Following the results of the EMPA-REG OUTCOME trial with empagliflozin, is it possible to speak of a class effect?, Int. J. Gen. Med, vol.10, pp.23-26, 2017. ,
Compositions and methods for improving mitochondrial function and treating neurodenegenerative diseases and cognitive disorders, 2012. ,
Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM, Diabetes, vol.42, pp.1731-1736, 1993. ,
Polyphenols and type 2 diabetes: A prospective review, pp.105-114, 2013. ,
Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?, Gut Microbes, vol.7, pp.146-153, 2016. ,
Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic ?-Cells via Activation of mTORC1, PLoS ONE, vol.4, p.4954, 2009. ,
Endoplasmic Reticulum Stress and Type 2 Diabetes, Annu. Rev. Biochem, vol.81, pp.767-793, 2012. ,
Identification of proliferative and mature ?-cells in the islets of Langerhans, Nature, vol.535, pp.430-434, 2016. ,
Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells: Quercetin increases L-type Ca currents in beta cells, Br. J. Pharmacol, vol.169, pp.1102-1113, 2013. ,
Pathophysiology of impaired pulsatile insulin release, Diabetes Metab. Res. Rev, vol.16, pp.179-191, 2000. ,
The Elevation of Glutamate Content and the Amplification of Insulin Secretion in Glucose-stimulated Pancreatic Islets Are Not Causally Related, J. Biol. Chem, vol.277, pp.32883-32891, 2002. ,
Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR?-Dependent Switch From Lipogenesis to Fat Oxidation, Diabetes, vol.64, pp.2398-2408, 2015. ,
Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus, Nutr. Res, vol.32, pp.537-541, 2012. ,
T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulin-secreting beta-cell line, INS-1. Endocrinology, vol.138, pp.3735-3740, 1997. ,
Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay, J. Agric. Food Chem, vol.57, pp.10181-10186, 2009. ,
Handbook of Diabetes, 4th Edition, Excerpt #4: Normal Physiology of Insulin Secretion and Action, 2014. ,
Physiology: Pancreatic ?-cell heterogeneity revisited, Nature, vol.535, pp.365-366, 2016. ,
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ? Cells, PLOS Biol, vol.4, p.31, 2005. ,
Impact of the gut microbiota on inflammation, obesity, and metabolic disease, Genome Med, vol.8, 2016. ,
Voltage-Gated Ion Channels in Human Pancreatic -Cells: Electrophysiological Characterization and Role in Insulin Secretion, Diabetes, vol.57, pp.1618-1628, 2008. ,
The genetics of Caenorhabditis elegans, Genetics, vol.77, pp.71-94, 1974. ,
Differential activation mechanisms of Erk-1/2 and p70S6K by glucose in pancreatic ?-cells, Diabetes, vol.52, pp.974-983, 2003. ,
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy, J. Histochem. Cytochem, vol.53, pp.1087-1097, 2005. ,
TRPM5 regulates glucose-stimulated insulin secretion. Pflüg. Arch. -Eur, J. Physiol, vol.460, pp.69-76, 2010. ,
Structure and function of the ? subunit of voltage-gated Ca2+ channels, Biochim. Biophys. Acta BBA -Biomembr, vol.1828, pp.1530-1540, 2013. ,
?-cell deficit and increased ?-cell apoptosis in humans with type 2 diabetes, Diabetes, vol.52, pp.102-110, 2003. ,
Genome sequence of the nematode C. elegans: a platform for investigating biology, Science, vol.282, pp.2012-2018, 1998. ,
Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic ? Cells, J. Agric. Food Chem, vol.57, pp.9817-9827, 2009. ,
Short-chain fatty acids in control of body weight and insulin sensitivity, Nat. Rev. Endocrinol, vol.11, pp.577-591, 2015. ,
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, Diabetes, vol.56, pp.1761-1772, 2007. ,
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia, Diabetologia, vol.50, pp.2374-2383, 2007. ,
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice, Diabetes, vol.57, pp.1470-1481, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00410066
Structure and regulation of voltage-gated Ca2+ channels, Annu. Rev. Cell Dev. Biol, vol.16, pp.521-555, 2000. ,
