, retinal pigment epithelium, PLoS One, vol.8, p.54552, 2013.

S. Zhou, A. Flamier, and M. Abdouh, Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFb and Wnt signaling, Development, vol.142, pp.3294-3306, 2015.

A. Yanai, C. Laver, and A. W. Joe, Differ-Methods, vol.19, pp.755-764, 2013.

D. A. Lamba, M. O. Karl, and C. B. Ware, Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc Natl Acad Sci, vol.103, pp.12769-12774, 2006.

B. A. Tucker, R. F. Mullins, and L. M. Streb, Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa, Elife, vol.2, p.824, 2013.

C. B. Mellough, E. Sernagor, and I. Moreno-gimeno, Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells, STEM CELLS, vol.30, pp.673-686, 2012.

J. S. Meyer, S. E. Howden, and K. A. Wallace, Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment, STEM CELLS, vol.29, pp.1206-1218, 2011.

T. Nakano, S. Ando, and N. Takata, Selfformation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785, 2012.

X. Zhong, C. Gutierrez, and T. Xue, Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat Commun, vol.5, p.4047, 2014.

C. B. Mellough, J. Collin, and M. Khazim, CELLS, vol.33, pp.2416-2430, 2015.

S. Reichman, A. Terray, and A. Slembrouck, From confluent human iPS cells to selfforming neural retina and retinal pigmented epithelium, Proc Natl Acad Sci, vol.111, pp.8518-8523, 2014.

R. K. Singh, R. K. Mallela, and P. K. Cornuet, Characterization of three-dimensional retinal tissue derived from human embryonic stem cells in adherent monolayer cultures, Stem Cells Dev, vol.24, pp.2778-2795, 2015.

G. Chen, D. R. Gulbranson, and Z. Hou, Chemically defined conditions for human iPSC derivation and culture, Nat Methods, vol.8, pp.424-429, 2011.

H. Vaajasaari, T. Ilmarinen, and K. Juuti-uusitalo, Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells, Mol Vis, vol.17, pp.558-575, 2011.

B. O. Pennington, D. O. Clegg, and Z. K. Melkoumian, Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate, STEM CELLS TRANSL MED, vol.4, pp.165-177, 2015.

R. A. Plaza, S. Petrus-reurer, and L. Antonsson, Xeno-free and defined human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate in a large-eyed preclinical model, Stem Cell Rep, vol.6, pp.1-9, 2015.

S. D. Schwartz, G. Tan, and H. Hosseini, Subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium for the treatment of macular degeneration: An assessment at 4 years, Invest Ophthalmol Vis Sci, vol.57, pp.1-9, 2016.

B. A. Tucker, K. R. Anfinson, and R. F. Mullins, Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation, STEM CELLS TRANSL MED, vol.2, pp.16-24, 2013.

A. Sridhar, M. M. Steward, and J. S. Meyer, Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells, STEM CELLS TRANSL MED, vol.2, pp.255-264, 2013.

S. Reichman and O. Goureau, Production of retinal cells from confluent human iPS cells, Methods Mol Biol, vol.1357, pp.339-351, 2016.

M. Belle, D. Godefroy, and C. Dominici, A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system, Cell Rep, vol.9, pp.1191-1201, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01944649

S. Fuhrmann, Eye morphogenesis and patterning of the optic vesicle, Curr Top Dev Biol, vol.93, pp.61-84, 2010.

P. H. Mathers and M. Jamrich, Regulation of eye formation by the Rx and pax6 homeobox genes, Cell Mol Life Sci, vol.57, pp.186-194, 2000.

R. E. Maclaren, R. A. Pearson, and A. Macneil, Retinal repair by transplantation of photoreceptor precursors, Nature, vol.444, pp.203-207, 2006.

A. C. Barber, C. Hippert, and Y. Duran, Repair of the degenerate retina by photoreceptor transplantation, Proc Natl Acad Sci, vol.110, pp.354-359, 2013.

J. Lakowski, Y. Han, and R. A. Pearson, Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, STEM CELLS, vol.29, pp.1391-1404, 2011.

D. Eberle, S. Schubert, and K. Postel, Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina, Invest Ophthalmol Vis Sci, vol.52, pp.6462-6471, 2011.

T. S. Ferreira, K. Postel, and H. Stutzki, Daylight vision repair by cell transplantation, STEM CELLS, vol.1, pp.1-15, 2015.

S. C. Finnemann, V. L. Bonilha, and A. D. Marmorstein, Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization, Proc Natl Acad Sci, vol.94, pp.12932-12937, 1997.

E. F. Nandrot, M. Anand, and D. Almeida, Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis, Proc Natl Acad Sci, vol.104, pp.12005-12010, 2007.

M. J. Hollenberg and A. W. Spira, Human retinal development: Ultrastructure of the outer retina, Am J Anat, vol.137, pp.357-385, 1973.

H. Koso, C. Minami, and Y. Tabata, CD73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells, Invest Ophthalmol Vis Sci, vol.50, pp.5411-5418, 2009.

H. Shirai, M. Mandai, and K. Matsushita, Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration, Proc Natl Acad Sci, vol.113, 2016.

H. Kamao, M. Mandai, and S. Okamoto, Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application, Stem Cell Rep, vol.2, pp.205-218, 2014.

C. J. Taylor, S. Peacock, and A. N. Chaudhry, Synthesis generating an iPSC bank for HLAmatched tissue transplantation based on known donor and recipient HLA types, Cell Stem Cell, vol.11, pp.147-152, 2012.

I. Wilmut, S. Leslie, and N. G. Martin, Development of a global network of induced pluripotent stem cell haplobanks, Regen Med, vol.10, pp.235-238, 2015.

, See www.StemCells.com for supporting information available online

M. Belle, D. Godefroy, C. Dominici, C. Heitz-marchaland, P. Zelina et al., A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system, Cell Rep, vol.9, pp.1191-1201, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01944649

D. Dalkara, O. Goureau, K. Marazova, and J. Sahel, Let there be light: gene and cell therapy for blindness, Gene Ther, vol.27, pp.134-147, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01258538

S. Decembrini, U. Koch, F. Radtke, A. Moulin, A. et al., Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells, Stem Cell Reports, vol.2, pp.853-865, 2014.

S. Decembrini, C. Martin, F. Sennlaub, S. Chemtob, M. Biel et al., Cone genesis tracing by the Chrnb4-EGFP mouse line: evidences of cellular material fusion after cone precursor transplantation, Mol. Ther, vol.25, pp.634-653, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01466245

D. Eberle, S. Schubert, K. Postel, D. Corbeil, M. Ader et al., The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells, Invest. Opthalmol. Vis. Sci, vol.52, pp.1640-1647, 2002.

A. Gonzalez-cordero, E. L. West, R. A. Pearson, Y. Duran, L. S. Carvalho et al., Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina, Nat. Biotechnol, vol.31, pp.741-747, 2013.

A. Gonzalez-cordero, K. Kruczek, A. Naeem, M. Fernando, M. Kloc et al., Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors, Stem Cell Reports, vol.9, pp.820-837, 2017.

R. Handgretinger, P. Lang, M. Schumm, G. Taylor, S. Neu et al., Isolation and transplantation of autologous peripheral CD34+ progenitor cells highly purified by magnetic-activated cell sorting, Bone Marrow Transplant, vol.21, pp.987-993, 1998.

A. Hoshino, R. Ratnapriya, M. J. Brooks, V. Chaitankar, M. S. Wilken et al., Molecular anatomy of the developing human retina, Dev. Cell, vol.43, pp.763-779, 2017.

S. A. Jayakody, A. Gonzalez-cordero, R. R. Ali, and R. A. Pearson, Cellular strategies for retinal repair by photoreceptor replacement, Prog. Retin. Eye Res, vol.46, pp.31-66, 2015.

R. Kaewkhaw, K. D. Kaya, M. Brooks, K. Homma, J. Zou et al., Transcriptome dynamics of developing photoreceptors in three-dimensional retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks, Stem Cells, vol.33, pp.3504-3518, 2015.

J. Lakowski, Y. T. Han, R. A. Pearson, A. Gonzalez-cordero, E. L. West et al., Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, Stem Cells, vol.29, pp.1391-1404, 2011.

J. Lakowski, A. Gonzalez-cordero, E. L. West, Y. T. Han, E. Welby et al., Transplantation of photoreceptor precursors isolated via a cell surface biomarker panel from embryonic stem cellderived self-forming retina, Stem Cells, vol.33, pp.2469-2482, 2015.

J. Lakowski, E. Welby, D. Budinger, F. Di-marco, V. Di-foggia et al., Isolation of human photoreceptor precursors via a cell surface marker panel from stem cell-derived retinal organoids and fetal retinae, Stem Cells, vol.36, pp.709-722, 2018.

D. A. Lamba, M. O. Karl, C. B. Ware, and T. A. Reh, Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc. Natl. Acad. Sci. USA, vol.103, pp.12769-12774, 2006.

D. A. Lamba, J. Gust, and T. A. Reh, Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice, Cell Stem Cell, vol.4, pp.73-79, 2009.

C. R. Laver and J. A. Matsubara, Structural divergence of essential triad ribbon synapse proteins among placental mammals -implications for preclinical trials in photoreceptor transplantation therapy, Exp. Eye Res, vol.159, pp.156-167, 2017.

M. Mandai, M. Fujii, T. Hashiguchi, and G. A. Sunagawa, , 2017.

C. B. Mellough, J. Collin, M. Khazim, K. White, E. Sernagor et al., IGF-1 signaling plays an important role in the formation of three-dimensional laminated neural retina and other ocular structures from human embryonic stem cells, Stem Cells, vol.33, pp.2416-2430, 2015.

