPR/Cas9 gene editing corrects retinal dystrophy in the S334ter-3 rat model of autosomal dominant retinitis pigmentosa, Mol. Ther, vol.24, pp.556-563, 2016. ,
A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation, Stem Cell Reports, vol.4, pp.1031-1045, 2015. ,
Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells, Stem Cells, vol.24, pp.246-257, 2006. ,
Repair of the degenerate retina by photoreceptor transplantation, Proc. Natl. Acad. Sci, vol.110, pp.354-359, 2013. ,
Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era, Cell Stem Cell, vol.21, pp.569-573, 2017. ,
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice, Sci. Rep, vol.6, p.29784, 2016. ,
Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice, Exp. Eye Res, vol.86, pp.691-700, 2008. ,
Cell fate determination in the vertebrate retina, Trends Neurosci, vol.35, pp.565-573, 2012. ,
Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen, Cell Stem Cell, vol.12, pp.167-179, 2013. ,
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro, Nature, vol.448, pp.1015-1021, 2007. ,
The molecular basis of human retinal and vitreoretinal diseases, Prog. Retin. Eye Res, vol.29, pp.335-375, 2010. ,
Reference maps of human es and ips cell variation enable high-throughput characterization of pluripotent cell lines, Cell, vol.144, pp.439-452, 2011. ,
Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages, Curr. Opin. Neurobiol, vol.27, pp.68-74, 2014. ,
Adult mice generated from induced pluripotent stem cells, Nature, vol.461, pp.91-94, 2009. ,
Brief report: Self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors, Stem Cells, vol.31, pp.408-414, 2013. ,
Hereditary degeneration of the rat retina, Br. J. Ophthalmol, vol.22, pp.613-622, 1938. ,
Evolution of vertebrate visual pigments, Curr. Biol, vol.16, pp.484-489, 2006. ,
Do Human Leukocyte Antigen-Typed Cellular Therapeutics Based on Induced Pluripotent Stem Cells Make Commercial Sense?, Stem Cells Dev, vol.24, pp.1-10, 2015. ,
Photoreceptor cell fate specification in vertebrates, Development, vol.142, pp.3263-3273, 2015. ,
Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence, Dev. Biol, vol.384, pp.194-204, 2013. ,
CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype, Gene Ther, vol.21, pp.662-672, 2014. ,
Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration, Mol. Ther, vol.25, pp.1999-2013, 2017. ,
CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration, Prog. Retin. Eye Res, pp.1-22, 2018. ,
MiRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function, Neuron, vol.83, pp.586-600, 2014. ,
Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration, J. Clin. Invest, vol.125, pp.105-116, 2015. ,
Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit, Proc. Natl. Acad. Sci, vol.97, pp.13913-13918, 2000. ,
Autoradiographic analysis of cell generation using tritiated thymidine, J. Comp. Neurol, vol.188, pp.263-272, 1979. ,
Intrinsically different retinal progenitor cells produce specific types of progeny, Nat. Rev. Neurosci, vol.15, pp.615-627, 2014. ,
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells, Cell, vol.113, pp.643-655, 2003. ,
Retinal degeneration mutants in the mouse, Vision Res, vol.42, pp.517-525, 2002. ,
A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.19581-19586, 2009. ,
Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate, Transl. Vis. Sci. Technol, vol.6, p.4, 2017. ,
The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes, J. Neurosci, vol.25, pp.118-129, 2005. ,
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes, Neuron, vol.19, pp.1017-1030, 1997. ,
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development, Hum. Mol. Genet, vol.15, pp.2588-2602, 2006. ,
Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors during Pluripotent Stem Cell Differentiation, Stem Cells, vol.34, pp.311-321, 2016. ,
Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration, Invest. Ophthalmol. Vis. Sci, vol.54, pp.6745-6756, 2013. ,
Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration, Front. Neuroanat, vol.8, 2014. ,
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat, Hum. Mol. Genet, vol.9, pp.645-651, 2000. ,