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels, Pharmacol. Rev, vol.57, pp.411-425, 2005. ,
Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice, Eur. J. Nutr, vol.42, pp.18-28, 2003. ,
The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans, Eur. J. Nutr, vol.43, pp.205-220, 2004. ,
Identification of Urolithin A as a Metabolite Produced by Human Colon Microflora from Ellagic Acid and Related Compounds, J. Agric. Food Chem, vol.53, pp.5571-5576, 2005. ,
Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability, J. Agric. Food Chem, vol.53, pp.227-235, 2005. ,
Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum, Br. J. Nutr, vol.91, p.849, 2004. ,
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action, Diabetes, vol.50, pp.1302-1310, 2001. ,
Uncoupling protein 2 and islet function, Diabetes, vol.53, pp.136-142, 2004. ,
Did the gradual loss of GLUT2 cause a shift to diabetic disorders in the New Zealand obese mouse (NZO/Hl)?, Exp. Clin. Endocrinol. Diabetes Off. J. Ger. Soc. Endocrinol. Ger. Diabetes Assoc, vol.114, pp.262-269, 2006. ,
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice, Cell, vol.84, pp.491-495, 1996. ,
TRPM4 controls insulin secretion in pancreatic beta-cells, Cell Calcium, vol.41, pp.51-61, 2007. ,
Mitochondrial Ca2+ sequestration and precipitation revisited, FEBS J, vol.277, pp.3637-3651, 2010. ,
Estimated dietary flavonoid intake and major food sources of US adults, J. Nutr, vol.137, pp.1244-1252, 2007. ,
Transient Receptor Potential Cation Channels in Pancreatic ? Cells, Reviews of Physiology, vol.161, pp.87-110, 2011. ,
Excerpt #4: Normal Physiology of Insulin Secretion and Action, 2014. ,
Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas, Pharmacol. Res, vol.51, pp.117-123, 2005. ,
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network, Nat. Med, vol.21, pp.498-505, 2015. ,
Dietary phenolics: chemistry, bioavailability and effects on health, Nat. Prod. Rep, vol.26, p.1001, 2009. ,
Inhibition of Pancreatic -Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance, J. Biol. Chem, vol.289, pp.12435-12445, 2014. ,
Functional biology of the ?2? subunits of voltage-gated calcium channels, Trends Pharmacol. Sci, vol.28, pp.220-228, 2007. ,
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase, FEBS Lett, vol.468, pp.166-170, 2000. ,
PIP 2 in pancreatic ?-cells regulates voltage-gated calcium channels by a voltage-independent pathway, Am. J. Physiol. -Cell Physiol, vol.311, pp.630-640, 2016. ,
, , 2013.
, Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases, Antioxid. Redox Signal, vol.18, pp.1818-1892
Modelling the possible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior, Food Funct, vol.4, pp.1442-1451, 2013. ,
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1, Diabetologia, vol.46, pp.1383-1393, 2003. ,
Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets, Mol. Metab, vol.5, pp.449-458, 2016. ,
Insulin effects in muscle and adipose tissue, Diabetes Res. Clin. Pract, vol.93, pp.52-59, 2011. ,
Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis, Diabetes Care, vol.37, pp.569-586, 2014. ,
Targeting inflammation in the treatment of type 2 diabetes: time to start, Nat. Rev. Drug Discov, vol.13, pp.465-476, 2014. ,
Ca2+-dependent Dephosphorylation of Kinesin Heavy Chain on -Granules in Pancreatic -Cells: IMPLICATIONS FOR REGULATED -GRANULE TRANSPORT AND INSULIN EXOCYTOSIS, J. Biol. Chem, vol.277, pp.24232-24242, 2002. ,
Human islets contain four distinct subtypes of ? cells, Nat. Commun, vol.7, p.11756, 2016. ,
Glucotoxicity inhibits late steps of insulin exocytosis, Endocrinology, vol.148, pp.1605-1614, 2007. ,
Cholecystokinin and Gastrin Receptors, Physiol. Rev, vol.86, pp.805-847, 2006. ,
, , 2016.
, Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion, Mol. Metab, vol.5, pp.980-987
, , 2007.
