A unified framework for classification of methods for benefitrisk assessment, Value Health J Int Soc Pharmacoeconomics Outcomes Res, vol.18, issue.2, pp.250-259, 2015. ,
A first step to assess harm and benefit in clinical trials in one scale, J Clin Epidemiol, vol.63, issue.6, pp.627-659, 2010. ,
Preliminary definition of improvement in juvenile arthritis, Arthritis Rheum ,
Optimisation of disease assessments in juvenile idiopathic arthritis ,
, Clin Exp Rheumatol, vol.32, issue.5, 2014.
Clinical Trial Design in Juvenile Idiopathic Arthritis. Paediatr Drugs, vol.19, pp.379-89, 2017. ,
Challenges in coding adverse events in clinical trials: a systematic review, PloS One, vol.7, issue.7, p.41174, 2012. ,
Quality of serious adverse events reporting to academic sponsors of clinical trials: far from optimal, Pharmacoepidemiol Drug Saf, vol.25, issue.6, pp.719-743, 2016. ,
Cochrane handbook for systematic reviews of interventions, 2008. ,
, Cochrane book series)
International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, J Rheumatol, vol.6, issue.7, pp.390-392, 2001. ,
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials, BMJ, vol.343, p.5928, 2011. ,
Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events, Stat Med, vol.26, issue.1, pp.53-77, 2007. ,
Quantifying heterogeneity in a meta-analysis, Stat Med, vol.21, issue.11, pp.1539-58, 2002. ,
Bias in meta-analysis detected by a simple, graphical test, BMJ, vol.315, issue.7109, pp.629-663, 1997. ,
The effect of ,
, Asia Pac Leag Assoc Rheumatol Congr APLAR China Conf, 2016.
Efficacy and safety of Infliximab in juvenile idiopathic arthritis and juvenile ankylosing spondylitis: a randomized, double-blind, controlled study, Int J Rheum Conf 18th Asia Pac Leag Assoc Rheumatol Congr APLAR China Conf, 2016. ,
Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis, N Engl J Med, vol.376, issue.17, pp.1637-1683, 201727. ,
,
Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial ,
, Ann Rheum Dis, vol.70, pp.1605-1617, 2011.
Trial of Early Aggressive Therapy in Polyarticular Juvenile Idiopathic Arthritis, Arthritis Rheum, vol.64, issue.6, pp.2012-2033, 2012. ,
Double-Blind, Placebo-Controlled Multicenter Study of Adalimumab in Pediatric Patients With Enthesitis-Related Arthritis, Arthritis Care Res ,
,
Clinical trials in children, Br J Clin Pharmacol, vol.79, pp.357-69, 2015. ,
Etanercept in children with polyarticular juvenile rheumatoid arthritis, N Engl J Med, vol.342, pp.763-772, 2000. ,
A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis, Arthritis Rheum, vol.56, pp.3096-106, 2007. ,
Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial, Lancet Lond Engl, vol.372, pp.383-91, 2008. ,
Efficacy and safety of etanercept in patients with the enthesitis-related arthritis category of juvenile idiopathic arthritis: results from a phase III randomized, double-blind study, Arthritis Rheumatol Hoboken NJ, vol.67, pp.2240-2249, 2015. ,
Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial, Ann Rheum Dis, vol.74, pp.1110-1117, 2015. ,
Adalimumab plus methotrexate for uveitis in juvenile idiopathic arthritis, N Engl J Med, vol.376, pp.1637-1683, 2017. ,
Use of canakinumab in the cryopyrin-associated periodic syndrome, N Engl J Med, vol.360, pp.2416-2441, 2009. ,
Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study, Arthritis Res Ther, vol.13, p.202, 2011. ,
Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER), Lupus, vol.20, pp.709-725, 2011. ,
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the lupus nephritis assessment with rituximab study, Arthritis Rheum, vol.64, pp.1215-1241, 2012. ,
Efficacy and safety of canakinumab in cryopyrin-associated periodic syndromes: results from a Spanish cohort, Clin Exp Rheumatol, vol.33, pp.67-71, 2015. ,
Occurrence of adverse events in patients with JIA receiving biologic agents: long-term follow-up in a real-life setting, Rheumatol Oxf Engl, vol.54, pp.1170-1176, 2015. ,
Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national arthritis and biologics in children register, Ann Rheum Dis, vol.74, pp.1379-86, 2015. ,
Real-life effectiveness of canakinumab in cryopyrin-associated periodic syndrome, Rheumatol Oxf Engl, vol.55, pp.689-96, 2016. ,
