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Synthèse de nouveaux agents chélatants PCTA du 68Ga - Application au marquage de lipoprotéines pour l’imagerie TEP de la plaque d’athérosclérose

Abstract : Cardiovascular disease is the leading cause of mortality and morbidity worldwide. Atherosclerosis accounts for 50% of deaths in industrialized countries. This multifactorial pathology is characterized by the accumulation of lipids within the arterial wall forming an atheromatous plaque. Clinical manifestations due to plaque rupture depend on the affected vascular territory, ranging from ischemic stroke to myocardial infarction. In order to overcome this major public health problem, which is twice more prevalent in Reunion Island relative to Mainland France, we aimed at developing new diagnostic tools using tomography by positron emission (PET) imaging. To date, no specific tool allows the early detection of atheromatous plaques. We chose to label two types of lipoproteins (HDLs and LDLs) in order to image these plaques. They both have opposite roles but have in common a proven tropism for atheromatous plaque. Our work allowed the synthesis and the radiolabelling of a new Gallium 68 PCTA chelating agent coupled to the phospholipid biovector, 1,2-distearoyl-sn-glycero-3phosphoethanolamine (DSPE), which was then inserted in the lipid layer of lipoproteins in order to study its biodistribution in mouse in vivo and in human ex vivo models of atherosclerosis.
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  • HAL Id : tel-02477373, version 1

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Jennyfer Yong-Sang. Synthèse de nouveaux agents chélatants PCTA du 68Ga - Application au marquage de lipoprotéines pour l’imagerie TEP de la plaque d’athérosclérose. Chimie organique. Université de la Réunion, 2017. Français. ⟨NNT : 2017LARE0062⟩. ⟨tel-02477373⟩

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