Pancreatic cancer, Nature reviews Disease primers, vol.2, p.16022, 2016. ,
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy, Nat Med, vol.17, pp.500-503, 2011. ,
Genomic analyses identify molecular subtypes of pancreatic cancer, Nature, vol.531, pp.47-52, 2016. ,
Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma, Nat Genet, vol.47, pp.1168-78, 2015. ,
Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts, Cell reports, vol.21, pp.2458-70, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01985259
Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer, Gastroenterology, vol.154, pp.820-858, 2018. ,
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance, Curr Mol Med, vol.12, pp.288-303, 2012. ,
The biology and function of fibroblasts in cancer, Nat Rev Cancer, vol.16, pp.582-98, 2016. ,
Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers, Clin Cancer Res, vol.23, pp.4429-4469, 2017. ,
Translational Significance for Tumor Metastasis of Tumor-Associated Macrophages and Epithelial-Mesenchymal Transition, Frontiers in immunology, vol.8, p.1106, 2017. ,
,
, Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype, Cell reports, vol.23, pp.1448-60, 2018.
TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells, Nature, vol.554, pp.544-552, 2018. ,
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancerassociated fibroblasts abrogates pancreatic tumour chemoresistance, EMBO Mol Med, vol.7, pp.735-53, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02421448
Antimetastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts, Oncotarget, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02421440
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models, Cancer Res, vol.74, pp.5057-69, 2014. ,
,
, Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors, Cancer Cell, vol.32, pp.654-68, 2017.
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice, Cancer Cell, vol.7, pp.469-83, 2005. ,
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma, Genes Dev, vol.17, pp.3112-3138, 2003. ,
Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma, Cancer medicine, vol.6, pp.463-70, 2017. ,
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression, Nat Med, vol.22, pp.497-505, 2016. ,
Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis, Faseb J, vol.13, pp.647-55, 1999. ,
Beyond the M-CSF receptor -novel therapeutic targets in tumor-associated macrophages, FEBS J, vol.285, pp.777-87, 2018. ,
CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer, Cancer Res, vol.73, pp.2782-94, 2013. ,
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses, Cancer Res, vol.73, pp.1128-1169, 2013. ,
Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer, Br J Cancer, vol.114, pp.269-80, 2016. ,
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas, Science, vol.352, p.3018, 2016. ,
The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor, Cancer immunology research, vol.2, pp.765-76, 2014. ,
Phase I study of combination of pasireotide LAR + gemcitabine in locally advanced or metastatic pancreatic cancer, Cancer Chemother Pharmacol, vol.76, pp.481-488, 2015. ,
Somatostatin receptors: from signaling to clinical practice, Front Neuroendocrinol, 2013. ,
Somatostatin receptors as a new active targeting sites for nanoparticles, Saudi Pharmaceutical Journal, 2018. ,
Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium, Br. J. Cancer, vol.92, pp.1493-1498, 2005. ,
Tumor macrophages are pivotal constructors of tumor collagenous matrix, Journal of Experimental Medicine jem, 2016. ,
Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine, Cancer Discovery CD, 2018. ,
Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis, FASEB J, vol.13, pp.647-655, 1999. ,
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts, Nat Commun, vol.6, p.10204, 2015. ,
, miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review, vol.10, pp.113-124, 2015.
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells, J. Clin. Invest, 2018. ,
Stromal disrupting effects of nab-paclitaxel in pancreatic cancer, Br. J. Cancer, vol.109, pp.926-933, 2013. ,
Inhibitory effects of somatostatin on tumor necrosis factor-alphainduced interleukin-6 secretion in human pancreatic periacinar myofibroblasts, Int. J. Mol. Med, vol.10, pp.89-93, 2002. ,
Ras and the FAK Paradox, Molecular Cell, vol.35, pp.141-142, 2009. ,
The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells, Antioxid. Redox Signal, vol.15, pp.2711-2722, 2011. ,
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors, Immunity, vol.46, pp.577-586, 2017. ,
Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages, J. Leukoc. Biol, vol.81, pp.845-855, 2007. ,
Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma, Clin. Cancer Res, vol.10, pp.7427-7437, 2004. ,
Cancer-associated fibroblasts lead tumor invasion through integrin-?3-dependent fibronectin assembly, J. Cell Biol, vol.216, pp.3509-3520, 2017. ,
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.3414-3419, 2009. ,
GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling, Cancer Res, vol.70, pp.7630-7639, 2010. ,
Genomic analyses identify molecular subtypes of pancreatic cancer, Nature, vol.531, pp.47-52, 2016. ,
Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer, Clin. Cancer Res, vol.22, pp.415-425, 2016. ,
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway, Cancer Cell, vol.5, pp.329-339, 2004. ,
Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits, Cancer Res, vol.77, pp.3431-3441, 2017. ,
Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2, Endocrinology, vol.149, pp.4736-4746, 2008. ,
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer, Cancer Cell, vol.21, pp.822-835, 2012. ,
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans, Science, vol.331, pp.1612-1616, 2011. ,
Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer, Oncol. Rep, vol.25, pp.709-716, 2011. ,
Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238, Proc. Natl. Acad. Sci. U.S.A, vol.97, pp.9180-9185, 2000. ,
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis, Nat. Cell Biol, vol.2, pp.737-744, 2000. ,
Detection of circulating tumor DNA in earlyand late-stage human malignancies, Sci Transl Med, vol.6, pp.224-248, 2014. ,
Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier, Oncotarget, vol.7, pp.23263-23281, 2016. ,
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, vol.303, pp.848-851, 2004. ,
Organoid models of human and mouse ductal pancreatic cancer, Cell, vol.160, pp.324-338, 2015. ,
Targeting the tumor microenvironment, JAK-STAT, vol.2, 2013. ,
Antiproliferative effect of somatostatin and analogs, Chemotherapy, vol.47, issue.2, pp.30-39, 2001. ,
Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway, EMBO J, vol.25, pp.3943-3954, 2006. ,
Focus on an unusual rise in pancreatic cancer incidence in France, Int J Epidemiol, vol.46, pp.1764-1772, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01541663
Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer, New England Journal of Medicine, vol.366, pp.2455-2465, 2012. ,
Serum Biomarker Panels for the Detection of Pancreatic Cancer, Clin Cancer Res, vol.17, pp.805-816, 2011. ,
, , 1973.
, Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone, Science, vol.179, pp.77-79
Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer, Cancer Res, vol.78, pp.475-488, 2018. ,
SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile, Eur. J. Endocrinol, vol.146, pp.707-716, 2002. ,
Epidermal Growth Factor Receptor Blockade with C225 Plus Gemcitabine Results in Regression of Human Pancreatic Carcinoma Growing Orthotopically in Nude Mice by Antiangiogenic Mechanisms, p.14 ,
Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration, J. Biol. Chem, vol.277, pp.28431-28438, 2002. ,
Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer, Cancer Res, vol.56, pp.1823-1827, 1996. ,
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancerassociated fibroblasts, Nat. Cell Biol, vol.15, pp.637-646, 2013. ,
The patterns and dynamics of genomic instability in metastatic pancreatic cancer, Nature, vol.467, pp.1109-1113, 2010. ,
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype, Cell Rep, vol.23, pp.1448-1460, 2018. ,
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy, Cancer Cell, vol.30, pp.968-985, 2016. ,
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production, Cell Cycle, vol.11, pp.2285-2302, 2012. ,
Distinctive properties of metastasis-initiating cells, Genes Dev, vol.30, pp.892-908, 2016. ,
Somatostatin analogs: does pharmacology impact antitumor efficacy?, Trends Endocrinol. Metab, vol.25, pp.115-127, 2014. ,
Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16, Gastroenterology, vol.148, pp.1452-1465, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02472216
Validation of biomarkers that complement CA19.9 in detecting early pancreatic cancer, Clin Cancer Res, vol.20, pp.5787-5795, 2014. ,
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression, Cell, vol.162, pp.1229-1241, 2015. ,
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels, Nat Commun, vol.4, p.2516, 2013. ,
Tissue Factor-Expressing Tumor-Derived Extracellular Vesicles Activate Quiescent Endothelial Cells via Protease-Activated Receptor, 2017. ,
, Front Oncol, vol.7, p.261
Role of fibrillar Tenascin-C in metastatic pancreatic cancer, Int. J. Oncol, vol.34, pp.1029-1036, 2009. ,
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling, Nat Commun, vol.5, p.3472, 2014. ,
Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program, EMBO Mol Med, 2018. ,
Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways, Oncotarget, vol.5, pp.9939-9951, 2014. ,
In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes, Cancer Discov, vol.5, pp.740-751, 2015. ,
Tumor cell intravasation, Am J Physiol Cell Physiol, vol.311, pp.1-14, 2016. ,
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer, Nat Genet, vol.47, pp.911-916, 2015. ,
An essential role for the IL-2 receptor in Treg cell function, Nat. Immunol, vol.17, pp.1322-1333, 2016. ,
Phase 1 pharmacogenetic and pharmacodynamic study of sorafenib with concurrent radiation therapy and gemcitabine in locally advanced unresectable pancreatic cancer, Int. J. Radiat. Oncol. Biol. Phys, vol.89, pp.284-291, 2014. ,
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma, Nat Commun, vol.8, p.517, 2017. ,
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice, Gastroenterology, vol.143, pp.1095-1107, 2012. ,
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion, Nat Commun, vol.7, p.12630, 2016. ,
IL-17-producing ?? T cells and neutrophils conspire to promote breast cancer metastasis, Nature, vol.522, pp.345-348, 2015. ,
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers, Proc. Natl. Acad. Sci. U.S.A, vol.114, pp.10202-10207, 2017. ,
Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy, Nat Med, vol.17, pp.500-503, 2011. ,
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer, Cancer Cell, vol.33, pp.463-479, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437793
Pancreatic cancer exosomes initiate premetastatic niche formation in the liver, Nat. Cell Biol, vol.17, pp.816-826, 2015. ,
A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile, Am. J. Gastroenterol, vol.109, pp.1942-1952, 2014. ,
Tumor Heterogeneity in Pancreatic Adenocarcinoma, Pathobiology, vol.85, pp.64-71, 2018. ,
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat. Med, vol.10, pp.942-949, 2004. ,
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis, Cell Metab, 2018. ,
Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells, Am. J. Physiol. Endocrinol. Metab, vol.285, pp.344-353, 2003. ,
Circulating and disseminated tumor cells: harbingers or initiators of metastasis?, Mol Oncol, vol.11, pp.40-61, 2017. ,
Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression, Cancer Res, vol.78, pp.1321-1333, 2018. ,
Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer, Cancer Research, vol.77, pp.5952-5962, 2017. ,
Overcoming resistance to checkpoint blockade therapy by targeting PI3K? in myeloid cells, Nature, vol.539, pp.443-447, 2016. ,
Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer, J. Exp. Med, vol.208, pp.469-478, 2011. ,
Phenotype and genotype of pancreatic cancer cell lines, Pancreas, vol.39, pp.425-435, 2010. ,
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis, Nature, vol.501, pp.252-256, 2013. ,
Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements, Am. J. Pathol, vol.185, pp.1297-1303, 2015. ,
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis, Nature, vol.475, pp.106-109, 2011. ,
Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma, Cell Rep, vol.19, pp.601-616, 2017. ,
Tissue plasminogen activator is required for the growth, invasion, and angiogenesis of pancreatic tumor cells, Gastroenterology, vol.122, pp.806-819, 2002. ,
Circulating mutant DNA to assess tumor dynamics, Nature Medicine, vol.14, pp.985-990, 2008. ,
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors, Proc. Natl. Acad. Sci. U.S.A, vol.115, pp.1147-1156, 2018. ,
Establishment and Characteristics of Cell Strains From Some Epithelial Tumors of Human Origin, J Natl Cancer Inst, vol.31, pp.1173-1195, 1963. ,
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation, J. Cell Biol, vol.216, pp.4331-4349, 2017. ,
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancerassociated fibroblasts abrogates pancreatic tumour chemoresistance, EMBO Mol Med, vol.7, pp.735-753, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02421448
Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells, Int. J. Oncol, vol.41, pp.855-861, 2012. ,
, , 1999.
, SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-gamma release, Eur. J. Immunol, vol.29, pp.2454-2463
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma, Gastroenterology, vol.145, pp.1121-1132, 2013. ,
Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin, J. Cell Biol, vol.216, pp.3799-3816, 2017. ,
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner, Cancer Cell, vol.17, pp.135-147, 2010. ,
Lysyl oxidase is essential for hypoxia-induced metastasis, Nature, vol.440, pp.1222-1226, 2006. ,
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche, Cancer Cell, vol.15, pp.35-44, 2009. ,
Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2, J. Surg. Res, vol.156, pp.155-160, 2009. ,
Targeting CXCL12 from FAPexpressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer, Proc. Natl. Acad. Sci. U.S.A, vol.110, pp.20212-20217, 2013. ,
Challenges and Opportunities in Modeling Pancreatic Cancer, Cold Spring Harb. Symp. Quant. Biol, vol.81, pp.231-235, 2016. ,
The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited, Nat. Rev. Cancer, vol.3, pp.453-458, 2003. ,
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance, Nature, vol.527, pp.472-476, 2015. ,
Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis, Nat. Cell Biol, vol.17, pp.183-194, 2015. ,
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat. Immunol, vol.4, pp.330-336, 2003. ,
Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden, Oncotarget, vol.9, pp.19006-19013, 2018. ,
Mouse models of advanced spontaneous metastasis for experimental therapeutics, Nat. Rev. Cancer, vol.11, pp.135-141, 2011. ,
B cell-regulated immune responses in tumor models and cancer patients, Oncoimmunology, vol.2, p.25443, 2013. ,
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer, Cancer Discov, vol.2, pp.260-269, 2012. ,
Proteolytic interstitial cell migration: a five-step process, Cancer Metastasis Rev, vol.28, pp.129-135, 2009. ,
Mechanically activated integrin switch controls alpha5beta1 function, Science, vol.323, pp.642-644, 2009. ,
Retinoic Acid-Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-?-Catenin Signaling to Slow Tumor Progression, Gastroenterology, vol.141, pp.1486-1497, 2011. ,
High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin, Oncotarget, vol.7, pp.50239-50257, 2016. ,
, , 2013.
, Overexpression of clusterin promotes angiogenesis via the vascular endothelial growth factor in primary ovarian cancer, Mol Med Rep, vol.7, pp.1726-1732
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression, Cancer Cell, vol.19, pp.441-455, 2011. ,
CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma, Pancreas, vol.28, pp.26-31, 2004. ,
A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws, Nucleic Acids Res, vol.39, pp.7900-7907, 2011. ,
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat. Cell Biol, vol.9, pp.1392-1400, 2007. ,
Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells, Cell Death Dis, vol.9, p.468, 2018. ,
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome, Science, vol.313, pp.1960-1964, 2006. ,
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response, Nat. Med, vol.21, pp.1318-1325, 2015. ,
Preclinical mouse solid tumour models: status quo, challenges and perspectives, Nature Reviews Cancer, vol.17, pp.751-765, 2017. ,
Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma, Cancer Immunol. Immunother, vol.62, pp.1083-1091, 2013. ,
Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer, Seminars in Cancer Biology, vol.44, pp.43-59, 2017. ,
Designer matrices for intestinal stem cell and organoid culture, Nature, vol.539, pp.560-564, 2016. ,
Cancer-associated fibroblasts induce metalloproteaseindependent cancer cell invasion of the basement membrane, Nat Commun, vol.8, p.924, 2017. ,
GEMMs as preclinical models for testing pancreatic cancer therapies, Disease Models & Mechanisms, vol.8, pp.1185-1200, 2015. ,
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop, Cancer Res, vol.65, pp.5278-5283, 2005. ,
Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells, Cancer Res, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02347409
NF-?B c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer, Cell, vol.170, pp.1096-1108, 2017. ,
Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms, Endocr. Relat. Cancer, vol.15, pp.701-720, 2008. ,
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver, Gastroenterology, vol.151, pp.1011-1024, 2016. ,
The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines, Br. J. Cancer, vol.94, pp.1311-1319, 2006. ,
Integrinmediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells, Surgery, vol.141, pp.804-814, 2007. ,
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells, Cancer Lett, vol.345, pp.132-139, 2014. ,
Somatostatin: the beginnings, 1972, Mol. Cell. Endocrinol, vol.286, pp.3-4, 2008. ,
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis, Proc. Natl. Acad. Sci. U.S.A, vol.100, pp.155-160, 2003. ,
Physiology of somatostatin receptors, J. Endocrinol. Invest, vol.28, pp.5-9, 2005. ,
Translation of Research Evidence From Animals to Humans, JAMA, vol.296, p.1727, 2006. ,
The role of cortistatin in the human immune system, Mol. Cell. Endocrinol, vol.286, pp.141-147, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00532017
Endothelial destabilization by angiopoietin-2 via integrin ?1 activation, Nature Communications, vol.6, p.5962, 2015. ,
The JAK/STAT Pathway, Cold Spring Harbor Perspectives in Biology, vol.4, pp.11205-011205, 2012. ,
The sonic hedgehog signaling pathway maintains the cancer stem cell self-renewal of anaplastic thyroid cancer by inducing snail expression, J. Clin. Endocrinol. Metab, vol.99, pp.2178-2187, 2014. ,
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer, Cell Stem Cell, vol.1, pp.313-323, 2007. ,
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer, 2017. ,
, , 2006.
