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, Les signaux physiques du microenvironnement de la cellule peuvent-être transduits au noyau par l'intermédiaire du cytosquelette, qui va alors moduler l'organisation de la chromatine et donc l'expression des gènes : c'est la mécano transduction. Plusieurs études illustrent l'importance du cytosquelette d'actine dans les cellules adhérentes dans ce phénomène mais le rôle d'autres éléments du cytosquelette, comme les microtubules, reste encore mal connu. De plus, la mécano transduction dans les cellules non-adhérentes a peu été étudiées, cellules où l'organisation de l'actine ne permet pas de générer des forces sur le noyau. Le travail présenté ici montre que les microtubules peuvent déformer le noyau et réguler l'organisation de la chromatine dans un système de cellules souches non adhérentes, Rôle de l'interaction entre le noyau et les microtubules dans la régulation de l'organisation de la chromatine dans les cellules souches hématopoïétiques Résumé : Les cellules souches hématopoïétiques sont caractérisées