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Traitement des ulcérations cutanées par nanoencapsulation d’agents actifs. Mise au point et preuve de concept

Abstract : Wound healing is a multifactorial process. In diabetes, there is a change in the processes involved in healing. Indeed, chronic hyperglycemia in diabetic patients modifies tissue function at the endothelial level and at the cutaneous level.Chronic ulcers in diabetic patients are a major public health problem with limited efficacy of current therapy. They represent a major factor in the deterioration of quality of life with a significant risk of lower limb amputation.In this thesis, we evaluated the potential of encapsulation of active ingredients in lipid nanoparticles for local delivery. Lipid nanoparticles are galenic forms that stabilize the active pharmaceutical ingredients and improve skin delivery. The active pharmaceutical ingredients used in this thesis will be vasodilators. They can increase wound healing by their effect on vascular function, but also on the processes of inflammation, proliferation and tissue remodelling.We were able to validate the effect of encapsulation in lipid nanoparticles to improve the stability of formulations of different vasodilator active ingredients. In the healing of diabetic wounds, we have observed an improvement in healing when administering prostacyclin analogues. Additional studies are being carried out to describe the mechanisms used to improve healing by these formulations.
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Submitted on : Wednesday, February 12, 2020 - 4:14:22 PM
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  • HAL Id : tel-02476378, version 1



Raphaël Bouvet. Traitement des ulcérations cutanées par nanoencapsulation d’agents actifs. Mise au point et preuve de concept. Médecine humaine et pathologie. Université Grenoble Alpes, 2019. Français. ⟨NNT : 2019GREAS018⟩. ⟨tel-02476378⟩



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