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Theses

Déterminants à la participation ou non à un essai vaccinal préventif

Abstract : The development of new vaccines remains crucial, particularly in the context of epidemics due to emerging pathogens and the fight against antibiotic resistance. Clinical development of vaccines is time consuming and expensive. Optimizing recruitment in these trials is therefore essential. The objective was therefore to identify the barriers and motivations to participation in a vaccine trial. Altruism and financial incentives were identified in our literature review as the main motivating factors and fear of side effects and study design as the main obstacles. On the one hand, we studied the attitude of primary physicians towards their patients who were offered to participate in a preventive vaccine trial. They are not well informed about clinical research and would like to have more information in advance in order to give an objective opinion to the patient. We also studied the barriers and motivations of people approached to participate in a preventive vaccine trial. We were able to highlight that altruism was the main motivation to participate and that a favorable opinion for vaccines in general was associated with agreeing to participate in this type of trial. In addition, fear of potential side effects was found to be the main reason for the decision to participate. Financial incentives, which are a motivation for younger people, were a barrier to participation among older people. The quality of the information given to the potential participant by the physician is crucial and reinforces the importance of sharing information with the patient's primary physician.
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Maëlle Detoc. Déterminants à la participation ou non à un essai vaccinal préventif. Médecine humaine et pathologie. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSES016⟩. ⟨tel-02468317⟩

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