Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, vol.136, issue.5, pp.359-386, 2014. ,
Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries, Eur Urol, vol.70, issue.5, pp.862-74, 2016. ,
Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer, Oncotarget, vol.7, issue.39, pp.64447-70, 2016. ,
Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer, Nat Rev Cancer, vol.15, issue.12, pp.701-712, 2015. ,
Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. Prostate Cancer Prostatic Dis, vol.19, pp.231-272, 2016. ,
The link between androgen receptor splice variants and castration resistant prostate cancer. Horm Cancer, vol.5, pp.207-224, 2014. ,
Emerging data on androgen receptor splice variants in prostate cancer, Endocr Relat Cancer, vol.23, issue.12, pp.199-210, 2016. ,
Androgen receptors in hormone-dependent and castrationresistant prostate cancer, Pharmacol Ther, vol.140, issue.3, pp.223-261, 2013. ,
Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting, Eur Urol, vol.73, issue.5, pp.715-738, 2018. ,
Biologic and Clinical Significance of Androgen Receptor Variants in Castration Resistant Prostate Cancer, Endocr Relat Cancer, vol.21, issue.4, pp.87-103, 2014. ,
Decoding the androgen receptor splice variants, Transl Androl Urol, vol.2, issue.3, pp.178-86, 2013. ,
Understanding the mechanisms of androgen deprivation resistance in prostate cancer at the molecular level, Eur Urol, vol.67, issue.3, pp.470-479, 2015. ,
Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer, Asian J Androl, vol.18, issue.4, pp.580-585, 2016. ,
AR-V7 and prostate cancer: The watershed for treatment selection?, Cancer Treat Rev, vol.43, pp.27-35, 2016. ,
A yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer, Eur J Endocrinol, vol.148, issue.1, pp.99-110, 2003. ,
Constitutively Active Androgen Receptor Variants Upregulate Expression of Mesenchymal Markers in Prostate Cancer Cells, PLoS ONE, vol.8, issue.5, p.63466, 2013. ,
Dual effects of constitutively active androgen receptor and full-length androgen receptor for N-cadherin regulation in prostate cancer, Oncotarget, vol.8, issue.42, pp.72008-72028, 2017. ,
Androgen Receptor Splice Variant AR3 Promotes Prostate Cancer via Modulating Expression of Autocrine/Paracrine Factors, J Biol Chem, vol.289, issue.3, pp.1529-1568, 2014. ,
Microenvironmental regulation of tumor progression and metastasis, Nat Med, vol.19, p.1423, 2013. ,
Tumor microenvironment: Sanctuary of the devil, Cancer Lett, vol.368, issue.1, pp.7-13, 2015. ,
Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts. Tumor Biol, vol.36, pp.1385-94, 2015. ,
A peek into cancer-associated fibroblasts: origins, functions and translational impact, Dis Model Mech, vol.11, issue.4, p.29447, 2018. ,
The biology and function of fibroblasts in cancer, Nat Rev Cancer, vol.16, p.582, 2016. ,
Fibroblast heterogeneity in the cancer wound, J Exp Med, vol.211, issue.8, pp.1503-1526, 2014. ,
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth, Cancers, vol.7, issue.4, pp.2443-58, 2015. ,
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis, Nat Commun, vol.4, p.1795, 2013. ,
Cancer associated fibroblasts: An essential role in the tumor microenvironment, Oncol Lett, vol.14, issue.3, pp.2611-2631, 2017. ,
Stromal Androgen Receptor Roles in the Development of Normal Prostate, Benign Prostate Hyperplasia, and Prostate Cancer, Am J Pathol, vol.185, issue.2, pp.293-301, 2015. ,
Stromal Androgen Receptor in Prostate Development and Cancer, Am J Pathol, vol.184, issue.10, pp.2598-607, 2014. ,
Cancer associated fibroblasts: the dark side of the coin, Am J Cancer Res, vol.1, issue.4, pp.482-97, 2011. ,
Review of Cancer -Associated Fibroblasts and Therapies that Interfere with Their Activity, Tumor Microenviron Ther, vol.1, p.19, 2013. ,
Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling, PLoS Genet, vol.12, issue.8, p.1006244, 2016. ,
Characterization of tumorderived mesenchymal stem cells potentially differentiating into cancer-associated fibroblasts in lung cancer, Clin Transl Oncol [Internet], 2018. ,
, CANCER OF THE BREAST. Orig Publ, vol.1, issue.3421, pp.571-574, 1889.
Carcinomaassociated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium, Cancer Res, vol.59, p.5002, 1999. ,
Role of stromal-epithelial interactions in hormonal responses, Arch Histol Cytol, vol.67, issue.5, pp.417-451, 2004. ,
Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer, Oncotarget, vol.4, issue.1, pp.106-123, 2013. ,
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer, J Exp Med, 2017. ,
Influence of tumour micro-environment heterogeneity on therapeutic response, Nature, vol.501, p.346, 2013. ,
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer, Cancer Cell, vol.33, issue.3, pp.463-479, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437793
CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis, Tumour Biol, vol.35, issue.8, pp.7765-73, 2014. ,
Anatomy & Physiology: An Integrative Approach. 2nd Edition. McGraw-Hill Education, 2015. ,
Regional morphology and pathology of the prostate, Am J Clin Pathol, vol.49, issue.3, pp.347-57, 1968. ,
An introduction to acinar pressures in BPH and prostate cancer, Nat Rev Urol, vol.10, p.358, 2013. ,
, Cancer statistics, vol.68, issue.1, pp.7-30, 2018.
Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries, Eur Urol, vol.70, issue.5, pp.862-74, 2016. ,
Le cancer de la prostate, évolution de l'incidence et de la mortalité en France entre, Progrès En Urol, vol.25, issue.9, pp.536-578, 1980. ,
Prostate Cancer Screening, Medical Clinics of North America, vol.102, issue.2, pp.199-214, 2018. ,
Epidemiology, etiology, diagnosis and treatment of prostate cancer, Asian Pac J Cancer Prev APJCP, vol.15, issue.22, pp.9575-9583, 2014. ,
Reducing Prostate Cancer Racial Disparity: Evidence for Aggressive Early Prostate Cancer PSA Testing of African American Men, Cancer Epidemiol Biomarkers Amp Prev, vol.23, issue.8, p.1505, 2014. ,
diagnostic et pronostic du cancer de la prostate. Médecine Nucléaire, vol.41, pp.329-363, 2017. ,
Prediction of Prognosis for Prostatic Adenocarcinoma by Combined Histological Grading and Clinical Staging, J Urol, vol.111, issue.1, pp.58-64, 1974. ,
Grading of prostatic adenocarcinoma: current state and prognostic implications, Diagn Pathol, vol.11, p.25, 2016. ,
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours, Eur Urol, vol.70, issue.1, pp.106-125, 2016. ,
Recommandations en onco-urologie 2016-2018 du CCAFU : Cancer de la prostate, Recommandations, vol.27, pp.95-143, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02297771
, International Society of Urological Pathology (ISUP) Consensus Conference, p.125, 2014.