P. Menasché, V. Vanneaux, A. Hagège, A. Bel, B. Cholley et al., Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report, Eur. Heart J, vol.36, pp.2011-2017, 2015.

J. S. Meyer, R. L. Shearer, E. E. Capowski, L. S. Wright, K. A. Wallace et al., , 2009.

, Modeling early retinal development with human embryonic and induced pluripotent stem cells, Proc. Natl. Acad. Sci. USA, vol.106, pp.16698-16703

T. Nakano, S. Ando, N. Takata, M. Kawada, K. Muguruma et al., , 2012.

, Self-formation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785

E. Orhan, D. Dalkara, M. Neuillé, C. Lechauve, C. Michiels et al., Genotypic and phenotypic characterization of P23H line 1 rat model, PLoS One, vol.10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01228055

A. Ortin-martinez, E. L. Tsai, P. E. Nickerson, M. Bergeret, Y. Lu et al., A reinterpretation of cell transplantation: GFP transfer from donor to host photoreceptors, Stem Cells, vol.35, pp.932-939, 2017.

F. Osakada, H. Ikeda, M. Mandai, T. Wataya, K. Watanabe et al., Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells, Nat. Biotechnol, vol.26, pp.215-224, 2008.

R. A. Pearson, A. C. Barber, M. Rizzi, C. Hippert, T. Xue et al., Restoration of vision after transplantation of photoreceptors, Nature, vol.485, pp.99-103, 2012.

R. A. Pearson, A. Gonzalez-cordero, E. L. West, J. R. Ribeiro, N. Aghaizu et al., Donor and host photoreceptors engage in material transfer following transplantation of postmitotic photoreceptor precursors, Nat. Commun, vol.7, p.13029, 2016.

J. Phillips, P. Jiang, S. Howden, P. Barney, J. Min et al., , 2017.

S. Reichman, A. Terray, A. Slembrouck, C. Nanteau, G. Orieux et al., From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium, Proc. Natl. Acad. Sci. USA, vol.111, pp.8518-8523, 2014.

S. Reichman, A. Slembrouck, G. Gagliardi, A. Chaffiol, A. Terray et al., Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xenofree and feeder-free conditions, Stem Cells, vol.35, pp.1176-1188, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01480587

T. Santos-ferreira, K. Postel, H. Stutzki, T. Kurth, G. Zeck et al., Daylight vision repair by cell transplantation, Stem Cells, vol.33, pp.79-90, 2015.

T. Santos-ferreira, M. Völkner, O. Borsch, J. Haas, P. Cimalla et al., Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy, Invest. Ophthalmol. Vis. Sci, vol.57, pp.3509-3520, 2016.

T. Santos-ferreira, S. Llonch, O. Borsch, K. Postel, J. Haas et al., Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange, Nat. Commun, vol.7, p.13028, 2016.

T. F. Santos-ferreira, O. Borsch, and M. Ader, Rebuilding the missing part-a review on photoreceptor transplantation, Front. Syst. Neurosci, vol.10, pp.1-14, 2017.

M. S. Singh, P. Issa, R. Butler, C. Martin, D. M. Lipinski et al., Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation, Proc. Natl. Acad. Sci. USA, vol.110, pp.1101-1106, 2013.

M. S. Singh, J. Balmer, A. R. Barnard, S. A. Aslam, D. Moralli et al., Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion, Stem Cell Reports, vol.10, pp.1-16, 2016.

E. Welby, J. Lakowski, V. Di-foggia, D. Budinger, A. Gonzalez-cordero et al., Isolation and comparative transcriptome analysis of human fetal and iPSC-derived cone photoreceptor cells, Stem Cell Reports, vol.9, pp.1898-1915, 2017.

L. A. Wiley, E. R. Burnight, A. P. Deluca, K. R. Anfinson, C. M. Cranston et al., cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness, Sci. Rep, vol.6, p.30742, 2016.

C. Zhao, Q. Wang, and S. Temple, Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells, Development, vol.144, pp.1368-1381, 2017.

X. Zhong, C. Gutierrez, T. Xue, C. Hampton, M. N. Vergara et al., Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat. Commun, vol.5, pp.1-14, 2014.

J. Zhu, H. Cifuentes, J. Reynolds, and D. A. Lamba, Immunosuppression via loss of IL2rg enhances long-term functional integration of hESC-derived photoreceptors in the mouse retina, Cell Stem Cell, vol.20, pp.374-384, 2017.

G. Gagliardi, K. Ben, M. Barek, A. Chaffiol, A. Slembrouck-brec et al., Oriane Rabesandratana, José-Alain Sahel, Jens Duebel, Gael Orieux, Sacha Reichman

L. Cong, F. A. Ran, D. Cox, S. Lin, R. Barretto et al., , 2013.

, Multiplex Genome Engineering Using CRISPR/VCas Systems. Science (80-. ), vol.339, pp.819-823

D. Hockemeyer, F. Soldner, C. Beard, Q. Gao, M. Mitalipova et al., Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases, Nat. Biotechnol, vol.27, pp.851-857, 2009.

K. Loulier, R. Barry, P. Mahou, Y. Franc, . Le et al., Multiplex Cell and Lineage Tracking with Combinatorial Labels, vol.81, pp.505-520, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01086032

K. M'barek, . Ben, W. Habeler, A. Plancheron, M. Jarraya et al., Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration, Sci. Transl. Med, vol.9, 2017.

G. Orieux, L. Picault, A. Slembrouck, J. E. Roger, X. Guillonneau et al., Involvement of Bcl-2-Associated Transcription Factor 1 in the Differentiation of Early-Born Retinal Cells, J. Neurosci, vol.34, pp.1530-1541, 2014.

F. A. Ran, P. D. Hsu, J. Wright, V. Agarwala, D. A. Scott et al., Genome engineering using the CRISPR-Cas9 system, Nat. Protoc, vol.8, pp.2281-2308, 2013.

G. M. Acland, G. D. Aguirre, J. Ray, Q. Zhang, T. S. Aleman et al., Gene therapy restores vision in a canine model of childhood blindness, Nat. Genet, vol.28, pp.92-95, 2001.

R. Adler and M. V. Canto-soler, Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies, Dev. Biol, vol.305, pp.1-13, 2007.

U. Aftab, C. Jiang, B. Tucker, J. Y. Kim, H. Klassen et al., , 2009.

, Growth kinetics and transplantation of human retinal progenitor cells, Exp. Eye Res, vol.89, pp.301-310

I. Ahmad, L. Tang, and H. Pham, Identification of neural progenitors in the adult mammalian eye, Biochem. Biophys. Res. Commun, vol.270, pp.517-521, 2000.

M. Akimoto, H. Cheng, D. Zhu, J. A. Brzezinski, R. Khanna et al., Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.3890-3895, 2006.

I. Aldiri, B. Xu, L. Wang, X. Chen, D. Hiler et al., The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis, Neuron, vol.94, pp.550-568, 2017.

R. Allikmets, N. Singh, H. Sun, N. F. Shroyer, A. Hutchinson et al., A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy, Nat. Genet, vol.15, pp.236-246, 1997.

N. Amirpour, F. Karamali, F. Rabiee, L. Rezaei, E. Esfandiari et al., Differentiation of Human Embryonic Stem Cell-Derived Retinal Progenitors into Retinal Cells by Sonic Hedgehog and/or Retinal Pigmented Epithelium and Transplantation into the Subretinal Space of Sodium Iodate-Injected Rabbits, Stem Cells Dev, vol.21, pp.42-53, 2012.

M. L. Applebury, M. P. Antoch, L. C. Baxter, L. L. Chun, J. D. Falk et al., The Murine Cone Photoreceptor, Neuron, vol.27, pp.513-523, 2000.

R. B. Aramant and M. J. Seiler, Retinal transplantation -Advantages of intact fetal sheets, Prog. Retin. Eye Res, 2002.

R. B. Aramant, M. J. Seiler, and S. L. Ball, Successful cotransplantation of intact sheets of fetal retina with retinal pigment epithelium, Investig. Ophthalmol. Vis. Sci, 1999.

J. Assawachananont, M. Mandai, S. Okamoto, C. Yamada, M. Eiraku et al., Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice, Stem Cell Reports, vol.2, pp.662-674, 2014.

I. Audo, G. Manes, S. Mohand-saïd, A. Friedrich, M. E. Lancelot et al., Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patients, Investig. Ophthalmol. Vis. Sci, vol.51, pp.3687-3700, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00472460

A. A. Avilion, S. K. Nicolis, L. H. Pevny, L. Perez, N. Vivian et al., Multipotent cell lineages in early mouse development depend on SOX2 function, Genes Dev, vol.17, pp.126-140, 2003.

W. Baehr, F. , and J. , Inherited Retinal Diseases: Vertebrate Animal Models, Encyclopedia of Life Sciences, 2006.

B. Bakondi, W. Lv, B. Lu, M. K. Jones, Y. Tsai et al., In vivo CRISPR/Cas9 gene editing corrects retinal dystrophy in the S334ter-3 rat model of autosomal dominant retinitis pigmentosa, Mol. Ther, vol.24, pp.556-563, 2016.

B. G. Ballios, M. J. Cooke, L. Donaldson, B. L. Coles, C. M. Morshead et al., A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation, Stem Cell Reports, vol.4, pp.1031-1045, 2015.

E. Banin, A. Obolensky, M. Idelson, I. Hemo, E. Reinhardtz et al., Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells, Stem Cells, vol.24, pp.246-257, 2006.