Genes and mutations causing retinitis pigmentosa, Clin. Genet, vol.84, pp.132-141, 2013. ,
Let There Be Light: Gene and Cell Therapy for Blindness, Gene Ther, vol.27, pp.134-147, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01258538
Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse, Investig. Ophthalmol. Vis. Sci, vol.46, pp.2156-2167, 2005. ,
Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells, Stem Cell Reports, vol.2, pp.853-865, 2014. ,
Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation, Mol. Ther, vol.25, pp.634-653, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01466245
A Photon Accurate Model of the Human Eye, ACM SIGGRAPH 2005 Pap. -SIGGRAPH '05, pp.1-14, 2004. ,
Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients, Stem Cell Reports, vol.10, pp.1267-1281, 2018. ,
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain, Proc Natl Acad Sci U S A, vol.92, pp.377-381, 1995. ,
Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors, Stem Cell Reports, vol.10, pp.1-14, 2017. ,
Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa, N Engl J Med, vol.323, pp.1302-1307, 1990. ,
A point mutation of the rhodopsin gene in one form of retinitis pigmentosa, Nature, vol.343, pp.364-366, 1990. ,
Increased Integration of Transplanted CD73-Positive Photoreceptor Precursors into Adult Mouse Retina, Investig. Opthalmology Vis. Sci, vol.52, p.6462, 2011. ,
Outer Segment Formation of Transplanted Photoreceptor Precursor Cells, PLoS One, vol.7, 2012. ,
10 Questions: Clinical Outlook for iPSCs, Cell Stem Cell, vol.18, pp.170-173, 2016. ,
Self-organizing optic-cup morphogenesis in three-dimensional culture, Nature, vol.472, pp.51-56, 2011. ,
Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors, Dev. Cell, vol.26, pp.59-72, 2013. ,
Establishment in culture of pluripotential cells from mouse embryos, Nature, vol.292, pp.154-156, 1981. ,
Production of Human Pluripotent Stem Cell Therapeutics under Defined Xeno-free Conditions: Progress and Challenges, Stem Cell Rev. Reports, vol.11, pp.96-109, 2015. ,
Eye morphogenesis and patterning of the optic vesicle, Curr. Top. Dev. Biol, vol.93, pp.61-84, 2010. ,
Retinal pigment epithelium development, plasticity, and tissue homeostasis, Exp. Eye Res, vol.123, pp.141-150, 2014. ,
Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development, J. Neurochem, vol.108, pp.91-101, 2009. ,
Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function, Sci. Rep, vol.6, 2016. ,
Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation, Cell, vol.91, pp.531-541, 1997. ,
Retinopathy and attenuated circadian entrainment in Crx-deficient mice, Nat. Genet, vol.23, pp.466-470, 1999. ,
Efcient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome, Proc. Jpn. Acad., Ser. B, vol.85, 2009. ,
Protection of visual functions by human neural progenitors in a rat model of retinal disease, PLoS One, vol.2, p.338, 2007. ,
Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions, Development, vol.138, pp.227-235, 2011. ,
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina, Nat. Biotechnol, vol.31, pp.741-747, 2013. ,
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors, Stem Cell Reports, vol.9, pp.820-837, 2017. ,
Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells, Hum. Gene Ther. hum, p.27, 2018. ,
Somatic coding mutations in human induced pluripotent stem cells, Nature, vol.471, pp.63-67, 2011. ,
Eye Development, Curr. Top. Dev. Biol, vol.90, pp.343-386, 2010. ,
Changes in intermediate filament immunolabeling occur in response to retinal detachment and reattachment in primates, Investig. Ophthalmol. Vis. Sci, vol.31, pp.1474-1482, 1990. ,
Adult donor rod photoreceptors integrate into the mature mouse retina, Investig. Ophthalmol. Vis. Sci, vol.52, pp.5266-5272, 2011. ,
Pathobiology of the Outer Retina: Genetic and Nongenetic Causes of Disease, 2014. ,
Stargardt-Fundus Flavimaculatus: Recent Advancements and Treatment, Semin. Ophthalmol, vol.28, pp.372-376, 2013. ,
Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in unimmunosuppressed mouse retina, Mol. Vis, vol.18, pp.920-936, 2012. ,
Retinitis pigmentosa, Orphanet J. Rare Dis, vol.1, pp.1-40, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00122147
