Radiotherapy combined with cetuximab for locally advanced head and neck cancer: results and toxicity, Cancer Radiother. J. Soc. Francaise Radiother. Oncol, vol.16, pp.601-603, 2012. ,
Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: an Eastern Cooperative Oncology Group pilot study, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.11, pp.2136-2142, 1993. ,
,
, The p16 (CDKN2a/INK4a) Tumor-Suppressor Gene in Head and Neck Squamous Cell Carcinoma: A Promoter Methylation and Protein Expression Study in 100 Cases, Mod. Pathol, vol.16, pp.944-950
Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4, Adv. Exp. Med. Biol, vol.532, pp.253-268, 2003. ,
, , 1997.
Analysis of Collective Invasion of Carcinoma Cells in a 3D Organotypic Model, Molecular Dermatology: Methods and Protocols, C. Has, and C, 2013. ,
, , pp.243-252
LIF mediates proinvasive activation of stromal fibroblasts in cancer, Cell Rep, vol.7, pp.1664-1678, 2014. ,
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts, Nat. Commun, vol.6, p.10204, 2015. ,
Ncadherin Gene Expression in Prostate Carcinoma Is Modulated by Integrin-Dependent Nuclear Translocation of Twist1, Cancer Res, vol.66, pp.3365-3369, 2006. ,
Adhesion-related Kinase Repression of Gonadotropin-releasing Hormone Gene Expression Requires Rac Activation of the Extracellular Signal-regulated Kinase Pathway, J. Biol. Chem, vol.277, pp.38133-38140, 2002. ,
Axl/Gas6/NF?B signalling in schwannoma pathological proliferation, adhesion and survival, Oncogene, vol.33, pp.336-346, 2014. ,
and neck carcinoma: RTOG 0522, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.32, pp.2940-2950, 2014. ,
Impact of Epidermal Growth Factor Receptor Expression on Survival and Pattern of Relapse in Patients with Advanced Head and Neck Carcinoma, vol.8 ,
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing, Nat. Commun, vol.9, p.5150, 2018. ,
The EGFR as a target for anticancer therapy--focus on cetuximab, Eur. J. Cancer Oxf. Engl, vol.37, pp.16-22, 1990. ,
Fibroblasts and Myofibroblasts: What are we talking about?, J. Cardiovasc. Pharmacol, vol.57, pp.376-379, 2011. ,
Prognostic significance of p16INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma, J. Cell. Physiol, vol.192, pp.286-293, 2002. ,
The epidermal growth factor receptor family, Endocr. Relat. Cancer, vol.12, issue.1, pp.17-27, 2005. ,
, , 2012.
Role of liver ICAM-1 in metastasis, Oncol. Lett, vol.14, pp.3883-3892, 2017. ,
Inflammation meets cancer, with NF-?B as the matchmaker, Nat. Immunol, vol.12, pp.715-723, 2011. ,
, p53: new roles in metabolism, vol.17, pp.286-291, 2007.
Tumorigenesis and the angiogenic switch, Nat. Rev. Cancer, vol.3, pp.401-410, 2003. ,
, , 2006.
, Panitumumab antitumor activity in patients (pts) with metastatic colorectal cancer (mCRC) expressing ? 10% epidermal growth factor receptor (EGFr), J. Clin. Oncol, vol.24, pp.3548-3548
Chemoradiation after Surgery for High-Risk Head and Neck Cancer Patients: How Strong Is the Evidence?, The Oncologist, vol.10, pp.215-224, 2005. ,
Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer, N. Engl. J. Med, vol.350, pp.1945-1952, 2004. ,
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy, Cell Metab, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01998873
A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis, Biochem. Pharmacol, vol.60, pp.1143-1151, 2000. ,
Radiation Therapy for Head and Neck Cancers: A Case-Based Review, 2014. ,
Stromal fibroblasts in cancer initiation and progression, Nature, vol.432, pp.332-337, 2004. ,
Met, metastasis, motility and more, Nat. Rev. Mol. Cell Biol, vol.4, pp.915-925, 2003. ,
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function, J. Biol. Chem, vol.274, pp.8335-8343, 1999. ,
How does the extracellular matrix direct gene expression?, J. Theor. Biol, vol.99, pp.31-68, 1982. ,
Smoking and drinking in relation to oral and pharyngeal cancer, Cancer Res, vol.48, pp.3282-3287, 1988. ,
Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts, Oncotarget, vol.8, pp.1304-1320, 2016. ,
, , 2009.
, The Lysyl Oxidase Inhibitor, ?-Aminopropionitrile, Diminishes the Metastatic Colonization Potential of Circulating Breast Cancer Cells, PLOS ONE, vol.4, p.5620
, Int. J. Radiat. Oncol. ? Biol. ? Phys, vol.29, pp.243-247, 1994.
Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck, N. Engl. J. Med, vol.354, pp.567-578, 2006. ,
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N. Engl. J. Med, vol.354, pp.567-578, 2006. ,
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximabinduced rash and survival, Lancet Oncol, vol.11, pp.21-28, 2010. ,
Cytokine mediated tissue fibrosis, Biochim. Biophys. Acta, vol.1832, pp.1049-1060, 2013. ,
Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.5, pp.2810-2819, 1999. ,
Induction and regulation of epithelial-mesenchymal transitions, Biochem. Pharmacol, vol.60, pp.1091-1099, 2000. ,
EMT in cancer, Nat. Rev. Cancer, vol.18, pp.128-134, 2018. ,
AXL mediates resistance to cetuximab therapy, Cancer Res, vol.74, pp.5152-5164, 2014. ,
AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.21, pp.2601-2612, 2015. ,
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site, Oncogene, vol.14, pp.2619-2631, 1997. ,
TNFAIP3/A20 as a potential regulator of NF-?B-mediated resistance to O6-alkylating chemotherapy in glioblastoma multiforme, Cancer Res, vol.66, pp.1054-1054, 2006. ,
The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer, J. Thorac. Oncol. Off. Publ. Int, 2011. ,
, Assoc. Study Lung Cancer, vol.6, pp.209-217
, p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis, vol.30, pp.2623-2636, 2016.
Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer, N. Engl. J. Med, vol.338, pp.1798-1804, 1998. ,
, Stat3 as an Oncogene, vol.98, pp.295-303, 1999.
Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines, Proc. Natl. Acad. Sci. U. S. A, vol.84, pp.5763-5767, 1987. ,
Meta-analysis of microarray data identifies GAS6 expression as an independent predictor of poor survival in ovarian cancer, BioMed Res. Int, p.238284, 2013. ,
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors, Mol. Cell, vol.12, pp.541-552, 2003. ,
neck cancer: an Eastern Cooperative Oncology Group study, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.23, pp.8646-8654, 2005. ,
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth, J. Cell Biol, vol.119, pp.629-641, 1992. ,
A tense situation: forcing tumour progression, 2009. ,
, Nat. Rev. Cancer, vol.9, pp.108-122
Cell spheroids: the new frontiers in in vitro models for cancer drug validation, Drug Discov. Today, vol.21, pp.1553-1560, 2016. ,
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis, Eur. Respir. J, vol.29, pp.976-985, 2007. ,
Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets, Stem Cells Int, 2018. ,
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma, Ann. Diagn. Pathol, vol.17, pp.425-429, 2013. ,
, , 2015.
, Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells, Leuk. Res, vol.39, pp.976-983
,
Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel, Cancer Res, vol.67, pp.1979-1987, 2007. ,
APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa, Sci. Transl. Med, vol.10, 2018. ,
The quest to overcome resistance to EGFR-targeted therapies in cancer, Nat. Med, vol.19, pp.1389-1400, 2013. ,
Expanding role of the medical oncologist in the management of head and neck cancer, CA. Cancer J. Clin, vol.58, pp.32-53, 2008. ,
The Molecular Structure of Cell Adhesion Molecules, Annu. Rev. Biochem, vol.66, pp.823-862, 1997. ,
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis, Cancer Res, vol.66, pp.8319-8326, 2006. ,
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression, Cancer Cell, vol.5, pp.489-500, 2004. ,
Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-?B Signaling as Characteristics of a Highrisk Head and Neck Squamous Cell Carcinoma, Cancer Res, vol.66, pp.8210-8218, 2006. ,
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.6, pp.2053-2063, 2000. ,
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression, Cancer Metastasis Rev, vol.31, pp.195-208, 2012. ,
, The deaf and the dumb: the biology of ErbB-2 and ErbB, 2003.
, Exp. Cell Res, vol.284, pp.54-65
, , 2014.
Chemotherapy for head and neck cancer: progress and controversy in the management of patients with M0 disease, Semin. Oncol, vol.16, pp.44-57, 1989. ,
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases, J. Cell Biol, vol.142, pp.573-586, 1998. ,
Genetic susceptibility to head and neck squamous cell carcinoma, J. Natl. Cancer Inst, vol.88, pp.530-535, 1996. ,
, , 1999.
Head and Neck Cancer: An Evolving Treatment Paradigm, Cancer, vol.113, pp.1911-1932, 2008. ,
Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal, J. Biol. Chem, vol.237, pp.1555-1562, 1962. ,
Human epidermal growth factor: isolation and chemical and biological properties, Proc. Natl. Acad. Sci. U. S. A, vol.72, pp.1317-1321, 1975. ,
The cell cycle and cancer, Proc. Natl. Acad. Sci. U, 1997. ,
, , vol.94, pp.2776-2778
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, Cell, vol.124, pp.263-266, 2006. ,
Aligned collagen is a prognostic signature for survival in human breast carcinoma, Am. J. Pathol, vol.178, pp.1221-1232, 2011. ,
Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck, N. Engl. J. Med, vol.350, pp.1937-1944, 2004. ,
A20: Central Gatekeeper in Inflammation and Immunity, J. Biol. Chem, vol.284, pp.8217-8221, 2009. ,
The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on, Breast Cancer Cells. Cell, vol.147, pp.759-772, 2011. ,
The role of reactive oxygen species and metabolism on cancer cells and their microenvironment, Semin. Cancer Biol, vol.25, pp.23-32, 2014. ,
BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations, PLOS Med, vol.4, p.315, 2007. ,
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver, Nat. Cell Biol, vol.17, pp.816-826, 2015. ,
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer, Dis. Model. Mech, vol.4, pp.165-178, 2011. ,
LOXmediated collagen crosslinking is responsible for fibrosis-enhanced metastasis, Cancer Res, vol.73, pp.1721-1732, 2013. ,
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3, 2007. ,
, PLOS Med, vol.4, p.316
VEGF inhibition: insights from preclinical and clinical studies, Cell Tissue Res, vol.335, pp.261-269, 2009. ,
Concomitant radiation therapy and cis-diamminedichloroplatinum (II) in patients with advanced head and neck cancer, Med. Pediatr. Oncol, vol.9, pp.119-120, 1981. ,
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy, Oncotarget, vol.7, pp.11539-11552, 2016. ,
Detecting Cleaved Caspase-3 in Apoptotic Cells by Flow Cytometry, Cold Spring Harb. Protoc, 2016. ,
, , 1999.