Comparison of treatment response, remission rate and drug adherence in polyarticular juvenile idiopathic arthritis patients treated with etanercept, adalimumab or tocilizumab, Arthritis Res Ther, vol.18, p.272, 2016. ,
Clinical characteristics of children with membranous lupus nephritis: the childhood arthritis and rheumatology research alliance legacy registry, Lupus, vol.26, pp.299-306, 2017. ,
Biological agents in polyarticular juvenile idiopathic arthritis: A meta-analysis of randomized withdrawal trials, Semin Arthritis Rheum, vol.46, pp.312-320, 2016. ,
Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis: a systematic review and meta-analysis of randomized trials, Rheumatol Oxf Engl, vol.55, pp.669-79, 2016. ,
Long-term safety of etanercept and adalimumab compared to methotrexate in patients with juvenile idiopathic arthritis (JIA), Ann Rheum Dis, vol.75, pp.855-61, 2016. ,
Rates of malignancy associated with juvenile idiopathic arthritis and its treatment, Arthritis Rheum, vol.64, pp.1263-71, 2012. ,
Malignancy incidence in 5294 patients with juvenile arthritis, RMD Open, vol.2, p.212, 2016. ,
What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis? Arthritis, Res Ther, vol.15, p.213, 2013. ,
Quality of serious adverse events reporting to academic sponsors of clinical trials: far from optimal, Pharmacoepidemiol Drug Saf, vol.25, pp.719-743, 2016. ,
International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, J Rheumatol, vol.31, pp.390-392, 2001. ,
The German etanercept registry for treatment of juvenile idiopathic arthritis, Ann Rheum Dis, vol.63, pp.1638-1682, 2004. ,
Long-term follow-up on effectiveness and safety of etanercept in juvenile idiopathic arthritis: the Dutch national register ,
, Ann Rheum Dis, vol.68, pp.635-676, 2009.
Safety and efficacy of etanercept in children with the JIA categories extended oligoarthritis, enthesitis-related arthritis and psoriasis arthritis, Clin Rheumatol, vol.34, pp.61-70, 2015. ,
Safety and efficacy of adalimumab treatment in Greek children with juvenile idiopathic arthritis, Scand J Rheumatol, vol.40, pp.101-108, 2011. ,
Efficacy and safety of adalimumab as the first and second biologic agent in juvenile idiopathic arthritis: the German biologics JIA registry, Arthritis Rheumatol, vol.66, pp.2580-2589, 2014. ,
Adverse effects of biologics: a network meta-analysis and Cochrane overview, Cochrane Database Syst Rev, vol.16, p.8794, 2011. ,
Adverse events of low-to medium-dose oral glucocorticoids in inflammatory diseases: a meta-analysis ,
, Ann Rheum Dis, vol.68, pp.1833-1841, 2009.
Society for rheumatology biologics register. Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study, Arthritis Rheum, vol.56, pp.13-20, 2007. ,
Methotrexate improves the health-related quality of life of children with juvenile idiopathic arthritis ,
, Ann Rheum Dis, vol.67, pp.309-323, 2008.
Impact of juvenile idiopathic arthritis on quality of life during transition period at the era of biotherapies, J Bone Spine Rev Rhum, vol.83, pp.69-74, 2016. ,
Effectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.pt, Rheumatol Oxf Engl, vol.55, pp.697-703, 2016. ,
Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial, Ann Rheum Dis, vol.70, pp.1605-1617, 2011. ,
Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis, Arthritis Rheum, vol.64, pp.2012-2033, 2012. ,
Management of juvenile idiopathic arthritis: hitting the target, Nat Rev Rheumatol, vol.11, pp.290-300, 2015. ,
Infectious complications with the use of biologic response modifiers in infants and children, Pediatrics, vol.138, p.20161209, 2016. ,
Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey, Arthritis Res Ther, vol.7, pp.545-51, 2005. ,
Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: findings from an open-label treatment extension, Ann Rheum Dis, vol.69, pp.718-740, 2009. ,
Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA registry, Ann Rheum Dis, vol.68, pp.519-544, 2009. ,
Managing monoarthritis in children, J Bone Spine Rev Rhum, vol.83, pp.25-30, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01353495
Learning the hard way: clinical trials in juvenile idiopathic arthritis ,
, Ann Rheum Dis, vol.77, issue.1, pp.1-2, 2018.
Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries, Arthritis Res Ther, vol.20, issue.1, p.285, 201827. ,
What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?, Arthritis Res Ther, vol.15, issue.3, p.213, 2013. ,
What is a Serious Adverse Event? FDA, 2019. ,
Harms are assessed inconsistently and reported inadequately Part 2: nonsystematic adverse events, J Clin Epidemiol ,
OP0001 Risk of malignancy in children with juvenile idiopathic arthritis: a register-based cohort study ,
, Ann Rheum Dis, vol.77, issue.2, pp.50-50, 2018.
, Cancer Risk in 5,108 Patients with Juvenile Idiopathic Arthritis (JIA). ACR Meeting Abstracts
Biologic-associated infections in pediatric rheumatology, Curr Rheumatol Rep, vol.17, issue.11, p.66, 2015. ,
Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group, JAMA, vol.283, issue.15, pp.2008-2020, 2000. ,
Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data ,
, Int J Evid Based Healthc, vol.13, issue.3, pp.147-53, 2015.
,
,
How should meta-regression analyses be undertaken and interpreted? Stat Med, vol.21, pp.1559-73, 2002. ,
Quantifying heterogeneity in a meta-analysis, Stat Med, vol.21, issue.11, pp.1539-58, 2002. ,
Bias in meta-analysis detected by a simple, graphical test, BMJ, vol.315, issue.7109, pp.629-663, 1997. ,
,
, Clin Rheumatol, vol.35, issue.12, pp.2925-2956, 2016.
Safety and efficacy of etanercept in children with juvenile idiopathic arthritis below the age of 4 years, Rheumatol Int ,
,
,
Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study, Ann Rheum Dis, vol.62, issue.3, p.245, 2003. ,
Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan, Clin Rheumatol, vol.31, issue.12, pp.1713-1734, 2012. ,
,
, Events Associated with Anti-Tumor Necrosis Factor Alpha Agents in Pediatric-Onset Inflammatory Bowel Disease and Juvenile Idiopathic Arthritis in A Real-Life Setting, Paediatr Drugs, 2018.
, Apr, vol.20, issue.2, pp.165-71
The new Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry: design, rationale, and characteristics of patients enrolled in the first 12 months, Pediatr Rheumatol Online J, vol.15, issue.1, p.30, 2017. ,
,
,
, Ann Rheum Dis, 2008.
Safety and effectiveness of etanercept for treatment of juvenile idiopathic arthritis: Results from a postmarketing surveillance, Mod Rheumatol, vol.28, issue.1, p.101, 2018. ,
Etanercept treatment in juvenile idiopathic arthritis: the Polish registry, Med Sci Monit Int Med J Exp Clin Res, vol.17, issue.12, pp.35-42, 2011. ,
Safety of biological agents in paediatric rheumatic diseases: A real-life ,
Proposal for the development of biologics in pediatric rheumatology, Pediatr Int Off J Jpn Pediatr Soc ,
, Feb, vol.60, issue.2, pp.108-122
Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of fortysix patients from an international multicenter series, Arthritis Rheum, vol.63, issue.2, pp.545-55, 2011. ,
A randomized, placebocontrolled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis, Arthritis Rheum, vol.56, issue.9, pp.3096-106, 2007. ,
Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial, Ann Rheum Dis, vol.70, issue.9, pp.1605-1617, 2011. ,
A multicentre, randomised, double-blind ,
Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis, N Engl J Med, vol.367, issue.25, pp.2385-95, 2012. ,
Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement, Arthritis Res Ther, vol.14, issue.5, p.230, 2012. ,
Double-Blind, Placebo-Controlled Multicenter Study of Adalimumab in Pediatric Patients With Enthesitis-Related Arthritis, Arthritis Care Res ,
Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis, N Engl J Med, vol.376, issue.17, pp.1637-1683, 201727. ,
Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis, N Engl J Med, 2012. ,
Long-term safety and efficacy of rilonacept in patients with systemic juvenile idiopathic arthritis, Arthritis Rheum, vol.65, issue.9, pp.2486-96, 2013. ,
Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis. Arthritis Rheumatol Hoboken NJ, vol.66, pp.2570-2579, 2014. ,
,
Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group, N Engl J Med, vol.342, issue.11, pp.763-772, 2000. ,
Adalimumab with or without methotrexate in juvenile rheumatoid arthritis, N Engl J Med, vol.359, issue.8, pp.810-830, 2008. ,