, Genetics and biology of pancreatic ductal adenocarcinoma, Genes Dev, vol.20, pp.1218-1249
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research, Cancer Discovery, vol.4, pp.998-1013, 2014. ,
Pancreas Cancer Meets the Thunder God, Science Translational Medicine, vol.4, pp.156-177, 2012. ,
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse, CANCER CELL, vol.14, 2003. ,
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice, Cancer Cell, vol.7, pp.469-483, 2005. ,
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions, Clin. Cancer Res, vol.12, pp.5423-5434, 2006. ,
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis, Cancer Cell, vol.2, pp.289-300, 2002. ,
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis, Nat. Cell Biol, vol.8, pp.1369-1375, 2006. ,
Tumour exosome integrins determine organotropic metastasis, Nature, vol.527, pp.329-335, 2015. ,
Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression, Nat Commun, vol.8, 2017. ,
?3 Chains of type V collagen regulate breast tumour growth via glypican-1, Nat Commun, vol.8, p.14351, 2017. ,
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids, Nat Med, vol.21, pp.1364-1371, 2015. ,
Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment, Cellular & Molecular Immunology, vol.1, 2018. ,
Fluid shear stress and tumor metastasis, Am J Cancer Res, vol.8, pp.763-777, 2018. ,
, , 2009.
, Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines, Mol. Cancer, vol.8, p.125
A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance, Cell, vol.172, pp.643-644, 2018. ,
N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation, Cancer Res, vol.67, pp.3106-3116, 2007. ,
Pre-clinical Models of Pancreatic Ductal Adenocarcinoma, J Pathol, vol.238, pp.197-204, 2016. ,
Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer, Mol. Cancer Res, vol.10, pp.1147-1157, 2012. ,
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity, Nat. Med, vol.21, pp.530-536, 2015. ,
A randomised, double-blind, placebocontrolled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas, Eur. J. Cancer, vol.50, pp.2072-2081, 2014. ,
Complex role for the immune system in initiation and progression of pancreatic cancer, World J Gastroenterol, vol.20, pp.11160-11181, 2014. ,
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer, Gut, vol.62, pp.112-120, 2013. ,
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function, J. Cell Biol, vol.204, pp.247-263, 2014. ,
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy, Nat. Med, 2016. ,
Tissue invasion and metastasis: Molecular, biological and clinical perspectives, Seminars in Cancer Biology, vol.35, pp.244-275, 2015. ,
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials, Br J Cancer, vol.84, pp.1424-1431, 2001. ,
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses, Science, vol.321, pp.1801-1806, 2008. ,
Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature, Oncotarget, vol.7, pp.62533-62546, 2016. ,
Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation, Br J Pharmacol, vol.143, pp.819-826, 2004. ,
Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis, Front Oncol, vol.8, 2018. ,
The biology and function of fibroblasts in cancer, Nature Reviews Cancer, vol.16, pp.582-598, 2016. ,
Macrophage PI3K? drives pancreatic ductal adenocarcinoma progression, 2016. ,
PI3K? is a molecular switch that controls immune suppression, Nature, vol.539, pp.437-442, 2016. ,
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis, PLoS ONE, vol.10, 2015. ,
Checkpoint inhibitors for malignant melanoma: a systematic review and meta-analysis, Clin Cosmet Investig Dermatol, vol.10, pp.325-339, 2017. ,
Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer, Cancer, vol.113, pp.1387-1395, 2008. ,
,
, Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study, J. Cell. Sci, vol.123, pp.431-440
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis, Nature, vol.457, pp.102-106, 2009. ,
Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma, Cancer Lett, vol.425, pp.65-77, 2018. ,
Autocrine TGF-? and stromal cellderived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts, MEDICAL SCIENCES, vol.6 ,
Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action, Clin. Cancer Res, vol.10, pp.4776-4783, 2004. ,
Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancer, Cancer Chemother. Pharmacol, vol.75, pp.1135-1141, 2015. ,
A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin, Cancer Lett, vol.299, pp.130-136, 2010. ,
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha, Science, vol.330, pp.827-830, 2010. ,
The EMTactivator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer, Nat. Cell Biol, vol.19, pp.518-529, 2017. ,
Preclinical models of pancreatic ductal adenocarcinoma, Chinese Clinical Oncology, vol.6, 2017. ,
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis, J. Exp. Med, vol.206, pp.1089-1102, 2009. ,
The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts, Cell Rep, vol.12, pp.992-1005, 2015. ,
Somatostatin and somatostatin receptors, Results Probl Cell Differ, vol.50, pp.137-184, 2010. ,
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors, Cancer Cell, vol.32, pp.654-668, 2017. ,
A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer, Cancer Lett, vol.393, pp.86-93, 2017. ,
Cancerassociated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells, Nat Commun, vol.9, p.948, 2018. ,
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.17769-17774, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00504705
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression, Nat. Med, vol.22, pp.497-505, 2016. ,
Phenotype molding of stromal cells in the lung tumor microenvironment, Nature Medicine, 2018. ,
Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression, Front Immunol, vol.5, p.489, 2014. ,
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer, J. Immunother, vol.36, pp.382-389, 2013. ,
Origin and Function of Myofibroblasts in Kidney Fibrosis, Nat Med, vol.19, pp.1047-1053, 2013. ,
Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness, J. Clin. Invest, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01408056
Stromal response to Hedgehog signaling restrains pancreatic cancer progression, Proc. Natl. Acad. Sci. U.S.A, vol.111, pp.3091-3100, 2014. ,
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia, Cancer Discov, vol.6, pp.256-269, 2016. ,
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer, Nat. Cell Biol, 2018. ,
Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, vol.139, pp.891-906, 2009. ,
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture, Nat Med, vol.20, pp.769-777, 2014. ,
Blood-Derived microRNAs for Pancreatic Cancer Diagnosis: A Narrative Review and Meta-Analysis, Front Physiol, vol.9, p.685, 2018. ,
, , 2010.
