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Interplay between the nucleus and the microtubules : role in the regulation of chromatin organization in hematopoietic stem cells

Abstract : Hematopoietic stem cells are characterized, like every stem cells, by their self-renewal and differentiation ability so they can sustain mature blood cells populations. How stem cells engage in one or the other path is poorly understood but increasing number of evidence in different stem cell types highlight the importance of mechanical signal integration. Physical cues form the environment can be transduced to the nucleus via the cytoskeleton, to impact chromatin organization and therefore gene expression: this process is called mechanotransduction. Many studies bring light to the importance of the actin cytoskeleton in adherent cells in this process but very little is known about the contribution of microtubules in this process. Moreover, even less is known about mechanotransduction in non adherent cells, in which actin organization is likely to have smaller impact than in adherent cells. The present work show that microtubules can impact nuclear shape and chromatin organization in a system of non-adherent stem cells, the hematopoietic stem cells (HSCs).
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Stéphane Biedzinski. Interplay between the nucleus and the microtubules : role in the regulation of chromatin organization in hematopoietic stem cells. Human health and pathology. Université Sorbonne Paris Cité, 2018. English. ⟨NNT : 2018USPCC228⟩. ⟨tel-02470737⟩

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