A. C. Barber, C. Hippert, Y. Duran, E. L. West, J. W. Bainbridge et al., Repair of the degenerate retina by photoreceptor transplantation, Proc. Natl. Acad. Sci, vol.110, pp.354-359, 2013.

R. A. Barker, M. Parmar, L. Studer, and J. Takahashi, Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era, Cell Stem Cell, vol.21, pp.569-573, 2017.

A. O. Barnea-cramer, W. Wang, S. Lu, M. S. Singh, C. Luo et al., Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice, Sci. Rep, vol.6, p.29784, 2016.

U. Bartsch, W. Oriyakhel, P. F. Kenna, S. Linke, G. Richard et al., Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice, Exp. Eye Res, vol.86, pp.691-700, 2008.

E. A. Bassett and V. A. Wallace, Cell fate determination in the vertebrate retina, Trends Neurosci, vol.35, pp.565-573, 2012.

U. Ben-david, Q. F. Gan, T. Golan-lev, P. Arora, O. Yanuka et al., Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen, Cell Stem Cell, vol.12, pp.167-179, 2013.

S. C. Bendall, M. H. Stewart, P. Menendez, D. George, K. Vijayaragavan et al., IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro, Nature, vol.448, pp.1015-1021, 2007.

W. Berger, B. Kloeckener-gruissem, and J. Neidhardt, The molecular basis of human retinal and vitreoretinal diseases, Prog. Retin. Eye Res, vol.29, pp.335-375, 2010.

C. Bock, E. Kiskinis, G. Verstappen, H. Gu, G. Boulting et al., Reference maps of human es and ips cell variation enable high-throughput characterization of pluripotent cell lines, Cell, vol.144, pp.439-452, 2011.

H. Boije, R. B. Macdonald, and W. A. Harris, Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages, Curr. Opin. Neurobiol, vol.27, pp.68-74, 2014.

M. J. Boland, J. L. Hazen, K. L. Nazor, A. R. Rodriguez, W. Gifford et al., Adult mice generated from induced pluripotent stem cells, Nature, vol.461, pp.91-94, 2009.

C. Boucherie, S. Mukherjee, E. Henckaerts, A. J. Thrasher, and J. C. Sowden, Brief report: Self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors, Stem Cells, vol.31, pp.408-414, 2013.

M. C. Bourne, D. A. Campbell, and K. Tansley, Hereditary degeneration of the rat retina, Br. J. Ophthalmol, vol.22, pp.613-622, 1938.

J. K. Bowmaker and D. M. Hunt, Evolution of vertebrate visual pigments, Curr. Biol, vol.16, pp.484-489, 2006.

C. A. Bravery, Do Human Leukocyte Antigen-Typed Cellular Therapeutics Based on Induced Pluripotent Stem Cells Make Commercial Sense?, Stem Cells Dev, vol.24, pp.1-10, 2015.

J. A. Brzezinski and T. A. Reh, Photoreceptor cell fate specification in vertebrates, Development, vol.142, pp.3263-3273, 2015.

J. A. Brzezinski, K. Park, and T. A. Reh, Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence, Dev. Biol, vol.384, pp.194-204, 2013.

E. R. Burnight, L. A. Wiley, A. V. Drack, T. A. Braun, K. R. Anfinson et al., CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype, Gene Ther, vol.21, pp.662-672, 2014.

E. R. Burnight, M. Gupta, L. A. Wiley, K. R. Anfinson, A. Tran et al., Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration, Mol. Ther, vol.25, pp.1999-2013, 2017.

E. R. Burnight, J. C. Giacalone, J. A. Cooke, J. R. Thompson, L. R. Bohrer et al., CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration, Prog. Retin. Eye Res, pp.1-22, 2018.

V. Busskamp, J. Krol, D. Nelidova, J. Daum, T. Szikra et al., MiRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function, Neuron, vol.83, pp.586-600, 2014.

L. C. Byrne, D. Dalkara, G. Luna, S. K. Fisher, E. Clérin et al., Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration, J. Clin. Invest, vol.125, pp.105-116, 2015.

P. D. Calvert, N. V. Krasnoperova, A. L. Lyubarsky, T. Isayama, M. Nicolo et al., Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit, Proc. Natl. Acad. Sci, vol.97, pp.13913-13918, 2000.

L. D. Carter-dawson and M. M. Lavail, Autoradiographic analysis of cell generation using tritiated thymidine, J. Comp. Neurol, vol.188, pp.263-272, 1979.

C. Cepko, Intrinsically different retinal progenitor cells produce specific types of progeny, Nat. Rev. Neurosci, vol.15, pp.615-627, 2014.

I. Chambers, D. Colby, M. Robertson, J. Nichols, S. Lee et al., Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells, Cell, vol.113, pp.643-655, 2003.

B. Chang, N. L. Hawes, R. E. Hurd, M. T. Davisson, S. Nusinowitz et al., Retinal degeneration mutants in the mouse, Vision Res, vol.42, pp.517-525, 2002.

B. Chang, T. Grau, S. Dangel, R. Hurd, B. Jurklies et al., A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.19581-19586, 2009.

J. R. Chao, D. A. Lamba, T. R. Klesert, A. Torre, . La et al., Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate, Transl. Vis. Sci. Technol, vol.6, p.4, 2017.

J. Chen, A. Rattner, and J. Nathans, The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes, J. Neurosci, vol.25, pp.118-129, 2005.

S. Chen, Q. L. Wang, Z. Nie, H. Sun, G. Lennon et al., Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes, Neuron, vol.19, pp.1017-1030, 1997.

H. Cheng, T. S. Aleman, A. V. Cideciyan, R. Khanna, S. G. Jacobson et al., In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development, Hum. Mol. Genet, vol.15, pp.2588-2602, 2006.

J. Collin, C. B. Mellough, B. Dorgau, S. Przyborski, I. Moreno-gimeno et al., Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors during Pluripotent Stem Cell Differentiation, Stem Cells, vol.34, pp.311-321, 2016.

N. Cuenca, L. Fernández-sánchez, T. J. Mcgill, B. Lu, S. Wang et al., Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration, Invest. Ophthalmol. Vis. Sci, vol.54, pp.6745-6756, 2013.

N. Cuenca, L. Fernanndez-sanchez, Y. Sauvé, F. J. Segura, G. Marti-nez-navarrete et al., Correlation between SD-OCT, immunocytochemistry and functional findings in an animal model of retinal degeneration, Front. Neuroanat, vol.8, 2014.

P. M. D'cruz, D. Yasumura, J. Weir, M. T. Matthes, H. Abderrahim et al., Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat, Hum. Mol. Genet, vol.9, pp.645-651, 2000.

S. P. Daiger, L. S. Sullivan, and S. J. Bowne, Genes and mutations causing retinitis pigmentosa, Clin. Genet, vol.84, pp.132-141, 2013.

D. Dalkara, O. Goureau, K. Marazova, and J. Sahel, Let There Be Light: Gene and Cell Therapy for Blindness, Gene Ther, vol.27, pp.134-147, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01258538

L. L. Daniele, C. Lillo, A. L. Lyubarsky, S. S. Nikonov, N. Philp et al., Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse, Investig. Ophthalmol. Vis. Sci, vol.46, pp.2156-2167, 2005.

S. Decembrini, U. Koch, F. Radtke, A. Moulin, A. et al., Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells, Stem Cell Reports, vol.2, pp.853-865, 2014.

S. Decembrini, C. Martin, F. Sennlaub, S. Chemtob, M. Biel et al., Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation, Mol. Ther, vol.25, pp.634-653, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01466245

M. F. Deering, A Photon Accurate Model of the Human Eye, ACM SIGGRAPH 2005 Pap. -SIGGRAPH '05, pp.1-14, 2004.

W. L. Deng, M. L. Gao, X. L. Lei, J. N. Lv, H. Zhao et al., Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients, Stem Cell Reports, vol.10, pp.1267-1281, 2018.

J. P. Disanto, W. Muller, D. Guy-grand, A. Fischer, and K. Rajewsky, Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain, Proc Natl Acad Sci U S A, vol.92, pp.377-381, 1995.

T. Distefano, H. Y. Chen, C. Panebianco, K. D. Kaya, M. J. Brooks et al., Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors, Stem Cell Reports, vol.10, pp.1-14, 2017.

T. P. Dryja, T. L. Mcgee, L. B. Hahn, G. S. Cowley, J. E. Olsson et al., Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa, N Engl J Med, vol.323, pp.1302-1307, 1990.

T. P. Dryja, T. L. Mcgee, E. Reichel, L. B. Hahn, G. S. Cowley et al., A point mutation of the rhodopsin gene in one form of retinitis pigmentosa, Nature, vol.343, pp.364-366, 1990.

D. Eberle, S. Schubert, K. Postel, D. Corbeil, and M. Ader, Increased Integration of Transplanted CD73-Positive Photoreceptor Precursors into Adult Mouse Retina, Investig. Opthalmology Vis. Sci, vol.52, p.6462, 2011.

D. Eberle, T. Kurth, T. Santos-ferreira, J. Wilson, D. Corbeil et al., Outer Segment Formation of Transplanted Photoreceptor Precursor Cells, PLoS One, vol.7, 2012.

K. Eggan, M. Parmar, M. Takahashi, Y. , and S. , 10 Questions: Clinical Outlook for iPSCs, Cell Stem Cell, vol.18, pp.170-173, 2016.

M. Eiraku, N. Takata, H. Ishibashi, M. Kawada, E. Sakakura et al., Self-organizing optic-cup morphogenesis in three-dimensional culture, Nature, vol.472, pp.51-56, 2011.

