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ASGART-fast & efficient de novo mapping of segmental duplications at the genome scale

Franklin Delehelle 1, 2
1 IRIT-APO - Algorithmes Parallèles et Optimisation
IRIT - Institut de recherche en informatique de Toulouse
2 IRIT-REVA - Real Expression Artificial Life
IRIT - Institut de recherche en informatique de Toulouse
Abstract : The large numbers of newly sequenced genomes these last decades highlighted the large proportions of duplicated sequences – of many scales and scopes – they nearly all harbor. Among these duplications, SDs (segmental duplications) are of a peculiar interest due to the role they play during the creation of genetic variation, both at the species and at the individual level. These areas, while historically difficult to sequence, are starting to be more easily accessible thanks to both the improving of existing processes and the development of new ones.To ease in silico exploration of these new datasets, we developed ASGART, a fast and efficient tool designed toward precise mapping of duplicated areas in DNA fragments. We then present a few preliminary results obtained thanks to ASGART, especially in the field of the sex chromosomes evolutive patterns.
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Franklin Delehelle. ASGART-fast & efficient de novo mapping of segmental duplications at the genome scale. Quantitative Methods [q-bio.QM]. INSA de Toulouse, 2019. English. ⟨NNT : 2019ISAT0020⟩. ⟨tel-02497362⟩

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