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Expansion ex vivo des Cellules Tumorales Circulantes comme modele de pharmacologie predictive des cancers

Abstract : The emergence of targeted therapies in cancer treatment has made essential the development of more specific and sensitive markers for monitoring patients. At the invasive stage, tumor cells can pass to blood. These cells are called Circulating Tumor Cells (CTC). CTCs are accessible through a simple blood test, avoiding invasive biopsies. Moreover, they represent the only residual tumor after treatment. It is why CTCs are a very active center of research with more than 400 clinical trials involving these cells as biomarkers. These tests provide important information on the risk of recurrence or metastatic progression and aim to manage in real time the therapeutic conduct. But the CTC potentially metastatic represents only a fraction very minority of these circulating cells. Existing technologies, mainly based on simple enumeration, are not enough to effectively guide therapeutic strategy. This project has evaluated a set of criteria to make appropriate therapeutic decisions, adapted to each patient, and able to measure the effectiveness of treatments. This project will focus on melanoma. Evolution stages of this cancer are well defined, and in advanced stages, the risk of developing metastases is very high and the early detection is an important issue. Moreover, CTC could be is an interesting tool to test the effectiveness of these new treatments.
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Submitted on : Wednesday, January 15, 2020 - 5:23:24 PM
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  • HAL Id : tel-02441343, version 1



Jessica Groult. Expansion ex vivo des Cellules Tumorales Circulantes comme modele de pharmacologie predictive des cancers. Cancer. Université Paris Saclay (COmUE), 2019. Français. ⟨NNT : 2019SACLS236⟩. ⟨tel-02441343⟩



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