, on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System, Am J Surg Pathol, vol.40, issue.2, pp.244-52, 2016.
American Joint Committee on Cancer Staging Manual for Staging of Cancer, J. B. LIPPINCOTT COMPANY Philadelphia, 1992. ,
Prostate cancer -major changes in the American Joint Committee on Cancer eighth edition cancer staging manual, CA Cancer J Clin, vol.67, issue.3, pp.245-53, 2017. ,
Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer, JAMA, vol.280, issue.11, pp.969-74, 1998. ,
Evaluation of D'Amico criteria for low-risk prostate cancer, Scand J Urol, vol.48, issue.4, pp.344-353, 2014. ,
Impact of Comorbidity on Survival Among Men With Localized Prostate Cancer, J Clin Oncol, vol.29, issue.10, pp.1335-1376, 2011. ,
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer, N Engl J Med, vol.375, issue.15, pp.1415-1439, 2016. ,
Transperitoneal versus extraperitoneal robot-assisted laparoscopic radical prostatectomy: A prospective single surgeon randomized comparative study, Int J Urol, vol.22, issue.10, pp.916-937, 2015. ,
Urinary Incontinence and Erectile Dysfunction After Robotic Versus Open Radical Prostatectomy: A Prospective, Controlled, Nonrandomised Trial, Eur Urol, vol.68, issue.2, pp.216-241, 2015. ,
Current management of erectile dysfunction in prostate cancer survivors, Curr Opin Urol, vol.24, issue.4, pp.401-407, 2014. ,
Curiethérapie du cancer prostatique par implants permanents : le point en 2013. Curiethérapie Coordonné Par Jean-Michel Hannoun-Lévi, vol.17, pp.111-118, 2013. ,
Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (the ASCENDE-RT Trial): An Analysis of Survival Endpoints for a Randomized Trial Comparing a Low-Dose-Rate Brachytherapy Boost to a Dose-Escalated External Beam Boost for High-and Intermediate-risk Prostate Cancer, Int J Radiat Oncol, vol.98, issue.2, pp.275-85, 2017. ,
EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent, Eur Urol, vol.71, issue.4, pp.618-647, 2017. ,
Longterm results of the Dutch randomized prostate cancer trial: Impact of doseescalation on local, biochemical, clinical failure, and survival, Radiother Oncol, vol.110, issue.1, pp.104-113, 2014. ,
Short Androgen Suppression and Radiation Dose Escalation for Intermediate-and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991, J Clin Oncol, vol.34, issue.15, pp.1748-56, 2016. ,
Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, noninferiority, phase 3 CHHiP trial, Lancet Oncol, vol.17, issue.8, pp.1047-60, 2016. ,
Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland, Arch Surg, vol.43, issue.2, pp.209-232, 1941. ,
Prostate cancer: making the switch from LHRH antagonist to LHRH agonist, Nat Rev Urol, vol.9, issue.3, pp.125-131, 2012. ,
Risk of disease flare with LHRH agonist therapy in men with prostate cancer: myth or fact? Urol Oncol, vol.33, pp.7-15, 2015. ,
New agents for prostate cancer, Ann Oncol, vol.25, issue.9, pp.1700-1709, 2014. ,
Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer, Nat Rev Cancer, vol.15, issue.12, pp.701-712, 2015. ,
New Compounds Targeting the Androgen Receptor for Treatment of Advanced Prostate Cancer, Curr Drug Targets, vol.17, issue.3, pp.290-302, 2016. ,
Molecular underpinnings of enzalutamide resistance, Endocr Relat Cancer, 2018. ,
Androgen receptor antagonists for prostate cancer therapy, Endocr Relat Cancer, vol.21, issue.4, pp.105-118, 2014. ,
Emerging mechanisms of enzalutamide resistance in prostate cancer, Nat Rev Urol, vol.11, p.712, 2014. ,
Castration Resistant Prostate Cancer (CRPC): State of the Art, Perspectives and New Challenges, Former Curr Med Chem -Anti-Cancer Agents, vol.13, issue.6, pp.872-86, 2013. ,
Enzalutamide versus abiraterone acetate for the treatment of men with metastatic castration-resistant prostate cancer, Expert Opin Pharmacother, vol.16, issue.4, pp.473-85, 2015. ,
The influence of steroid metabolism on CYP17A1 inhibitor activity, Nat Rev Urol, vol.14, p.590, 2017. ,
Abiraterone acetate in the treatment of prostate cancer, Biomed Pharmacother, vol.101, pp.211-219, 2018. ,
Abiraterone Acetate: Targeting Persistent Androgen Dependence in Castration-Resistant Prostate Cancer, Adv Ther, vol.30, issue.8, pp.727-774, 2013. ,
Experimental Evidence of Persistent Androgen-Receptor-Dependency in Castration-Resistant Prostate Cancer, Int J Mol Sci, vol.14, issue.8, pp.15615-15650, 2013. ,
The nuclear receptor superfamily: the second decade, Cell, vol.83, issue.6, pp.835-844, 1995. ,
Looking at nuclear receptors from a new angle, Mol Cell Endocrinol, vol.382, issue.1, pp.97-106, 2014. ,
Switching and withdrawing hormonal agents for castration-resistant prostate cancer, Nat Rev Urol, vol.12, issue.1, pp.37-47, 2015. ,
Intrinsic disorder in the androgen receptor: identification, characterisation and drugability, Mol Biosyst, vol.8, issue.1, pp.82-90, 2012. ,
A sting in the tail: the N-terminal domain of the androgen receptor as a drug target, Asian J Androl, vol.18, issue.5, pp.687-94, 2016. ,
Muscle matters in Kennedy's disease. Neuron, vol.82, pp.251-254, 2014. ,
Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy, Rev Neurol, vol.173, issue.5, pp.326-363, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01520284
Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate 128 cancer, Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol, vol.23, issue.10, pp.2027-2058, 2014. ,
Correlation study between the polymorphism of repetitive sequence in gene CAG of androgen receptor and the occurrence and progression of prostate cancer, Asian Pac J Trop Med, vol.7, issue.4, pp.301-305, 2014. ,
Reversible Amyloid Fiber Formation in the N Terminus of Androgen Receptor, ChemBioChem, vol.15, issue.16, pp.2370-2373, 2014. ,
An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation, vol.7, p.44, 2017. ,
Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF, Proc Natl Acad Sci, vol.94, issue.16, p.8485, 1997. ,
Androgen receptor: structure, role in prostate cancer and drug discovery, Acta Pharmacol Sin, vol.36, issue.1, pp.3-23, 2015. ,
Androgen Receptor Structure, Function and Biology: From Bench to Bedside, Clin Biochem Rev, vol.37, issue.1, pp.3-15, 2016. ,