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing, Lab. Investig. J. Tech. Methods Pathol, vol.63, pp.21-29, 1990. ,
Fibroblasts and myofibroblasts in wound healing, Clin. Cosmet. Investig. Dermatol, vol.7, pp.301-311, 2014. ,
Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells, Oncotarget, vol.8, pp.28628-28640, 2017. ,
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors, Nature, vol.379, pp.557-560, 1996. ,
Dishonorable discharge: the oncogenic roles of cleaved Ecadherin fragments, Cancer Res, vol.72, pp.2917-2923, 2012. ,
Crystal structure of human CDK4 in complex with a D-type cyclin, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.4166-4170, 2009. ,
,
produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.18, pp.1016-1018 ,
,
, Soluble cadherins as cancer biomarkers, Clin. Exp. Metastasis, vol.24, pp.685-697
Carcinomaassociated fibroblasts provide operational flexibility in metastasis, Semin. Cancer Biol, vol.25, pp.33-46, 2014. ,
Persistent foot ulcer due to ruxolitinib therapy for primary myelofibrosis, J. Oncol. Pharm. Pract. Off. Publ. Int. Soc. Oncol. Pharm. Pract, vol.24, pp.226-228, 2018. ,
,
, N. Engl. J. Med, vol.324, pp.1685-1690
Iatrogenic immunosuppression and cutaneous malignancy, Clin. Dermatol, vol.29, pp.602-613, 2011. ,
, , 1995.
, , 2008.
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers, Nature, vol.486, pp.537-540, 2012. ,
In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts, Int. J. Cancer, vol.56, pp.512-521, 1994. ,
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion, Cancer Res, vol.71, pp.2455-2465, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00819288
, , 1990.
, J. Biol. Chem, vol.265, pp.2973-2978
, , 2018.
, Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program
, J. Immunol. Baltim. Md, pp.663-674, 1950201.
Targeting A20 enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells, Biochem. Biophys. Res. Commun, vol.418, pp.433-438, 2012. ,
, , 2007.
, Dominant-negative E-cadherin inhibits the invasiveness of inflammatory breast cancer cells in vitro, J. Cancer Res. Clin. Oncol, vol.133, pp.83-92
Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.1643-1648, 2012. ,
Case-control study of human papillomavirus and oropharyngeal cancer, 2007. ,
, J. Med, vol.356, pp.1944-1956
, , 2014.
, J. Am. Assoc. Cancer Res, vol.20, pp.164-175
Role of YAP/TAZ in mechanotransduction, Nature, vol.474, pp.179-183, 2011. ,
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains, J. Immunol. Baltim. Md, vol.182, pp.7718-7728, 1950. ,
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N. Engl. J. Med, vol.315, pp.1650-1659, 1986. ,
Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis, Springer Semin. Immunopathol, vol.21, pp.415-429, 1999. ,
Tumors as organs: complex tissues that interface with the entire organism, Dev. Cell, vol.18, pp.884-901, 2010. ,
N-and/or C-terminal tails, Proc. Natl. Acad. Sci. U. S. A, vol.89, pp.4309-4313, 1992. ,
, , 2017.
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation, Exp. Cell Res, vol.264, pp.169-184, 2001. ,
Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase, Oncogene, vol.18, pp.2607-2615, 1999. ,
, AXL mediates resistance to, 2015.
The extracellular matrix at a glance, J. Cell Sci, vol.123, pp.4195-4200, 2010. ,
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase, Mol. Cell. Biol, vol.16, pp.135-145, 1996. ,
Mechanically Activated Integrin Switch Controls a5b1 Function ,
Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications, Nat. Clin. Pract. Gastroenterol. Hepatol, vol.1, pp.98-105, 2004. ,
Control of adhesion-dependent cell survival by focal adhesion kinase, J. Cell Biol, vol.134, pp.793-799, 1996. ,
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy, J. Clin. Invest, vol.118, pp.1669-1679, 2008. ,
Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial, J. Clin. Oncol, vol.5, pp.1410-1418, 1987. ,
Evolution of the Radiation Therapy Oncology Group clinical trials for head and neck cancer, Int. J. Radiat. Oncol. Biol. Phys, vol.35, pp.425-438, 1996. ,
Tumor microvasculature and microenvironment: Targets for antiangiogenesis and normalization, Microvasc. Res, vol.74, pp.72-84, 2007. ,
Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression, BMC Cancer, vol.15, p.256, 2015. ,
Abl interconnects oncogenic Met and p53 core pathways in cancer cells, Cell Death Differ, vol.18, pp.1608-1616, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00628278
Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly, Dev. Dyn. Off. Publ. Am. Assoc. Anat, vol.240, pp.1502-1511, 2011. ,
Synovial sarcoma Electron microscopic study of a typical case, Cancer, vol.28, pp.1031-1039, 1971. ,
,
, Nat. Cell Biol, vol.9, pp.1392-1400
OSM, LIF, Its Receptors, and Its Relationship with the Malignance in Human Breast Carcinoma, Situ and in Infiltrative), vol.26, pp.222-229, 2008. ,
Protein kinase C and cancer: what we know and what we do not, Oncogene, vol.33, pp.5225-5237, 2014. ,
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis, Am. J. Physiol. Gastrointest. Liver Physiol, vol.293, pp.1147-1154, 2007. ,
Cellular pH Gradient in Tumor versus Normal Tissue: Potential Exploitation for the Treatment of Cancer, Cancer Res, vol.56, pp.1194-1198, 1996. ,
YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC, vol.19, pp.1012-1021, 2017. ,
Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization, 2000. ,
, J. Cell Biol, vol.149, pp.431-446
CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia, J. Pathol, vol.237, pp.14-24, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02400440
miR200-regulated CXCL12? promotes fibroblast heterogeneity and immunosuppression in ovarian cancers, Nat. Commun, vol.9, p.1056, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437797
Axl is an essential epithelial-to-mesenchymal transitioninduced regulator of breast cancer metastasis and patient survival, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.1124-1129, 2010. ,
Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis, Front. Oncol, vol.8, 2018. ,
,
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis, Cell, vol.146, pp.148-163, 2011. ,
Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system, Cancer, vol.92, pp.1331-1346, 2001. ,
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.1, pp.1311-1318, 1995. ,
Pre-irradiation 5-fluorouracil infusion in advanced head and neck carcinomas, Cancer, vol.27, pp.768-770, 1971. ,
FAK and p53 Protein Interactions, Anticancer Agents Med. Chem, vol.11, pp.617-619, 2011. ,
Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas, PLOS Med, vol.4, p.294, 2007. ,
Pancreatic cancer stroma: friend or foe?, Cancer Cell, vol.25, pp.711-712, 2014. ,
Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts, Oncogene, vol.12, pp.471-480, 1996. ,
Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts, Mol. Cell. Biol, vol.17, pp.4442-4453, 1997. ,
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression, Cell Rep, vol.23, pp.1476-1490, 2018. ,
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells, Cell. Signal, vol.24, pp.532-538, 2012. ,
Cloning and mRNA expression analysis of a novel human protooncogene, c-mer, Cell Growth Differ. Mol. Biol. J. Am. Assoc. Cancer Res, vol.5, pp.647-657, 1994. ,
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer, Nat. Rev. Cancer, vol.14, pp.769-785, 2014. ,
, , 1993.
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics, Nature, vol.466, pp.263-266, 2010. ,
Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells, Cancer Res, vol.78, pp.5229-5242, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02347409
Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors, Nat. Rev. Cancer, vol.13, p.559, 2013. ,
ALK inhibitors in the treatment of advanced NSCLC, Cancer Treat. Rev, vol.40, pp.300-306, 2014. ,
Tumor Budding: The Name is EMT, Partial EMT. J. Clin. Med, vol.5, 2016. ,
Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival, PloS One, vol.10, p.126522, 2015. ,
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells, EMBO J, vol.22, pp.2411-2421, 2003. ,
The discovery of receptor tyrosine kinases: targets for cancer therapy, Nat. Rev. Cancer, vol.4, pp.361-370, 2004. ,
Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development, Matrix Biol. J. Int. Soc. Matrix Biol, vol.63, pp.1-10, 2017. ,
Tropomyosin -master regulator of actin filament function in the cytoskeleton, J. Cell Sci, vol.128, pp.2965-2974, 2015. ,
HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors, Oncogene, vol.32, pp.3846-3856, 2013. ,
Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.15, pp.4742-4749, 2009. ,
,
, neck: role, controversy, and future directions, Ann. Oncol, vol.29, pp.1130-1140
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily, FEBS J, vol.273, pp.5231-5244, 2006. ,
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin, Biochem. Biophys. Res. Commun, vol.299, pp.793-800, 2002. ,
C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.19, pp.971-973, 2005. ,
Hippo signaling: growth control and beyond, Dev. Camb. Engl, vol.138, pp.9-22, 2011. ,
Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma, The Oncologist, vol.14, pp.900-908, 2009. ,
RhoAmediated signaling in mechanotransduction of osteoblasts, Connect. Tissue Res, vol.53, pp.398-406, 2012. ,
Every step of the way: integrins in cancer progression and metastasis, 2018. ,
, Nat. Rev. Cancer, vol.18, p.533
Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients, Biochem. Biophys. Res. Commun, vol.435, pp.493-500, 2013. ,
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment, Cancer Cell, vol.21, pp.309-322, 2012. ,
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
, , 1999.
, Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase, Oncogene, vol.18, pp.2681-2689
Integrin signalling at a glance, J. Cell Sci, vol.122, pp.159-163, 2009. ,
Hypoxia and Anemia: Factors in Decreased Sensitivity to Radiation Therapy and Chemotherapy?, The Oncologist, vol.9, pp.31-40, 2004. ,
Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells, Am. J. Physiol. Heart Circ. Physiol, vol.287, pp.1207-1213, 2004. ,
,
, Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma, Ann. Surg. Oncol, vol.23, pp.663-670
An overview of epithelio-mesenchymal transformation, Acta Anat. (Basel), vol.154, pp.8-20, 1995. ,
, , 2012.
