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Theses

Déterminants sociaux et professionnels de la cognition

Abstract : Cognitive aging is a slow and progressive process influenced by many individual and contextual factors, including working conditions and residential environment characteristics. However, the impact of these environmental exposures on cognition remains largely under-studied. The main objective of this thesis is to study the role of social and occupational determinants on cognition, in the general French population. The implementation in 2012 of the Constances cohort allows us to study this issue on a population aged 45 to 70 years (~70,000 participants) in cross-sectional, while the 3C cohort (9,294 participants) allows us to analyze from a social perspective a population aged over 65 years followed since the 2000s. We have observed in these two different populations, an effect of socio-economic characteristics living environment on cognitive performances and risk of dementia, independently of individual socio-economic level and many other individual characteristics. In Constances, we have shown that cognitive performances is early associated with occupational exposure to chemicals (solvents and formaldehyde), regardless of individual characteristics and working conditions. These results suggest that living environments, socio-economic and/or work environment, have an impact on cognitive performances level and dementia, and can be a source of social health inequalities in cognitive aging.
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Noémie Letellier. Déterminants sociaux et professionnels de la cognition. Médecine humaine et pathologie. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTT044⟩. ⟨tel-02479472⟩

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