, Up-regulation of miR-146a contributes to the inhibition of invasion of pancreatic cancer cells, Cancer Res, vol.70, p.5703
?-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis, World J Gastroenterol, vol.11, pp.2117-2123, 2005. ,
Do anti-stroma therapies improve extrinsic resistance to increase the efficacy of gemcitabine in pancreatic cancer?, Cell. Mol. Life Sci, vol.75, pp.1001-1012, 2018. ,
Differential expression of somatostatin receptor subtypes in human peripheral blood mononuclear cell subsets, Eur. J. Endocrinol, vol.150, pp.565-577, 2004. ,
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy, J. Exp. Med, vol.193, pp.727-740, 2001. ,
Macrophages orchestrate breast cancer early dissemination and metastasis, Nat Commun, vol.9, p.21, 2018. ,
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-?B and MMPs, J. Cell Biol, vol.202, pp.563-577, 2013. ,
Characteristics and Significance of the Pre-metastatic Niche, Cancer Cell, vol.30, pp.668-681, 2016. ,
Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer, Clinical Chemistry, vol.58, pp.610-618, 2012. ,
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling, J. Cell Biol, vol.130, pp.227-237, 1995. ,
, , 2018.
, Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition, Nat Commun, vol.9, p.249
Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling, Oncotarget, 2016. ,
Role of microenvironmental periostin in pancreatic cancer progression, Oncotarget, vol.8, pp.89552-89565, 2017. ,
Effects of octreotide on activated pancreatic stellate cell-induced pancreas graft fibrosis in rats, J. Surg. Res, vol.176, pp.248-259, 2012. ,
Emerging roles of proteases in tumour suppression, Nat. Rev. Cancer, vol.7, pp.800-808, 2007. ,
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A, J. Exp. Med, vol.210, pp.2851-2872, 2013. ,
The stromal compartments in pancreatic cancer: are there any therapeutic targets?, Cancer Lett, vol.343, pp.147-155, 2014. ,
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer, Nature, vol.449, pp.682-688, 2007. ,
Pancreatic Cancer Metastases Harbor Evidence of Polyclonality, Cancer Discov, vol.5, pp.1086-1097, 2015. ,
Differential diagnosis between chronic pancreatitis and pancreatic cancer: value of the detection of KRAS2 mutations in circulating DNA, Br J Cancer, vol.87, pp.551-554, 2002. ,
Precursors to invasive pancreatic cancer, Adv Anat Pathol, vol.12, pp.81-91, 2005. ,
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor, Nat. Immunol, vol.18, pp.1332-1341, 2017. ,
Lost in translation: animal models and clinical trials in cancer treatment, Am J Transl Res, vol.6, pp.114-118, 2014. ,
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer, Nature Genetics, vol.49, pp.358-366, 2017. ,
Precancerous neoplastic cells can move through the pancreatic ductal system, Nature, vol.1, 2018. ,
Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice, Gastroenterology, vol.143, pp.1375-1384, 2012. ,
Tumourassociated macrophages as treatment targets in oncology, Nat Rev Clin Oncol advance online publication, 2017. ,
The M1 and M2 paradigm of macrophage activation: time for reassessment, 1000. ,
The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice, Scand. J. Gastroenterol, vol.48, pp.602-609, 2013. ,
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer, Nature, vol.523, pp.177-182, 2015. ,
Somatostatin inhibits the production of vascular endothelial growth factor in human glioma cells, Int. J. Cancer, vol.92, pp.545-550, 2001. ,
Current concepts and novel targets in advanced pancreatic cancer, Gut, vol.62, pp.317-326, 2013. ,
Impact of tumour associated macrophages in pancreatic cancer, BMB Rep, vol.46, pp.131-138, 2013. ,
Stepping out of the flow: capillary extravasation in cancer metastasis, Clin. Exp. Metastasis, vol.25, pp.305-324, 2008. ,
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy, EMBO Mol Med, vol.7, pp.1063-1076, 2015. ,
On the origin of myeloid-derived suppressor cells, Oncotarget, vol.8, pp.3649-3665, 2017. ,
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses, Cancer Res, vol.73, pp.1128-1141, 2013. ,
MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer, Cancer Discov, vol.2, pp.1100-1108, 2012. ,
Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancerassociated fibroblasts, Oncotarget, vol.7, pp.41584-41598, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02421440
Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma, Nat Genet, vol.47, pp.1168-1178, 2015. ,
, , 2018.
Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer, Cell Mol Gastroenterol Hepatol, vol.5, pp.289-298 ,
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma, Cancer Res, vol.57, pp.2140-2143, 1997. ,
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cellsuppressive activity, Blood, vol.111, pp.4233-4244, 2008. ,
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes, Nature, vol.554, pp.62-68, 2018. ,
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices, Mol Cell Proteomics, vol.11, 2012. ,
Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine, Br. J. Cancer, vol.103, pp.1644-1648, 2010. ,
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study, Cancer Res, vol.53, pp.3632-3637, 1993. ,
Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer, Scientific Reports, vol.8, p.4013, 2018. ,
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer, Proc. Natl. Acad. Sci. U.S.A, vol.110, pp.12325-12330, 2013. ,
Stromal biology and therapy in pancreatic cancer: a changing paradigm, Gut, vol.64, pp.1476-1484, 2015. ,
Therapeutic developments in pancreatic cancer: current and future perspectives, Nat Rev Gastroenterol Hepatol, vol.15, pp.333-348, 2018. ,
, Cancer du pancréas». Thésaurus National de Cancérologie Digestive, 2018.
YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity, Cancer Discov, vol.8, pp.1026-1043, 2018. ,
Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts, Cell Reports, vol.21, pp.2458-2470, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01985259
MicroRNAsthe micro steering wheel of tumour metastases, Nature Reviews Cancer, vol.9, pp.293-302, 2009. ,
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis, Nat. Cell Biol, vol.18, pp.549-560, 2016. ,
Should every patient with pancreatic cancer receive perioperative/neoadjuvant therapy?, Indian J Med Paediatr Oncol, vol.37, pp.211-213, 2016. ,
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis, Oncogene, vol.21, 2000. ,
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma, Nature Medicine, vol.22, pp.278-287, 2016. ,
NF?B-Mediated Invasiveness in CD133 + Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling, Molecular Cancer Research, vol.16, pp.162-172, 2018. ,
Targeting tumourassociated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial, The Lancet Oncology, vol.17, pp.651-662, 2016. ,
Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma, Gut, vol.67, pp.1112-1123, 2018. ,
An NF-?B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function, Immunity, vol.47, pp.450-465, 2017. ,
Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer, Br. J. Cancer, vol.101, pp.91-97, 2009. ,
Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop, BMC Cancer, vol.13, p.154, 2013. ,
Fibroblast heterogeneity in the cancer wound, J Exp Med, vol.211, pp.1503-1523, 2014. ,
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer, J. Exp. Med, 2017. ,
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions, Nat Commun, vol.8, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01788014
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer, Science, vol.324, p.1457, 2009. ,
Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents, Cell Rep, vol.19, pp.101-113, 2017. ,
The pancreatic stellate cell: a star on the rise in pancreatic diseases, J Clin Invest, vol.117, pp.50-59, 2007. ,
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, vol.121, pp.335-348, 2005. ,
microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-? actions, Oncogene, vol.33, pp.4664-4674, 2014. ,
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade, Nature Communications, vol.8, p.14979, 2017. ,
Interferon-? Drives Treg Fragility to Promote Anti-tumor Immunity, Cell, vol.169, pp.1130-1141, 2017. ,
Depletion of carcinomaassociated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival, Cancer Cell, vol.25, pp.719-734, 2014. ,
Targeting metastasis-initiating cells through the fatty acid receptor CD36, Nature, vol.541, pp.41-45, 2017. ,
Somatostatin and Its Receptor Family, Frontiers in Neuroendocrinology, vol.20, pp.157-198, 1999. ,
Microenvironment in metastasis: roadblocks and supportive niches, American Journal of Physiology-Cell Physiology, vol.309, pp.627-638, 2015. ,
Pre-metastatic niches: organ-specific homes for metastases, Nature Reviews Cancer, vol.17, pp.302-317, 2017. ,
Eligibility of Metastatic Pancreatic Cancer Patients for First-Line Palliative Intent nab-Paclitaxel Plus Gemcitabine Versus FOLFIRINOX, Am. J. Clin. Oncol, vol.40, pp.507-511, 2017. ,
Myeloid-derived suppressor cells and their role in pancreatic cancer, Cancer Gene Ther, vol.24, pp.100-105, 2017. ,
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205, J. Clin. Oncol, vol.28, pp.3605-3610, 2010. ,
The extracellular matrix modulates the hallmarks of cancer, EMBO Rep, vol.15, pp.1243-1253, 2014. ,
Screening for pancreatic cancer: why, how, and who?, Ann. Surg, vol.257, pp.17-26, 2013. ,
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma, Immunity, vol.44, pp.1444-1454, 2016. ,
,
, Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer, Br. J. Cancer, vol.114, pp.269-280
Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer, Oncotarget, vol.8, pp.76722-76739, 2017. ,
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy, Blood, vol.115, pp.1461-1471, 2010. ,
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma, Cancer Cell, vol.21, pp.418-429, 2012. ,
The metastatic niche: adapting the foreign soil, Nat. Rev. Cancer, vol.9, pp.285-293, 2009. ,
CSF-1R inhibition alters macrophage polarization and blocks glioma progression, Nat. Med, vol.19, pp.1264-1272, 2013. ,
Antitumor effects of somatostatin, Mol. Cell. Endocrinol, vol.286, pp.230-237, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00531996
CCL2 recruits inflammatory monocytes to facilitate breasttumour metastasis, Nature, vol.475, pp.222-225, 2011. ,
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas, Science, vol.352, p.3018, 2016. ,
Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer, Cancer Res, vol.78, pp.4253-4269, 2018. ,
Therapeutic uses of somatostatin and its analogues: Current view and potential applications, Pharmacol. Ther, vol.152, pp.98-110, 2015. ,
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma, 2018. ,
The JAK/STAT signaling pathway, Journal of Cell Science, vol.117, pp.1281-1283, 2004. ,
STAT3 activation: A key factor in tumor immunoescape, p.23010, 2013. ,
Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer, Dev. Cell, vol.45, pp.696-711, 2018. ,
Minimal functional driver gene heterogeneity among untreated metastases, Science, vol.361, pp.1033-1037, 2018. ,
Crossing the endothelial barrier during metastasis, Nature Reviews Cancer, vol.13, pp.858-870, 2013. ,
Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1, Gastroenterology, vol.121, pp.915-930, 2001. ,
Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells, Br. J. Pharmacol, vol.146, pp.77-88, 2005. ,
EMT and dissemination precede pancreatic tumor formation, Cell, vol.148, pp.349-361, 2012. ,
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma, Cancer Cell, vol.25, pp.735-747, 2014. ,
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy, Cancer Cell, vol.25, pp.846-859, 2014. ,
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer, Cancer Discov, vol.6, pp.166-175, 2016. ,
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigenspecific T-cell responses, Cancer Res, vol.64, pp.5839-5849, 2004. ,
Tumour macrophages as potential targets of bisphosphonates, J Transl Med, vol.9, p.177, 2011. ,
Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma, Clin. Cancer Res, vol.22, pp.6021-6030, 2016. ,
, Integrins In Mechanotransduction. Curr Opin Cell Biol, vol.25, pp.613-618, 2013.