The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation, Ann N Y Acad Sci, vol.1030, pp.587-92, 2004. ,
The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor, Cancer Res, vol.67, issue.9, pp.4514-4537, 2007. ,
The hinge region in androgen receptor control, Mol Cell Endocrinol, vol.358, issue.1, pp.1-8, 2012. ,
Structure of the homodimeric androgen receptor ligand-binding domain, Nat Commun, vol.8, p.14388, 2017. ,
Chemistry and Structural Biology of Androgen Receptor, Chem Rev, vol.105, issue.9, pp.3352-70, 2005. ,
Compartmentalization of androgen receptor protein-protein interactions in living cells, J Cell Biol, vol.177, issue.1, pp.63-72, 2007. ,
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling, Nucl Recept Signal, vol.6, p.8, 2008. ,
Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer, Mol Endocrinol, vol.21, issue.12, pp.2855-63, 2007. ,
The Critical Role of Androgens in Prostate Development. Horm Cancer Breast Prostate, vol.40, pp.577-90, 2011. ,
The differential role of androgens in early human sex development, BMC Med, vol.11, pp.152-152, 2013. ,
Androgens and prostate disease, Asian J Androl, vol.16, issue.2, pp.248-55, 2014. ,
Molecular cell biology of androgen receptor signalling, Int J Biochem Cell Biol, vol.42, issue.6, pp.813-840, 2010. ,
Androgen receptor signaling in prostate cancer development and progression, J Carcinog, vol.10, issue.20, 2011. ,
Androgen receptor signaling pathways as a target for breast cancer treatment, Endocr Relat Cancer, vol.23, issue.10, pp.485-498, 2016. ,
Androgen Receptor Mediates Non-genomic Activation of Phosphatidylinositol 3-OH Kinase in Androgen-sensitive Epithelial Cells, J Biol Chem, vol.279, issue.15, pp.14579-86, 2004. ,
The Importance of Non-Nuclear AR Signaling in Prostate Cancer Progression and Therapeutic Resistance, Cell Signal, vol.28, issue.5, pp.348-56, 2016. ,
Non-classical actions of testosterone: an update, Trends Endocrinol Metab TEM, vol.18, issue.10, pp.371-379, 2007. ,
Overlapping nongenomic and genomic actions of thyroid hormone and steroids, Best Pract Res Clin Endocrinol Metab, vol.29, issue.4, pp.581-93, 2015. ,
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy, Cancer Res, vol.61, issue.11, pp.4315-4324, 2001. ,
Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer, vol.9, p.22, 2017. ,
Androgen Receptor Activation in Castration-Recurrent Prostate Cancer: The Role of Src-Family and Ack1 Tyrosine Kinases, Int J Biol Sci, vol.10, issue.6, pp.620-626, 2014. ,
The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation, Eur Cytokine Netw, vol.27, issue.4, pp.108-121, 2016. ,
Controlling nuclear receptors: the circular logic of cofactor cycles, Nat Rev Mol Cell Biol, vol.6, issue.7, pp.542-54, 2005. ,
Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression, Clin Cancer Res Off J Am Assoc Cancer Res, vol.22, issue.15, pp.3937-3986, 2016. ,
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation, Am J Clin Exp Urol, vol.2, issue.3, pp.169-87, 2014. ,
Characterization of the Prostate-specific Antigen gene: A novel human kallikreinlike gene, Biochem Biophys Res Commun, vol.159, issue.1, pp.95-102, 1989. ,
Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter, J Biol Chem, vol.271, issue.11, pp.6379-88, 1996. ,
Androgen receptor in prostate cancer, Endocr Rev, vol.25, issue.2, pp.276-308, 2004. ,
The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease, Endocr Rev, vol.22, issue.2, pp.184-204, 2001. ,
Development of sensitive immunoassays for free and total human glandular kallikrein 2, Clin Chem, vol.50, issue.9, pp.1607-1624, 2004. ,
A Highly Sensitive Porous Silicon (P-Si)-Based Human Kallikrein 2 (hK2) Immunoassay Platform toward Accurate Diagnosis of Prostate Cancer. Star A, editor, Sensors, vol.15, issue.5, pp.11972-87, 2015. ,
Prostatelocalized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS2, Cancer Res, vol.59, issue.17, p.4180, 1999. ,
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer. Science, vol.310, p.644, 2005. ,
TMPRSS2-ERG gene fusion in prostate cancer, Biomed Pap, vol.158, issue.4, pp.502-512, 2014. ,
Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature Review, Clin Genitourin Cancer, vol.14, issue.2, pp.117-138, 2016. ,
TMPRSS2, a novel membrane-anchored mediator in cancer pain, Pain, vol.156, issue.5, pp.923-953, 2015. ,
Young-age prostate cancer, J Clin Pathol, vol.68, issue.7, pp.511-516, 2015. ,
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity, Eur Urol, vol.63, issue.5, pp.920-926, 2013. ,
Integrative Clinical Genomics of Advanced Prostate Cancer, vol.161, pp.1215-1243, 2015. ,
Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer, Nat Med, vol.22, p.369, 2016. ,
Tumor clone dynamics in lethal prostate cancer, Sci Transl Med, vol.6, issue.254, pp.254-125, 2014. ,
FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells, Cancer Res, vol.73, issue.5, pp.1570-80, 2013. ,
Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade, Cell, vol.155, issue.6, pp.1309-1331, 2013. ,
Glucocorticoids and prostate cancer treatment: friend or foe?, Asian J Androl, vol.16, issue.3, pp.354-362, 2014. ,
PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance, Asian J Androl, vol.16, issue.3, pp.378-86, 2014. ,
SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation, Cancer Res, vol.76, issue.5, pp.1112-1133, 2016. ,
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell, vol.19, pp.575-86, 2011. ,
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer. Horm Cancer, vol.7, pp.84-103, 2016. ,
Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer, J Clin Invest, vol.124, issue.11, pp.5013-5039, 2014. ,
Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer, Cancer Res, vol.74, p.5631, 2014. ,
Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients, Genome Biol, vol.17, issue.1, p.10, 2016. ,
A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to antiandrogens, Biochem Biophys Res Commun, vol.173, issue.2, pp.534-574, 1990. ,
Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity, Biochem Biophys Res Commun, vol.196, issue.1, pp.173-80, 1993. ,
Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR), Biochem J, vol.379, issue.3, p.731, 2004. ,
A Clinically Relevant Androgen Receptor Mutation Confers Resistance to Second-Generation Antiandrogens Enzalutamide and ARN-509. Cancer Discov, vol.3, p.1020, 2013. ,
Overcoming mutation-based resistance to antiandrogens with rational drug design, Elife, vol.2, p.499, 2009. ,
Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer, Clin Cancer Res, vol.21, issue.10, p.2315, 2015. ,
The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide, Mol Cancer Ther, vol.15, issue.7, p.1702, 2016. ,
Functional Analysis of 44 Mutant Androgen Receptors from Human Prostate Cancer, Cancer Res, vol.62, issue.5, p.1496, 2002. ,
Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer, Sci Reports, vol.6, p.35354, 2016. ,
Estrogen-Mediated Activation of H875Y Androgen Receptor Mutation in a Prostate Cancer Patient, Clin Genitourin Cancer, vol.15, issue.1, pp.111-113, 2017. ,
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor, Nat Med, vol.6, issue.6, pp.703-709, 2000. ,
Plasma AR and abiraterone-resistant prostate cancer, Sci Transl Med, vol.7, issue.312, pp.312-322, 2015. ,
Genomic alterations in cell-free DNA and enzalutamide resistance in castration-resistant prostate cancer, JAMA Oncol, vol.2, issue.12, pp.1598-606, 2016. ,
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome, Cancer Res, vol.63, issue.1, pp.149-53, 2003. ,
Interaction mechanism exploration of Rbicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations, Mol Biosyst, vol.11, issue.12, pp.3347-54, 2015. ,
Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation, J Comput Aided Mol Des, vol.30, issue.12, pp.1189-200, 2016. ,
Androgen receptor mutants detected in recurrent prostate cancer exhibit diverse functional characteristics. The Prostate, vol.63, pp.395-406, 2004. ,
Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy, Cancer Res, vol.69, issue.10, p.4434, 2009. ,
Constitutive activity of the androgen receptor, Adv Pharmacol San Diego Calif, vol.70, pp.327-66, 2014. ,
Promoter-dependent activity on androgen receptor N-terminal domain mutations in androgen insensitivity syndrome, Sex Dev Genet Mol Biol Evol Endocrinol Embryol Pathol Sex Determ Differ, vol.8, issue.6, pp.339-388, 2014. ,
Pleiotropic functional properties of androgen receptor mutants in prostate cancer, Hum Mutat, vol.30, issue.2, pp.145-57, 2008. ,
Functional domains of the human androgen receptor, J Steroid Biochem Mol Biol, vol.41, issue.3-8, pp.671-676, 1992. ,
Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer, Int J Cancer, vol.108, issue.1, pp.152-159, 2004. ,
Emerging data on androgen receptor splice variants in prostate cancer, Endocr Relat Cancer, vol.23, issue.12, pp.199-210, 2016. ,
A yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer, Eur J Endocrinol, vol.148, issue.1, pp.99-110, 2003. ,
Specific properties of a C-terminal truncated androgen receptor detected in hormone refractory prostate cancer, Adv Exp Med Biol, vol.617, pp.529-563, 2008. ,
Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation--a new paradigm for cooperation among prostate tumor cells, Int J Cancer, vol.121, issue.6, pp.1238-1282, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00189179
Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression, Trends Cell Biol, vol.25, issue.11, pp.675-86, 2015. ,
Constitutively Active Androgen Receptor Variants Upregulate Expression of Mesenchymal Markers in Prostate Cancer Cells, PLoS One, vol.8, issue.5, 2013. ,
Dual effects of constitutively active androgen receptor and full-length androgen receptor for N-cadherin regulation in prostate cancer, Oncotarget, vol.8, issue.42, pp.72008-72028, 2017. ,
AR-Q640X, a model to study the effects of constitutively active C-terminally truncated AR variants in prostate cancer cells, World J Urol, vol.30, issue.3, pp.333-342, 2012. ,
Androgen Receptor Splice Variants Dimerize to Transactivate Target Genes. Cancer Res, vol.75, p.3663, 2015. ,
Stilbene Induced Inhibition of Androgen Receptor Dimerization: Implications for AR and AR?LBD-Signalling in Human Prostate Cancer Cells, PLOS ONE, vol.9, issue.6, p.98566, 2014. ,
LncRNA-Dependent Mechanisms of Androgen Receptor-regulated Gene Activation Programs, Nature, vol.500, issue.7464, pp.598-602, 2013. ,
Inhibition of IGF-1R diminishes transcriptional activity of the androgen receptor and its constitutively active, C-terminally truncated counterparts Q640X and, World J Urol, vol.34, issue.5, pp.633-642, 2016. ,
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models, Cancer Cell Int, vol.18, issue.1, p.71, 2009. ,
The BET-inhibitor PFI-1 diminishes AR/AR-V7 signaling in prostate cancer cells, World J Urol, 2018. ,
A novel nonsense mutation in androgen receptor confers resistance to CYP17 inhibitor treatment in prostate cancer, Oncotarget, vol.8, issue.4, pp.6796-808, 2017. ,
Alternative splicing as a biomarker and potential target for drug discovery, Acta Pharmacol Sin, vol.36, issue.10, pp.1212-1220, 2015. ,
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance, Cancer Res, vol.68, issue.13, pp.5469-77, 2008. ,
A Novel Androgen Receptor Splice Variant Is Upregulated during Prostate Cancer Progression and Promotes Androgen-depletion-resistant Growth, Cancer Res, vol.69, issue.6, pp.2305-2318, 2009. ,
Androgen Receptor Splice Variants in the Era of Enzalutamide and Abiraterone. Horm Cancer, vol.5, pp.265-73, 2014. ,
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines, Cancer Res, vol.73, issue.2, pp.483-492, 2013. ,
Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer, Clin Cancer Res Off J Am Assoc Cancer Res, vol.20, issue.6, pp.1590-600, 2014. ,
Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival, PLoS ONE, vol.6, issue.4, p.19059, 2011. ,
Constitutively Active AR-V7 Plays an Essential Role in the Development and Progression of Castration-Resistant Prostate Cancer, Sci Reports, vol.5, p.7654, 2015. ,
Characterization of Prostate Cancer Bone Metastases According to Expression Levels of Steroidogenic Enzymes and Androgen Receptor Splice Variants, PLoS ONE, vol.8, issue.11, p.77407, 2013. ,
Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal, J Biol Chem, vol.287, issue.23, pp.19736-19785, 2012. ,
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer, Cancer Res, vol.72, issue.14, pp.3457-62, 2012. ,
Constitutively active androgen receptor splice variants expressed in castrationresistant prostate cancer require full-length androgen receptor, Proc Natl Acad Sci, vol.107, issue.39, pp.16759-65, 2010. ,
Serial blood-based analysis of AR-V7 in men with advanced prostate cancer, Ann Oncol, vol.26, issue.9, pp.1859-65, 2015. ,
Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer, Asian J Androl, vol.18, issue.4, pp.580-585, 2016. ,
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the aminoterminus domain of the androgen receptor, Cancer Cell, vol.17, issue.6, pp.535-581, 2010. ,
An androgen receptor N-terminal domain antagonist for treating prostate cancer, J Clin Invest, vol.123, issue.7, pp.2948-60, 2013. ,
Targeting androgen receptor activation function-1 with EPI to overcome resistance mechanisms in castration-resistant prostate cancer, Clin Cancer Res Off J Am Assoc Cancer Res, vol.22, issue.17, pp.4466-77, 2016. ,
EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer, Oncotarget, vol.6, issue.6, pp.3811-3835, 2015. ,
EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor, ACS Chem Biol, vol.11, issue.9, pp.2499-505, 2016. ,
Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors, J Biol Chem, vol.289, issue.3, pp.1529-1568, 2014. ,
Microenvironmental regulation of tumor progression and metastasis, Nat Med, vol.19, p.1423, 2013. ,
Hallmarks of cancer: the next generation, Cell, vol.144, issue.5, pp.646-74, 2011. ,
Influence of tumour micro-environment heterogeneity on therapeutic response, Nature, vol.501, p.346, 2013. ,
Extracellular matrix: not just pretty fibrils, Science, vol.326, issue.5957, pp.1216-1225, 2009. ,
Remodelling the extracellular matrix in development and disease, Nat Rev Mol Cell Biol, vol.15, issue.12, pp.786-801, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01952416
The extracellular matrix modulates the hallmarks of cancer, EMBO Rep, vol.15, issue.12, pp.1243-53, 2014. ,
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity, Cell, vol.147, issue.5, pp.992-1009, 2011. ,
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome, J Pathol, vol.214, issue.3, pp.357-67, 2008. ,
Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro-and Anti-angiogenic Signaling, Cell Reports, vol.17, issue.10, pp.2607-2626, 2016. ,
Cancer-Stromal Cell Interactions Mediated by Hypoxia-Inducible Factors Promote Angiogenesis, Lymphangiogenesis, and Metastasis. Oncogene, vol.32, pp.4057-63, 2013. ,
Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer, Angiogenesis, vol.17, issue.1, pp.37-50, 2014. ,
Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor. The Oncologist, vol.20, pp.660-73, 2015. ,
Angiogenesis and tumor microenvironment: bevacizumab in the breast cancer model, Target Oncol, vol.10, issue.2, pp.189-98, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02286714
Interaction of tumor cells and lymphatic vessels in cancer progression, Oncogene, vol.31, p.4499, 2011. ,
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors, Oncogene, vol.33, issue.14, pp.1799-808, 2014. ,
T cell exclusion, immune privilege, and the tumor microenvironment, Science, vol.348, issue.6230, pp.74-80, 2015. ,
Recognition of tumors by the innate immune system and natural killer cells, Adv Immunol, vol.122, pp.91-128, 2014. ,
Tumor microenvironment: Sanctuary of the devil, Cancer Lett, vol.368, issue.1, pp.7-13, 2015. ,
Die Cellularpathologie in Ihrer Begründung auf Physiologische und Pathologische Gewebelehre, p.1859 ,
Tumors: Wounds That Do Not Heal, N Engl J Med, vol.315, issue.26, pp.1650-1659, 1986. ,
Cellular and molecular mechanisms of repair in acute and chronic wound healing, Br J Dermatol, vol.173, issue.2, pp.370-378, 2015. ,
Anoikis molecular pathways and its role in cancer progression, Biochim Biophys Acta, vol.1833, issue.12, pp.3481-98, 2013. ,
Wounds That Will Not Heal: Pervasive Cellular Reprogramming in Cancer, Am J Pathol, vol.182, issue.4, pp.1055-64, 2013. ,
Fibroblasts in cancer, Nat Rev Cancer, vol.6, issue.5, pp.392-401, 2006. ,
Myofibroblasts in an avascular fibrous tissue, Lab Investig J Tech Methods Pathol, vol.29, issue.2, pp.197-206, 1973. ,
Myofibroblasts in human granulation tissue, Hum Pathol, vol.5, issue.1, pp.55-67, 1974. ,
Cancer associated fibroblasts (CAFs) in tumor microenvironment, Front Biosci Landmark Ed, vol.15, pp.166-79, 2010. ,
Cancer associated fibroblasts: the dark side of the coin, Am J Cancer Res, vol.1, issue.4, pp.482-97, 2011. ,
Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis, Cancer Res, vol.75, issue.2, p.284, 2015. ,
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth, Cancers, vol.7, issue.4, pp.2443-58, 2015. ,
Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction, Br J Cancer, vol.110, issue.2, pp.469-78, 2014. ,
Cancer-associated fibroblasts in pancreatic adenocarcinoma, Future Oncol Lond Engl, vol.11, issue.18, pp.2603-2613, 2015. ,
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7, Cancer Sci, vol.106, issue.10, pp.1278-87, 2015. ,
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, vol.121, issue.3, pp.335-383, 2005. ,
Expression patterns of SDF1/CXCR4 in human invasive breast carcinoma and adjacent normal stroma: Correlation with tumor clinicopathological parameters and patient survival, vol.210, pp.662-669, 2014. ,
Cancerassociated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients, Cancer Sci, vol.104, issue.4, pp.437-481, 2009. ,
Regulation of the anti-tumour immune response by cancer-associated fibroblasts. Cancer-Assoc Fibroblasts, vol.25, pp.69-77, 2014. ,
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma, Cancer Immunol Immunother, vol.64, issue.11, pp.1407-1424, 2015. ,
Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors, Biochem Biophys Res Commun, vol.437, issue.3, pp.397-402, 2013. ,
From sentinel cells to inflammatory culprits: cancerassociated fibroblasts in tumour-related inflammation, J Pathol, vol.229, issue.2, pp.198-207, 2013. ,