Long-term safety and efficacy of abatacept in children with juvenile idiopathic arthritis, Arthritis Rheum, vol.62, issue.6, pp.1792-802, 2010. ,
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial, Lancet Lond Engl, vol.371, issue.9617, pp.998-1006, 2008. ,
,
Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis, N Engl J Med, 2012. ,
Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial, Ann Rheum Dis, vol.74, issue.6, pp.1110-1117, 2015. ,
Efficacy and safety of etanercept in patients with the enthesitis-related arthritis category of juvenile idiopathic arthritis: results from a phase III randomized, double-blind study, Arthritis Rheumatol Hoboken NJ, vol.67, issue.8, pp.2240-2249, 2015. ,
The case of the misleading funnel plot, BMJ, vol.333, issue.7568, pp.597-600, 2006. ,
Clinical trials in children, Br J Clin Pharmacol, vol.79, issue.3, pp.357-69, 2015. ,
,
Adalimumab: longterm safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease, Ann Rheum Dis, 2012. ,
Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis, N Engl J Med, vol.342, issue.11, p.763, 2000. ,
,
EULAR points to consider when establishing, analysing and reporting safety data of biologics registers in rheumatology ,
, Ann Rheum Dis, vol.69, issue.9, pp.1596-602, 2010.
,
, Heterogeneity: I 2 = 86%, ? 2 = 0.0116, p.1
, Heterogeneity: I 2 = 95%, ? 2 = 0.0104, p.1
, Heterogeneity: I 2 = 91%, ? 2 = 0.0130, p.1
, , 2008.
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, , 2008.
, , 2013.
, , 2018.
, , 2008.
, , 2011.
, , 2018.
, Heterogeneity: I 2 = 78%, ? 2 = 0.0133, p.1
, Heterogeneity: I 2 = 66%, ? 2 = 0.0024, p.1
, Heterogeneity: I 2 = 76%, ? 2 = 0.0015, p.1
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, , 2017.
, , 2017.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
, , 2018.
,
Improving Care Delivery Outcomes in Pediatric Rheumatic Diseases, Curr Opin Rheumatol, vol.28, issue.2, pp.110-116, 2016. ,
, Disclosure of Interests: None
, AB0947 TREATMENT WITH SIMULTANEOUS BIOLOGICAL AGENTS IN JUVENILE IDIOPATHIC ARTHRITIS: SINGLE-CENTER CASE SERIES AND REVIEW OF LITERATURE
, Hospital Woman Mère Enfant -Hcl, Paediatric Rheumatology, vol.2
How I treat juvenile idiopathic arthritis: A state of the art review, Autoimmun Rev, vol.16, issue.10, pp.1008-1023, 2017. ,
Combination Therapy of Abatacept and Anakinra in Children with Refractory Systemic Juvenile Idiopathic Arthritis: A Retrospective Case Series, J Rheumatol, vol.38, issue.1, pp.180-181, 2011. ,
Anti-TNF-Alpha induced psoriasiform eruptions with severe scalp involvement and alopecia: report of five cases and review of the literature, Dermatology, vol.225, issue.2, pp.163-170, 2012. ,
Pityriasis amiantacea: a distinctive presentation of psoriasis associated with tumour necrosis factor-a inhibitor therapy, Gabriele Simonini Grant/research support from: Abbvie, Speakers bureau: Abbvie, Rolando Cimaz: None declared, vol.37, pp.639-680, 2012. ,
,
Post Graduate Institute of, Medical Education and Research ,
ESR: erythrocyte sedimentation rate, GH : growth hormone, IVIG: intravenous immunoglobulin, JIA: juvenile idiopathic arthritis, MTX: methotrexate, Neg: negative, NSAIDs: non-steroidal anti-inflammatory drugs, P: patient, Pos: positive, RF: Rheumatoid factor, So JIA (systemic-onset juvenile idiopathic arthritis) a: genu valgus bilateral, b: serious adverse event: Acute cholestatic hepatitis, tocilizumab was stopped (liver biopsy reveal ed an inflammatory infiltrate with hepatocellular drop out suggesting drug induced liver injury), c: complicated therapeutic compliance by the family, d: substitutive dose (replacement therapy), e: stopped during treatment with anakinra, f: infiltrations at knees, ankles and elbows, g: serious adverse event: No clinical (vomiting) and biological (hepatic cytolysis) tolerance. 6 : Bibliographie 1, Rituximab (10.7)* in years, *bDMARD combined. ACE: angiotensin-converting-enzyme, ANA: antinuclear antibodies, Aredia : pamidronate disodium pentahydrate, bDMARDs: biological disease-modifying antirheumatic drugs, CIO: corticosteroid-induced osteoporosis, CRP: C reactive protein, vol.46, pp.584-93, 2017. ,
,
,
,
, Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases, Int J Mol Sci, vol.20, issue.8, 2019.
