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Theses

Le silicium pour la production catalytique d'hydrogène et la synthèse d'amides

Abstract : This thesis is based on the use of silicon and its derivatives as species that can meet some current technical challenges. The silylation of alcohols by phenylsilane is an attractive method for the gentle production of hydrogen. This project has demonstrated efficient catalysis with simple and available nitrogen bases. The study of the reaction mechanism suggests that alcohol deprotonation is decisive for this reaction. Phenylsilane has proved its utility in the context of amide synthesis, but also for peptide synthesis in the absence of epimerization. Subsequently, this methodology was extended to synthesis of several Weinreb amides. In order to better understand the reaction mechanism, the synthesis of some substituted phenylsilanes with electron-withdrawing groups and electron-donor groups was undertaken. Finally, the acetylation of amines using silicon acetate was examined. A large panel of primary, secondary amines and anilines were easily acetylated, revealing the synthetic interest of silicon acetate in organic chemistry.
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Eleonore Morisset. Le silicium pour la production catalytique d'hydrogène et la synthèse d'amides. Chimie organique. Normandie Université, 2019. Français. ⟨NNT : 2019NORMC233⟩. ⟨tel-02468972⟩

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