M. M. Emerson, N. Surzenko, J. J. Goetz, J. Trimarchi, and C. L. Cepko, Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors, Dev. Cell, vol.26, pp.59-72, 2013.

M. J. Evans and M. H. Kaufman, Establishment in culture of pluripotential cells from mouse embryos, Nature, vol.292, pp.154-156, 1981.

Y. Fan, J. Wu, P. Ashok, M. Hsiung, and E. S. Tzanakakis, Production of Human Pluripotent Stem Cell Therapeutics under Defined Xeno-free Conditions: Progress and Challenges, Stem Cell Rev. Reports, vol.11, pp.96-109, 2015.

S. Fuhrmann, Eye morphogenesis and patterning of the optic vesicle, Curr. Top. Dev. Biol, vol.93, pp.61-84, 2010.

S. Fuhrmann, C. Zou, and E. M. Levine, Retinal pigment epithelium development, plasticity, and tissue homeostasis, Exp. Eye Res, vol.123, pp.141-150, 2014.

H. Fujieda, R. Bremner, A. J. Mears, and H. Sasaki, Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development, J. Neurochem, vol.108, pp.91-101, 2009.

M. Fujii, G. A. Sunagawa, M. Kondo, M. Takahashi, and M. Mandai, Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function, Sci. Rep, vol.6, 2016.

T. Furukawa, E. M. Morrow, and C. L. Cepko, Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation, Cell, vol.91, pp.531-541, 1997.

T. Furukawa, E. M. Morrow, T. Li, F. C. Davis, and C. L. Cepko, Retinopathy and attenuated circadian entrainment in Crx-deficient mice, Nat. Genet, vol.23, pp.466-470, 1999.

N. Fusaki, H. Ban, A. Nishiyama, K. Saeki, and M. Hasegawa, Efcient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome, Proc. Jpn. Acad., Ser. B, vol.85, 2009.

D. M. Gamm, S. Wang, B. Lu, S. Girman, T. Holmes et al., Protection of visual functions by human neural progenitors in a rat model of retinal disease, PLoS One, vol.2, p.338, 2007.

F. L. Gomes, G. Zhang, F. Carbonell, J. A. Correa, W. A. Harris et al., Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions, Development, vol.138, pp.227-235, 2011.

A. Gonzalez-cordero, E. L. West, R. A. Pearson, Y. Duran, L. S. Carvalho et al., Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina, Nat. Biotechnol, vol.31, pp.741-747, 2013.

A. Gonzalez-cordero, K. Kruczek, A. Naeem, M. Fernando, M. Kloc et al., Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors, Stem Cell Reports, vol.9, pp.820-837, 2017.

A. Gonzalez-cordero, D. Goh, K. Kruczek, A. Naeem, M. Fernando et al., Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells, Hum. Gene Ther. hum, p.27, 2018.

A. Gore, Z. Li, H. Fung, J. E. Young, S. Agarwal et al., Somatic coding mutations in human induced pluripotent stem cells, Nature, vol.471, pp.63-67, 2011.

J. Graw, Eye Development, Curr. Top. Dev. Biol, vol.90, pp.343-386, 2010.

C. J. Guerin, D. H. Anderson, and S. K. Fisher, Changes in intermediate filament immunolabeling occur in response to retinal detachment and reattachment in primates, Investig. Ophthalmol. Vis. Sci, vol.31, pp.1474-1482, 1990.

J. Gust and T. A. Reh, Adult donor rod photoreceptors integrate into the mature mouse retina, Investig. Ophthalmol. Vis. Sci, vol.52, pp.5266-5272, 2011.

N. B. Haider, N. M. Cruz, M. Allocca, and J. Yuan, Pathobiology of the Outer Retina: Genetic and Nongenetic Causes of Disease, 2014.

H. Abdollahi, S. Hirose, and T. , Stargardt-Fundus Flavimaculatus: Recent Advancements and Treatment, Semin. Ophthalmol, vol.28, pp.372-376, 2013.

D. Hambright, K. Park, M. Brooks, R. Mckay, A. Swaroop et al., Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in unimmunosuppressed mouse retina, Mol. Vis, vol.18, pp.920-936, 2012.

C. Hamel, Retinitis pigmentosa, Orphanet J. Rare Dis, vol.1, pp.1-40, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00122147

J. Hanna, M. Wernig, S. Markoulaki, C. W. Sun, A. Meissner et al., Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin, Science, vol.318, pp.1920-1923, 2007.

D. T. Hartong, E. L. Berson, and T. P. Dryja, Retinitis pigmentosa, Lancet, vol.368, pp.1795-1809, 2006.

J. Hatakeyama and R. Kageyama, Retinal cell fate determination and bHLH factors, Semin. Cell Dev. Biol, vol.15, pp.83-89, 2004.

S. Haverkamp, The Primordial, Blue-Cone Color System of the Mouse Retina, J. Neurosci, vol.25, pp.5438-5445, 2005.

J. He, G. Zhang, A. D. Almeida, M. Cayouette, B. D. Simons et al., How variable clones build an invariant retina, Neuron, vol.75, pp.786-798, 2012.

A. K. Hennig, G. Peng, C. , and S. , Regulation of photoreceptor gene expression by Crxassociated transcription factor network, Brain Res, vol.1192, pp.114-133, 2008.

D. Hiler, X. Chen, J. Hazen, S. Kupriyanov, P. A. Carroll et al., Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors, Cell Stem Cell, vol.17, pp.101-115, 2015.

Y. Hirami, F. Osakada, K. Takahashi, K. Okita, S. Yamanaka et al., Generation of retinal cells from mouse and human induced pluripotent stem cells, Neurosci. Lett, vol.458, pp.126-131, 2009.

A. C. Ho, M. S. Humayun, J. D. Dorn, L. Da-cruz, G. Dagnelie et al., Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind, Ophthalmology, vol.122, pp.1547-1554, 2015.

A. I. Hollander, R. Roepman, R. K. Koenekoop, and F. P. Cremers, Leber congenital amaurosis: genes, proteins and disease mechanisms, Prog. Retin. Eye Res, vol.27, pp.391-419, 2008.

K. Homma, F. Osakada, Y. Hirami, Z. B. Jin, M. Mandai et al., Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system, J. Neurosci. Res, vol.87, pp.2175-2182, 2009.

K. Homma, S. Okamoto, M. Mandai, N. Gotoh, H. K. Rajasimha et al., Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors, Stem Cells, vol.31, pp.1149-1159, 2013.

K. Homma, S. Usui, and M. Kaneda, Knock-in strategy at ??-end of Crx gene by CRISPR/Cas9 system shows the gene expression profiles during human photoreceptor differentiation, Genes to Cells, vol.22, pp.250-264, 2017.

M. Hoon, H. Okawa, L. Della-santina, and R. O. Wong, Functional architecture of the retina: Development and disease, Prog. Retin. Eye Res, vol.42, pp.44-84, 2014.

A. Hoshino, R. Ratnapriya, M. J. Brooks, V. Chaitankar, M. S. Wilken et al., Molecular Anatomy of the Developing Human Retina, Dev. Cell, vol.43, pp.763-779, 2017.

P. Hou, Y. Li, X. Zhang, C. Liu, J. Guan et al., , 2013.

, Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds, Science, vol.341, pp.651-654

H. C. Howland, S. Merola, and J. R. Basarab, The allometry and scaling of the size of vertebrate eyes, Vision Res, vol.44, pp.2043-2065, 2004.

A. Hughes, A schematic eye for the rat, Vision Res, vol.19, pp.569-588, 1979.

M. M. Humphries, D. Rancourt, G. J. Farrar, P. Kenna, M. Hazel et al., Retinopathy induced in mice by targeted disruption of the rhodopsin gene, Nat. Genet, vol.15, pp.216-219, 1997.

N. C. Hunt, D. Hallam, A. Karimi, C. B. Mellough, J. Chen et al., 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development, Acta Biomater, vol.49, pp.329-343, 2017.

S. M. Hussein, N. N. Batada, S. Vuoristo, R. W. Ching, R. Autio et al., Copy number variation and selection during reprogramming to pluripotency, Nature, vol.471, pp.58-62, 2011.

H. Ikeda, F. Osakada, K. Watanabe, K. Mizuseki, T. Haraguchi et al., Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.11331-11336, 2005.

M. E. Illing, R. S. Rajan, N. F. Bence, and R. R. Kopito, A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system, J. Biol. Chem, vol.277, pp.34150-34160, 2002.

S. Iraha, H. Y. Tu, S. Yamasaki, T. Kagawa, M. Goto et al., Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation, Stem Cell Reports, vol.10, pp.1059-1074, 2018.

M. Ito, H. Hiramatsu, K. Kobayashi, K. Suzue, M. Kawahata et al., NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells, Blood, vol.100, pp.3175-3182, 2002.

G. H. Jacobs, J. Neitz, and J. F. Deegan, Retinal receptors in rodents maximally sensitive to ultraviolet light, Nature, vol.353, pp.737-740, 1991.

A. P. Jadhav, H. A. Mason, and C. L. Cepko, Notch 1 inhibits photoreceptor production in the developing mammalian retina, Development, vol.133, pp.913-923, 2006.

S. A. Jayakody, A. Gonzalez-cordero, R. R. Ali, and R. A. Pearson, Cellular strategies for retinal repair by photoreceptor replacement, Prog. Retin. Eye Res, vol.46, pp.31-66, 2015.

L. Jia, E. C. Oh, L. Ng, M. Srinivas, M. Brooks et al., Retinoidrelated orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.17534-17539, 2009.

