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, Hz, 2H), 7.60 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.1 Hz, 2H), 7.31 (t, J=7.4 Hz, 2H), 5.52 (d, J=7.9 Hz, 1H)

, 9H-fluoren-9-yl)methyl (1-hydroxy-3-tert-butoxybutan-2-yl)carbamate M12a : Solid

, Hz, 2H), 7.60 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.1 Hz, 2H), vol.7

, 9H-fluoren-9-yl)methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate M13a : Solid

, Hz, 2H), 7.54 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.4 Hz, 2H), vol.7

, Hz, 4H), 7.21 (m, 3H), 4.96 (bs, 1H)

, 9H-fluoren-9-yl)methyl (1-hydroxy-4-tert-butoxycarbonyl butan-2-yl)carbamate M14a : Solid ; yield 93% ; 1 H NMR (CDCl3, 300 MHz) ? (ppm) : 7.76 (d, J=7.4 Hz, 2H), 7.59 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.5 Hz, 2H), vol.7

, 9H-fluoren-9-yl)methyl (1-iodo-3-tertbutoxypropan-2-yl)carbamate M11b : Oil ; yield 86% ; 1 H NMR (CDCl3, 300 MHz) ? (ppm) : 7.77 (d, J=7.4 Hz, 2H), 7.60 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.1 Hz, 2H), vol.7

, 9H-fluoren-9-yl)methyl (1-iodo-3-tert-Butoxybutan-2-yl)carbamate M12b : Oil ; yield 82% ; 1 H NMR (CDCl3, 300 MHz) ? (ppm) : 7.77 (d, J=7.4 Hz, 2H), 7.60 (d, J=7.4 Hz, 2H), 7.40 (t, J=7.1 Hz, 2H), vol.7

, 9H-fluoren-9-yl)methyl (1-iodo-3-phenylpropan-2-yl)carbamate M13b : Solid

, Hz, 2H), 7.57 (dd, J=7.4 Hz, J=3.3 Hz, 2H), 7.41 (t, J=7.2 Hz, 2H), 7.31 (m, 6H), 7.24 (m, 1H)

, 9H-fluoren-9-yl)methyl (1-iodo-4-tert-Butoxycarbonylbutan-2-yl)carbamate M14b : Solid

, Hz, 2H), 7.60 (d, J=7.4 Hz, 2H), 7.41 (t, J=7.2 Hz, 2H), vol.7

, 79 (s, 4H), 1.20 (s, 9H) ; 13 C NMR (CDCl3, 75 MHz) ? (ppm) : 169.88, 156.67, 151.94, 144.15, 143.99, 141.45, 127.83, 127.21, 125.35, 125.25, 120.09, 73.96, 67.20, 62.72, 50.23, 47.35, 45.17, 27.47, 25.59 ; HRMS (ESI) : m/z cald for C27H31N3O7Na [M+Na] + : 532.20542 found 532.20511. (S)-(9H-fluoren-9-yl)methyl (1-(2,5-dioxopyrrolidin-1-yl)-3-tert-Butoxybutan-2-yl)-1,2-carbamate M12: Solid ; yield 80%, N-Fmoc protected amino iodine derivate : M11b, M12b, M13b, or M14b, (1eq) was dissolved in DMF, then NaN3 (3eq) was added and the reaction mixture was stirred at room temperature. After 24 hours the reaction was completed. EtOAc was added. The crude was washed five times with H2O, two times with a 1M solution of HCl, one time with brine, dried over sodium sulfate and concentrated under reduced pressure. Silica gel flash chromatography was performed in cyclohexane/EtOAc, vol.1

, found 552.23389. (R)-2,5-dioxopyrrolidin-2-yl (1-azido-3-methylbutyl) carbamate M23 Solid, HRMS (ESI) : m/z cald for C29H34N3O8

, Hz, 1H), 3.53 (m, 3H), vol.2

C. Nmr,

, 5-dioxopyrrolidin-2-yl (1-azido-4-methylpentyl) carbamate M24 Solid

, Hz, 1H), 3.84 (m, 1H), 3.48 (m, 2H), 2.82 (s, 4H), 1.68 (m, 1H), 1.50 (m, 1H), 1.37 (m,1H), p.75

. Mhz, ): m/z cald for C11H17N5O4Na, pp.306-11797

, ACN (0.1% TFA); gradient 30-38%, 15 min; 38-100%, 2 min; 100%, 1 min), flow = 20 ml/min. 18.0 mg was obtained with total yield 27 %. ESI-MS, III.25 was synthetized on 50 µmol scale with the use of monomers M1, M3 and M15 following the general procedure B. The product was purified by prep HPLC : H2O (0.1% TFA)

, ACN (0.1% TFA); gradient 10-100%, HPLC (H2O (0.1% TFA)

, ACN (0.1% TFA); gradient 30-45%, 20 min; 45-100%, 2 min; 100%, 1 min), flow = 20 ml/min. 20.0 mg was obtained with total yield 33 %. ESI-MS, III.42 was synthetized on 50 µmol scale with the use of monomers M18, M1 and M22 following the general procedure B. The product was purified by prep HPLC : H2O (0.1% TFA), p.27

, 1% TFA); gradient 10-100%, 10 min; 100%, 3min) tR= 4.15 min. Figure 281 : RP-HPLC chromatogram of III.42 after purification H-Thr-Ser-Phe-Ala-Glu-Tyr-Trp U -Ala U -Ala INVU -NH2 (III.43) III.43 was synthetized on 50 µmol scale with the use of monomers M18, M1 and M22 following the general procedure B. The product was purified by prep HPLC : H2O (0.1% TFA), ACN (0.1% TFA); gradient 25-35%, 20 min; 35-100%, 2 min; 100%, 1 min), flow = 20 ml/min. 23.0 mg was obtained with total yield 41 %. ESI-MS

, ACN (0.1% TFA); gradient 10-100%, 10 min; 100%, 3min) tR= 4.00 min. Figure 282 : RP-HPLC chromatogram of III.43 after purification, HPLC (H2O (0.1% TFA)

, ACN (0.1% TFA); gradient 30-45%, 20 min; 45-100%, 2 min; 100%, 1 min), flow = 20 ml/min. 21.0 mg was obtained with total yield 37 %. ESI-MS, III.44 was synthetized on 50 µmol scale with the use of monomers M18 and M1 following the general procedure B. The product was purified by prep HPLC : H2O (0.1% TFA)

, ACN (0.1% TFA), HPLC (H2O (0.1% TFA), vol.gradient, pp.10-100

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