, Iberian Pig as a Model To Clarify Obscure Points in the Bioavailability and Metabolism of Ellagitannins in Humans, J. Agric. Food Chem, vol.55, pp.10476-10485
Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far, Evid. Based Complement. Alternat. Med, vol.2013, pp.1-15, 2013. ,
Toward Connecting Metabolism to the Exocytotic Site, Trends Cell Biol, vol.27, pp.163-171, 2017. ,
The role of interleukins in insulin resistance and type 2 diabetes mellitus, Nat. Rev. Endocrinol, vol.5, pp.305-311, 2009. ,
Inositol Trisphosphate Receptor Ca2+ Release Channels, Physiol. Rev, vol.87, pp.593-658, 2007. ,
A Double-Blind, Randomized, Neoadjuvant Study of the Tissue Effects of POMx Pills in Men with Prostate Cancer Before Radical Prostatectomy, Cancer Prev. Res. (Phila. Pa.), vol.6, pp.1120-1127, 2013. ,
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes, Curr. Diabetes Rev, vol.9, pp.25-53, 2013. ,
SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol, Diabetes, vol.59, pp.551-553, 2010. ,
Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay, Pharm, vol.60, pp.796-797, 2005. ,
Mécanisme de la fusion membranaire, 2002. ,
, Médecine/Sciences, vol.18, pp.1113-1119
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice, Diabetes, vol.58, pp.1509-1517, 2009. ,
Time Course Production of Urolithins from Ellagic Acid by Human Gut Microbiota, J. Agric. Food Chem, vol.61, pp.8797-8806, 2013. ,
Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids, Endocrinology, vol.149, pp.4519-4526, 2008. ,
, , 2017.
, Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients, Eur. J. Clin. Nutr, vol.71, pp.92-96
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function, Endocr. Rev, vol.22, pp.565-604, 2001. ,
Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo, Diabetes, vol.51, pp.144-151, 2002. ,
Calcium signaling in pancreatic ?-cells in health and in Type 2 diabetes, Cell Calcium, vol.56, pp.340-361, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01942948
Intestinal Ellagitannin Metabolites Ameliorate Cytokine-Induced Inflammation and Associated Molecular Markers in Human Colon Fibroblasts, J. Agric. Food Chem, vol.60, pp.8866-8876, 2012. ,
Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-?-induced inflammation and associated molecular markers in human aortic endothelial cells, Mol. Nutr. Food Res, vol.56, pp.784-796, 2012. ,
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells, Mol. Nutr. Food Res, vol.59, pp.2155-2167, 2015. ,
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance, Cell Metab, vol.15, pp.635-645, 2012. ,
Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies, Drug Metab. Dispos, vol.39, pp.1680-1688, 2011. ,
Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins, Mol. Nutr. Food Res, vol.53, pp.686-698, 2009. ,
Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice, Mol. Nutr. Food Res, vol.54, pp.311-322, 2010. ,
NF-?Bdependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts, Br. J. Nutr, vol.104, pp.503-512, 2010. ,
Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells, Eur. J. Nutr, vol.53, pp.853-864, 2014. ,
The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells, Food Funct, vol.6, pp.1460-1469, 2015. ,
Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved, Mol. Nutr. Food Res, vol.60, pp.701-716, 2016. ,
Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomised clinical trial, Mol. Nutr. Food Res, 2016. ,
Production of spontaneous diabetic rats by repetition of selective breeding, Tohoku J. Exp. Med, vol.119, pp.85-90, 1976. ,
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse, Biochem. J, vol.199, pp.393-398, 1981. ,
Inflammatory Mechanisms in Obesity, Annu. Rev. Immunol, vol.29, pp.415-445, 2011. ,
Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-? pathway, Mol. Nutr. Food Res, vol.60, pp.1933-1943, 2016. ,
Advances in flavonoid research since 1992, Phytochemistry, vol.55, pp.481-504, 2000. ,
Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells, J. Biol. Chem, vol.280, pp.11107-11113, 2005. ,
High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects, Diabetes Care, vol.35, pp.375-382, 2012. ,
, HAS, 2013.
Formation of Urolithins in Normal Volunteers Following Pomegranate Extract Consumption for 28 Days is Associated with Differences in the Gut Microflora Population, FASEB J, vol.29, 2015. ,
Triggering and amplifying pathways of regulation of insulin secretion by glucose, Diabetes, vol.49, pp.1751-1760, 2000. ,
Regulation of insulin secretion: a matter of phase control and amplitude modulation, Diabetologia, vol.52, pp.739-751, 2009. ,
, , 2014.