Z. B. Jin, S. Okamoto, F. Osakada, K. Homma, J. Assawachananont et al., Modeling retinal degeneration using patient-specific induced pluripotent stem cells, PLoS One, vol.6, 2011.

B. W. Jones and R. E. Marc, Retinal remodeling during retinal degeneration, Exp. Eye Res, vol.81, pp.123-137, 2005.

P. T. De-jong, Age-Related Macular Degeneration, N. Engl. J. Med, vol.355, pp.1474-1485, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00477813

Y. Junying, H. Kejin, S. O. Kim, T. Shulan, R. Stewart et al., Human induced pluripotent stem cells free of vector and transgene sequences, Science, vol.324, pp.797-801, 2009.

R. Kaewkhaw, K. D. Kaya, M. Brooks, K. Homma, J. Zou et al.,

, Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks, Stem Cells, vol.33, pp.3504-3518

H. Kamao, M. Mandai, S. Okamoto, N. Sakai, A. Suga et al., Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application, Stem Cell Reports, vol.2, pp.205-218, 2014.

K. Katoh, Y. Omori, A. Onishi, S. Sato, M. Kondo et al., Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development, J. Neurosci, vol.30, pp.6515-6526, 2010.

C. Keeler, Retinal degeneration in the mouse is rodless retina, J. Hered, vol.57, p.50, 1966.

I. Kelava and M. A. Lancaster, Dishing out mini-brains: Current progress and future prospects in brain organoid research, Dev. Biol, vol.420, pp.199-209, 2016.

H. Khabou, M. Garita-hernandez, A. Chaffiol, S. Reichman, C. Jaillard et al., Noninvasive gene delivery to foveal cones for vision restoration, JCI Insight, vol.3, p.96029, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01718061

D. Kim, C. Kim, J. Moon, Y. Chung, M. Chang et al., , 2009.

K. Kim, A. Doi, B. Wen, K. Ng, R. Zhao et al., Epigenetic memory in induced pluripotent stem cells, Nature, vol.467, pp.285-290, 2010.

H. Klassen, P. H. Schwartz, B. Ziaeian, H. Nethercott, M. J. Young et al., Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat, Vet. Ophthalmol, vol.10, pp.245-253, 2007.

H. J. Klassen, T. F. Ng, Y. Kurimoto, I. Kirov, M. Shatos et al., , 2004.

, Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior, Investig. Ophthalmol. Vis. Sci, vol.45, pp.4167-4173

C. Koike, A. Nishida, S. Ueno, H. Saito, R. Sanuki et al., Functional roles of Otx2 transcription factor in postnatal mouse retinal development, Mol. Cell. Biol, vol.27, pp.8318-8329, 2007.

B. Kolomiets, E. Dubus, M. Simonutti, S. Rosolen, J. A. Sahel et al., Late histological and functional changes in the P23H rat retina after photoreceptor loss, Neurobiol. Dis, vol.38, pp.47-58, 2010.

H. Koso, C. Minami, Y. Tabata, M. Inoue, E. Sasaki et al., CD73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells, Investig. Ophthalmol. Vis. Sci, vol.50, pp.5411-5418, 2009.

T. W. Kraft, D. Allen, R. M. Petters, Y. Hao, Y. Peng et al., Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin, Mol. Vis, vol.11, pp.1246-1256, 2005.

T. U. Krohne, P. D. Westenskow, T. Kurihara, D. F. Friedlander, M. Lehmann et al., Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells, Stem Cells Transl. Med, vol.1, pp.96-109, 2012.

K. Kruczek, A. Gonzalez-cordero, D. Goh, A. Naeem, M. Jonikas et al., Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration, Stem Cell Reports, vol.8, pp.1659-1674, 2017.

A. Kuwahara, C. Ozone, T. Nakano, K. Saito, M. Eiraku et al., Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue, Nat. Commun, vol.6, p.6286, 2015.

J. Lakowski, Y. T. Han, R. A. Pearson, A. Gonzalez-cordero, E. L. West et al., Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression, Stem Cells, vol.29, pp.1391-1404, 2011.

J. Lakowski, A. Gonzalez-cordero, E. L. West, Y. T. Han, E. Welby et al., Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel from Embryonic Stem Cell-Derived Self-Forming Retina, Stem Cells, vol.33, pp.2469-2482, 2015.

J. Lakowski, E. Welby, D. Budinger, F. Di-marco, V. Di-foggia et al., Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-derived Retinal Organoids and Fetal Retinae, Stem Cells, 2018.

D. A. Lamba, M. O. Karl, C. B. Ware, and T. A. Reh, Efficient generation of retinal progenitor cells from human embryonic stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.12769-12774, 2006.

D. A. Lamba, J. Gust, and T. A. Reh, Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice, Cell Stem Cell, vol.4, pp.73-79, 2009.

D. A. Lamba, A. Mcusic, R. K. Hirata, P. Wang, D. Russell et al., Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells, PLoS One, vol.5, p.8763, 2010.

M. M. Lavail, S. Nishikawa, R. H. Steinberg, M. I. Naash, J. L. Duncan et al., Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration, Exp. Eye Res, vol.167, pp.56-90, 2018.

C. R. Laver and J. A. Matsubara, Structural divergence of essential triad ribbon synapse proteins among placental mammals -Implications for preclinical trials in photoreceptor transplantation therapy, Exp. Eye Res, vol.159, pp.156-167, 2017.

M. Lee, S. H. Moon, H. Jeong, J. Yi, T. Lee et al., Inhibition of pluripotent stem cell-derived teratoma formation by small molecules, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.3281-90, 2013.

B. Lin, B. T. Mclelland, A. Mathur, R. B. Aramant, and M. J. Seiler, Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration, Exp. Eye Res, vol.174, pp.13-28, 2018.

R. Lister, M. Pelizzola, Y. S. Kida, R. D. Hawkins, J. R. Nery et al., Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells, Nature, vol.471, pp.68-73, 2011.

M. M. Liu and D. J. Zack, Alternative splicing and retinal degeneration, Clin. Genet, vol.84, pp.142-149, 2013.

F. J. Livesey and C. L. Cepko, Vertebrate neural cell-fate determination: lessons from the retina, Nat. Rev. Neurosci, vol.2, pp.109-118, 2001.

S. Llonch, M. Carido, and M. Ader, Organoid technology for retinal repair, Dev. Biol, vol.433, pp.132-143, 2018.

R. N. Lolley, H. Rong, and C. M. Craft, Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction, Invest. Ophthalmol. Vis. Sci, vol.35, pp.358-362, 1994.

B. Lu, C. W. Morgans, S. Girman, J. Luo, J. Zhao et al., Neural Stem Cells Derived by Small Molecules Preserve Vision, Transl. Vis. Sci. Technol, vol.2, p.1, 2013.

R. J. Lund, E. Närvä, and R. Lahesmaa, Genetic and epigenetic stability of human pluripotent stem cells, Nat. Rev. Genet, vol.13, pp.732-744, 2012.

J. Luo, P. Baranov, S. Patel, H. Ouyang, J. Quach et al., Human retinal progenitor cell transplantation preserves vision, J. Biol. Chem, vol.289, pp.6362-6371, 2014.

M. Ben, K. Barek, W. Habeler, A. Plancheron, M. Jarraya et al., Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration, Sci. Transl. Med, vol.9, p.7471, 2017.

R. E. Maclaren, Cone fusion confusion in photoreceptor transplantation, Stem Cell Investig, vol.4, pp.71-71, 2017.

R. E. Maclaren, R. A. Pearson, A. Macneil, R. H. Douglas, T. E. Salt et al., Retinal repair by transplantation of photoreceptor precursors, Nature, vol.444, pp.203-207, 2006.

M. Mandai, M. Fujii, T. Hashiguchi, and G. A. Sunagawa, iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice, Stem Cell Reports, vol.8, pp.69-83, 2017.

M. Mandai, A. Watanabe, Y. Kurimoto, Y. Hirami, C. Morinaga et al., Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration, N. Engl. J. Med, vol.376, pp.1038-1046, 2017.

R. H. Masland, The fundamental plan of the retina, Nat. Neurosci, vol.4, pp.877-886, 2001.

R. H. Masland, The Neuronal Organization of the Retina, Neuron, vol.76, pp.266-280, 2012.

R. W. Massof, C. , and F. W. , A revision of the rat schematic eye, Vision Res, vol.12, pp.793-796, 1972.

P. Mathur, Y. , and J. , Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities, Biochim. Biophys. Acta, vol.1852, pp.406-420, 2015.

B. T. Mclelland, B. Lin, A. Mathur, R. B. Aramant, B. B. Thomas et al., Transplanted hESC-Derived Retina Organoid Sheets Differentiate , Integrate , and Improve Visual Function in Retinal Degenerate Rats, 2018.

B. Mead, M. Berry, A. Logan, R. A. Scott, W. Leadbeater et al., Stem cell treatment of degenerative eye disease, Stem Cell Res, vol.14, pp.243-257, 2015.

A. J. Mears, M. Kondo, P. K. Swain, Y. Takada, R. A. Bush et al., Nrl is required for rod photoreceptor development, Nat. Genet, vol.29, pp.447-452, 2001.

C. B. Mellough, E. Sernagor, I. Moreno-gimeno, D. H. Steel, and M. Lako, Efficient stagespecific differentiation of human pluripotent stem cells toward retinal photoreceptor cells, Stem Cells, vol.30, pp.673-686, 2012.