, Ann. Surg. Oncol, vol.19, pp.3042-3049
The Epidermal Growth Factor Receptor Modulates the Interaction of E-cadherin with the Actin Cytoskeleton, J. Biol. Chem, vol.273, pp.9078-9084, 1998. ,
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma, Cancer Biol. Ther, vol.10, pp.1009-1018, 2010. ,
Surgical margins in head and neck cancer: a contemporary review, Head Neck, vol.35, pp.1362-1370, 2013. ,
Formation and Function of the Myofibroblast during Tissue Repair, J. Invest. Dermatol, vol.127, pp.526-537, 2007. ,
Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity, Mol. Biol. Cell, vol.12, pp.2730-2741, 2001. ,
The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo, J. Cell Biol, vol.157, pp.657-663, 2002. ,
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin ?1/FAK signaling, Cancer Cell, vol.27, pp.574-588, 2015. ,
Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth, PLOS Biol, vol.8, p.1000319, 2010. ,
Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer, Onkologie, vol.26, pp.44-48, 2003. ,
Effects of calcium omission on acetylcholine-stimulated amylase secretion and phospholipid synthesis in pigeon pancreas slices, Biochim. Biophys. Acta, vol.115, pp.219-221, 1966. ,
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer, Cancer Res, vol.70, pp.1544-1554, 2010. ,
Surgery in head and neck cancer: United Kingdom National Multidisciplinary Guidelines, J. Laryngol. Otol, vol.130, pp.68-70, 2016. ,
The YAP and TAZ transcription coactivators: key downstream effectors of the mammalian Hippo pathway, Semin. Cell Dev. Biol, vol.23, pp.785-793, 2012. ,
, , 2008.
ABL regulation by AXL promotes cisplatin resistance in esophageal cancer, Cancer Res, vol.73, pp.331-340, 2013. ,
An Ovol2-Zeb1, 2015. ,
, Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States, PLoS Comput. Biol, vol.11, p.1004569
Cetuximab hypersensitivity infusion reactions: Incidence and risk factors, J. Oncol. Pharm. Pract. Off. Publ. Int. Soc. Oncol. Pharm. Pract, vol.19, pp.222-227, 2013. ,
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly, Nat. Cell Biol, vol.17, pp.1577-1587, 2015. ,
The integrin adhesome network at a glance, J. Cell Sci, vol.129, pp.4159-4163, 2016. ,
Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain -Implication in Mechanosensing, PLOS Comput. Biol, vol.10, p.1003532, 2014. ,
, , 2016.
, , 2017.
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma, Proc. Natl. Acad. Sci. U. S. A, vol.104, pp.12867-12872, 2007. ,
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression, J. Clin. Invest, vol.114, pp.569-581, 2004. ,
Integrin ligands at a glance, J. Cell Sci, vol.119, pp.3901-3903, 2006. ,
Bevacizumab combined with standard fluoropyrimidine-based chemotherapy regimens to treat colorectal cancer, Oncology, vol.69, pp.17-24, 2005. ,
Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed, J. Clin. Oncol, vol.33, pp.4039-4047, 2015. ,
p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis, J. Nippon Med. Sch. Nippon Ika Daigaku Zasshi, vol.73, pp.54-64, 2006. ,
, , 2008.
, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.14, pp.130-138
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway, Mol. Cell. Biol, vol.27, pp.7451-7461, 2007. ,
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies, Semin. Cancer Biol, vol.45, pp.13-22, 2017. ,
Integrins: bidirectional, allosteric signaling machines, Cell, vol.110, pp.673-687, 2002. ,
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix, J. Biol. Chem, vol.261, pp.4337-4345, 1986. ,
Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor, Exp. Cell Res, vol.317, pp.838-848, 2011. ,
Inherited epidermolysis bullosa: new diagnostic criteria and classification, Clin. Dermatol, vol.30, pp.70-77, 2012. ,
, , 2006.
Matrix proteoglycans: from molecular design to cellular function, Annu. Rev. Biochem, vol.67, pp.609-652, 1998. ,
,
, Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck, Br. J. Cancer, vol.59, pp.559-562
Mechanotransduction gone awry, Nat. Rev. Mol. Cell Biol, vol.10, pp.63-73, 2009. ,
Clinical Definition of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer, J. Clin. Oncol, vol.28, pp.357-360, 2010. ,
From tissue mechanics to transcription factors, Differ. Res. Biol. Divers, vol.86, pp.112-120, 2013. ,
Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?, Expert Rev. Hematol, vol.8, pp.135-138, 2015. ,
Mechanosensors in integrin signaling: The emerging role of p130Cas, Eur. J. Cell Biol, vol.93, pp.445-454, 2014. ,
Classes of phosphoinositide 3-kinases at a glance, J. Cell Sci, vol.127, pp.923-928, 2014. ,
, , 2014.
Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma, PloS One, vol.10, 2015. ,
Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers, 2012. ,
Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cells, Mol. Cancer Res. MCR, vol.10, pp.1158-1168, 2012. ,
Understanding Radiotherapy for Head and Neck Cancer: A Guide for Adults and Their Caregivers, Eisenberg Center for Clinical Decisions and CommunicationsScience, p.p, 2005. ,
, , 1996.
Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts, Inflamm. Bowel Dis, vol.19, pp.891-903, 2013. ,
,
Tracking the intermediate stages of epithelialmesenchymal transition in epithelial stem cells and cancer, Cell Cycle Georget. Tex, vol.10, pp.2865-2873, 2011. ,
Therapeutic targeting of the tumor microenvironment, Cancer Cell, vol.7, pp.513-520, 2005. ,
, , 2015.
, High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Facilitate Wound Healing in Dystrophic Epidermolysis Bullosa, Mol. Ther. J. Am. Soc. Gene Ther, vol.23, pp.1368-1379
High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia, Arch. Otolaryngol. Head Neck Surg, vol.129, pp.106-112, 2003. ,
Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity, J. Invest. Dermatol, vol.134, pp.2381-2389, 2014. ,
Fibroblast activation in cancer: when seed fertilizes soil, Cell Tissue Res, vol.365, pp.607-619, 2016. ,
Fibroblast activation in cancer: when seed fertilizes soil, Cell Tissue Res, vol.365, pp.607-619, 2016. ,
, , 2002.
A mechanically active heterotypic Ecadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion, Nat. Cell Biol, vol.19, pp.224-237, 2017. ,
Structure, expression, and activity of Tyro 3, a neural adhesionrelated receptor tyrosine kinase, Oncogene, vol.9, pp.2567-2578, 1994. ,
Preliminary analysis of ECOG 3303: Concurrent radiation (RT), cisplatin (DDP) and cetuximab (C) in unresectable, locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN), J. Clin. Oncol, vol.26, pp.6006-6006, 2008. ,
Radiation therapy in the treatment of cancer: the past, the present, and the future, Aust. N. Z. J. Surg, vol.52, pp.331-335, 1982. ,
Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034, Int. J. Radiat. Oncol. Biol. Phys, vol.23, pp.705-713, 1992. ,
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.27, pp.5924-5930, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00618089
, , 2008.
Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL, Cancer Res, vol.67, pp.3878-3887, 2007. ,
Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy, Oncogene, vol.33, pp.5405-5414, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-00916587
,
Mitogenic signal transduction by integrin-and growth factor receptormediated pathways, Mol. Cells, vol.17, pp.188-202, 2004. ,
, , 2012.
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice, Science, vol.289, pp.2350-2354, 2000. ,
, Persistently Activated Stat3 Maintains Constitutive NF-?B Activity in Tumors, vol.15, pp.283-293, 2009.
Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance, Biochem. Biophys. Res. Commun, vol.474, pp.154-160, 2016. ,
A20 promotes metastasis of aggressive basal-like breast cancers through multimonoubiquitylation of Snail1, Nat. Cell Biol, vol.19, pp.1260-1273, 2017. ,
Stromal response to Hedgehog signaling restrains pancreatic cancer progression, Proc. Natl. Acad. Sci. U. S. A, vol.111, pp.3091-3100, 2014. ,
Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.21, pp.357-364, 2015. ,
The molecular biology of head and neck cancer, Nat. Rev. Cancer, vol.11, pp.9-22, 2011. ,
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial, 1996. ,
, J. Natl. Cancer Inst, vol.88, pp.890-899
Matrix rigidity regulates a switch between TGF-?1-induced apoptosis and epithelial-mesenchymal transition, Mol. Biol. Cell, vol.23, pp.781-791, 2012. ,
Mammalian collagen receptors, Matrix Biol. J. Int. Soc. Matrix Biol, vol.26, pp.146-155, 2007. ,
Biology of the TAM receptors, Cold Spring Harb. Perspect. Biol, vol.5, p.9076, 2013. ,
Immunobiology of the TAM receptors, Nat. Rev. Immunol, vol.8, pp.327-336, 2008. ,
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice, J. Clin. Invest, vol.121, pp.1709-1721, 2011. ,
, , 2009.
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1, Mol. Cell, vol.4, pp.1029-1040, 1999. ,
Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype, PLOS ONE, vol.5, 2010. ,
Cisplatin versus cetuximab given concurrently with definitive radiation therapy for locally advanced head and neck squamous cell carcinoma, Oncology, vol.85, pp.290-296, 2013. ,
Functions of galectin-3 and its role in fibrotic diseases, J. Pharmacol. Exp. Ther, vol.351, pp.336-343, 2014. ,
The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes, FEBS Lett, vol.584, pp.4145-4150, 2010. ,
Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway, J. Cancer Res. Clin. Oncol, vol.141, pp.269-281, 2015. ,
, , 2009.
, Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis, Oncogene, vol.28, pp.3442-3455
The epidermal growth factor receptor mediates radioresistance, Int. J. Radiat. Oncol, vol.57, pp.246-254, 2003. ,
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer, Cancer Res, vol.66, pp.3992-3995, 2006. ,
Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration, Oncogene, vol.25, pp.5416-5425, 2006. ,
Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation, Mol. Cell, vol.29, pp.9-22, 2008. ,
Influence of Crosslink Density and Stiffness on Mechanical Properties of Type I Collagen Gel, Materials, vol.8, pp.551-560, 2015. ,
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20, J. Biol. Chem, vol.281, pp.2095-2103, 2006. ,
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer, Adv. Cancer Res, vol.100, pp.35-83, 2008. ,
Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis, Cancer Res, vol.54, pp.2025-2028, 1994. ,
,
Skin Rash could Predict the Response to EGFR Tyrosine Kinase Inhibitor and the Prognosis for Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis, PLoS ONE, vol.8, 2013. ,
, , 2016.
, Axl Expression Stratifies Patients with Poor Prognosis after Hepatectomy for Hepatocellular Carcinoma, PloS One, vol.11, 154767.
Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy, Biochim. Biophys. Acta Mol. Basis Dis, vol.1864, pp.2871-2880, 2018. ,
, , 2011.
, Fibroblast growth factor receptor mediates fibroblast-dependent growth in EMMPRIN-depleted head and neck cancer tumor cells, Mol. Cancer Res. MCR, vol.9, pp.1008-1017
, , 2000.
Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review, Cancers, vol.10, 2018. ,
The extracellular matrix: A dynamic niche in cancer progression, J Cell Biol, vol.196, pp.395-406, 2012. ,
, , 1999.