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin, Science, vol.318, pp.1920-1923, 2007. ,
Retinitis pigmentosa, Lancet, vol.368, pp.1795-1809, 2006. ,
Retinal cell fate determination and bHLH factors, Semin. Cell Dev. Biol, vol.15, pp.83-89, 2004. ,
The Primordial, Blue-Cone Color System of the Mouse Retina, J. Neurosci, vol.25, pp.5438-5445, 2005. ,
How variable clones build an invariant retina, Neuron, vol.75, pp.786-798, 2012. ,
Regulation of photoreceptor gene expression by Crxassociated transcription factor network, Brain Res, vol.1192, pp.114-133, 2008. ,
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors, Cell Stem Cell, vol.17, pp.101-115, 2015. ,
Generation of retinal cells from mouse and human induced pluripotent stem cells, Neurosci. Lett, vol.458, pp.126-131, 2009. ,
Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind, Ophthalmology, vol.122, pp.1547-1554, 2015. ,
Leber congenital amaurosis: genes, proteins and disease mechanisms, Prog. Retin. Eye Res, vol.27, pp.391-419, 2008. ,
Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system, J. Neurosci. Res, vol.87, pp.2175-2182, 2009. ,
Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors, Stem Cells, vol.31, pp.1149-1159, 2013. ,
Knock-in strategy at ??-end of Crx gene by CRISPR/Cas9 system shows the gene expression profiles during human photoreceptor differentiation, Genes to Cells, vol.22, pp.250-264, 2017. ,
Functional architecture of the retina: Development and disease, Prog. Retin. Eye Res, vol.42, pp.44-84, 2014. ,
Molecular Anatomy of the Developing Human Retina, Dev. Cell, vol.43, pp.763-779, 2017. ,
, , 2013.
, Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds, Science, vol.341, pp.651-654
The allometry and scaling of the size of vertebrate eyes, Vision Res, vol.44, pp.2043-2065, 2004. ,
A schematic eye for the rat, Vision Res, vol.19, pp.569-588, 1979. ,
Retinopathy induced in mice by targeted disruption of the rhodopsin gene, Nat. Genet, vol.15, pp.216-219, 1997. ,
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development, Acta Biomater, vol.49, pp.329-343, 2017. ,
Copy number variation and selection during reprogramming to pluripotency, Nature, vol.471, pp.58-62, 2011. ,
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.11331-11336, 2005. ,
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system, J. Biol. Chem, vol.277, pp.34150-34160, 2002. ,
Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation, Stem Cell Reports, vol.10, pp.1059-1074, 2018. ,
NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells, Blood, vol.100, pp.3175-3182, 2002. ,
Retinal receptors in rodents maximally sensitive to ultraviolet light, Nature, vol.353, pp.737-740, 1991. ,
Notch 1 inhibits photoreceptor production in the developing mammalian retina, Development, vol.133, pp.913-923, 2006. ,
Cellular strategies for retinal repair by photoreceptor replacement, Prog. Retin. Eye Res, vol.46, pp.31-66, 2015. ,
Retinoidrelated orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.17534-17539, 2009. ,
Modeling retinal degeneration using patient-specific induced pluripotent stem cells, PLoS One, vol.6, 2011. ,
Retinal remodeling during retinal degeneration, Exp. Eye Res, vol.81, pp.123-137, 2005. ,
Age-Related Macular Degeneration, N. Engl. J. Med, vol.355, pp.1474-1485, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00477813
Human induced pluripotent stem cells free of vector and transgene sequences, Science, vol.324, pp.797-801, 2009. ,
,
, Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks, Stem Cells, vol.33, pp.3504-3518
Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application, Stem Cell Reports, vol.2, pp.205-218, 2014. ,
Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development, J. Neurosci, vol.30, pp.6515-6526, 2010. ,
Retinal degeneration in the mouse is rodless retina, J. Hered, vol.57, p.50, 1966. ,
Dishing out mini-brains: Current progress and future prospects in brain organoid research, Dev. Biol, vol.420, pp.199-209, 2016. ,
Noninvasive gene delivery to foveal cones for vision restoration, JCI Insight, vol.3, p.96029, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01718061
, , 2009.
