Skip to Main content Skip to Navigation
Theses

Imagerie multiparamétrique en échographie de contraste ultrasonore (DCE-US) pour caractériser la vascularisation tumorale : de la modélisation numérique à l'expérimentation préclinique

Abstract : Evaluation of tumor vascularization by dynamic contrast-enhanced ultrasonography showed interest for the assessment of the effectiveness of anti-angiogenic treatments. Nevertheless, this technique raises many questions about the sensitivity of quantification methods of the ultrasound signal. To address this issue, this thesis focused on the development of the first digital modeling of blood flow and contrast agents in vascular networks to study the methods of quantification of the ultrasound signal and theirs sensitivity according to variations of tumor network volume and blood velocity. A first step of the thesis was to validate by an experimental comparison, the assumptions of the digital modeling and mainly the taking into account of the blood as a homogeneous Newtonian fluid. Digital modeling allowed to highlight parameters sensitive to the modification of the blood flow which are in the case of the semi-quantitative method the area under the enhancement curve, the maximum of the enhancement curve and the slope of the enhancement curve. When it comes to follow variations of the tumor vascular volume, it appears that the quantitative method by deconvolution of the arterial function is more sensitive. The quantification methods have also been investigated throught an in vivo study of 44 mice. This digital approach of the flow of the contrast agents is promising and may eventually enable a more extensive evaluation of other quantification methods developed in dynamic contrast-enhanced ultrasonography to date.
Complete list of metadatas

Cited literature [120 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02487369
Contributor : Abes Star :  Contact
Submitted on : Friday, February 21, 2020 - 3:16:09 PM
Last modification on : Wednesday, September 16, 2020 - 5:16:29 PM
Long-term archiving on: : Friday, May 22, 2020 - 4:11:02 PM

File

77891_BOYER_2016_diffusion.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02487369, version 1

Collections

Citation

Laure Boyer. Imagerie multiparamétrique en échographie de contraste ultrasonore (DCE-US) pour caractériser la vascularisation tumorale : de la modélisation numérique à l'expérimentation préclinique. Cancer. Université Paris Saclay (COmUE), 2016. Français. ⟨NNT : 2016SACLS161⟩. ⟨tel-02487369⟩

Share

Metrics

Record views

774

Files downloads

114