The Physiology of Glucagon-like Peptide 1, Physiol. Rev, vol.87, pp.1409-1439, 2007. ,
High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress-Mediated ?-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes, Diabetes, vol.56, pp.2016-2027, 2007. ,
Dominant Role of Sarcoendoplasmic Reticulum Ca 2+ -ATPase Pump in Ca 2+ Homeostasis and Exocytosis in Rat Pancreatic ?-Cells, Endocrinology, vol.147, pp.1396-1407, 2006. ,
SGLT-2 inhibitors and cardiovascular risk in diabetes mellitus: A comprehensive and critical review of the literature, Curr. Pharm. Des, 2017. ,
,
, A 3D map of the islet routes throughout the healthy human pancreas, Sci. Rep, vol.5, p.14634
In vivo antiinflammatory and antioxidant properties of ellagitannin metabolite urolithin A, Bioorg. Med. Chem. Lett, vol.21, pp.5901-5904, 2011. ,
, , 2005.
, Redox Control of Exocytosis. Diabetes, vol.54, pp.2132-2142
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide, Proc. Natl. Acad. Sci, vol.93, pp.7283-7288, 1996. ,
Insulin Secretion by Bioactive Anthocyanins and Anthocyanidins Present in Fruits, J. Agric. Food Chem, vol.53, pp.28-31, 2005. ,
Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species: Effects of green tea on fecal microbiota, Microbiol. Immunol, vol.56, pp.729-739, 2012. ,
CaV2.3 calcium channels control second-phase insulin release, J. Clin. Invest, vol.115, pp.146-154, 2005. ,
The Origins and Drivers of Insulin Resistance, Cell, vol.152, pp.673-684, 2013. ,
Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells, FEBS Lett, vol.579, pp.1653-1657, 2005. ,
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose, Cell Metab, vol.24, pp.389-401, 2016. ,
Diacylglycerol Activation of Protein Kinase C? and Hepatic Insulin Resistance, Cell Metab, vol.15, pp.574-584, 2012. ,
Subunit of Voltage-activated Calcium Channels, J. Biol. Chem, vol.278, pp.21315-21318, 2003. ,
Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms, Adv. Nutr. Int. Rev. J, vol.7, pp.961-972, 2016. ,
Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes, Mol. Nutr. Food Res, vol.60, pp.1129-1138, 2016. ,
Munc13-1 is required for the sustained release of insulin from pancreatic ? cells, Cell Metab, vol.3, pp.463-468, 2006. ,
Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic ?-Cell Apoptosis, Endocrinology, vol.147, pp.3398-3407, 2006. ,
Assessing the Human Gut Microbiota in Metabolic Diseases, Diabetes, vol.62, pp.3341-3349, 2013. ,
Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells, J. Agric. Food Chem, vol.57, pp.10636-10644, 2009. ,
Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins, J. Agric. Food Chem, vol.58, pp.2180-2187, 2010. ,
OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain, Diabetes Res. Clin. Pract, vol.24, pp.317-320, 1994. ,
Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation, Pancreas, vol.35, pp.1-9, 2007. ,
Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity, Physiol. Genomics, vol.22, pp.171-181, 2005. ,
Polyphenols and Glycemic Control, Nutrients, vol.8, p.17, 2016. ,
The use of animal models in diabetes research: Animal models of diabetes, Br. J. Pharmacol, vol.166, pp.877-894, 2012. ,
Rodent models of diabetic nephropathy: their utility and limitations, Int. J. Nephrol. Renov. Dis, vol.9, pp.279-290, 2016. ,
Quercetin Stimulates Insulin Secretion and Reduces the Viability of Rat INS-1 Beta-Cells, Cell. Physiol. Biochem, vol.39, pp.278-293, 2016. ,
Adipokines Mediate Inflammation and Insulin Resistance, 2013. ,
Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health, Food Res. Int, vol.44, pp.1150-1160, 2011. ,
, , 2006.