Epigenetic memory in induced pluripotent stem cells, Nature, vol.467, pp.285-290, 2010. ,
Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat, Vet. Ophthalmol, vol.10, pp.245-253, 2007. ,
, , 2004.
, Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior, Investig. Ophthalmol. Vis. Sci, vol.45, pp.4167-4173
Functional roles of Otx2 transcription factor in postnatal mouse retinal development, Mol. Cell. Biol, vol.27, pp.8318-8329, 2007. ,
Late histological and functional changes in the P23H rat retina after photoreceptor loss, Neurobiol. Dis, vol.38, pp.47-58, 2010. ,
CD73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells, Investig. Ophthalmol. Vis. Sci, vol.50, pp.5411-5418, 2009. ,
Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin, Mol. Vis, vol.11, pp.1246-1256, 2005. ,
Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells, Stem Cells Transl. Med, vol.1, pp.96-109, 2012. ,
Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration, Stem Cell Reports, vol.8, pp.1659-1674, 2017. ,
Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue, Nat. Commun, vol.6, p.6286, 2015. ,
Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, Stem Cells, vol.29, pp.1391-1404, 2011. ,
Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel from Embryonic Stem Cell-Derived Self-Forming Retina, Stem Cells, vol.33, pp.2469-2482, 2015. ,
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-derived Retinal Organoids and Fetal Retinae, Stem Cells, 2018. ,
Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.12769-12774, 2006. ,
Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice, Cell Stem Cell, vol.4, pp.73-79, 2009. ,
Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells, PLoS One, vol.5, p.8763, 2010. ,
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration, Exp. Eye Res, vol.167, pp.56-90, 2018. ,
Structural divergence of essential triad ribbon synapse proteins among placental mammals -Implications for preclinical trials in photoreceptor transplantation therapy, Exp. Eye Res, vol.159, pp.156-167, 2017. ,
Inhibition of pluripotent stem cell-derived teratoma formation by small molecules, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.3281-90, 2013. ,
Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration, Exp. Eye Res, vol.174, pp.13-28, 2018. ,
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells, Nature, vol.471, pp.68-73, 2011. ,
Alternative splicing and retinal degeneration, Clin. Genet, vol.84, pp.142-149, 2013. ,
Vertebrate neural cell-fate determination: lessons from the retina, Nat. Rev. Neurosci, vol.2, pp.109-118, 2001. ,
Organoid technology for retinal repair, Dev. Biol, vol.433, pp.132-143, 2018. ,
Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction, Invest. Ophthalmol. Vis. Sci, vol.35, pp.358-362, 1994. ,
Neural Stem Cells Derived by Small Molecules Preserve Vision, Transl. Vis. Sci. Technol, vol.2, p.1, 2013. ,
Genetic and epigenetic stability of human pluripotent stem cells, Nat. Rev. Genet, vol.13, pp.732-744, 2012. ,
Human retinal progenitor cell transplantation preserves vision, J. Biol. Chem, vol.289, pp.6362-6371, 2014. ,
Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration, Sci. Transl. Med, vol.9, p.7471, 2017. ,
Cone fusion confusion in photoreceptor transplantation, Stem Cell Investig, vol.4, pp.71-71, 2017. ,
Retinal repair by transplantation of photoreceptor precursors, Nature, vol.444, pp.203-207, 2006. ,
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice, Stem Cell Reports, vol.8, pp.69-83, 2017. ,
Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration, N. Engl. J. Med, vol.376, pp.1038-1046, 2017. ,
The fundamental plan of the retina, Nat. Neurosci, vol.4, pp.877-886, 2001. ,
The Neuronal Organization of the Retina, Neuron, vol.76, pp.266-280, 2012. ,
A revision of the rat schematic eye, Vision Res, vol.12, pp.793-796, 1972. ,
Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities, Biochim. Biophys. Acta, vol.1852, pp.406-420, 2015. ,
Transplanted hESC-Derived Retina Organoid Sheets Differentiate , Integrate , and Improve Visual Function in Retinal Degenerate Rats, 2018. ,
Stem cell treatment of degenerative eye disease, Stem Cell Res, vol.14, pp.243-257, 2015. ,
Nrl is required for rod photoreceptor development, Nat. Genet, vol.29, pp.447-452, 2001. ,
Efficient stagespecific differentiation of human pluripotent stem cells toward retinal photoreceptor cells, Stem Cells, vol.30, pp.673-686, 2012. ,
, , 2015.
, Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures from Human Embryonic Stem Cells, Stem Cells, vol.33, pp.2416-2430
Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1, Eur. Heart J, vol.36, pp.2011-2017, 2015. ,
Mechanisms of cell death in rhodopsin retinitis pigmentosa: Implications for therapy, Trends Mol. Med, vol.11, pp.177-185, 2005. ,
Modeling early retinal development with human embryonic and induced pluripotent stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.16698-16703, 2009. ,
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment, Stem Cells, vol.29, pp.1206-1218, 2011. ,
The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells, Cell, vol.113, pp.631-642, 2003. ,
Retinal dystrophy in Bardet-Biedl syndrome and related syndromic ciliopathies, Prog. Retin. Eye Res, vol.30, pp.258-274, 2011. ,
Structure of cone photoreceptors, Prog. Retin. Eye Res, vol.28, pp.289-302, 2009. ,
Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.5499-5503, 1993. ,
Self-formation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785, 2012. ,
HLA-haplotype banking and iPS cells, Nat. Biotechnol, vol.26, pp.739-740, 2008. ,
Hurdles to clinical translation of human induced pluripotent stem cells, J. Clin. Invest, vol.125, pp.2551-2557, 2015. ,
Immune modulation by MANF promotes tissue repair and regenerative success in the retina, Science, p.3646, 2016. ,
The Muller cell: A functional element of the retina, Trends Neurosci, vol.19, pp.307-312, 1996. ,
A thyroid hormone receptor that is required for the development of green cone photoreceptors, Nat. Genet, vol.27, pp.94-98, 2001. ,
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4, Cell, vol.95, pp.379-391, 1998. ,
Material Exchange in Photoreceptor Transplantation: Updating Our Understanding of Donor/Host Communication and the Future of, Cell Engraftment Science. Front. Neural Circuits, vol.12, 2018. ,
The opsins of the vertebrate retina: Insights from structural, biochemical, and evolutionary studies, Cell. Mol. Life Sci, vol.64, pp.2917-2932, 2007. ,
Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents, Stem Cells Transl. Med, vol.6, pp.937-948, 2017. ,
A New H-2-Linked Mutation, rds, Causing Retinal Degeneration in the Mouse, Tissue Antigens, vol.12, pp.106-108, 1978. ,
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development, Nat. Neurosci, vol.6, pp.1255-1263, 2003. ,
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells, Nat. Genet, vol.24, pp.372-376, 2000. ,
Human oocytes reprogram somatic cells to a pluripotent state, Nature, vol.478, pp.70-75, 2011. ,
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation, Nat. Protoc, vol.12, pp.1962-1979, 2017. ,
Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors, Brain Res, vol.1236, pp.16-29, 2008. ,
Regulation of retinal cell fate specification by multiple transcription factors, Brain Res, vol.1192, pp.90-98, 2008. ,
Generation of germline-competent induced pluripotent stem cells, Nature, vol.448, pp.313-317, 2007. ,
A more efficient method to generate integration-free human iPS cells, Nat. Methods, vol.8, pp.409-412, 2011. ,
Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa, Neuron, vol.9, pp.815-830, 1992. ,
Genotypic and phenotypic characterization of P23H line 1 rat model, PLoS One, vol.10, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01228055
A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors, Stem Cells, vol.35, pp.932-939, 2017. ,
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells, Nat. Biotechnol, vol.26, pp.215-224, 2008. ,
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction, J. Cell Sci, vol.122, pp.3169-3179, 2009. ,
Use of bioreactors for culturing human retinal organoids improves photoreceptor yields, Stem Cell Res. Ther, vol.9, p.156, 2018. ,
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina, Mol. Cell. Neurosci, vol.26, pp.258-270, 2004. ,
Retinal Photoreceptor Count, Retinal Surface Area, and Optic Disc Size in Normal Human Eyes, Ophthalmology, vol.101, pp.519-523, 1994. ,
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups, Cell Stem Cell, vol.18, pp.769-781, 2016. ,
Restoration of vision after transplantation of photoreceptors, Nature, vol.485, pp.99-103, 2012. ,