Cancer stem cells: implications for cancer therapy, Oncol Williston Park N, vol.28, issue.12, pp.1101-1108, 1110. ,
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A, J Exp Med, vol.210, issue.13, pp.2851-72, 2013. ,
CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment. STEM CELLS, vol.32, pp.145-56, 2013. ,
Nestin and other putative cancer stem cell markers in pancreatic cancer, Med Mol Morphol, vol.45, issue.2, pp.59-65, 2012. ,
CCL2 mediates crosstalk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells, Cancer Res, vol.72, issue.11, pp.2768-79, 2012. ,
On the Origin of Cancer Cells, Science, vol.123, issue.3191, p.309, 1956. ,
Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer, BioMed Res Int, p.926729, 2014. ,
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma, Cell Cycle Georget Tex, vol.8, issue.23, pp.3984-4001, 2009. ,
Targeting hypoxic response for cancer therapy, Oncotarget, vol.7, issue.12, pp.13464-78, 2016. ,
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors, Cell Cycle Georget Tex, vol.9, issue.12, pp.2423-2456, 2010. ,
Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review), Oncol Lett, vol.8, issue.4, pp.1409-1430, 2014. ,
Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis, BioMed Res Int, p.242437, 2015. ,
Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts, Exp Cell Res, vol.362, issue.2, pp.332-374, 2018. ,
Cancer-Associated Fibroblasts Connect Metastasis-Promoting Communication in Colorectal Cancer, Front Oncol, vol.5, p.63, 2015. ,
TGF?1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells, Oncotarget, vol.8, issue.56, pp.96035-96082, 2017. ,
Cancerassociated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1, J Cell Commun Signal [Internet], 2018. ,
The role of CXCL12 in tumor microenvironment, Gene, vol.641, pp.105-115, 2018. ,
The challenge of targeting metastasis, Cancer Metastasis Rev, vol.34, issue.4, pp.635-676, 2015. ,
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells, Cancer Lett, vol.345, issue.1, pp.132-141, 2014. ,
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-? signalling, Br J Cancer, vol.110, issue.3, pp.724-756, 2014. ,
Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis, Cancer Res, vol.76, issue.21, p.6205, 2016. ,
Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer, Oncotarget, vol.6, issue.33, pp.34288-99, 2015. ,
Senescent cancerassociated fibroblasts secrete active MMP-2 that promotes keratinocyte discohesion and invasion, Br J Cancer, vol.111, issue.6, pp.1230-1237, 2009. ,
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of, J Cell Sci, vol.118, pp.2143-53, 2005. ,
Matrix Metalloproteinase (MMP)-9 in Cancer-Associated Fibroblasts (CAFs) Is Suppressed by Omega-3 Polyunsaturated Fatty Acids In Vitro and In, PLoS ONE, vol.9, issue.2, p.89605, 2014. ,
A new front in cell invasion: The invadopodial membrane. Integr Mechano-Chem Signals Invasion, vol.95, pp.441-449, 2016. ,
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts, Oncogene, vol.33, issue.10, pp.1265-73, 2014. ,
Cancerassociated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane, Nat Commun, vol.8, p.924, 2017. ,
Co-migration of colon cancer cells and CAFs induced by TGF?1 enhances liver metastasis, Cell Tissue Res, vol.359, issue.3, pp.829-868, 2015. ,
Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer, Cancer Res, vol.75, issue.22, p.4681, 2015. ,
Cancer-associated fibroblast promote transmigration through endothelial brain cells in threedimensional in vitro models, Int J Cancer, vol.135, issue.9, pp.2024-2057, 2014. ,
Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression, Front Cell Dev Biol, vol.6, p.48, 2018. ,
Fibroblast heterogeneity in the cancer wound, J Exp Med, vol.211, issue.8, pp.1503-1526, 2014. ,
Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information, Mol Oncol, vol.8, issue.7, pp.1290-305, 2014. ,
Autocrine TGF-? and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts, Proc Natl Acad Sci, vol.107, issue.46, 2010. ,
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma, Hepatology, vol.58, issue.3, pp.1042-53, 2013. ,
Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer, Int J Cancer, vol.132, issue.4, pp.813-836, 2013. ,
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast, Clin Cancer Res Off J Am Assoc Cancer Res, vol.5, issue.5, pp.1041-56, 1999. ,
Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation, Kidney Int, vol.57, issue.4, pp.1521-1559, 2000. ,
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state, Nat Cell Biol, vol.16, p.889, 2014. ,
Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling, PLoS Genet, vol.12, issue.8, p.1006244, 2016. ,
Review of Cancer -Associated Fibroblasts and Therapies that Interfere with Their Activity. Tumor Microenviron Ther, vol.1, pp.19-36, 2013. ,
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression, Cancer Metastasis Rev, vol.31, issue.1-2, pp.195-208, 2012. ,
Cancer associated fibroblasts" -more than meets the eye, Trends Mol Med, vol.19, issue.8, pp.447-53, 2013. ,
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy, Genes Dev, vol.30, issue.9, pp.1002-1021, 2016. ,
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice, J Clin Invest, vol.121, issue.2, pp.784-99, 2011. ,
Fibrosis and Cancer: Do Myofibroblasts Come Also From Epithelial Cells Via EMT?, J Cell Biochem, vol.101, issue.4, pp.830-839, 2007. ,
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts, Cancer Res, vol.67, issue.21, p.10123, 2007. ,
Activity of mesenchymal stem cells in therapies for chronic skin wound healing, Organogenesis, vol.10, issue.1, pp.29-37, 2014. ,
Advances in the mechanism of mesenchymal stem cells in promoting wound healing, Chin J Burns, vol.31, issue.6, pp.476-484, 2015. ,
Tumor microenvironment: bone marrow-mesenchymal stem cells as key players, Biochim Biophys Acta, vol.1836, issue.2, pp.321-356, 2013. ,
Associated Fibroblast Like Differentiation of Human Mesenchymal Stem Cells, Cancer Res, vol.68, issue.11, pp.4331-4340, 2008. ,
Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts, Cancer Res, vol.64, issue.23, pp.8492-8497, 2004. ,