Ellagic Acid-Derived Metabolites Produced by Human Colonic Microflora, Exhibit Estrogenic and Antiestrogenic Activities, J. Agric. Food Chem, vol.54, pp.1611-1620 ,
Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism?, J. Nutr. Biochem, vol.21, pp.717-725, 2010. ,
Richness of human gut microbiome correlates with metabolic markers, Nature, vol.500, pp.541-546, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01190602
Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice, PLoS ONE, vol.7, 2012. ,
Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications, Diabetologia, vol.30, pp.443-452, 1987. ,
Zinc and insulin in pancreatic beta-cells, Endocrine, vol.45, pp.178-189, 2014. ,
Purified Anthocyanin Supplementation Reduces Dyslipidemia, Enhances Antioxidant Capacity, and Prevents Insulin Resistance in Diabetic Patients, J. Nutr, vol.145, pp.742-748, 2015. ,
Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers, Food Funct, vol.6, pp.2487-2495, 2015. ,
Effect of Lipopolysaccharide on Inflammation and Insulin Action in Human Muscle, PLoS ONE, vol.8, p.63983, 2013. ,
A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.3202-3206, 2009. ,
The Physiology of Obese-Hyperglycemic Mice, 2007. ,
, Sci. World J, vol.7, pp.666-685
Extracellularly Regulated Kinases 1/2 (p44/42 Mitogen-Activated Protein Kinases) Phosphorylate Synapsin I and Regulate Insulin Secretion in the MIN6 ?-Cell Line and Islets of Langerhans, Endocrinology, vol.146, pp.643-654, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00358808
The RalA GTPase Is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells, J. Biol. Chem, vol.283, pp.17939-17945, 2008. ,
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes, Exp. Mol. Med, vol.49, p.291, 2017. ,
TRP-ing Down the Path to Insulin Secretion, Diabetes, vol.60, pp.28-29, 2011. ,
Mitochondrial glutamate acts as a messenger in glucoseinduced insulin exocytosis, Nature, vol.402, pp.685-689, 1999. ,
In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion, Int. J. Biochem. Cell Biol, vol.38, pp.696-709, 2006. ,
Production et sécrétion de l'insuline par la cellule ? pancréatique, EMC -Endocrinol, vol.2, pp.241-264, 2005. ,
Polyphenols: food sources and bioavailability, Am. J. Clin. Nutr, vol.79, pp.727-747, 2004. ,
The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?, Trends Endocrinol. Metab, vol.24, pp.398-407, 2013. ,
Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic ?-Cells, Pancreas, vol.46, pp.97-101, 2017. ,
TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic ?-cells, Mol. Cell. Endocrinol, vol.299, pp.194-203, 2009. ,
Anti-obesogenic and antidiabetic effects of plants and mushrooms, Nat. Rev. Endocrinol, 2016. ,
Loss of ?2?-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes, Diabetes db151349, 2017. ,
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm, Diabetes, vol.45, pp.223-241, 1996. ,
Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes, Ilar J, vol.47, pp.225-233, 2006. ,
Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance: The Role of IAPP-Induced -Cell Endoplasmic Reticulum Stress, Diabetes, vol.58, pp.906-916, 2009. ,
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus, Mol. Genet. Metab, vol.104, pp.648-653, 2011. ,
The inhibitory effects of berry polyphenols on digestive enzymes, BioFactors Oxf. Engl, vol.23, pp.189-195, 2005. ,
Antiatherogenic effects of ellagic acid and urolithins in vitro, Arch. Biochem. Biophys, vol.599, pp.42-50, 2016. ,
Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine, J. Gerontol, vol.34, pp.28-36, 1979. ,
Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat, Diabetologia, vol.40, pp.916-925, 1997. ,
A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes, Obesity, vol.17, pp.310-317, 2009. ,
Overexpression of GPR40 in Pancreatic -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice, Diabetes, vol.58, pp.1067-1076, 2009. ,
Dietary flavonoids and flavonoid-rich foods are not associated with risk of type 2 diabetes in postmenopausal women, J. Nutr, vol.136, pp.3039-3045, 2006. ,
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods, Database J. Biol. Databases Curation, 2010. ,
A Direct Interaction between Cdc42 and Vesicle-associated Membrane Protein 2 Regulates SNARE-dependent Insulin Exocytosis, J. Biol. Chem, vol.280, pp.1944-1952, 2005. ,
Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells, Br. J. Pharmacol, vol.172, pp.5050-5067, 2015. ,
Breeding of Mice Strains for Diabetes Mellitus, Exp. Anim, vol.18, pp.147-157, 1969. ,
CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells, J. Mol. Endocrinol, vol.41, pp.1-11, 2008. ,
Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients, Mol. Nutr. Food Res, vol.58, pp.1199-1211, 2014. ,
Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane, Diabetes, vol.56, pp.1888-1897, 2007. ,
Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus, J. Clin. Invest, vol.92, p.262, 1993. ,
Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes, N. Engl. J. Med, vol.318, pp.1225-1230, 1988. ,
, The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility, vol.8, p.78, 2016.
