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Localized protein-assisted self-assembly : from mechanism to applications

Abstract : The cell is a complex chemical system that has benefited from billions of years of evolution to perfect itself, and represents a very well organized machinery leaving nothing to chance. To ensure its role, it controls a set of self-assembly processes where isolated components interact spontaneously with each other to lead to the formation of organized and functional structures such as microtubules, collagen or actin fibers. Inspired by cellular organization, my doctoral project involves the design of artificial chemical systems based on the self-assembly of original peptides. These buildings give rise to supramolecular hydrogels of interest in the field of biomaterials. I am interested at the same time in fundamental aspects concerning the comprehension of the initiation of the processes of self-assembly in the presence of biomacromolecules, but also with more applied problems of elaborating strategies to control the place but also the moment where these self-assembled molecular structures originate. Finally, I am interested in the emergence of the different properties appearing during the formation of certain self-assemblies such as catalysis and auto-catalysis.
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  • HAL Id : tel-02494094, version 1



Jennifer Rodon Fores. Localized protein-assisted self-assembly : from mechanism to applications. Other. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAE017⟩. ⟨tel-02494094⟩



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