Bone marrowderived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell, vol.19, pp.257-72, 2011. ,
GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts, Biochem Biophys Res Commun, vol.440, issue.4, pp.558-63, 2013. ,
Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts, Biochem Biophys Res Commun, vol.451, issue.1, pp.68-73, 2014. ,
Transforming growth factor-beta1 induces bone marrow-derived mesenchymal stem cells to differentiate into cancerassociated fibroblasts, Chin J Oncol, vol.37, issue.11, pp.804-813, 2015. ,
bFGF Promotes Migration and Induces Cancer-Associated Fibroblast Differentiation of Mouse Bone Mesenchymal Stem Cells to Promote Tumor Growth, Stem Cells Dev, 2016. ,
Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. Carcinogenesis, vol.32, pp.477-87, 2011. ,
Osteopontin Mediates an MZF1-TGF-?1-Dependent Transformation of Mesenchymal Stem Cells into Cancer Associated Fibroblasts in Breast Cancer, Oncogene, vol.34, issue.37, pp.4821-4854, 2015. ,
Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression, Cancer Lett, vol.361, issue.2, pp.155-63, 2015. ,
A peek into cancer-associated fibroblasts: origins, functions and translational impact, Dis Model Mech, vol.11, issue.4, p.29447, 2018. ,
The biology and function of fibroblasts in cancer, Nat Rev Cancer, vol.16, p.582, 2016. ,
Carcinomaassociated fibroblasts provide operational flexibility in metastasis. Cancer-Assoc Fibroblasts, vol.25, pp.33-46, 2014. ,
Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go, Cancers, vol.8, issue.2, p.19, 2016. ,
Role of tumor microenvironment in tumorigenesis, J Cancer, vol.8, issue.5, pp.761-73, 2017. ,
Cancer-associated fibroblasts and tumor growth--bystanders turning into key players, Curr Opin Genet Dev, vol.19, issue.1, pp.67-73, 2009. ,
Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment, Front Oncol, vol.4, p.62, 2014. ,
Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biol Ther, vol.5, issue.12, pp.1640-1646, 2006. ,
The hallmarks of CAFs in cancer invasion. Integr Mechano-Chem Signals Invasion, vol.95, pp.493-502, 2016. ,
Fibroblast activation in cancer: when seed fertilizes soil, Cell Tissue Res, vol.365, issue.3, pp.607-626, 2016. ,
The reactive stroma microenvironment and prostate cancer progression, Endocr Relat Cancer, vol.19, issue.6, pp.187-204, 2012. ,
Prostate cancer stroma: an important factor in cancer growth and progression, Bosn J Basic Med Sci, vol.15, issue.2, pp.1-8, 2015. ,
Prognostic role of vascular endothelial growth factor in prostate cancer: a systematic review and meta-analysis, Int J Clin Exp Med, vol.8, issue.2, pp.2289-98, 2015. ,
Targeting angiogenesis for the treatment of prostate cancer, Expert Opin Ther Targets, vol.16, issue.4, pp.365-76, 2012. ,
Ten years of anti-vascular endothelial growth factor therapy, Nat Rev Drug Discov, vol.15, issue.6, pp.385-403, 2016. ,
Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma, Exp Mol Pathol, 2009. ,
, Apr, vol.86, issue.2, pp.108-121
Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial(, Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol, vol.23, issue.5, pp.847-56, 2014. ,
The Controversial Relationship Between Benign Prostatic Hyperplasia and Prostate Cancer: The Role of Inflammation, Eur Urol, vol.60, issue.1, pp.106-123, 2011. ,
CD4 helper T cells, CD8 cytotoxic T cells, and FOXP3+ regulatory T cells with respect to lethal prostate cancer, Mod Pathol, vol.26, p.448, 2012. ,
Tumor infiltrating B-cells are increased in prostate cancer tissue, J Transl Med, vol.12, pp.30-30, 2014. ,
The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy, BioMed Res Int, p.486798, 2014. ,
Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression, Oncogene, vol.33, issue.19, pp.2423-2454, 2014. ,
Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium, Cancer Res, vol.59, pp.5002-5013, 1999. ,
Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness, Cancer Res, vol.70, issue.17, p.6945, 2010. ,
Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells, Cancer Res, vol.70, issue.18, pp.7294-303, 2010. ,
CAFsecreted Annexin A1 Induces Prostate Cancer Cells to Gain Stem Cell-like Features, Mol Cancer Res MCR, vol.12, issue.4, pp.607-628, 2014. ,
Dependence of Castration-Resistant Prostate Cancer (CRPC) Stem Cells on CRPC-Associated Fibroblasts, J Cell Physiol, vol.229, issue.9, pp.1170-1176, 2014. ,
Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness. Antioxidants Redox Signal, vol.14, pp.2361-71, 2011. ,
Circulating fibroblast-like cells in men with metastatic prostate cancer. The Prostate, vol.73, pp.176-81, 2013. ,
Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation, Oncotarget, vol.6, issue.31, pp.31441-60, 2015. ,
Recruitment of Mesenchymal Stem Cells Into Prostate Tumors Promotes Metastasis, Nat Commun, vol.4, pp.1795-1795, 2013. ,
Characterization of a Novel Metastatic Prostate Cancer Cell Line of LNCaP Origin. The Prostate, vol.76, pp.215-240, 2016. ,
Immuno-PET and Immuno-SPECT of Rheumatoid Arthritis with Radiolabeled Anti-Fibroblast Activation Protein Antibody Correlates with Severity of Arthritis, J Nucl Med, vol.56, issue.5, pp.778-83, 2015. ,
Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy, PROTEOMICS -Clin Appl, vol.8, issue.5-6, pp.454-63, 2014. ,
Polyphyllin I inhibits gastric cancer cell proliferation by downregulating the expression of fibroblast activation protein alpha (FAP) and hepatocyte growth factor (HGF) in cancer-associated fibroblasts, Biochem Biophys Res Commun, vol.497, issue.4, pp.1129-1163, 2018. ,
High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis, Tumour Biol, vol.34, issue.2, pp.1013-1033, 2013. ,
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia, J Exp Med, vol.210, issue.6, pp.1125-1160, 2013. ,
Microwave-assisted Synthesis of HYNIC Protected Analogue for 99mTc Labeled Antibody, Curr Radiopharm, vol.7, issue.2, pp.84-90, 2014. ,
Molecular SPECT Imaging: An Overview, Int J Mol Imaging, p.796025, 2011. ,
, Chemistry and Radiopharmaceutical Applications By K. Schwochau (Forschungszentrum, vol.123, pp.12126-12126, 2001.