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors, Nat. Commun, vol.7, p.13029, 2016. ,
The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes, Hum. Mol. Genet, vol.14, pp.747-764, 2005. ,
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa, Nat. Biotechnol, vol.15, pp.965-970, 1997. ,
,
, A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types, Stem Cells, pp.1-16
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses, Invest. Ophthalmol. Vis. Sci, vol.53, pp.2007-2019, 2012. ,
Modeling human retinal development with patientspecific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2, Stem Cells, vol.32, pp.1480-1492, 2014. ,
PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect, Proc. Natl. Acad. Sci, vol.90, pp.9616-9619, 1993. ,
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells, Nat. Biotechnol, vol.28, pp.848-855, 2010. ,
Analysis of cell surface markers specific for transplantable rod photoreceptors, Mol. Vis, vol.19, pp.2058-2067, 2013. ,
Concise review: Embryonic stem cells versus induced pluripotent stem cells: The game is on, Stem Cells, vol.30, pp.10-14, 2012. ,
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.6027-6032, 2004. ,
Cell diversity and network dynamics in photosensitive human brain organoids, Nature, vol.545, pp.48-53, 2017. ,
Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium, Am. J. Ophthalmol. Ophthalmol, vol.146, pp.172-182, 2008. ,
Leber congenital amaurosis linked to AIPL1: A mouse model reveals destabilization of cGMP phosphodiesterase, Proc. Natl. Acad. Sci, vol.101, pp.13897-13902, 2004. ,
Distribution of Bergmann glial somata and processes: implications for function, J. F?r Hirnforsch, vol.36, pp.509-517, 1995. ,
From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.8518-8523, 2014. ,
Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions, Stem Cells, vol.35, pp.1176-1188, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01480587
A schematic eye for the mouse, and comparisons with the rat, Vision Res, vol.25, pp.21-31, 1985. ,
Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina, J. Neurosci, vol.24, pp.9779-9788, 2004. ,
Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina, Invest. Ophthalmol. Vis. Sci, vol.46, pp.2897-2904, 2005. ,
Packing arrangement of the three cone classes in primate retina, Vision Research, pp.1291-1306, 2001. ,
Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: An in vivo system for studying stem/progenitor cell plasticity, Dev. Neurosci, vol.26, pp.336-345, 2004. ,
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations, J. Biol. Chem, vol.286, pp.10551-10567, 2011. ,
The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation, J. Cell Sci, vol.115, pp.2907-2918, 2002. ,
Daylight vision repair by cell transplantation, Stem Cells, vol.33, pp.79-90, 2015. ,
Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy, Investig. Ophthalmol. Vis. Sci, vol.57, pp.3509-3520, 2016. ,
Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange, Nat. Commun, vol.7, p.13028, 2016. ,
Rebuilding the Missing Part-A Review on Photoreceptor Transplantation, Front. Syst. Neurosci, vol.10, pp.1-14, 2017. ,
The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors, J. Neurosci, vol.29, pp.12401-12411, 2009. ,
A Pro23His mutation alters prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa, Investig. Ophthalmol. Vis. Sci, vol.55, pp.2452-2459, 2014. ,
Progression of Pro23His Retinopathy in a Miniature Swine Model of Retinitis Pigmentosa, Transl. Vis. Sci. Technol, vol.6, p.4, 2017. ,
Positional cloning of the nude locus: Genetic, physical, and transcription maps of the region and mutations in the mouse and rat, Genomics, vol.28, pp.549-559, 1995. ,
Intact sheets of fetal retina transplanted to restore damaged rat retinas, Investig. Ophthalmol. Vis. Sci, 1998. ,
Cell replacement and visual restoration by retinal sheet transplants, Prog. Retin. Eye Res, vol.31, pp.661-687, 2012. ,
Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets, Eur. J. Neurosci, vol.31, pp.508-520, 2010. ,
A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefe's Arch, Clin. Exp. Ophthalmol, vol.252, pp.1079-1092, 2014. ,