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers, Cancer Discov, vol.3, pp.761-769, 2013. ,
Planned combination of surgery and radiation in treatment of advanced primary head and neck cancers, Am. J. Roentgenol. Radium Ther. Nucl. Med, vol.77, pp.397-414, 1957. ,
Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models, J. Skin Cancer, p.684050, 2013. ,
Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial, J. Clin. Oncol, vol.34, pp.427-435, 2015. ,
Interactions between cancer stem cells and their niche govern metastatic colonization, Nature, vol.481, pp.85-89, 2011. ,
Precision Medicine in Head and Neck Cancer: Myth or Reality? Clin, 2018. ,
, Med. Insights Oncol, vol.12
A mechanosensitive transcriptional mechanism that controls angiogenesis, Nature, vol.457, pp.1103-1108, 2009. ,
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, pp.704-715, 2008. ,
Neck dissection, Cancer, vol.4, pp.441-499, 1951. ,
, , 2016.
, Br. J. Cancer, vol.115, pp.1223-1233
Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation, Anticancer Agents Med. Chem, vol.10, pp.753-768, 2010. ,
CXCL8/IL-8 and CXCL12/SDF-1? Co-operatively Promote Invasiveness and Angiogenesis in Pancreatic Cancer, Int. J. Cancer J. Int. Cancer, vol.124, pp.853-861, 2009. ,
Effects of matrix stiffness on epithelial to mesenchymal transition-like processes of endometrial epithelial cells: Implications for the pathogenesis of endometriosis, Sci. Rep, vol.7, p.44616, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01655210
,
Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma, Br. J. Cancer, vol.74, pp.1253-1257, 1996. ,
Surgery or radiotherapy for tonsil cancer?, Cancer, vol.16, pp.195-198, 1963. ,
Environment-mediated drug resistance: a major contributor to minimal residual disease, Nat. Rev. Cancer, vol.9, pp.665-674, 2009. ,
,
, P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration, PLoS ONE, vol.5
The EGF receptor family as targets for cancer therapy, Oncogene, vol.19, pp.6550-6565, 2000. ,
Definitive radiotherapy for tonsillar squamous cell carcinoma, Am. J. Clin. Oncol, vol.29, pp.290-297, 2006. ,
Cancer Cell Invasion Is Enhanced by Applied Mechanical Stimulation, PLOS ONE, vol.6, 2011. ,
Cancer as an evolutionary and ecological process, Nat. Rev. Cancer, vol.6, pp.924-935, 2006. ,
, , 2013.
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy, EMBO Mol. Med, vol.7, pp.1063-1076, 2015. ,
Twice-a-day irradiation technique for squamous cell carcinomas of the head and neck, Cancer, vol.55, pp.2096-2099, 1985. ,
Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice, EMBO J, vol.31, pp.4428-4440, 2012. ,
, Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL. Cell, vol.113, pp.329-342, 2003.
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer, Nature, vol.486, pp.532-536, 2012. ,
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy, J. Leukoc. Biol, vol.89, pp.31-39, 2011. ,
Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression, Cancer Res, vol.76, pp.940-951, 2016. ,
Mechanisms and impact of altered tumour mechanics, Nat. Cell Biol, vol.20, p.766, 2018. ,
The role of the miR-200 family in epithelial-mesenchymal transition, Cancer Biol. Ther, vol.10, pp.219-222, 2010. ,
, , 2012.
Carcinoma of the tongue and floor of the mouth. Results of radical radiotherapy, Cancer, vol.23, pp.1284-1289, 1969. ,
Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo, Int. J. Cancer, vol.139, pp.1340-1349, 2016. ,
Biophysics of substrate interaction: influence on neural motility, differentiation and repair, Dev. Neurobiol, vol.71, pp.1090-1101, 2011. ,
Phosphoproteomics strategies for the functional analysis of signal transduction, Proteomics, vol.6, pp.4047-4056, 2006. ,
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression, Nat. Med, vol.20, pp.360-367, 2014. ,
, , 2004.
The emperor of all maladies: a biography of cancer, 2010. ,
Human papillomavirus immortalization and transformation functions, Virus Res, vol.89, pp.213-228, 2002. ,
The role of myeloid cells in the promotion of tumour angiogenesis, Nat. Rev. Cancer, vol.8, pp.618-631, 2008. ,
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas, Int. J. Oncol, vol.32, pp.101-111, 2008. ,
Collagens, modifying enzymes and their mutations in humans, flies and worms, Trends Genet. TIG, vol.20, pp.33-43, 2004. ,
for Axl, Sky, and Mer receptor tyrosine kinases, J. Biol. Chem, vol.271, pp.30022-30027, 1996. ,
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation, J. Biol. Chem, vol.283, pp.18393-18401, 2008. ,
Multi-institutional analysis of early squamous cell carcinoma of the hypopharynx treated with radical radiotherapy, Int. J. Radiat. Oncol. Biol. Phys, vol.65, pp.1045-1050, 2006. ,
Natural history of potentially malignant oral lesions and conditions: an overview of the literature, J. Oral Pathol. Med. Off. Publ. Int. Assoc. Oral Pathol. Am, 2008. ,
, Oral Pathol, vol.37, pp.1-10
Role of extracellular matrix assembly in interstitial transport in solid tumors, Cancer Res, vol.60, pp.2497-2503, 2000. ,
The Hedgehog's tale: developing strategies for targeting cancer, Nat. Rev. Cancer, vol.11, pp.493-501, 2011. ,
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer, Nat. Med, vol.18, pp.521-528, 2012. ,
, , 2012.
Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropinreleasing hormone neuronal cells, Endocrinology, vol.148, pp.2806-2814, 2007. ,
, , 1999.
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis, J. Clin. Invest, vol.117, pp.2766-2777, 2007. ,
, , 2017.
Tenascin-C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF?-induced TNC expression promotes migration in HCC cells, Am. J. Cancer Res, vol.5, pp.782-791, 2015. ,
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment, Endocr. Relat. Cancer, vol.10, pp.1-21, 2003. ,
The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas, Blood, vol.113, pp.4918-4921, 2009. ,
Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression, vol.4, p.165, 2015. ,
Is the combination of Cetuximab with chemo-radiotherapy regimens worthwhile in the treatment of locally advanced head and neck cancer? A review of current evidence, Crit. Rev. Oncol. Hematol, vol.85, pp.112-120, 2013. ,
Injury-and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa, Matrix Biol. J. Int. Soc. Matrix Biol, pp.547-560, 2018. ,
, , 2013.
, Collagen VII plays a dual role in wound healing, J. Clin. Invest, vol.123, pp.3498-3509
,
, Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms, EMBO Mol. Med, vol.7, pp.1211-1228
Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa, Proc. Natl. Acad. Sci. U. S. A, vol.115, pp.705-714, 2018. ,
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase, Mol. Cell. Biol, vol.11, pp.5016-5031, 1991. ,
Laminin-rich extracellular matrix association with mammary epithelial cells suppresses Brca1 expression, Cell Death Differ, vol.7, pp.360-367, 2000. ,
, , 2014.
Molecular Alterations in Tumors and Response to Combination Chemotherapy with Gefitinib for Advanced Colorectal Cancer, Clin. Cancer Res, vol.11, pp.6650-6656, 2005. ,
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1, Proc. Natl, 2012. ,
, Acad. Sci. U. S. A, vol.109, pp.2127-2133
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation, Genes Dev, vol.21, p.2788, 2007. ,
, , vol.324, pp.1457-1461, 2009.
, , 1999.
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity, J. Biol. Chem, vol.267, pp.12424-12427, 1992. ,
, Pathology and Genetics of Head and Neck Tumours (IARC), 2005.
, , 2005.
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs, Nat. Med, vol.17, pp.867-874, 2011. ,
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.308-313, 2011. ,
The tumor microenvironment controls drug sensitivity, Nat. Med, vol.18, pp.1332-1334, 2012. ,
, , 2012.
, Screening for germline EGFR T790M mutations through lung cancer genotyping, J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer, vol.7, pp.1049-1052
Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas, J. Pathol, vol.149, pp.9-14, 1986. ,
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival, Cancer Cell, vol.25, pp.719-734, 2014. ,
, , 2013.
,
THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST, The Lancet, vol.133, pp.571-573, 1889. ,
Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment, Annu. Rev. Pathol, vol.4, pp.49-70, 2009. ,
The third dimension bridges the gap between cell culture and live tissue, Nat. Rev. Mol. Cell Biol, vol.8, pp.839-845, 2007. ,
Structure and dynamic regulation of Abl kinases, J. Biol. Chem, vol.288, pp.5443-5450, 2013. ,
Cancer-Associated Fibroblasts Induce a Collagen Crosslink Switch in Tumor Stroma, Mol. Cancer Res. MCR, vol.14, pp.287-295, 2016. ,
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells, Nature, vol.507, pp.508-512, 2014. ,
Fibroblast-mediated drug resistance in cancer, Biochem. Pharmacol, vol.85, pp.1033-1041, 2013. ,
Sensing and modulation of invadopodia across a wide range of rigidities, Biophys. J, vol.100, pp.573-582, 2011. ,
Rac and Rho GTPases in cancer cell motility control, Cell Commun. Signal. CCS, vol.8, p.23, 2010. ,
Identification of the tumour transition states occurring during EMT, Nature, vol.556, p.463, 2018. ,
Tensional homeostasis and the malignant phenotype, Cancer Cell, vol.8, pp.241-254, 2005. ,
TNM staging of cancers of the head and neck: striving for uniformity among diversity, CA. Cancer J. Clin, vol.55, pp.242-258, 2005. ,
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation, J. Biol. Chem, vol.275, pp.41227-41233, 2000. ,
, , 1999.
, J. Biol. Chem, vol.274, pp.19347-19351
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.6638-6643, 2008. ,
The predictive role of skin rash with cetuximab and panitumumab in colorectal cancer patients: a systematic review and meta-analysis of published trials, Target. Oncol, vol.8, pp.173-181, 2013. ,
The extracellular matrix modulates the hallmarks of cancer, EMBO Rep, vol.15, pp.1243-1253, 2014. ,
, , 2003.
Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting, PLOS Med, vol.5, p.19, 2008. ,
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data, The Lancet, vol.355, pp.949-955, 2000. ,
, , 2013.
NF-kappaB Is Involved in the Regulation of, EMT Genes in Breast Cancer Cells. PLoS ONE, vol.12, 2017. ,
TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck, N. Engl. J. Med, vol.357, pp.2552-2561, 2007. ,
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits, Nat. Rev. Cancer, vol.9, pp.265-273, 2009. ,
The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through ?1 integrin, Breast Cancer Res. Treat, vol.133, pp.459-471, 2012. ,
AXL and acquired resistance to EGFR inhibitors, Nat. Genet, vol.44, pp.835-836, 2012. ,
Magnetic Resonance Elastography -A Novel Technique for Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation, Mayo Clin. Proc, vol.90, pp.882-894, 2015. ,
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature, vol.402, pp.884-888, 1999. ,
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms, Sci. Transl. Med, vol.10, 2018. ,
Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera, EMBO J, vol.13, pp.2831-2841, 1994. ,
, , 2006.
