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Caractérisation par imagerie par Tomographie par Emission de position de la réponse tumorale après traitement de l'hépatocarcinome chez le petit animal : chimiothérapie, protonthérapie et potentialisation

Abstract : My thesis work consisted of closely monitor tumoral response of hepatocarcinoma inoculated to mice, using 18F-FDG and 18F-FLT PET imaging during chemotherapy, protontherapy and both. Tumoral model was Sk-hep1 cells xenograft inoculate in subcutaneous tissue to female 8-week-old athymic nude mice. Chemotherapy protocol included Topotecan deliver at 12,5mg/kg or 6,25mg/kg. Protontherapy was delivered in one fraction of 5 Gy, 10 Gy or 20 Gy. 18F-FDG and 18F-FLT PET imaging were performed once a week. Both 18F-FDG and 18F-FLT imaging permitted to follow chemotherapy efficacity, and to observe an insufficient dose of Topotecan at 6,25mg/kg. 18F-FLT was better to observe tumoral escape with lower doses of protontherapy. Concerning proto-chemotherapy protocol, TEP imaging could not individualize significant difference in favor of potentiation.
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Nastassja Muller. Caractérisation par imagerie par Tomographie par Emission de position de la réponse tumorale après traitement de l'hépatocarcinome chez le petit animal : chimiothérapie, protonthérapie et potentialisation. Médecine humaine et pathologie. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAE024⟩. ⟨tel-02497001⟩

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