Technetium-99m-Human Polyclonal IgG Radiolabeled via the Hydrazino Nicotinamide Derivative for Imaging Focal Sites of Infection in Rats, J Nucl Med, vol.31, issue.12, pp.2022-2030, 1990. ,
Metastatic model for human prostate cancer using orthotopic implantation in nude mice, J Natl Cancer Inst, vol.84, issue.12, pp.951-958, 1992. ,
A detector response function design in pinhole SPECT including geometrical calibration, Phys Med Biol, vol.58, issue.7, pp.2395-411, 2013. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00936803
Stromal TGF-? signaling induces AR activation in prostate cancer, Oncotarget, vol.5, issue.21, pp.10854-69, 2014. ,
Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion, Med Oncol, vol.30, issue.3, p.674, 2013. ,
Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome, Oncotarget, vol.6, issue.18, pp.16135-50, 2015. ,
Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1?) Binding to CXCR4, J Chem Inf Model, vol.54, issue.4, pp.1174-88, 2014. ,
Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion, Cancers, vol.7, issue.4, pp.2054-62, 2015. ,
Functional subsets of mesenchymal cell types in the tumor microenvironment. Cancer-Assoc Fibroblasts, vol.25, pp.3-9, 2014. ,
Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic "activated" state that enhances prostate cancer cell migration, Int J Cancer, vol.142, issue.10, pp.2056-67, 2018. ,
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer, Cancer Cell, vol.33, issue.3, pp.463-479, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437793
Tumourassociated fibroblasts and mesenchymal stem cells: more similarities than differences, J Cell Mol Med, vol.15, issue.3, pp.635-681, 2011. ,
Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?, Stem Cells Int, p.914632, 2015. ,
Mesenchymal stem cells: key players in cancer progression. Mol Cancer, vol.16, p.31, 2017. ,
Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts, Carcinogenesis, vol.36, issue.12, pp.1453-63, 2015. ,
Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation, Cancer Res, vol.76, issue.18, pp.5395-404, 2016. ,
Unlike Pancreatic Cancer Cells Pancreatic Cancer Associated Fibroblasts Display Minimal Gene Induction after 5-Aza-2?-Deoxycytidine, PLoS ONE, vol.7, issue.9, p.43456, 2012. ,
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition, PLoS ONE, vol.10, issue.9, p.139179, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01207281
Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change, PLoS ONE, vol.7, issue.4, p.35128, 2012. ,
Single-cell RNA sequencing: Technical advancements and biological applications, vol.59, pp.36-46, 2018. ,
The Natural History and Outcome Predictors of Metastatic Castration-resistant Prostate Cancer, Eur Urol Focus, vol.2, issue.5, pp.480-487, 2016. ,
ELISA in the multiplex era: Potentials and pitfalls, PROTEOMICS -Clin Appl, vol.9, issue.3-4, pp.406-428, 2015. ,
Mass spectrometry analysis of adipose-derived stem cells reveals a significant effect of hypoxia on pathways regulating extracellular matrix, Stem Cell Res Ther, vol.7, p.52, 2016. ,
Three-Dimensional Culture Systems in Cancer Research: Focus on Tumor Spheroid Model, Pharmacol Ther, vol.163, pp.94-108, 2016. ,
Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid Culture, Int J Mol Sci, vol.17, issue.9, p.1458, 2016. ,
PET Tracers Based on Zirconium-89, Curr Radiopharm, vol.4, issue.2, pp.131-140, 2011. ,
, Comparative Genomic and Transcriptomic Analyses of LNCaP, pp.4-6
, Prostate Cancer Cell Lines. Agoulnik IU, editor. PLoS ONE, vol.9, issue.2, p.90002, 2014.
Curcumin inhibits cancerassociated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1? signaling, Int J Oncol, vol.47, issue.6, pp.2064-72, 2015. ,
Unraveling the Anticancer Effect of Curcumin and Resveratrol, Nutrients, vol.8, issue.11, p.628, 2016. ,
Molecular Mechanisms of Curcumin and Its Semisynthetic Analogues in Prostate Cancer Prevention and Treatment, Life Sci, vol.152, pp.135-179, 2016. ,
Curcumin-Based Anti-Prostate Cancer Agents, Former Curr Med Chem -Anti-Cancer Agents, vol.15, issue.2, pp.138-56, 2015. ,
,
, Jocelyn Céraline Med Sci, pp.758-764, 2017.
, Détail ci-après
,
,
DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information, Cell Death Dis, vol.5, 2014. ,
Insight into glucocorticoid receptor signalling through interactome model analysis, PLoS Comput Biol, vol.13, 2017. ,
Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements, Mol Endocrinol, vol.25, pp.621-634, 2011. ,
Applications of p53 interactome analysis to personalised drug discovery, Conference: International Work-Conference on Bioinformatics and Biomedical Engineering, pp.192-203, 2014. ,
A signal transduction score flow algorithm for cyclic cellular pathway analysis, which combines transcriptome and ChIP-seq data, Mol Biosyst, vol.8, 2012. ,
Structural and functional analysis of cellular networks with CellNetAnalyzer, BMC Syst Biol, vol.1, 2007. ,
Stochastic simulation of Boolean rxncon models: towards quantitative analysis of large signaling networks, 2015. ,
, BMC Syst Biol, vol.9
,
Variants du récepteur des androgènes dans le cancer de la prostate, Med Sci, vol.33, pp.758-764, 2017. ,
Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, vol.13, pp.2498-2504, 2003. ,
The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible, Nucleic Acids Res, vol.45, 2017. ,
Androgen receptor: structure, role in prostate cancer and drug discovery, Acta Pharmacologica Sinica, vol.36, 2014. ,
Dynamics of DNA Damage Induced Pathways to Cancer, PLoS One, vol.8, 2013. ,
Cancer Systems Biology: a peak into the future of patient care?, Nat Rev Clin Oncol, vol.11, pp.167-176, 2014. ,
, , pp.26-27
, EMBO Conference on Nuclear Receptors, pp.24-28
,
Jocelyn Céraline 3) 9ème Forum du Cancéropôle Grand Est, pp.12-13, 2015. ,
, Poster Androgen receptor variants and microenvironment in prostate cancer
,
, Jocelyn Céraline 4) 24ème Journée de l'ARTP, 2015.
, Poster Androgen receptor variants and microenvironment in prostate cancer
,
, 9th UK Stem Cell Meeting, 2015.
, Poster Androgen receptor variants and microenvironment in prostate cancer
,
, 4èmes Journées de la FMTS, pp.28-29, 2016.
,
, 6ème Journée des Récepteurs Nucléaires, vol.9, 2016.
,
, 23rd Annual Meeting of the European Cancer Center, vol.13, 2016.
, Poster Androgen receptor variants and microenvironment in prostate cancer
,
, , pp.15-17, 2016.
, Poster Androgen receptor variants and microenvironment in prostate cancer
, Jocelyn Céraline 10) 23rd Meeting of the EAU Section of Urological Research, p.20
, Jocelyn Céraline 11) 25ème Journée de l'ARTP, vol.16, 2016.
, Poster Stroma corruption by androgen receptor variants in prostate cancer
,
, Forum du Cancéropôle Grand Est, pp.24-25
,
, , pp.22-23
14) 18ème journée Scientifique Régionale de la Ligue Contre le Cancer, 2017. ,
, Poster Stroma corruption by androgen receptor variants in prostate cancer
15) 25rd Meeting of the EAU Section of, Urological Research ,
,