, , 2008.
Matrix density-induced mechanoregulation of breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage, Oncogene, vol.28, pp.4326-4343, 2009. ,
Stable incorporation of ?-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms, Cytoskelet. Hoboken NJ, vol.72, pp.257-267, 2015. ,
Oncogenic roles of EMT-inducing transcription factors, Nat. Cell Biol, vol.16, pp.488-494, 2014. ,
Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases, Am. J. Pathol, vol.179, pp.400-410, 2011. ,
Microenvironmental regulation of tumor progression and metastasis, 2013. ,
, Nat. Med, vol.19, pp.1423-1437
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth, Cancer Cell, vol.19, pp.257-272, 2011. ,
Classification and biology of tumour associated stromal cells, Immunol. Lett, vol.168, pp.175-182, 2015. ,
Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis, Int. J. Cancer, vol.121, pp.1813-1820, 2007. ,
,
, , 2005.
Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility, Mol. Biol. Cell, vol.12, pp.279-295, 2001. ,
Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging, Front. Oncol, vol.7, 2017. ,
AXL is an essential factor and therapeutic target for metastatic ovarian cancer, Cancer Res, vol.70, pp.7570-7579, 2010. ,
Proximal events in signaling by plasma membrane estrogen receptors, J. Biol. Chem, vol.278, pp.2701-2712, 2003. ,
Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome, Oncotarget, vol.6, pp.30859-30875, 2015. ,
, , 2005.
, Mol. Endocrinol. Baltim. Md, vol.19, pp.2564-2578
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma, Cancer Res, vol.56, pp.3630-3633, 1996. ,
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma, Cancer Cell, vol.25, pp.735-747, 2014. ,
Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells, vol.6, p.352, 2017. ,
Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells, vol.6, p.352, 2017. ,
Cell migration: integrating signals from front to back, Science, vol.302, pp.1704-1709, 2003. ,
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer, Cell, vol.131, pp.1190-1203, 2007. ,
, , 2009.
TGF-beta: regulation of extracellular matrix, Kidney Int, vol.41, pp.557-559, 1992. ,
Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis, Am. J. Kidney Dis. Off. J. Natl. Kidney Found, vol.17, pp.684-686, 1991. ,
, Insights into the Structure and Domain Flexibility of Full-Length Pro-Matrix Metalloproteinase-9/Gelatinase B. Structure, vol.15, pp.1227-1236, 2007.
EGFR probes matrix stiffness, Nat. Cell Biol, vol.19, p.600, 2017. ,
The molecular pathogenesis of head and neck squamous cell carcinoma, J. Clin. Invest, vol.122, pp.1951-1957, 2012. ,
Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival, J. Natl. Cancer Inst, vol.90, pp.824-832, 1998. ,
Anchorage dependence, integrins, and apoptosis, Cell, vol.77, pp.477-478, 1994. ,
The wound healing, chronic fibrosis, and cancer progression triad, Physiol. Genomics, vol.46, pp.223-244, 2014. ,
Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor, J. Cell. Physiol, vol.204, pp.36-44, 2005. ,
, , 2005.
, Immunol. Baltim. Md, vol.174, pp.1507-1512, 1950.
Epidermal growth factor-related peptides and their receptors in human malignancies, Crit. Rev. Oncol. Hematol, vol.19, pp.183-232, 1995. ,
Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation, Cancer Discov, vol.4, pp.186-199, 2014. ,
Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor, J. Clin. Oncol, vol.22, pp.1201-1208, 2004. ,
, , 2011.
Squamous cell carcinomas of the head and neck, BMJ, vol.325, pp.822-827, 2002. ,
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis, EMBO J, vol.18, pp.4657-4668, 1999. ,
Rac activation and inactivation control plasticity of tumor cell movement, Cell, vol.135, pp.510-523, 2008. ,
Pancreatic cancer stem cells and EMT in drug resistance and metastasis, Minerva Chir, vol.64, pp.489-500, 2009. ,
Oncostatin M is a novel inhibitor of TGF-?1-induced matricellular protein expression, Am. J. Physiol. Renal Physiol, vol.301, pp.1014-1025, 2011. ,
Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer, PloS One, vol.4, p.7287, 2009. ,
Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway, Mol. Carcinog, vol.46, pp.155-164, 2007. ,
Force sensing by mechanical extension of the Src family kinase substrate p130Cas, Cell, vol.127, pp.1015-1026, 2006. ,
EGFR and HER2 Activate Rigidity Sensing Only on Rigid Matrices, Nat. Mater, vol.16, pp.775-781, 2017. ,
Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.22, pp.1313-1317, 2016. ,
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma, J. Exp. Med, vol.206, pp.981-989, 2009. ,
JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms, Cancer Res, vol.75, pp.2187-2199, 2015. ,
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells, Hepatol. Baltim. Md, vol.53, pp.1192-1205, 2011. ,
, , 2014.
, Mol. Basel Switz, vol.19, pp.15196-15212
Pre-clinical testing of malignant fibroblast activation proteinspecific re-directed T cells for treatment of pleural mesothelioma, J. Immunother. Cancer, vol.1, p.35, 2013. ,
Integrins and Extracellular Matrix in Mechanotransduction, Cold Spring Harb. Perspect. Biol, vol.2, 2010. ,
Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to, Angiogenesis. J. Cell Biol, vol.141, pp.1659-1673, 1998. ,
Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors, Oncotarget, vol.7, 2016. ,
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial, Lancet Oncol, vol.17, pp.956-965, 2016. ,
Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response, Eur. Urol. Oncol, vol.1, pp.325-337, 2018. ,
Twist1-induced dissemination preserves epithelial identity and requires E-cadherin, J. Cell Biol, vol.204, pp.839-856, 2014. ,
Chronic leg ulceration associated with polycythemia vera responding to ruxolitinib (Jakafi(®)), J. Foot Ankle Surg. Off. Publ. Am. Coll. Foot Ankle Surg, vol.52, pp.781-785, 2013. ,
A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis, PloS One, vol.8, 2013. ,
Human breast carcinoma desmoplasia is PDGF initiated, Oncogene, vol.19, pp.4337-4345, 2000. ,
Efficacy of concurrent cetuximab vs. 5-fluorouracil/carboplatin or highdose cisplatin with intensity-modulated radiation therapy (IMRT) for locally-advanced head and neck cancer (LAHNSCC), Oral Oncol, vol.50, pp.947-955, 2014. ,
First Axl inhibitor enters clinical trials, Nat. Biotechnol, vol.31, pp.775-776, 2013. ,
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma, Cancer Res, vol.69, pp.2568-2576, 2009. ,
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy, Sci. Signal, vol.3, p.42, 2010. ,
Expression of axl in lung adenocarcinoma and correlation with tumor progression, vol.7, pp.1058-1064, 2005. ,
Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study, J. Cardiovasc. Pharmacol, vol.40, pp.751-761, 2002. ,
A20 expressing tumors and anticancer drug resistance, Adv. Exp. Med. Biol, vol.809, pp.65-81, 2014. ,
,
, Renal medullary carcinoma and ABL gene amplification, J. Urol, vol.173, pp.1883-1888
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer, Oncogene, vol.29, pp.4741-4751, 2010. ,
Autocrine, paracrine and juxtacrine signaling by EGFR ligands, Cell. Signal, vol.17, pp.1183-1193, 2005. ,
Beyond Tissue Stiffness and Bioadhesivity: Advanced Biomaterials to Model Tumor Microenvironments and Drug Resistance, Trends Cancer, vol.4, pp.281-291, 2018. ,
, , 1987.
Anticancer therapy targeting the erbB family of receptor tyrosine kinases, Semin. Oncol, vol.28, pp.67-79, 2001. ,
Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways, Int. J. Cancer, vol.128, pp.1596-1605, 2011. ,
Resection margins in oral cancer surgery: Room for improvement, Head Neck, vol.38, pp.2197-2203, 2016. ,
TNM: evolution and relation to other prognostic factors, Semin. Surg. Oncol, vol.21, pp.3-7, 2003. ,
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.12, pp.5064-5073, 2006. ,
The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemo-resistance in esophageal cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.21, pp.2580-2590, 2015. ,
, , vol.62, pp.1523-1532, 2010.
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions, J. Clin. Invest, vol.119, pp.1727-1740, 2009. ,
, , 2005.
Potential predictive markers of response to EGFR-targeted therapies in colorectal cancer, Crit. Rev. Oncol. Hematol, vol.66, pp.21-30, 2008. ,
Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck, Head Neck, vol.30, pp.281-288, 2008. ,
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells, Cancer Res, vol.66, pp.5648-5655, 2006. ,
APOBEC3 Proteins in Viral Immunity, J. Immunol. Baltim. Md, pp.4565-4570, 2015. ,
Functional dichotomy of A20 in apoptotic and necrotic cell death, Biochem. J, vol.387, pp.47-55, 2005. ,
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature, vol.487, pp.500-504, 2012. ,
, , 1995.
, Identification and characterization of a fibroblast marker: FSP1, J. Cell Biol, vol.130, pp.393-405
, , 2000.
, Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation, Kidney Int, vol.57, pp.1521-1538
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains, Cell Rep, vol.11, pp.390-404, 2015. ,
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, Lancet Oncol, vol.15, pp.1100-1108, 2014. ,
Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biol. Ther, vol.5, pp.1640-1646, 2006. ,
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation, Proc. Natl. Acad. Sci. U. S. A, vol.83, pp.3825-3829, 1986. ,
Inhibition of fibroblasts reduced head and neck cancer growth by targeting fibroblast growth factor receptor, The Laryngoscope, vol.122, pp.1539-1544, 2012. ,
Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease, Blood, vol.131, pp.2074-2085, 2018. ,
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR mutant lung cancers that lack the second-site EGFR T790M mutation, Cancer Discov, vol.2, pp.922-933, 2012. ,
, uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis, Sci. Transl. Med
A20 controls intestinal homeostasis through cellspecific activities, Nat. Commun, vol.5, p.5103, 2014. ,
Targeting Axl and Mer kinases in cancer, Mol. Cancer Ther, vol.10, pp.1763-1773, 2011. ,
Platinum-based chemotherapy plus cetuximab in head and neck cancer, N. Engl. J. Med, vol.359, pp.1116-1127, 2008. ,
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis, N. Engl. J. Med, vol.363, pp.1117-1127, 2010. ,
Expression, biological activities and mechanisms of action of A20 (TNFAIP3), Biochem. Pharmacol, vol.80, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00637146
Cancer as an evolutionary process at the cell level: an epidemiological perspective, Carcinogenesis, vol.24, pp.1-6, 2003. ,
Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre, 1859. ,
Paradoxical roles of the immune system during cancer development, Nat. Rev. Cancer, vol.6, pp.24-37, 2006. ,
Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.8, pp.911-934, 1990. ,
Radiotherapy with concomitant chemotherapy for head and neck cancer, Hematol. Oncol. Clin. North Am, vol.5, pp.753-767, 1991. ,
, , 1993.
