Skip to Main content Skip to Navigation
Theses

Approche biophysique de la fonction muco-ciliaire de l'épithélium bronchique : propriétés d'écoulement du mucus et coordination du battement ciliaire

Abstract : Understanding and treating chronic respiratory diseases are growing medical challenges due to changes in our lifestyles and environment. The epithelium of the respiratory tract is the first barrier against external aggression, in particular thanks to the mucociliary function. Functional elements are the mucus layer lining the tissue and the beating of cilia from the ciliated cells of the epithelium. Mucus is a complex and heterogeneous fluid that acts as a protective barrier by trapping particles and pathogens present in the inhaled air, while the coordination of the cilia beating allows the directed transport of the mucus layer and its evacuation from the bronchi. The mechanical properties of mucus coupled with the coordination mechanisms of beating cilia are still poorly understood. My thesis work focused on two biophysical aspects of these mechanisms: i) the study of mucus rheology at two scales, in macro-rheology and by active micro-rheology using optical tweezers directly on the tissue; ii) the understanding and quantification of the spatiotemporal coordination of ciliary activity and on the associated mucus transport, by developing a new tool for processing video-microscopy images and data analysis.
Complete list of metadatas

Cited literature [270 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02485748
Contributor : Abes Star :  Contact
Submitted on : Thursday, February 20, 2020 - 2:24:08 PM
Last modification on : Tuesday, September 8, 2020 - 5:42:10 AM
Long-term archiving on: : Thursday, May 21, 2020 - 3:16:09 PM

File

JORY_2019_archivage.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02485748, version 1

Collections

Citation

Myriam Jory. Approche biophysique de la fonction muco-ciliaire de l'épithélium bronchique : propriétés d'écoulement du mucus et coordination du battement ciliaire. Autre [cond-mat.other]. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTS078⟩. ⟨tel-02485748⟩

Share

Metrics

Record views

161

Files downloads

566