Vision recovery and connectivity by fetal retinal sheet transplantation in an immunodeficient retinal degenerate rat model, Investig. Ophthalmol. Vis. Sci, vol.58, pp.614-630, 2017. ,
A bilayer photoreceptor-retinal tissue model with gradient cell density design: A study of microvalve-based bioprinting, J. Tissue Eng. Regen. Med, vol.12, pp.1297-1306, 2018. ,
Induced pluripotent stem cell technology: A decade of progress, Nat. Rev. Drug Discov, vol.16, pp.115-130, 2017. ,
Transplantation of human embryonic stem cellderived retinal tissue in two primate models of retinal degeneration, Proc. Natl. Acad. Sci, vol.113, pp.81-90, 2016. ,
Multiple defects in innate and adaptive immunological function in NOD/LtSz-scid mice, J. Immunol, vol.154, pp.180-191, 1995. ,
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants, Proc. Natl. Acad. Sci, vol.103, pp.3896-3901, 2006. ,
Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina, Dev. Cell, vol.42, pp.68-81, 2017. ,
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.1101-1106, 2013. ,
Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion, Nat. Commun, vol.7, p.13537, 2016. ,
Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures, Stem Cells Dev, vol.24, 2015. ,
Stem cells and exosomes in cardiac repair, Curr. Opin. Pharmacol, vol.27, pp.19-23, 2016. ,
Mimicking Retinal Development and Disease With Human Pluripotent Stem Cells, Investig. Opthalmology Vis. Sci, vol.57, p.1, 2016. ,
The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies, Prog. Retin. Eye Res, vol.48, pp.137-159, 2015. ,
North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13, Ophthalmology, vol.123, pp.9-18, 2016. ,
, GFP reporter mouse line. Sci. Rep, vol.6, 2016.
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution, Cell, vol.137, pp.356-368, 2009. ,
Induced Pluripotent Stem Cells Generated Without Viral Integration, Science, vol.322, pp.945-949, 2008. ,
Transgenic rat models of inherited retinal degeneration caused by mutant opsin genes, Investig. Ophthalmol. Vis. Sci, vol.37, 1996. ,
Regenerating Eye Tissues to Preserve and Restore Vision, Cell Stem Cell, vol.22, pp.834-849, 2018. ,
Biological application of microelectrode arrays in drug discovery and basic research, Anal. Bioanal. Chem, vol.377, pp.486-495, 2003. ,
Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS, Proc. Biol. Sci, vol.280, 2013. ,
The Retinal Pigment Epithelium in Visual Function, Physiol. Rev, vol.85, pp.845-881, 2005. ,
Recruitment of the Rod Pathway by Cones in the Absence of Rods, J. Neurosci, vol.24, pp.7576-7582, 2004. ,
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina, Nat. Rev. Neurosci, vol.11, pp.563-576, 2010. ,
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.12991-12996, 2008. ,
Human embryonic stem cells derived by somatic cell nuclear transfer, Cell, vol.153, pp.1228-1238, 2013. ,
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Cell, vol.126, pp.663-676, 2006. ,
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, pp.861-872, 2007. ,
Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina, Mol. Cell. Neurosci, vol.12, pp.340-348, 1998. ,
, , 2009.
, Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders, Am. J. Hum. Genet, vol.85, pp.240-247
Embryonic Stem Cell Lines Derived from Human Blastocysts. Science (80-. ), vol.282, pp.1145-1147, 1998. ,
, Retinal stem cells in the adult mammalian eye. Science, vol.287, pp.2032-2036, 2000.
Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model, Stem Cells, vol.33, pp.2537-2549, 2015. ,
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice, PLoS One, vol.6, 2011. ,
Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa, Proc. Natl. Acad. Sci, vol.108, pp.569-576, 2011. ,
Patient-specifc iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa, pp.1-18, 2013. ,
A common progenitor for neurons and glia persists in rat retina late in development, Nature, vol.328, pp.131-136, 1987. ,
Biology and therapy of inherited retinal degenerative disease: insights from mouse models, Dis. Model. Mech, vol.8, pp.109-129, 2015. ,
, Enabling quantitative screening in retinal organoids: 3D automated reporter quantification technology, 2017.