, Engl. J. Med, vol.328, pp.184-194
Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells, Oncotarget, vol.6, pp.16183-16197, 2015. ,
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan, Br. J. Cancer, vol.75, pp.1167-1172, 1997. ,
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer, Oncogene, vol.30, pp.1436-1448, 2011. ,
Periostin: A Bridge between Cancer Stem Cells and Their Metastatic Niche, Cell Stem Cell, vol.10, pp.111-112, 2012. ,
,
, Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3?/?-catenin Signaling, Theranostics, vol.6, pp.1205-1219
Twice-a-day radiation therapy for cancer of the head and neck, Cancer, vol.55, pp.2100-2104, 1985. ,
Transition to resistance: An unexpected role of the EMT in cancer chemoresistance, Genes Dis, vol.3, pp.3-6, 2016. ,
Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity Without Severe Toxicity, Cancer Immunol. Res, vol.2, pp.154-166, 2014. ,
, , 2009.
, NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy. Front. Immunol, vol.6, 2015.
, , 2012.
Global epidemiology of oral and oropharyngeal cancer, Oral Oncol, vol.45, pp.309-316, 2009. ,
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species, 2003. ,
, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.17, pp.503-505
Treatment alternatives. Head and neck cancers, Cancer, vol.54, pp.2673-2681, 1984. ,
The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction. Can, J. Physiol. Pharmacol, vol.90, pp.1145-1149, 2012. ,
Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway, Nat. Cell Biol, vol.17, pp.678-688, 2015. ,
, Cancer, vol.124, pp.2986-2992, 2018.
ECM and Cell Surface Proteolysis: Regulating Cellular Ecology, Cell, vol.91, pp.439-442, 1997. ,
Understanding resistance to EGFR inhibitorsimpact on future treatment strategies, Nat. Rev. Clin. Oncol, vol.7, pp.493-507, 2010. ,
Cadherin switching, 2008. ,
, J. Cell Sci, vol.121, pp.727-735
The tumor microenvironment and its role in promoting tumor growth, Oncogene, vol.27, pp.5904-5912, 2008. ,
GAS6 expression identifies high-risk adult AML patients: potential implications for therapy, Leukemia, vol.28, pp.1252-1258, 2014. ,
, synergism. Circ. Res, vol.99, pp.853-860, 2006.
AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs, Cancer Res, vol.74, pp.5878-5890, 2014. ,
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors, Nature, vol.487, pp.505-509, 2012. ,
Stromal effects on mammary gland development and breast cancer, Science, vol.296, pp.1046-1049, 2002. ,
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force, J. Cell Biol, vol.201, pp.1069-1084, 2013. ,
Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation, Cell Death Differ, vol.17, pp.1830-1841, 2010. ,
Targeting Gas6/TAM in cancer cells and tumor microenvironment, Mol. Cancer, vol.17, 2018. ,
, , 2013.
,
Cellular and molecular mechanisms of fibrosis, J. Pathol, vol.214, pp.199-210, 2008. ,
EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy, Cell Death Dis, vol.9, p.269, 2018. ,
Syndecans as receptors and organizers of the extracellular matrix, Cell Tissue Res, vol.339, pp.31-46, 2010. ,
Activation of notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells, J. Cell. Biochem, vol.113, pp.1501-1513, 2012. ,
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis, Cell Rep, vol.22, pp.3625-3640, 2018. ,
,
Phosphotyrosine-binding domains in signal transduction, Nat. Rev. Mol. Cell Biol, vol.3, pp.177-186, 2002. ,
Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma, Int. J. Cancer, vol.126, pp.437-449, 2010. ,
Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer, Clin. Breast Cancer, vol.18, pp.1003-1009, 2018. ,
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone, Nature, vol.390, pp.91-96, 1997. ,
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis, Dev. Cell, vol.14, pp.818-829, 2008. ,
, , 2016.
, Mechanosensing Controlled Directly by Tyrosine Kinases, Nano Lett, vol.16, pp.5951-5961
, , 2018.
, /TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy, Cancer Res, vol.78, pp.1069-1082
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, vol.117, pp.927-939, 2004. ,
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin, Cell, vol.127, pp.139-155, 2006. ,
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth, Cell Metab, vol.24, pp.685-700, 2016. ,
, Br. J. Cancer, vol.110, pp.1958-1967, 2014.
,
The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities, Eur. J. Cancer, vol.37, pp.3-8, 2001. ,
Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation, Proc. Natl. Acad. Sci. U. S. A, vol.98, pp.4472-4477, 2001. ,
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.11, pp.8686-8698, 2005. ,
Toxicity and outcomes in combined modality treatment of head and neck squamous cell carcinoma: cisplatin versus cetuximab, J. Cancer Res. Ther, vol.9, pp.607-612, 2013. ,
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies, Oncogene, vol.29, pp.5254-5264, 2010. ,
,
, Transoral robotic surgery vs. radiotherapy for management of oropharyngeal squamous cell carcinoma -A systematic review of the literature, Eur. J. Surg. Oncol. J. Eur. Soc. Surg. Oncol. Br
, Surg. Oncol, vol.41, pp.1603-1614
EMT, the cytoskeleton, and cancer cell invasion, Cancer Metastasis Rev, vol.28, pp.15-33, 2009. ,
, , 2019.
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab, Sci. Transl. Med, vol.3, pp.99-86, 2011. ,
TAZ Expression as a Prognostic Indicator in Colorectal Cancer, PLOS ONE, vol.8, p.54211, 2013. ,
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity, Cancer Cell, vol.11, pp.217-227, 2007. ,
Ultrasound elastography -review of techniques and its clinical applications, Adv. Clin. Exp. Med. Off. Organ Wroclaw Med. Univ, vol.23, pp.645-655, 2014. ,
, , 2011.
YAP/TAZ at the Roots of Cancer, Cancer Cell, vol.29, pp.783-803, 2016. ,
Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions, Microvasc. Res, vol.83, pp.71-81, 2012. ,
The tyrosine phosphatase SHP2 controls TGF?-induced STAT3 signaling to regulate fibroblast activation and fibrosis, Nat. Commun, vol.9, p.3259, 2018. ,
The integrin-collagen connection--a glue for tissue repair?, J. Cell Sci, vol.129, pp.653-664, 2016. ,
AXL is a marker for epithelial-mesenchymal transition in esophageal squamous cell carcinoma, Oncol. Lett, vol.15, pp.1900-1906, 2018. ,
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells, Cell Cycle, vol.13, pp.3143-3149, 2014. ,
, , 2015.
, , p.1, 2018.
AXL is a potential target for therapeutic intervention in breast cancer progression, Cancer Res, vol.68, pp.1905-1915, 2008. ,
Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer, Nat. Genet, vol.44, pp.852-860, 2012. ,
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control, Genes Dev, vol.21, pp.2747-2761, 2007. ,
Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer, EBioMedicine, vol.8, pp.30-39, 2016. ,
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease, Nat. Genet, vol.48, pp.67-73, 2016. ,
Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin, J. Cell. Biochem, vol.112, pp.2508-2517, 2011. ,
, Drugs Approved for Head and Neck Cancer
Stat3 as an Oncogene, Cell, vol.98, issue.3, pp.295-303, 1999. ,
Collagen VII deficient mice show morphologic and histologic corneal changes that phenotypically mimic human dystrophic epidermolysis bullosa of the eye, Exp. Eye Res, vol.175, pp.133-174, 2018. ,
APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa ,
, Sci. Transl. Med, vol.10, issue.455, 2018.
Persistent foot ulcer due to ruxolitinib therapy for primary myelofibrosis, J. Oncol. Pharm. Pract. Off. Publ. Int. Soc. Oncol. Pharm. Pract, vol.24, issue.3, pp.226-234, 2018. ,
Iatrogenic immunosuppression and cutaneous malignancy, Clin. Dermatol, vol.29, issue.6, pp.602-615, 2011. ,
, Myeloid Cell-Restricted, p.3
, Signaling Controls a Cell-Autonomous Antifibrotic Repair Program, J. Immunol. Baltim. Md, vol.201, issue.2, pp.663-74, 1950.
Epidermolysis bullosa and the risk of lifethreatening cancers: the National EB Registry experience, J. Am. Acad. Dermatol, vol.60, issue.2, pp.203-214, 1986. ,
Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas, Matrix Biol. J. Int. Soc. Matrix Biol, vol.66, pp.1-21, 2018. ,
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy ,
, J. Clin. Invest, vol.118, issue.5, pp.1669-79, 2008.
Stromal microenvironment in type VII collagendeficient skin: The ground for squamous cell carcinoma development, Matrix Biol. J. Int. Soc. Matrix Biol, vol.63, pp.1-10, 2017. ,
Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed, J. Clin. Oncol, vol.33, issue.34, pp.4039-4086, 2015. ,
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies, Semin. Cancer Biol, vol.45, pp.13-22, 2017. ,
Inherited epidermolysis bullosa: new diagnostic criteria and classification ,
, Clin. Dermatol, vol.30, issue.1, pp.70-77, 2012.
Update on the pathogenesis of squamous cell carcinoma development in recessive dystrophic epidermolysis bullosa, Eur. J. Dermatol. EJD, vol.25, issue.1, pp.30-32, 2015. ,
Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita, J. Pathol, vol.225, issue.3, pp.401-414, 2011. ,
High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Facilitate Wound Healing in Dystrophic Epidermolysis Bullosa, Mol. Ther. J. Am. Soc. Gene Ther, vol.23, issue.8, pp.1368-79, 2015. ,
Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity, J. Invest. Dermatol, vol.134, issue.9, pp.2381-2390, 2014. ,
Fibroblast activation in cancer: when seed fertilizes soil, Cell Tissue Res, vol.365, issue.3, pp.607-626, 2016. ,
Persistently Activated Stat3 Maintains Constitutive NF-?B Activity in Tumors, Cancer Cell, vol.15, issue.4, pp.283-93, 2009. ,
Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration, Oncogene, vol.25, issue.39, pp.5416-5441, 2006. ,
Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models, J. Skin Cancer, vol.2013, p.684050, 2013. ,
Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression, Cancer Res, vol.76, issue.4, pp.940-51, 2016. ,
,
Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa, Proc. Natl. Acad. Sci. U ,
, , vol.115, pp.705-719, 2018.
