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Imagerie tissulaire ultrasonore 3D pour l’étude de l’anisotropie locale du muscle cardiaque

Abstract : Ultrasound imaging has strongly developed in recent years. It reaches now a frame rates of several thousand images per second, thanks to the emergence of ultrafast imaging. It is therefore the most suitable modality for cardiac applications. Not only does it allow the reconstruction of images, it also enables the extraction of parameters for tissue characterization, such as local anisotropy inside the heart muscle. Indeed, this fibrous layout can be modified in the case of cardiac pathologies. The aim of this doctoral work is the development of a method to extract the local orientation of an anisotropic environment by 3D ultrasound imaging. This approach should allow imaging with a wide field a view to be applied in cardiac imaging. Finally, the validation of the processing chain is necessary. To address these issues, several solutions have been proposed. First, the local orientation was evaluated using a spatial coherence method. It allowed assessing the orientation of fibres in a plane parallel to the surface of the probe. Once developed and validated, this strategy was extended to extract the local orientation in 3D and not only the angle in a plane. Finally, the study of different types of transmissions was also carried out in order to widen the imaged field of view. All these original methods have been applied and validated on phantom and in vivo data: the determination of the local orientation of an anisotropic environment was first performed on a monodirectional phantom and then on the biceps of a volunteer. For this purpose, an experimental system consisting of four research ultrasound scanners was developed thanks to the sharing of equipment from CREATIS and LabTAU, another laboratory in Lyon, in order to acquire 3D data. This work has thus made it possible both to extend an anisotropic environment to the case of an orientation not parallel to the surface of the probe and to improve the size of the field of view of the existing method. The validation of the entire processing chain has been completed. Applying this method to in vivo cardiac tissue is directly part of future studies
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Submitted on : Friday, February 21, 2020 - 4:05:12 PM
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  • HAL Id : tel-02464534, version 1


Emeline Turquin. Imagerie tissulaire ultrasonore 3D pour l’étude de l’anisotropie locale du muscle cardiaque. Imagerie médicale. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1213⟩. ⟨tel-02464534⟩



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