Generation of functional eyes from pluripotent cells, PLoS Biol, vol.7, 2009. ,
Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis, Stem Cell Reports, vol.6, pp.525-538, 2016. ,
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from, Human Pluripotent Stem Cells. Sci. Rep, vol.7, p.766, 2017. ,
Stem Cell Reports Transplanted Donor-or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner, Stem Cell Reports, vol.10, pp.1-16, 2017. ,
New medium used in the differentiation of human pluripotent stem cells to retinal cells is comparable to fetal human eye tissue, Biomaterials, vol.53, pp.40-49, 2015. ,
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA, Cell Stem Cell, vol.7, pp.618-630, 2010. ,
Cone Contacts, Mosaics, and Territories of Bipolar Cells in the Mouse Retina, J. Neurosci, vol.29, pp.106-117, 2009. ,
Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells, Stem Cell Reports, vol.9, pp.1898-1915, 2017. ,
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness, Sci. Rep, vol.6, p.30742, 2016. ,
Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3 -Associated Retinal Degeneration, Hum. Gene Ther, vol.27, pp.835-846, 2016. ,
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells, Nature, vol.336, pp.684-687, 1988. ,
, , 2011.
, Mouse Model Resources for Vision Research, J. Ophthalmol, 2011.
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis, Lancet Glob. Heal, vol.2, pp.106-116, 2014. ,
Two-photon polymerization for production of human iPSC-derived retinal cell grafts, Acta Biomater, vol.55, pp.385-395, 2017. ,
Photoreceptor degeneration: Genetic and mechanistic dissection of a complex trait, Nat. Rev. Genet, vol.11, pp.273-284, 2010. ,
BMP4 initiates human embryonic stem cell differentiation to trophoblast, Nat. Biotechnol, vol.20, pp.1261-1264, 2002. ,
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells, Nature, vol.510, pp.533-536, 2014. ,
Induced pluripotent stem cells: Past, present, and future, Cell Stem Cell, vol.10, pp.678-684, 2012. ,
Differentiation of human embryonic stem cells using size-controlled embryoid bodies and negative cell selection in the production of photoreceptor precursor cells, Tissue Eng. Part C. Methods, vol.19, pp.755-764, 2013. ,
Transplantation of Photoreceptor and Total Neural Retina Preserves Cone Function in P23H Rhodopsin Transgenic Rat, PLoS One, vol.5, 2010. ,
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice, J. Clin. Invest, vol.118, pp.2908-2916, 2008. ,
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3, Cell, vol.115, pp.281-292, 2003. ,
The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa, Mol. Brain, vol.7, p.45, 2014. ,
Visual cells and the concept of renewal, Investig. Opthalmology Vis. Sci, vol.15, pp.700-725, 1976. ,
Cell differentiation in the retina of the mouse, Anat. Rec, vol.212, pp.199-205, 1985. ,
Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats, Mol. Cell. Neurosci, vol.16, pp.197-205, 2000. ,
Induced pluripotent stem cell lines derived from human somatic cells, Science, vol.318, pp.1917-1920, 2007. ,
, , 2015.
, Using Stem Cells to Model Diseases of the Outer Retina, Comput. Struct. Biotechnol. J, vol.13, pp.382-389
Congenital stationary night blindness: an analysis and update of genotype-phenotype correlations and pathogenic mechanisms, Prog. Retin. Eye Res, vol.45, pp.58-110, 2015. ,
IPS cells produce viable mice through tetraploid complementation, Nature, vol.461, pp.86-90, 2009. ,
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat. Commun, vol.5, pp.1-14, 2014. ,
Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGF and Wnt signaling, Development, vol.142, pp.3294-3306, 2015. ,
Immunosuppression via Loss of IL2r Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina, Cell Stem Cell, vol.20, pp.374-384, 2017. ,
Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacture Practice-Manufactured Human Induced Pluripotent Stem Cell Line, Stem Cells Transl. Med, 2017. ,
Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium, PLoS One, vol.8, 2013. ,
Eye field specification in Xenopus laevis, In Current Topics in Developmental Biology, pp.29-60, 2010. ,