Injury-and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa, Matrix Biol. J. Int. Soc. Matrix Biol, pp.547-60, 2018. ,
Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms, EMBO Mol. Med, vol.7, issue.9, pp.1211-1239, 2015. ,
Collagen VII plays a dual role in wound healing, J. Clin. Invest, vol.123, issue.8, pp.3498-509, 2013. ,
Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-? signalling in modifying disease severity, Hum. Mol. Genet, vol.23, issue.15, pp.3907-3929, 2014. ,
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms, Sci. Transl. Med, vol.10, issue.429, 2018. ,
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis, EMBO J, vol.18, issue.17, pp.4657-68, 1999. ,
Oncostatin M is a novel inhibitor of TGF-?1-induced matricellular protein expression, Am. J. Physiol. Renal Physiol, vol.301, issue.5, pp.1014-1025, 2011. ,
Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms, Cancer Res, vol.75, issue.11, pp.2187-99, 2015. ,
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial, Lancet Oncol, vol.17, issue.7, pp.956-65, 2016. ,
Chronic leg ulceration associated with polycythemia vera responding to ruxolitinib (Jakafi(®)), J. Foot Ankle Surg. Off. Publ. Am. Coll. Foot Ankle Surg, vol.52, issue.6, pp.781-786, 2013. ,
APOBEC3 Proteins in Viral Immunity, J. Immunol. Baltim. Md, vol.195, issue.10, pp.4565-70, 1950. ,
Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease, Blood, vol.131, issue.18, pp.2074-85, 2018. ,
Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes, Mol. Cell. Proteomics MCP, vol.17, issue.4, pp.565-79, 2018. ,
The role of Nuclear Factorkappa B signaling in human cervical cancer, Crit. Rev. Oncol. Hematol, vol.120, pp.141-50, 2017. ,
miR-29 Regulates Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa, J. Invest. Dermatol, vol.136, issue.10, pp.2013-2034, 2016. ,
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis, N. Engl. J. Med, vol.363, issue.12, pp.1117-1144, 2010. ,
The tyrosine phosphatase SHP2 controls TGF?-induced STAT3 signaling to regulate fibroblast activation and fibrosis, Nat. Commun, vol.9, issue.1, p.3259, 2018. ,
, Antibodies Antibodies against STAT3 (#9139; 1/1000), vol.2, p.3672
, /500), vimentin (#5741) were purchased from Cell Signaling (Cell SignalingTechnology, Beverly MA), ?-tubulin from sigma (T4026, vol.1, p.416, 2101.
Mammographic density and the risk and detection of breast cancer, N Engl J Med, vol.356, pp.227-263, 2007. ,
Prognostic geneexpression signature of carcinoma-associated fibroblasts in non-small cell lung cancer, Proc Natl Acad Sci U S A, vol.108, pp.7160-7165, 2011. ,
Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance, World J Gastroenterol, vol.18, pp.840-846, 2012. ,
Fibrous stroma is associated with poorer prognosis in lung squamous cell carcinoma patients, J Thorac Oncol, vol.6, pp.1460-1467, 2011. ,
Stromal fibroblasts in cancer initiation and progression, Nature, vol.432, pp.332-339, 2004. ,
Cell communication networks in cancer invasion, Curr Opin Cell Biol, vol.23, pp.621-630, 2011. ,
Fibroblasts in cancer, Nat Rev Cancer, vol.6, pp.392-401, 2006. ,
The extracellular matrix: a dynamic niche in cancer progression, J Cell Biol, vol.196, pp.395-406, 2012. ,
LIF mediates proinvasive activation of stromal fibroblasts in cancer, Cell Rep, vol.7, pp.1664-78, 2014. ,
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma, Cancer Cell, vol.20, pp.229-274, 2011. ,
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation, Cell, vol.65, pp.961-71, 1991. ,
Regulation of leukocyteendothelium interaction and leukocyte transendothelial Oncotarget 1318 www.impactjournals.com/oncotarget migration by intercellular adhesion molecule 1-fibrinogen recognition, Proc Natl Acad Sci U S A, vol.92, pp.1505-1514, 1995. ,
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells, Nature, vol.331, pp.86-94, 1988. ,
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte functionassociated antigen 1 (LFA-1), Cell, vol.51, pp.813-822, 1987. ,
Identification of an active sequence within the first immunoglobulin domain of intercellular cell adhesion molecule-1 (ICAM-1) that interacts with fibrinogen, J Biol Chem, vol.271, pp.24270-24277, 1996. ,
The role of ICAM expression in immunity and disease, Cancer Surv, vol.24, pp.141-55, 1995. ,
Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies, Front Pharmacol, vol.4, p.127, 2013. ,
ICAM-1: isoforms and phenotypes, J Immunol, vol.192, pp.4469-74, 2014. ,
Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades, Free Radic Biol Med, vol.28, pp.1379-86, 2000. ,
Transcriptional regulation of the intercellular adhesion molecule-1 gene by proinflammatory cytokines in human astrocytes, Glia, vol.25, pp.21-32, 1999. ,
Regulation of intercellular adhesion molecule-1 (CD54) gene expression, J Leukoc Biol, vol.66, pp.876-88, 1999. ,
Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing, J Immunol, vol.154, pp.6080-93, 1995. ,
ICAM-1 isoforms: specific activity and sensitivity to cleavage by leukocyte elastase and cathepsin G, Eur J Immunol, vol.33, pp.1351-60, 2003. ,
Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1, Blood, vol.95, pp.1350-1355, 2000. ,
Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer, Oncol Rep, vol.9, pp.511-515, 2002. ,
Gastrinreleasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase, Am J Physiol Gastrointest Liver Physiol, vol.292, pp.182-90, 2007. ,
Tumorassociated fibroblasts isolated from colorectal cancer tissues exhibit increased ICAM-1 expression and affinity for monocytes, Oncol Rep, vol.31, pp.255-61, 2014. ,
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts, Nat Commun, vol.6, p.10204, 2015. ,
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion, Br J Cancer, vol.102, pp.392-402, 2010. ,
Mechanisms of fibrosis: therapeutic translation for fibrotic disease, Nat Med, vol.18, pp.1028-1068, 2012. ,
Carcinoma-associated fibroblasts provide operational flexibility in metastasis, Semin Cancer Biol, vol.25, pp.33-46, 2014. ,
The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells, FASEB J, vol.16, pp.1257-1266, 2002. ,
Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells, J Biol Chem, vol.278, pp.47731-47774, 2003. ,
Conditional regulation of a ROCKestrogen receptor fusion protein, Methods Enzymol, vol.406, pp.541-53, 2006. ,
Histamine induces human lung fibroblastmediated collagen gel contraction via histamine H1 receptor, Exp Lung Res, vol.40, pp.222-258, 2014. ,
Inflammation and cancer, Nature, vol.420, pp.860-867, 2002. ,
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner, Cancer Cell, vol.17, pp.135-182, 2010. ,
Hallmarks of cancer: the next generation, Cell, vol.144, issue.11, pp.127-136, 2011. ,
ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells, J Immunol, vol.161, pp.5755-61, 1998. ,
Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells, J Immunol, vol.169, pp.1007-1020, 2002. ,
Mechanotransduction and YAPdependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts, Nat Cell Biol, 2013. ,
Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis, J Pharmacol Exp Ther, vol.351, pp.87-95, 2014. ,
Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis, Kidney Int, vol.89, pp.68-81, 2016. ,
The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions, Immunol Res, vol.17, pp.313-340, 1998. ,
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells, J Cell Biol, vol.107, pp.321-352, 1988. ,
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1, J Exp Med, vol.174, pp.253-67, 1991. ,
Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95, Eur J Immunol, vol.25, pp.1008-1020, 1995. ,
LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids, Cell Adhes Commun, vol.2, pp.429-469, 1994. ,
Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients, Am J Gastroenterol, vol.98, pp.478-85, 2003. ,
Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage, Br J Cancer, vol.77, pp.801-808, 1998. ,
Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma, Cancer Res, vol.51, pp.5003-5008, 1991. ,
Clinical significance of serum soluble intercellular adhesion molecule 1 in gastric cancer, Clin Cancer Res, vol.6, pp.1175-1184, 2000. ,
Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis, Hepatology, vol.22, pp.525-556, 1995. ,
Serum levels of soluble intercellular adhesion molecule-1 and E-selectin in metastatic breast carcinoma: correlations with clinicopathological features and prognosis, Int J Oncol, vol.14, pp.71-78, 1999. ,
The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration, J Immunol, vol.192, pp.3390-3398, 2014. ,
Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes, Cell Mol Bioeng, vol.3, pp.50-59, 2010. ,
,
, Curr Opin Cell Biol, vol.25, pp.613-621, 2013.
Integrins control motile strategy through a Rho-cofilin pathway, J Cell Biol, vol.169, pp.515-541, 2005. ,
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat Cell Biol, vol.9, pp.1392-400, 2007. ,
alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration, J Cell Biol, vol.177, pp.515-540, 2007. ,
Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 mice, Mol Biol Cell, vol.22, pp.2777-86, 2011. ,
A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1, J Biol Chem, vol.272, pp.15474-80, 1997. ,
Analysis of Collective Invasion of Carcinoma Cells in a 3D ,
, Organotypic Model. Methods Mol Biol, vol.961, pp.243-52, 2013.
Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma, BMC Genomics, vol.7, p.252, 2006. ,
LIF mediates proinvasive activation of stromal fibroblasts in cancer, Cell Rep, vol.7, pp.1664-1678, 2014. ,
,
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts, Nat Commun, vol.6, p.10204, 2015. ,
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness, Nat Commun, vol.7, p.10305, 2016. ,
Cancer and the chemokine network, Nat Rev Cancer, vol.4, pp.540-550, 2004. ,
Inflammation meets cancer, with NF-?B as the matchmaker, Nat Immunol, vol.12, pp.715-723, 2011. ,
Stromal fibroblasts in cancer initiation and progression, Nature, vol.432, pp.332-337, 2004. ,
Met, metastasis, motility and more, Nat Rev Mol Cell Biol, vol.4, pp.915-925, 2003. ,
Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines, Proc Natl Acad Sci U S A, vol.84, pp.5763-5767, 1987. ,
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth, J Cell Biol, vol.119, pp.629-641, 1992. ,
Cell communication networks in cancer invasion, Curr Opin Cell Biol, vol.23, pp.621-629, 2011. ,
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancerassociated fibroblasts, Nat Cell Biol, vol.15, pp.637-646, 2013. ,
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis, Science, vol.310, pp.1504-1510, 2005. ,
The role of reactive oxygen species and metabolism on cancer cells and their microenvironment, Semin Cancer Biol, vol.25, pp.23-32, 2014. ,
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment, Cancer Cell, vol.15, pp.21-34, 2009. ,
Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac, FASEB J, vol.18, pp.1016-1018, 2004. ,
JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor ? in systemic sclerosis, Arthritis Rheum, vol.64, pp.3006-3015, 2012. ,
Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity, Cancer Metastasis Rev, vol.29, pp.309-316, 2010. ,
Smad-dependent and Smad-independent pathways in TGF-? family signalling, Nature, vol.425, pp.577-584, 2003. ,
Factors influencing myofibroblast differentiation during wound healing and fibrosis, Cell Biol Int, vol.19, pp.471-476, 1995. ,
Role of YAP/TAZ in mechanotransduction, Nature, vol.474, pp.179-183, 2011. ,
Tumors: wounds that do not heal, N Engl J Med, vol.315, pp.1650-1659, 1986. ,
Focal adhesion signaling and therapy resistance in cancer, Semin Cancer Biol, vol.31, pp.65-75, 2015. ,
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation, Exp Cell Res, vol.264, pp.169-184, 2001. ,
Cancerassociated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner, Cancer Cell, vol.17, pp.135-147, 2010. ,
Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma, Biochem Pharmacol, vol.82, pp.201-209, 2011. ,
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations, N Engl J Med, vol.367, pp.1694-1703, 2012. ,
A heparin-binding angiogenic protein-basic fibroblast growth factor-is stored within basement membrane, Am J Pathol, vol.130, pp.393-400, 1988. ,
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat Cell Biol, vol.9, pp.1392-1400, 2007. ,
OSM, LIF, its receptors, and its relationship with the malignance in human breast carcinoma (in situ and in infiltrative), Cancer Invest, vol.26, pp.222-229, 2008. ,
Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer, Cancer Res, vol.56, pp.1194-1198, 1996. ,
Multidrug resistance in cancer: role of ATP-dependent transporters, Nat Rev Cancer, vol.2, pp.48-58, 2002. ,
, Immunity, inflammation, and cancer. Cell, vol.140, pp.883-899, 2010.
, The hallmarks of cancer. Cell, vol.100, pp.57-70, 2000.
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
Structure and function of plateletderived growth factor (PDGF) and related proteins, Biochim Biophys Acta, vol.989, pp.1-10, 1989. ,
Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy, Oncologist, vol.9, issue.5, pp.31-40, 2004. ,
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition, Nat Med, vol.22, pp.262-269, 2016. ,
Roles of fibroblast growth factor receptors in carcinogenesis, Mol Cancer Res, vol.8, pp.1439-1452, 2010. ,
Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies, Cancer Metastasis Rev, vol.20, pp.43-50, 2001. ,
Mechanism of action and in vivo role of platelet-derived growth factor, Physiol Rev, vol.79, pp.1283-1316, 1999. ,
High interstitial fluid pressure-an obstacle in cancer therapy, Nat Rev Cancer, vol.4, pp.806-813, 2004. ,
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin ?1/FAK signaling, Cancer Cell, vol.27, pp.574-588, 2015. ,
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy, Nat Med, vol.17, pp.860-866, 2011. ,
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix, J Biol Chem, vol.261, pp.4337-4345, 1986. ,
Inflammatory alterations of the extracellular matrix in the tumor microenvironment, Cancers, vol.3, pp.3189-3205, 2011. ,
Basement membranes: structure, assembly and role in tumour angiogenesis, Nat Rev Cancer, vol.3, pp.422-433, 2003. ,
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche, Nature, vol.438, pp.820-827, 2005. ,
NF-kappaB: linking inflammation and immunity to cancer development and progression, Nat Rev Immunol, vol.5, pp.749-759, 2005. ,
Tumor angiogenesis, N Engl J Med, vol.358, pp.2039-2049, 2008. ,
Metalloproteinases and their natural inhibitors in inflammation and immunity, Nat Rev Immunol, vol.13, pp.649-665, 2013. ,
, , 2010.
, Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts, Proc Natl Acad Sci U S A, vol.107, 20009.
IKK? in intestinal mesenchymal cells promotes initiation of colitis-associated cancer, J Exp Med, vol.212, pp.2235-2251, 2015. ,
Specificity of desmin to avian and mammalian muscle cells, Cell, vol.14, pp.429-438, 1978. ,
TGF-? signaling and the fibrotic response, FASEB J, vol.18, pp.816-827, 2004. ,
The microenvironment of the tumour-host interface, Nature, vol.411, pp.375-379, 2001. ,
Dabrafenib in patients with Val600Glu or Val600Lys BRAFmutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial, Lancet Oncol, vol.13, pp.1087-1095, 2012. ,
Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis, EMBO Rep, vol.16, pp.1394-1408, 2015. ,
Hepatocyte growth factor, a versatile signal for developing neurons, Nat Neurosci, vol.2, pp.213-217, 1999. ,
Interactions between cancer stem cells and their niche govern metastatic colonization, Nature, vol.481, pp.85-89, 2012. ,
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells, J Biol Chem, vol.269, pp.31807-31813, 1994. ,
Raf kinases in cancer-roles and therapeutic opportunities, Oncogene, vol.30, pp.3477-3488, 2011. ,
Environment-mediated drug resistance: a major contributor to minimal residual disease, Nat Rev Cancer, vol.9, pp.665-674, 2009. ,
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers, Cell, vol.150, pp.549-562, 2012. ,
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy, J Leukoc Biol, vol.89, pp.31-39, 2011. ,
Basic fibroblast growth factor induces angiogenesis in vitro, Proc Natl Acad Sci U S A, vol.83, pp.7297-7301, 1986. ,
Regulation of vimentin expression in cultured human mammary epithelial cells, Differentiation, vol.43, pp.146-156, 1990. ,
Friends or foes-bipolar effects of the tumour stroma in cancer, Nat Rev Cancer, vol.4, pp.839-849, 2004. ,
Extracellular matrix component signaling in cancer, Adv Drug Deliv Rev, vol.97, pp.28-40, 2016. ,
Induction of hepatocyte growth factor in fibroblasts by tumorderived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions, Cancer Res, vol.57, pp.3305-3313, 1997. ,
Integrin ?11?1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer, Oncogene, vol.35, pp.1899-1908, 2015. ,
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis, J Clin Invest, vol.117, pp.2766-2777, 2007. ,
Fibroblast heterogeneity in the cancer wound, J Exp Med, vol.211, pp.1503-1523, 2014. ,
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer, Science, vol.324, pp.1457-1461, 2009. ,
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Cancer Res, vol.59, pp.5002-5011, 1999. ,
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/ CXCL12 secretion, Cell, vol.121, pp.335-348, 2005. ,
The tumor microenvironment controls drug sensitivity, Nat Med, vol.18, pp.1332-1334, 2012. ,
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival, Cancer Cell, vol.25, pp.719-734, 2014. ,
The distribution of secondary growths in cancer of the breast, Lancet, vol.133, pp.571-573, 1889. ,
IKK? acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis, J Exp Med, vol.212, pp.2253-2266, 2015. ,
Fibroblast-mediated drug resistance in cancer, Biochem Pharmacol, vol.85, pp.1033-1041, 2013. ,
Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts, J Biol Chem, vol.274, pp.36505-36512, 1999. ,
Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroblasts, Proc Natl Acad Sci U S A, vol.68, pp.645-648, 1971. ,
NF-kappaB functions as a tumour promoter in inflammation-associated cancer, Nature, vol.431, pp.461-466, 2004. ,
PDGF receptors as cancer drug targets, Cancer Cell, vol.3, pp.439-443, 2003. ,
PDGF receptors as cancer drug targets, Cancer Cell, vol.3, pp.439-443, 2003. ,
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E), Nature, vol.480, pp.387-390, 2011. ,
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma, Cancer Cell, vol.21, pp.418-429, 2012. ,
Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin, Cancer Res, vol.53, pp.3327-3335, 1993. ,
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma, Cancer Cell, vol.25, pp.735-747, 2014. ,
TGF-?: regulation of extracellular matrix, Kidney Int, vol.41, pp.557-559, 1992. ,
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma, Cancer Cell, vol.20, pp.229-245, 2011. ,
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy, Cell, vol.158, pp.564-578, 2014. ,
Human breast carcinoma desmoplasia is PDGF initiated, Oncogene, vol.19, pp.4337-4345, 2000. ,
Wound repair at a glance, J Cell Sci, vol.122, pp.3209-3213, 2009. ,
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression, Semin Cell Dev Biol, vol.21, pp.19-25, 2010. ,
Loss of the timp gene family is sufficient for the acquisition of the CAF-like cell state, Nat Cell Biol, vol.16, pp.889-901, 2014. ,
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF, Cell, vol.43, pp.277-286, 1985. ,
The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells, Development, vol.128, pp.3117-3131, 2001. ,
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib, N Engl J Med, vol.366, pp.707-714, 2012. ,
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature, vol.487, pp.500-504, 2012. ,
Identification and characterization of a fibroblast marker: FSP1, J Cell Biol, vol.130, pp.393-405, 1995. ,
Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation, Kidney Int, vol.57, pp.1521-1538, 2000. ,
Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biol Ther, vol.5, pp.1640-1646, 2006. ,
Microenvironment and tumor cell plasticity: an easy way out, Cancer Lett, vol.341, pp.80-96, 2013. ,
Epithelial-mesenchymal transitions in tumour progression, Nat Rev Cancer, vol.2, pp.442-454, 2002. ,
Epithelialmesenchymal transitions in development and disease, Cell, vol.139, pp.871-890, 2009. ,
Myofibroblasts and mechano-regulation of connective tissue remodelling, Nat Rev Mol Cell Biol, vol.3, pp.349-363, 2002. ,
Pten in stromal fibroblasts suppresses mammary epithelial tumours, Nature, vol.461, pp.1084-1091, 2009. ,
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis, Cancer Cell, vol.26, pp.121-135, 2014. ,
Paradoxical roles of the immune system during cancer development, Nat Rev Cancer, vol.6, pp.24-37, 2006. ,
Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan, Br J Cancer, vol.75, pp.1167-1172, 1997. ,
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors, Clin Cancer Res, vol.15, pp.6630-6638, 2009. ,
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species, FASEB J, vol.17, pp.503-505, 2003. ,
Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes, Oncogene, vol.34, pp.290-302, 2015. ,
Targeting hypoxia in cancer therapy, Nat Rev Cancer, vol.11, pp.393-410, 2011. ,
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors, Nature, vol.487, pp.505-509, 2012. ,
Stromal effects on mammary gland development and breast cancer, Science, vol.296, pp.1046-1049, 2002. ,
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion, Nat Cell Biol, vol.9, pp.893-904, 2007. ,
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer, Cancer Lett, vol.335, pp.128-135, 2013. ,
Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomas, Cancer Res, vol.67, pp.2131-2140, 2007. ,
A paracrine requirement for hedgehog signalling in cancer, Nature, vol.455, pp.406-410, 2008. ,
The integrin-collagen connection-a glue for tissue repair?, J Cell Sci, vol.129, pp.1284-1284, 2016. ,