,
Clinical trials in children, Br J Clin Pharmacol, vol.79, issue.3, pp.357-69, 2015. ,
Impact of the European paediatric legislation in paediatric rheumatology: past, present and future, Ann Rheum Dis, vol.72, issue.12, pp.1893-1899, 2013. ,
Randomized controlled trials and real-world data: differences and similarities to untangle literature data ,
Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis, N Engl J Med ,
,
,
, , vol.64, pp.2012-2033, 2012.
,
, Adalimumab with or without Methotrexate in Juvenile Rheumatoid Arthritis, N Engl J Med, vol.359, issue.8, pp.810-830, 2008.
,
Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement, Arthritis Res Ther, vol.14, issue.5, 2012. ,
Placebo-Controlled Multicenter Study of Adalimumab in Pediatric Patients With Enthesitis-Related Arthritis, Arthritis Care Res, vol.67, issue.11, pp.1503-1515, 2015. ,
,
,
, Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial, Ann Rheum Dis, 2011.
Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial, Ann Rheum Dis ,
A multicentre, randomised, double-blind ,
, Ann Rheum Dis, vol.70, issue.5, pp.747-54, 2011.
Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study, Clin Rheumatol, vol.28, issue.2, pp.129-166, 2009. ,
,
, Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis, N Engl J
, , vol.367, pp.2396-406, 2012.
,
Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis, Arthritis Rheumatol Hoboken NJ, vol.65, issue.9, pp.2486-96, 2013. ,
, , vol.66, pp.2570-2579
, Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial, Ann Rheum Dis
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial, Lancet Lond Engl, vol.74, issue.6, pp.1110-1117 ,
, , vol.371, pp.998-1006
Varnier GC, Ciurtin C. Paediatric and adolescent rheumatic diseases: measures of disease activity, Best Pract Res Clin Rheumatol, vol.62, issue.6, pp.338-380, 2005. ,
,
, Prince FHM, Ferket IS, vol.73, pp.897-906, 2014.
Development of a web-based register for the Dutch national study on biologicals in JIA: www.ABC-register.nl. Rheumatol Oxf Engl, vol.47, pp.1413-1419, 2008. ,
, The new Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry
Update on the treatment and outcome of systemic lupus erythematous in children, Curr Opin Rheumatol, vol.11, issue.5, pp.290-300, 2015. ,
Biologics in juvenile idiopathic arthritis: a narrative review, Eur J Pediatr, vol.176, issue.9, pp.1147-53, 2017. ,
,
Anti-infliximab and anti ,
Quality of serious adverse events reporting to academic sponsors of clinical trials: far from optimal, Pharmacoepidemiol Drug Saf, vol.17, issue.11, pp.719-743, 2015. ,
Harms are assessed inconsistently and reported inadequately Part 2: nonsystematic adverse events, PloS One, vol.7, issue.7, 2012. ,
, Learning the hard way: clinical trials in juvenile idiopathic arthritis, Clin Epidemiol, vol.113, issue.1, pp.1-2, 2018.
Adverse event reporting: A brief overview of MedDRA ,
Efficacy of biological agents in juvenile idiopathic arthritis: a systematic review using indirect comparisons, Ann Rheum Dis, vol.7, issue.7, pp.1806-1818, 2012. ,
Update on the pathogenesis and treatment of juvenile idiopathic arthritis, Curr Opin Rheumatol, vol.29, issue.5, pp.523-532, 2017. ,
,
,
,
, Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial, Ann Rheum Dis
, , vol.70, pp.1605-1617
, Treating juvenile idiopathic arthritis to target: recommendations of an international task force
, Ann Rheum Dis, vol.77, issue.6, pp.819-847, 2018.