C. B. Mellough, J. Collin, M. Khazim, K. White, E. Sernagor et al., , 2015.

, Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures from Human Embryonic Stem Cells, Stem Cells, vol.33, pp.2416-2430

P. Menasché, V. Vanneaux, A. Hagège, A. Bel, B. Cholley et al., Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report: Figure 1, Eur. Heart J, vol.36, pp.2011-2017, 2015.

H. F. Mendes, J. Van-der-spuy, J. P. Chapple, and M. E. Cheetham, Mechanisms of cell death in rhodopsin retinitis pigmentosa: Implications for therapy, Trends Mol. Med, vol.11, pp.177-185, 2005.

J. S. Meyer, R. L. Shearer, E. E. Capowski, L. S. Wright, K. Wallace et al., Modeling early retinal development with human embryonic and induced pluripotent stem cells, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.16698-16703, 2009.

J. S. Meyer, S. E. Howden, K. A. Wallace, A. D. Verhoeven, L. S. Wright et al., Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment, Stem Cells, vol.29, pp.1206-1218, 2011.

K. Mitsui, Y. Tokuzawa, H. Itoh, K. Segawa, M. Murakami et al., The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells, Cell, vol.113, pp.631-642, 2003.

A. Mockel, Y. Perdomo, F. Stutzmann, J. Letsch, V. Marion et al., Retinal dystrophy in Bardet-Biedl syndrome and related syndromic ciliopathies, Prog. Retin. Eye Res, vol.30, pp.258-274, 2011.

D. Mustafi, A. H. Engel, and K. Palczewski, Structure of cone photoreceptors, Prog. Retin. Eye Res, vol.28, pp.289-302, 2009.

M. I. Naash, J. G. Hollyfield, M. R. Ubaidi, and W. Baehr, Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.5499-5503, 1993.

T. Nakano, S. Ando, N. Takata, M. Kawada, K. Muguruma et al., Self-formation of optic cups and storable stratified neural retina from human ESCs, Cell Stem Cell, vol.10, pp.771-785, 2012.

N. Nakatsuji, F. Nakajima, and K. Tokunaga, HLA-haplotype banking and iPS cells, Nat. Biotechnol, vol.26, pp.739-740, 2008.

E. Neofytou, C. G. Brien, L. A. Couture, and J. C. Wu, Hurdles to clinical translation of human induced pluripotent stem cells, J. Clin. Invest, vol.125, pp.2551-2557, 2015.

J. Neves, J. Zhu, P. Sousa-victor, M. Konjikusic, R. Riley et al., Immune modulation by MANF promotes tissue repair and regenerative success in the retina, Science, p.3646, 2016.

E. Newman and A. Reichenbach, The Muller cell: A functional element of the retina, Trends Neurosci, vol.19, pp.307-312, 1996.

L. Ng, J. B. Hurley, B. Dierks, M. Srinivas, C. Saltó et al., A thyroid hormone receptor that is required for the development of green cone photoreceptors, Nat. Genet, vol.27, pp.94-98, 2001.

J. Nichols, B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-nebenius et al., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4, Cell, vol.95, pp.379-391, 1998.

P. E. Nickerson, A. Ortin-martinez, and V. A. Wallace, Material Exchange in Photoreceptor Transplantation: Updating Our Understanding of Donor/Host Communication and the Future of, Cell Engraftment Science. Front. Neural Circuits, vol.12, 2018.

B. Nickle, R. , and P. R. , The opsins of the vertebrate retina: Insights from structural, biochemical, and evolutionary studies, Cell. Mol. Life Sci, vol.64, pp.2917-2932, 2007.

J. C. Niclis, C. W. Gantner, W. F. Alsanie, S. J. Mcdougall, C. R. Bye et al., Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents, Stem Cells Transl. Med, vol.6, pp.937-948, 2017.

R. Van-nie, D. Iványi, and P. Démant, A New H-2-Linked Mutation, rds, Causing Retinal Degeneration in the Mouse, Tissue Antigens, vol.12, pp.106-108, 1978.

A. Nishida, A. Furukawa, C. Koike, Y. Tano, S. Aizawa et al., Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development, Nat. Neurosci, vol.6, pp.1255-1263, 2003.

H. Niwa, J. I. Miyazaki, and A. G. Smith, Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells, Nat. Genet, vol.24, pp.372-376, 2000.

S. Noggle, H. L. Fung, A. Gore, H. Martinez, K. C. Satriani et al., Human oocytes reprogram somatic cells to a pluripotent state, Nature, vol.478, pp.70-75, 2011.

S. Nolbrant, A. Heuer, M. Parmar, and A. Kirkeby, Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation, Nat. Protoc, vol.12, pp.1962-1979, 2017.

E. C. Oh, H. Cheng, H. Hao, L. Jia, N. W. Khan et al., Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors, Brain Res, vol.1236, pp.16-29, 2008.

R. Ohsawa and R. Kageyama, Regulation of retinal cell fate specification by multiple transcription factors, Brain Res, vol.1192, pp.90-98, 2008.

K. Okita, T. Ichisaka, Y. , and S. , Generation of germline-competent induced pluripotent stem cells, Nature, vol.448, pp.313-317, 2007.

K. Okita, Y. Matsumura, Y. Sato, A. Okada, A. Morizane et al., A more efficient method to generate integration-free human iPS cells, Nat. Methods, vol.8, pp.409-412, 2011.

J. E. Olsson, J. W. Gordon, B. S. Pawlyk, D. Roof, A. Hayes et al., Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa, Neuron, vol.9, pp.815-830, 1992.

E. Orhan, D. Dalkara, M. Neuillé, C. Lechauve, C. Michiels et al., Genotypic and phenotypic characterization of P23H line 1 rat model, PLoS One, vol.10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01228055

A. Ortin-martinez, E. L. Tsai, P. E. Nickerson, M. Bergeret, Y. Lu et al., A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors, Stem Cells, vol.35, pp.932-939, 2017.

F. Osakada, H. Ikeda, M. Mandai, T. Wataya, K. Watanabe et al., Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells, Nat. Biotechnol, vol.26, pp.215-224, 2008.

F. Osakada, Z. Jin, Y. Hirami, H. Ikeda, T. Danjyo et al., In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction, J. Cell Sci, vol.122, pp.3169-3179, 2009.

P. Ovando-roche, E. L. West, M. J. Branch, R. D. Sampson, M. Fernando et al., Use of bioreactors for culturing human retinal organoids improves photoreceptor yields, Stem Cell Res. Ther, vol.9, p.156, 2018.

Y. Ozawa, K. Nakao, T. Shimazaki, J. Takeda, S. Akira et al., Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina, Mol. Cell. Neurosci, vol.26, pp.258-270, 2004.

S. Panda-jonas, J. B. Jonas, M. Jakobczyk, and U. Schneider, Retinal Photoreceptor Count, Retinal Surface Area, and Optic Disc Size in Normal Human Eyes, Ophthalmology, vol.101, pp.519-523, 1994.

D. A. Parfitt, A. Lane, C. M. Ramsden, A. J. Carr, P. M. Munro et al., Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups, Cell Stem Cell, vol.18, pp.769-781, 2016.

R. A. Pearson, A. C. Barber, M. Rizzi, C. Hippert, T. Xue et al., Restoration of vision after transplantation of photoreceptors, Nature, vol.485, pp.99-103, 2012.

R. A. Pearson, A. Gonzalez-cordero, E. L. West, J. R. Ribeiro, N. Aghaizu et al., Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors, Nat. Commun, vol.7, p.13029, 2016.

G. H. Peng, O. Ahmad, F. Ahmad, J. Liu, C. et al., The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes, Hum. Mol. Genet, vol.14, pp.747-764, 2005.

R. M. Petters, C. A. Alexander, K. D. Wells, E. B. Collins, J. R. Sommer et al., Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa, Nat. Biotechnol, vol.15, pp.965-970, 1997.

J. Phillips, P. Jiang, S. , H. , P. et al.,

, A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types, Stem Cells, pp.1-16

M. J. Phillips, K. A. Wallace, S. J. Dickerson, M. J. Miller, A. D. Verhoeven et al., Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses, Invest. Ophthalmol. Vis. Sci, vol.53, pp.2007-2019, 2012.

M. J. Phillips, E. T. Perez, J. M. Martin, S. T. Reshel, K. A. Wallace et al., Modeling human retinal development with patientspecific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2, Stem Cells, vol.32, pp.1480-1492, 2014.

S. J. Pittler, C. E. Keeler, R. L. Sidman, and W. Baehr, PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect, Proc. Natl. Acad. Sci, vol.90, pp.9616-9619, 1993.

J. M. Polo, S. Liu, M. E. Figueroa, W. Kulalert, S. Eminli et al., Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells, Nat. Biotechnol, vol.28, pp.848-855, 2010.

K. Postel, J. Bellmann, V. Splith, and M. Ader, Analysis of cell surface markers specific for transplantable rod photoreceptors, Mol. Vis, vol.19, pp.2058-2067, 2013.

M. C. Puri and A. Nagy, Concise review: Embryonic stem cells versus induced pluripotent stem cells: The game is on, Stem Cells, vol.30, pp.10-14, 2012.

X. Qi, T. Li, J. Hao, J. Hu, J. Wang et al., BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.6027-6032, 2004.

G. Quadrato, T. Nguyen, E. Z. Macosko, J. L. Sherwood, S. M. Yang et al., Cell diversity and network dynamics in photosensitive human brain organoids, Nature, vol.545, pp.48-53, 2017.

N. D. Radtke, R. B. Aramant, H. M. Petry, P. T. Green, D. J. Pidwell et al., Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium, Am. J. Ophthalmol. Ophthalmol, vol.146, pp.172-182, 2008.