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance, Nat. Med, vol.18, pp.1279-1285, 2012. ,
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats, Biomed. Pharmacother. Biomedecine Pharmacother, vol.62, pp.598-605, 2008. ,
Plant polyphenols as dietary antioxidants in human health and disease, Oxid. Med. Cell. Longev, vol.2, pp.270-278, 2009. ,
A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM, Diabetologia, vol.38, pp.1213-1217, 1995. ,
Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial, Br. J. Nutr, vol.117, pp.519-531, 2017. ,
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals, Cell Metab, vol.8, pp.301-309, 2008. ,
Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans, PLoS ONE, vol.9, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01859365
TRP channels: An overview, Cell Calcium, vol.38, pp.233-252, 2005. ,
Heterogeneity in Pancreatic ?-cell Population, Diabetes, vol.41, pp.777-781, 1992. ,
Influence of Gut Microbiota-Derived Ellagitannins? Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils, Planta Med, vol.80, pp.887-895, 2014. ,
Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages, Mol. Nutr. Food Res, vol.59, pp.2168-2177, 2015. ,
Glucolipotoxicity: Fuel Excess and ?-Cell Dysfunction, Endocr. Rev, vol.29, pp.351-366, 2008. ,
Regulation of the insulin gene by glucose and fatty acids, J. Nutr, vol.136, pp.873-876, 2006. ,
Glucolipotoxicity of the pancreatic beta cell, Biochim. Biophys. Acta BBA -Mol. Cell Biol. Lipids, vol.1801, pp.289-298, 2010. ,
Estimating the Delay Between Onset and Diagnosis of Type 2 Diabetes From the Time Course of Retinopathy Prevalence, Diabetes Care, vol.37, pp.1668-1674, 2014. ,
TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.15166-15171, 2003. ,
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents, Int. J. Obes, vol.39, pp.424-429, 2005. ,
A metagenome-wide association study of gut microbiota in type 2 diabetes, Nature, vol.490, pp.55-60, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01204262
Different Metabolic Responses in ?-, ?-, and ?-Cells of the Islet of Langerhans Monitored by Redox Confocal Microscopy, Biophys. J, vol.90, pp.2641-2650, 2006. ,
Glutaredoxin-1 Mediates NADPH-Dependent Stimulation of Calcium-Dependent Insulin Secretion, Mol. Endocrinol, vol.23, pp.893-900, 2009. ,
The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes, Diabetologia, vol.56, pp.340-349, 2013. ,
Beta phorbol ester-and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs, Cell, vol.108, pp.121-133, 2002. ,
The composition of the gut microbiota throughout life, with an emphasis on early life, Microb. Ecol. Health Dis, vol.26, 2015. ,
Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production, J. Funct. Foods, vol.17, pp.785-791, 2015. ,
,
, Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome, Diabetes, vol.64, pp.2847-2858
Insulin granule dynamics in pancreatic beta cells, Diabetologia, vol.46, pp.1029-1045, 2003. ,
Regulation of calcium in pancreatic ?-and ?-cells in health and disease, Cell Calcium, vol.51, pp.300-308, 2012. ,
Resveratrol and curcumin enhance pancreatic ?-cell function by inhibiting phosphodiesterase activity, J. Endocrinol, vol.223, pp.107-117, 2014. ,
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents, Nat. Med, vol.22, pp.879-888, 2016. ,
Store-operated Ca 2+ entry: a key component of the insulin secretion machinery, J. Mol. Endocrinol, vol.57, pp.35-39, 2016. ,
Store-Operated Ca2+ Entry Mediated by Orai1 and TRPC1 participates to Insulin Secretion in Rat Beta-cells, J. Biol. Chem. jbc, 2015. ,
Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials, Pharmacol. Res, vol.115, pp.149-161, 2017. ,
Urolithin A causes p21 up-regulation in prostate cancer cells, Eur. J. Nutr, vol.55, pp.1099-1112, 2016. ,
Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII, Mol. Metab, vol.3, pp.484-489, 2014. ,
Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans, PLoS ONE, vol.8, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01189799
Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells, Proc. Natl. Acad. Sci. U. S. A, vol.85, pp.3865-3869, 1988. ,
Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours, J. Nutr, vol.136, pp.2481-2485, 2006. ,
Pharmacokinetics and tissue disposition of urolithin A, an ellagitannin-derived metabolite, in mice, FASEB J, vol.21, pp.1081-1081, 2007. ,
Interaction between Phenolics and Gut Microbiota: Role in Human Health, J. Agric. Food Chem, vol.57, pp.6485-6501, 2009. ,
Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species, Food Funct, vol.5, p.1779, 2014. ,
, , 2014.
, Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut, Int. J. Syst. Evol. Microbiol, vol.64, pp.2346-2352
The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism, Food Funct, vol.7, pp.1769-1774, 2016. ,
The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome, Clin. Nutr, 2017. ,
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase, Nature, vol.288, pp.187-189, 1980. ,
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people, Lancet Diabetes Endocrinol, vol.3, pp.105-113, 2015. ,
Effects of Fruit Ellagitannin Extracts, Ellagic Acid, and Their Colonic Metabolite, Urolithin A, on Wnt Signaling ?, J. Agric. Food Chem, vol.58, pp.3965-3969, 2010. ,
A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion, J. Mol. Med, 2017. ,
Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms, FEBS Lett, vol.587, pp.3281-3287, 2013. ,
Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells, J. Physiol, vol.499, pp.625-635, 1997. ,
Polyphenols: potential future arsenals in the treatment of diabetes, Curr. Pharm. Des, vol.22, pp.549-565, 2016. ,
Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis, J. Am. Coll. Nutr, vol.24, pp.376-384, 2005. ,
Overexpression of perilipin A and B blocks the ability of tumor necrosis factor ? to increase lipolysis in 3T3-L1 adipocytes, J. Biol. Chem, vol.273, pp.24665-24669, 1998. ,
Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, Human Aortic Endothelial Cells. Molecules, vol.21, p.1009, 2016. ,
Animal models in type 2 diabetes research: an overview, Indian J. Med. Res, vol.125, pp.451-472, 2007. ,
Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition, Islets, vol.2, pp.135-145, 2010. ,
Prediabetes: a high-risk state for diabetes development, The Lancet, vol.379, pp.2279-2290, 2012. ,
Inhibition of alpha-glucosidase and alpha-amylase by flavonoids, J. Nutr. Sci. Vitaminol. (Tokyo), vol.52, pp.149-153, 2006. ,
Estimated Dietary Polyphenol Intake and Major Food and Beverage Sources among Elderly Japanese, Nutrients, vol.7, pp.10269-10281, 2015. ,
Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects, Obes. Silver Spring Md, vol.20, pp.1530-1533, 2012. ,
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants, Proc. Natl. Acad. Sci, vol.96, pp.10857-10862, 1999. ,
Role of high-voltage-activated calcium channels in glucose-regulated -cell calcium homeostasis and insulin release, AJP Endocrinol. Metab, vol.289, pp.900-908, 2005. ,
, , 1990.
, RADIOIMMUNOASSAY MAY OVERESTIMATE INSULIN IN NON-INSULIN-DEPENDENT DIABETICS, vol.32, pp.689-693
Signal transduction via TRPM3 channels in pancreaticcells, J. Mol. Endocrinol, vol.50, pp.75-83, 2013. ,
Glucose-Stimulated Insulin Secretion Is Coupled to the Interaction of Actin with the t-SNARE (Target Membrane Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Protein) Complex, Mol. Endocrinol, vol.17, pp.732-742, 2003. ,
Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat, Diabetes, vol.44, pp.1447-1457, 1995. ,
Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2, Diabetes, vol.61, pp.364-371, 2012. ,
, , 2014.
, Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status, J. Agric. Food Chem, vol.62, pp.6535-6538
Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides, Physiol. Rev, vol.81, pp.1031-1064, 2001. ,
Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice, Diabetes, vol.60, pp.119-126, 2011. ,
Urocortin3 mediates somatostatindependent negative feedback control of insulin secretion, Nat. Med, vol.21, pp.769-776, 2015. ,
Coffee and tea consumption and risk of type 2 diabetes, Diabetologia, vol.52, pp.2561-2569, 2009. ,
Isoforms of endoplasmic reticulum Ca2+-ATPase are differentially expressed in normal and diabetic islets of Langerhans, Biochem. J, vol.319, pp.521-527, 1996. ,
Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells, Mol. Pharmacol, vol.90, pp.341-357, 2016. ,
Six-Week Consumption of a Wild Blueberry Powder Drink Increases Bifidobacteria in the Human Gut, J. Agric. Food Chem, vol.59, pp.12815-12820, 2011. ,
Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites, Mol. Nutr. Food Res, vol.55, pp.35-43, 2011. ,
Antidiabetic effects of quercetin in streptozocininduced diabetic rats, Comp. Biochem. Physiol. Toxicol. Pharmacol. CBP, vol.135, pp.357-364, 2003. ,
Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E -Cells and Human Islets through a SIRT1-dependent Mechanism, J. Biol. Chem, vol.286, pp.6049-6060, 2011. ,
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic ? cells, Nat. Cell Biol, vol.10, pp.1421-1430, 2008. ,
Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2, Diabetes. Cells, vol.2, pp.266-283, 2013. ,
Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans, J. Nutr, vol.135, pp.48-52, 2005. ,
Protein Kinase Activation Increases Insulin Secretion by Sensitizing the Secretory Machinery to Ca 2+, J. Gen. Physiol, vol.124, pp.653-662, 2004. ,
ER stress and SREBP-1 activation are implicated in -cell glucolipotoxicity, J. Cell Sci, vol.118, pp.3905-3915, 2005. ,
Mechanisms of biphasic insulin-granule exocytosis -roles of the cytoskeleton, small GTPases and SNARE proteins, J. Cell Sci, vol.122, pp.893-903, 2009. ,
Mechanisms of biphasic insulin-granule exocytosis -roles of the cytoskeleton, small GTPases and SNARE proteins, J. Cell Sci, vol.122, pp.893-903, 2009. ,
Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest, vol.112, pp.1796-1808, 2003. ,
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas, Regul. Pept, vol.107, pp.63-69, 2002. ,
Effect of rectal infusion of short chain fatty acids in human subjects, Am. J. Gastroenterol, vol.84, pp.1027-1033, 1989. ,
Interaction between colonic acetate and propionate in humans, Am. J. Clin. Nutr, vol.53, pp.681-687, 1991. ,
, Global report on diabetes, 2016.
Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic ?-Cells, Sci. Rep, vol.6, 2016. ,
Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, Biosci. Biotechnol. Biochem, vol.73, pp.570-576, 2009. ,
The Role of Voltage-Gated Calcium Channels in Pancreatic ?-Cell Physiology and Pathophysiology, Endocr. Rev, vol.27, pp.621-676, 2006. ,
Syntaxin 1 interacts with the LD subtype of voltage-gated Ca2+ channels in pancreatic ? cells, Proc. Natl. Acad. Sci. U. S. A, vol.96, pp.10164-10169, 1999. ,
Tea consumption and risk of type 2 diabetes: a dose-response meta-analysis of cohort studies, Br. J. Nutr, vol.111, pp.1329-1339, 2014. ,
Quercetin potentiates insulin secretion and protects INS-1 pancreatic ?-cells against oxidative damage via the ERK1/2 pathway: Quercetin effects on pancreatic ?-cells, Br. J. Pharmacol, vol.161, pp.799-814, 2010. ,
Pomegranate's Neuroprotective Effects against Alzheimer's Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites, ACS Chem. Neurosci, vol.7, pp.26-33, 2016. ,
Regulation of insulin secretion by phospholipase C, Am. J. Physiol, vol.271, pp.409-416, 1996. ,
Endoplasmic Reticulum Stress and Associated ROS, Int. J. Mol. Sci, vol.17, 2016. ,
Epigallocatechin-3-Ogallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition, Phytomedicine, vol.17, pp.14-18, 2010. ,
Diabetes Onset at 31-45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2, Diabetes. Sci. Rep, vol.6, p.38113, 2016. ,