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Elaboration of nanofibrous biomimetic scaffolds based on poly(glycerol sebacate) for cardiac tissue engineering

Abstract : Cardiac tissue engineering aims to regenerate the heart. This technic relies on the use of a scaffold where the cells can proliferate. To be efficient, this scaffold should mimic mechanical and structural properties of the myocardium. In this thesis, poly(glycerol sebacate) (PGS) was chosen as building material. Its synthesis was studied, showing which parameters should be controlled in order to get the expected properties. In particular, mechanical properties fitting cardiac muscle’s ones can be obtained. Electrospinning was chosen as process method. This method allows the fabrication of nanofibrous mats mimicking biological tissues structure. As PGS processing is difficult because it is insoluble, it was electrospun at the prepolymer state, blended with another polymer. In this way, cardiac patches composed of poly(lactic acid) and PGS were fabricated. Furthermore, PGS was blended with polyvinylpyrrolidone and cyclodextrin to prepare elastomeric membranes with mechanical properties adapted to the heart. Finally, PGS was used in particles in order to organize PLA fibers deposits into structures able to improve cells and tissues development.
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https://tel.archives-ouvertes.fr/tel-02469531
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Submitted on : Thursday, February 6, 2020 - 3:49:20 PM
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  • HAL Id : tel-02469531, version 1

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Florence Flaig. Elaboration of nanofibrous biomimetic scaffolds based on poly(glycerol sebacate) for cardiac tissue engineering. Polymers. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAE045⟩. ⟨tel-02469531⟩

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