V. Ramamurthy, G. Niemi, T. Reh, and J. B. Hurley, Leber congenital amaurosis linked to AIPL1: A mouse model reveals destabilization of cGMP phosphodiesterase, Proc. Natl. Acad. Sci, vol.101, pp.13897-13902, 2004.

A. Reichenbach, A. Siegel, M. Rickmann, J. R. Wolff, D. Noone et al., Distribution of Bergmann glial somata and processes: implications for function, J. F?r Hirnforsch, vol.36, pp.509-517, 1995.

S. Reichman, A. Terray, A. Slembrouck, C. Nanteau, G. Orieux et al., From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.8518-8523, 2014.

S. Reichman, A. Slembrouck, G. Gagliardi, A. Chaffiol, A. Terray et al., Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions, Stem Cells, vol.35, pp.1176-1188, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01480587

S. Remtulla and P. E. Hallett, A schematic eye for the mouse, and comparisons with the rat, Vision Res, vol.25, pp.21-31, 1985.

K. Rhee, . Do, O. Goureau, S. Chen, Y. et al., Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina, J. Neurosci, vol.24, pp.9779-9788, 2004.

M. R. Roberts, A. Hendrickson, C. R. Mcguire, and T. A. Reh, Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina, Invest. Ophthalmol. Vis. Sci, vol.46, pp.2897-2904, 2005.

A. Roorda, A. B. Metha, P. Lennie, and D. R. Williams, Packing arrangement of the three cone classes in primate retina, Vision Research, pp.1291-1306, 2001.

D. S. Sakaguchi, S. J. Van-hoffelen, E. Theusch, E. Parker, J. Orasky et al., Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: An in vivo system for studying stem/progenitor cell plasticity, Dev. Neurosci, vol.26, pp.336-345, 2004.

S. Sakami, T. Maeda, G. Bereta, K. Okano, M. Golczak et al., Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations, J. Biol. Chem, vol.286, pp.10551-10567, 2011.

R. S. Saliba, P. M. Munro, P. J. Luthert, and M. E. Cheetham, The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation, J. Cell Sci, vol.115, pp.2907-2918, 2002.

T. Santos-ferreira, K. Postel, H. Stutzki, T. Kurth, G. Zeck et al., Daylight vision repair by cell transplantation, Stem Cells, vol.33, pp.79-90, 2015.

T. Santos-ferreira, M. Völkner, O. Borsch, J. Haas, P. Cimalla et al., Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy, Investig. Ophthalmol. Vis. Sci, vol.57, pp.3509-3520, 2016.

T. Santos-ferreira, S. Llonch, O. Borsch, K. Postel, J. Haas et al., Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange, Nat. Commun, vol.7, p.13028, 2016.

T. F. Santos-ferreira, O. Borsch, and M. Ader, Rebuilding the Missing Part-A Review on Photoreceptor Transplantation, Front. Syst. Neurosci, vol.10, pp.1-14, 2017.

S. Satoh, K. Tang, A. Iida, M. Inoue, T. Kodama et al., The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors, J. Neurosci, vol.29, pp.12401-12411, 2009.

P. A. Scott, J. P. Fernandez-de-castro, H. J. Kaplan, and M. A. Mccall, A Pro23His mutation alters prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa, Investig. Ophthalmol. Vis. Sci, vol.55, pp.2452-2459, 2014.

P. A. Scott, J. P. De-castro, P. J. Demarco, J. W. Ross, J. Njoka et al., Progression of Pro23His Retinopathy in a Miniature Swine Model of Retinitis Pigmentosa, Transl. Vis. Sci. Technol, vol.6, p.4, 2017.

J. A. Segre, J. L. Nemhauser, B. A. Taylor, J. H. Nadeau, and E. S. Lander, Positional cloning of the nude locus: Genetic, physical, and transcription maps of the region and mutations in the mouse and rat, Genomics, vol.28, pp.549-559, 1995.

M. J. Seiler and R. B. Aramant, Intact sheets of fetal retina transplanted to restore damaged rat retinas, Investig. Ophthalmol. Vis. Sci, 1998.

M. J. Seiler and R. B. Aramant, Cell replacement and visual restoration by retinal sheet transplants, Prog. Retin. Eye Res, vol.31, pp.661-687, 2012.

M. J. Seiler, R. B. Aramant, B. B. Thomas, Q. Peng, S. R. Sadda et al., Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets, Eur. J. Neurosci, vol.31, pp.508-520, 2010.

M. J. Seiler, R. B. Aramant, M. K. Jones, D. L. Ferguson, E. C. Bryda et al., A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefe's Arch, Clin. Exp. Ophthalmol, vol.252, pp.1079-1092, 2014.

M. J. Seiler, R. E. Lin, B. T. Mclelland, A. Mathur, B. Lin et al., Vision recovery and connectivity by fetal retinal sheet transplantation in an immunodeficient retinal degenerate rat model, Investig. Ophthalmol. Vis. Sci, vol.58, pp.614-630, 2017.

P. Shi, Y. S. Tan, W. Y. Yeong, H. Y. Li, and A. Laude, A bilayer photoreceptor-retinal tissue model with gradient cell density design: A study of microvalve-based bioprinting, J. Tissue Eng. Regen. Med, vol.12, pp.1297-1306, 2018.

Y. Shi, H. Inoue, J. C. Wu, Y. , and S. , Induced pluripotent stem cell technology: A decade of progress, Nat. Rev. Drug Discov, vol.16, pp.115-130, 2017.

H. Shirai, M. Mandai, K. Matsushita, A. Kuwahara, S. Yonemura et al., Transplantation of human embryonic stem cellderived retinal tissue in two primate models of retinal degeneration, Proc. Natl. Acad. Sci, vol.113, pp.81-90, 2016.

L. D. Shultz, P. A. Schweitzer, and S. W. Christianson, Multiple defects in innate and adaptive immunological function in NOD/LtSz-scid mice, J. Immunol, vol.154, pp.180-191, 1995.

P. A. Sieving, R. C. Caruso, W. Tao, H. R. Coleman, D. J. Thompson et al., Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants, Proc. Natl. Acad. Sci, vol.103, pp.3896-3901, 2006.

S. Da-silva and C. L. Cepko, Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina, Dev. Cell, vol.42, pp.68-81, 2017.

M. S. Singh, P. Issa, R. Butler, C. Martin, D. M. Lipinski et al., Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.1101-1106, 2013.

M. S. Singh, J. Balmer, A. R. Barnard, S. A. Aslam, D. Moralli et al., Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion, Nat. Commun, vol.7, p.13537, 2016.

R. K. Singh, R. K. Mallela, P. K. Cornuet, A. N. Reifler, A. P. Chervenak et al., Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures, Stem Cells Dev, vol.24, 2015.

D. K. Singla, Stem cells and exosomes in cardiac repair, Curr. Opin. Pharmacol, vol.27, pp.19-23, 2016.

D. Sinha, J. Phillips, M. Joseph-phillips, and D. M. Gamm, Mimicking Retinal Development and Disease With Human Pluripotent Stem Cells, Investig. Opthalmology Vis. Sci, vol.57, p.1, 2016.

R. W. Slijkerman, F. Song, G. D. Astuti, M. A. Huynen, E. Van-wijk et al., The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies, Prog. Retin. Eye Res, vol.48, pp.137-159, 2015.

K. W. Small, A. P. Deluca, S. S. Whitmore, T. Rosenberg, R. Silva-garcia et al., North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13, Ophthalmology, vol.123, pp.9-18, 2016.

S. Smiley, P. E. Nickerson, L. Comanita, N. Daftarian, A. El-sehemy et al., GFP reporter mouse line. Sci. Rep, vol.6, 2016.

I. Solovei, M. Kreysing, C. Lanctôt, S. Kösem, L. Peichl et al., Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution, Cell, vol.137, pp.356-368, 2009.

M. Stadtfeld, M. Nagaya, J. Utikal, G. Weir, and K. Hochedlinger, Induced Pluripotent Stem Cells Generated Without Viral Integration, Science, vol.322, pp.945-949, 2008.

R. H. Steinberg, J. G. Flannery, M. Naash, P. Oh, M. T. Matthes et al., Transgenic rat models of inherited retinal degeneration caused by mutant opsin genes, Investig. Ophthalmol. Vis. Sci, vol.37, 1996.

J. H. Stern, Y. Tian, J. Funderburgh, G. Pellegrini, K. Zhang et al., Regenerating Eye Tissues to Preserve and Restore Vision, Cell Stem Cell, vol.22, pp.834-849, 2018.

A. Stett, U. Egert, E. Guenther, F. Hofmann, T. Meyer et al., Biological application of microelectrode arrays in drug discovery and basic research, Anal. Bioanal. Chem, vol.377, pp.486-495, 2003.

K. Stingl, K. U. Bartz-schmidt, D. Besch, A. Braun, A. Bruckmann et al., Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS, Proc. Biol. Sci, vol.280, 2013.

O. Strauss, The Retinal Pigment Epithelium in Visual Function, Physiol. Rev, vol.85, pp.845-881, 2005.

E. Strettoi, A. J. Mears, and A. Swaroop, Recruitment of the Rod Pathway by Cones in the Absence of Rods, J. Neurosci, vol.24, pp.7576-7582, 2004.

A. Swaroop, D. Kim, F. , and D. , Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina, Nat. Rev. Neurosci, vol.11, pp.563-576, 2010.

R. J. Swijnenburg, S. Schrepfer, J. A. Govaert, F. Cao, K. Ransohoff et al., Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.12991-12996, 2008.