, , 2018.
, Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer, Oncogene, vol.37, pp.197-207
Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide, J. Immunol, vol.167, pp.5583-5593, 2001. ,
Actomyosin-mediated cellular tension drives increased tissue stiffness and ?-catenin activation to induce interfollicular epidermal hyperplasia and tumor growth, Cancer Cell, vol.19, pp.776-791, 2011. ,
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination, Proceedings of the National Academy of Sciences, vol.112, pp.10995-11000, 2015. ,
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer, Proc. Natl. Acad. Sci. U.S.A, vol.102, pp.18538-18543, 2005. ,
Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche, Nature, vol.459, pp.262-265, 2009. ,
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium, Gastroenterology, vol.141, pp.1762-1772, 2011. ,
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients, Nat Commun, vol.6, p.7686, 2015. ,
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus, Proc. Natl. Acad. Sci. U.S.A, vol.77, pp.4489-4493, 1980. ,
Beta cells within single human islets originate from multiple progenitors, PLoS ONE, vol.3, p.3559, 2008. ,
Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay, J. Cell. Sci, vol.120, pp.512-519, 2007. ,
A next-generation dual-recombinase system for time and host specific targeting of pancreatic cancer, Nat Med, vol.20, pp.1340-1347, 2014. ,
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion, Science, vol.331, pp.1565-1570, 2011. ,
Gemcitabine combined with the monoclonal antibody nimotuzumab is an active first-line regimen in KRAS wildtype patients with locally advanced or metastatic pancreatic cancer: a multicenter, randomized phase IIb study, Ann Oncol, vol.28, pp.2429-2435, 2017. ,
Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3, Mol. Endocrinol, vol.10, pp.1688-1696, 1996. ,
Cancer related circulating and tumor-associated neutrophils -subtypes, sources and function, The FEBS Journal, vol.0 ,
Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review, Oncotarget, vol.9, pp.21613-21627, 2018. ,
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy, Cell, vol.159, pp.80-93, 2014. ,
A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397, Mol. Biol. Cell, vol.14, pp.4306-4315, 2003. ,
Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and upregulating N-cadherin expression, Cancer Res, vol.66, pp.11745-11753, 2006. ,
The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer, Oncotarget, vol.7, pp.41217-41232, 2016. ,
Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies, Cancer Treat. Rev, vol.40, pp.513-522, 2014. ,
Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms, PLOS ONE, vol.6, 2011. ,
Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat Rev Cancer, vol.14, pp.611-622, 2014. ,
The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis, Immunology, vol.133, pp.221-238, 2011. ,
, CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma, 2016.
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer, Cancer Cell, vol.13, pp.441-453, 2008. ,
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment, Mol. Cancer Ther, vol.10, pp.2135-2145, 2011. ,
Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis, Nat Commun, vol.9, p.2343, 2018. ,
CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells, vol.2, p.26968, 2013. ,
Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity, Gut, vol.63, pp.1769-1781, 2014. ,
T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma, Cancer Cell, vol.28, pp.638-652, 2015. ,
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness, Cell, vol.172, pp.841-856, 2018. ,
Emerging roles of microRNAs in pancreatic cancer diagnosis, therapy and prognosis (Review), Int J Oncol, vol.47, pp.1203-1210, 2015. ,
Phase I study of combination of pasireotide LAR + gemcitabine in locally advanced or metastatic pancreatic cancer, Cancer Chemother. Pharmacol, vol.76, pp.481-487, 2015. ,
Rationale for the use of somatostatin analogs as antitumor agents, Ann. Oncol, vol.17, pp.1733-1742, 2006. ,
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer, Oncotarget, vol.8, pp.66098-66111, 2017. ,
Combination of Two Targeted Medications (Bevacizumab Plus Cetuximab) Improve the Therapeutic Response of Pancreatic Carcinoma, p.3259, 2016. ,
Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages, Oncotarget, 2016. ,
Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation, Nat Commun, vol.9, p.1685, 2018. ,
, Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell, 2016.
The involvement of JAK-STAT3 in cell motility, invasion, and metastasis, vol.3, 2014. ,
Somatostatin receptors: from signaling to clinical practice, Front Neuroendocrinol, vol.34, pp.228-252, 2013. ,
Autocrine Transforming Growth Factor ? Stimulation of Extracellular Matrix Production by Fibroblasts From Fibrotic Human Gingiva, Journal of Periodontology, vol.69, pp.609-619, 1998. ,
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer, Cancer Discov, 2018. ,
Chemotherapy-induced Inflammatory Gene Signature and Pro-tumorigenic Phenotype in Pancreatic CAFs via Stress-associated MAPK, Mol Cancer Res, vol.14, pp.437-447, 2016. ,
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice, Cancer Cell, vol.14, pp.408-419, 2008. ,
Soils and Seeds That Initiate Pancreatic Cancer Metastasis, Cancer Discovery, vol.7, pp.1067-1068, 2017. ,
Tumor metastasis: molecular insights and evolving paradigms, Cell, vol.147, pp.275-292, 2011. ,
Targeting the tumour stroma to improve cancer therapy, Nature Reviews Clinical Oncology, vol.15, pp.366-381, 2018. ,
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis, Sci Transl Med, vol.9, 2017. ,
Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer, Gastroenterology, vol.154, pp.820-838, 2018. ,
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers, Science, vol.359, pp.920-926, 2018. ,
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells, Cancer Res, vol.68, pp.2085-2093, 2008. ,
Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models, p.14 ,
Whole genomes redefine the mutational landscape of pancreatic cancer, Nature, vol.518, pp.495-501, 2015. ,
, GM-CSF Mediates Mesenchymal-Epithelial Crosstalk in Pancreatic Cancer. Cancer Discov, 2016.
