Skip to Main content Skip to Navigation
Theses

Élaboration et caractérisation de matériaux nanofibreux fonctionnels à base d’acide hyaluronique et de nanoparticules lipidiques pour des applications à usage biomédical

Abstract : Hyaluronic acid (HA) is a polysaccharide for which biocompatibility and bioactivity properties make it a very interesting compound as wound dressings. In this work, biocompatible insoluble HA-based nanofibrous dressings were designed by electrospinning in pure water in order to overcome any toxicity issues. To this purpose, poly(vinyl alcohol) and hydroxypropyl-β-cyclodextrin were added to form uniform nanofibrous scaffolds. An in situ crosslinking process of the scaffolds is also investigated to ensure the stability of the fibrous structure during the use of the dressing. For opening the scope of wound application, various pathways of functionalization of these materials have been envisaged. The first one was the direct impregnation of naproxen, a model drug with anti-inflammatory properties, into the scaffolds either in aqueous solution or under supercritical CO2. The second way is based on the incorporation, within nanofibers, of lipid nanoparticles in which drugs can be encapsulated and then delivered to its wound sites.
Document type :
Theses
Complete list of metadatas

Cited literature [414 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02497203
Contributor : Abes Star :  Contact
Submitted on : Tuesday, March 3, 2020 - 3:06:09 PM
Last modification on : Wednesday, March 4, 2020 - 1:34:21 AM
Long-term archiving on: : Thursday, June 4, 2020 - 4:21:36 PM

File

SEON-LUTZ_Morgane_2019_ED182.p...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02497203, version 1

Collections

Citation

Morgane Seon-Lutz. Élaboration et caractérisation de matériaux nanofibreux fonctionnels à base d’acide hyaluronique et de nanoparticules lipidiques pour des applications à usage biomédical. Autre. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAE026⟩. ⟨tel-02497203⟩

Share

Metrics

Record views

78

Files downloads

432