M. Tachibana, P. Amato, M. Sparman, N. M. Gutierrez, R. Tippner-hedges et al., Human embryonic stem cells derived by somatic cell nuclear transfer, Cell, vol.153, pp.1228-1238, 2013.

K. Takahashi, Y. , and S. , Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Cell, vol.126, pp.663-676, 2006.

K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka et al., Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, pp.861-872, 2007.

M. Takahashi, T. D. Palmer, J. Takahashi, and F. H. Gage, Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina, Mol. Cell. Neurosci, vol.12, pp.340-348, 1998.

A. A. Thiadens, A. I. Hollander, S. Roosing, S. B. Nabuurs, R. C. Zekveld-vroon et al., , 2009.

, Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders, Am. J. Hum. Genet, vol.85, pp.240-247

J. A. Thomson, Embryonic Stem Cell Lines Derived from Human Blastocysts. Science (80-. ), vol.282, pp.1145-1147, 1998.

V. Tropepe, B. L. Coles, B. J. Chiasson, D. J. Horsford, A. J. Elia et al., Retinal stem cells in the adult mammalian eye. Science, vol.287, pp.2032-2036, 2000.

Y. Tsai, B. Lu, B. Bakondi, S. Girman, A. Sahabian et al., Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model, Stem Cells, vol.33, pp.2537-2549, 2015.

B. A. Tucker, I. H. Park, S. D. Qi, H. J. Klassen, C. Jiang et al., Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice, PLoS One, vol.6, 2011.

B. A. Tucker, T. E. Scheetz, R. F. Mullins, A. P. Deluca, J. M. Hoffmann et al., Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa, Proc. Natl. Acad. Sci, vol.108, pp.569-576, 2011.

B. A. Tucker, R. F. Mullins, L. M. Streb, K. Anfnson, M. E. Eyestone et al., Patient-specifc iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa, pp.1-18, 2013.

D. L. Turner and C. L. Cepko, A common progenitor for neurons and glia persists in rat retina late in development, Nature, vol.328, pp.131-136, 1987.

S. Veleri, C. H. Lazar, B. Chang, P. A. Sieving, E. Banin et al., Biology and therapy of inherited retinal degenerative disease: insights from mouse models, Dis. Model. Mech, vol.8, pp.109-129, 2015.

M. N. Vergara, M. Flores-bellver, S. Aparicio-domingo, M. Mcnally, K. J. Wahlin et al., Enabling quantitative screening in retinal organoids: 3D automated reporter quantification technology, 2017.

A. S. Viczian, E. C. Solessio, Y. Lyou, and M. E. Zuber, Generation of functional eyes from pluripotent cells, PLoS Biol, vol.7, 2009.

M. Völkner, M. Zschätzsch, M. Rostovskaya, R. W. Overall, V. Busskamp et al., Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis, Stem Cell Reports, vol.6, pp.525-538, 2016.

K. J. Wahlin, J. A. Maruotti, S. R. Sripathi, J. Ball, J. M. Angueyra et al., Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from, Human Pluripotent Stem Cells. Sci. Rep, vol.7, p.766, 2017.

P. V. Waldron, F. Marco, . Di, K. Kruczek, J. Ribeiro et al., Stem Cell Reports Transplanted Donor-or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner, Stem Cell Reports, vol.10, pp.1-16, 2017.

X. Wang, K. Xiong, C. Lin, L. Lv, J. Chen et al., New medium used in the differentiation of human pluripotent stem cells to retinal cells is comparable to fetal human eye tissue, Biomaterials, vol.53, pp.40-49, 2015.

L. Warren, P. D. Manos, T. Ahfeldt, Y. H. Loh, H. Li et al., Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA, Cell Stem Cell, vol.7, pp.618-630, 2010.

H. Wassle, C. Puller, F. Muller, and S. Haverkamp, Cone Contacts, Mosaics, and Territories of Bipolar Cells in the Mouse Retina, J. Neurosci, vol.29, pp.106-117, 2009.

E. Welby, J. Lakowski, V. Di-foggia, D. Budinger, A. Gonzalez-cordero et al., Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells, Stem Cell Reports, vol.9, pp.1898-1915, 2017.

L. A. Wiley, E. R. Burnight, A. P. Deluca, K. R. Anfinson, C. M. Cranston et al., cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness, Sci. Rep, vol.6, p.30742, 2016.

L. A. Wiley, E. R. Burnight, A. V. Drack, B. B. Banach, D. Ochoa et al., Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3 -Associated Retinal Degeneration, Hum. Gene Ther, vol.27, pp.835-846, 2016.

R. L. Williams, D. J. Hilton, S. Pease, T. Willson, C. L. Stewart et al., Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells, Nature, vol.336, pp.684-687, 1988.

J. Won, L. Y. Shi, W. Hicks, J. Wang, R. Hurd et al., , 2011.

, Mouse Model Resources for Vision Research, J. Ophthalmol, 2011.

W. L. Wong, X. Su, X. Li, C. M. Cheung, R. Klein et al., Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis, Lancet Glob. Heal, vol.2, pp.106-116, 2014.

K. S. Worthington, L. A. Wiley, E. E. Kaalberg, M. M. Collins, R. F. Mullins et al., Two-photon polymerization for production of human iPSC-derived retinal cell grafts, Acta Biomater, vol.55, pp.385-395, 2017.

A. F. Wright, C. F. Chakarova, A. El-aziz, M. M. Bhattacharya, and S. S. , Photoreceptor degeneration: Genetic and mechanistic dissection of a complex trait, Nat. Rev. Genet, vol.11, pp.273-284, 2010.

R. H. Xu, X. Chen, D. S. Li, R. Li, G. C. Addicks et al., BMP4 initiates human embryonic stem cell differentiation to trophoblast, Nat. Biotechnol, vol.20, pp.1261-1264, 2002.

M. Yamada, B. Johannesson, I. Sagi, L. C. Burnett, D. H. Kort et al., Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells, Nature, vol.510, pp.533-536, 2014.

S. Yamanaka, Induced pluripotent stem cells: Past, present, and future, Cell Stem Cell, vol.10, pp.678-684, 2012.

A. Yanai, C. R. Laver, A. W. Joe, . Viringipurampeer, X. Wang et al., Differentiation of human embryonic stem cells using size-controlled embryoid bodies and negative cell selection in the production of photoreceptor precursor cells, Tissue Eng. Part C. Methods, vol.19, pp.755-764, 2013.

Y. Yang, S. Mohand-said, T. Léveillard, V. Fontaine, M. Simonutti et al., Transplantation of Photoreceptor and Total Neural Retina Preserves Cone Function in P23H Rhodopsin Transgenic Rat, PLoS One, vol.5, 2010.

Z. Yang, Y. Chen, C. Lillo, J. Chien, Z. Yu et al., Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice, J. Clin. Invest, vol.118, pp.2908-2916, 2008.

Q. L. Ying, J. Nichols, I. Chambers, and A. Smith, BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3, Cell, vol.115, pp.281-292, 2003.

T. Yoshida, Y. Ozawa, K. Suzuki, K. Yuki, M. Ohyama et al., The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa, Mol. Brain, vol.7, p.45, 2014.

R. W. Young, Visual cells and the concept of renewal, Investig. Opthalmology Vis. Sci, vol.15, pp.700-725, 1976.

R. W. Young, Cell differentiation in the retina of the mouse, Anat. Rec, vol.212, pp.199-205, 1985.

M. J. Young, J. Ray, S. J. Whiteley, H. Klassen, and F. H. Gage, Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats, Mol. Cell. Neurosci, vol.16, pp.197-205, 2000.

J. Yu, M. A. Vodyanik, K. Smuga-otto, J. Antosiewicz-bourget, J. L. Frane et al., Induced pluripotent stem cell lines derived from human somatic cells, Science, vol.318, pp.1917-1920, 2007.

C. Yvon, C. M. Ramsden, A. Lane, M. B. Powner, L. Da-cruz et al., , 2015.

, Using Stem Cells to Model Diseases of the Outer Retina, Comput. Struct. Biotechnol. J, vol.13, pp.382-389

C. Zeitz, A. G. Robson, A. , and I. , Congenital stationary night blindness: an analysis and update of genotype-phenotype correlations and pathogenic mechanisms, Prog. Retin. Eye Res, vol.45, pp.58-110, 2015.

X. Y. Zhao, W. Li, Z. Lv, L. Liu, M. Tong et al., IPS cells produce viable mice through tetraploid complementation, Nature, vol.461, pp.86-90, 2009.

X. Zhong, C. Gutierrez, T. Xue, C. Hampton, M. N. Vergara et al., Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nat. Commun, vol.5, pp.1-14, 2014.

S. Zhou, A. Flamier, M. Abdouh, N. Tetreault, A. Barabino et al., Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGF and Wnt signaling, Development, vol.142, pp.3294-3306, 2015.

J. Zhu, H. Cifuentes, J. Reynolds, and D. A. Lamba, Immunosuppression via Loss of IL2r Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina, Cell Stem Cell, vol.20, pp.374-384, 2017.

J. Zhu, J. Reynolds, T. Garcia, H. Cifuentes, S. Chew et al., Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacture Practice-Manufactured Human Induced Pluripotent Stem Cell Line, Stem Cells Transl. Med, 2017.

Y. Zhu, M. Carido, A. Meinhardt, T. Kurth, M. O. Karl et al., Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium, PLoS One, vol.8, 2013.

M. E. Zuber, Eye field specification in Xenopus laevis, In Current Topics in Developmental Biology, pp.29-60, 2010.