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells, Cancer Cell, vol.27, pp.193-210, 2015. ,
Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1, Oncogene, vol.33, pp.514-524, 2014. ,
, , 2013.
, Endothelial cells enhance prostate cancer metastasis via IL-6?androgen receptor?TGF-??MMP-9 signals, Mol. Cancer Ther, vol.12, pp.1026-1037
Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3K? to promote pancreatic cancer metastasis, Cancer Res, 2018. ,
Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers, Oncotarget, vol.6, pp.35684-35698, 2015. ,
Growing vascular endothelial cells express somatostatin subtype 2 receptors, Br. J. Cancer, vol.85, pp.266-272, 2001. ,
Neutrophils support lung colonization of metastasisinitiating breast cancer cells, Nature, vol.528, pp.413-417, 2015. ,
Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines, Gastroenterology, vol.121, pp.657-667, 2001. ,
Analysis of the Human Pancreatic Stellate Cell Secreted Proteome, Pancreas, vol.40, pp.557-566, 2011. ,
A phase Ib study of pembrolizumab plus chemotherapy in patients with advanced cancer (PembroPlus), Br. J. Cancer, vol.117, pp.33-40, 2017. ,
Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation, Nat Cell Biol, vol.18, pp.632-644, 2016. ,
Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer, Clin Cancer Res, vol.21, pp.3561-3568, 2015. ,
Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer Normalization, Not Destruction, Cancer J, vol.21, pp.299-306, 2015. ,
Combination of CD40 Agonism and CSF-1R Blockade Reconditions Tumor-Associated Macrophages and Drives Potent Antitumor Immunity, Cancer Immunol Res, vol.5, pp.1109-1121, 2017. ,
, Endothelial Notch1 Activity Facilitates Metastasis, vol.31, pp.355-367, 2017.
Versican: a versatile extracellular matrix proteoglycan in cell biology, Curr. Opin. Cell Biol, vol.14, pp.617-623, 2002. ,
CTLA-4 Control over Foxp3+ Regulatory T Cell Function, Science, vol.322, pp.271-275, 2008. ,
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets, Nat Commun, vol.6, p.6744, 2015. ,
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer, Nat. Genet, vol.46, pp.994-1000, 2014. ,
The immune network in pancreatic cancer development and progression, Oncogene, vol.33, pp.2956-2967, 2014. ,
, , 2012.
, Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity, Proc Natl Acad Sci U S A, vol.109, pp.11312-11317
Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors, Cancer Res, vol.67, pp.2649-2656, 2007. ,
Activation of stat3 in human melanoma promotes brain metastasis, Cancer Res, vol.66, pp.3188-3196, 2006. ,
, , 2016.
, Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer, vol.7, pp.25408-25419
Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis, Am J Pathol, vol.177, pp.2585-2596, 2010. ,
Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer, Nature, vol.467, pp.1114-1117, 2010. ,
, , 2018.
, Liquid biopsy in pancreatic cancer: the beginning of a new era, Oncotarget, vol.9, pp.26900-26933
Integrin ?v?6 Promotes Lung Cancer Proliferation and Metastasis through Upregulation of IL-8-Mediated MAPK/ERK Signaling, Transl Oncol, vol.11, pp.619-627, 2018. ,
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling, Cancer Research, vol.76, pp.4124-4135, 2016. ,
nab-Paclitaxel mechanisms of action and delivery, J Control Release, vol.170, pp.365-372, 2013. ,
A positive feedback loop bi-stably activates fibroblasts, Nat Commun, vol.9, p.3016, 2018. ,
Novel methylation biomarker panel for the early detection of pancreatic cancer, Clin. Cancer Res, vol.19, pp.6544-6555, 2013. ,
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells, Nat. Cell Biol, vol.8, pp.1398-1406, 2006. ,
The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity, Eur J Immunol, vol.40, pp.2969-2975, 2010. ,
MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway, Oncol. Rep, vol.38, pp.1075-1082, 2017. ,
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis, Nature, vol.487, pp.510-513, 2012. ,
, , 2012.
, CD8+ T Cells Are Compromised In Human Pancreatic Cancer, Translational Medicine, vol.2, pp.1-4
CSF-1R regulates non-small cell lung cancer cells dissemination through Wnt3a signaling, Am J Cancer Res, vol.7, pp.2144-2156, 2017. ,
, , 2017.
, Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma, Cancer Med, vol.6, pp.463-470
High-frequency aberrantly methylated targets in pancreatic adenocarcinoma identified via global DNA methylation analysis using methylCap-seq, Clin Epigenetics, vol.6, p.18, 2014. ,
Paradoxical roles of FAK in tumor cell migration and metastasis, Cell Cycle, vol.8, pp.3474-3479, 2009. ,
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer, Nature, vol.527, pp.525-530, 2015. ,
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion, World J. Gastroenterol, vol.15, pp.1072-1078, 2009. ,
Mutant p53 Together with TGF? Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer, Clin. Cancer Res, vol.23, pp.1607-1620, 2017. ,
Early detection of pancreatic cancer: Where are we now and where are we going?, Int. J. Cancer, vol.141, pp.231-241, 2017. ,
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models, Cancer Res, vol.74, pp.5057-5069, 2014. ,
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression, Immunity, vol.47, pp.323-338, 2017. ,
miR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patients, Carcinogenesis, vol.36, pp.676-684, 2015. ,
High expression of sLex associated with poor survival in Argentinian colorectal cancer patients, Int. J. Biol. Markers, vol.29, pp.30-39, 2014. ,