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Analyse automatique de l’écriture manuscrite sur tablette pour la détection et le suivi thérapeutique de personnes présentant des pathologies

Abstract : We present, in this thesis, a novel paradigm for assessing Alzheimer’s disease by analyzing impairment of handwriting (HW) on tablets, a challenging problem that is still in its infancy. The state of the art is dominated by methods that assume a unique behavioral trend for each cognitive profile, and that extract global kinematic parameters, assessed by standard statistical tests or classification models, for discriminating the neuropathological disorders (Alzheimer’s (AD), Mild Cognitive Impairment (MCI)) from Healthy Controls (HC). Our work tackles these two major limitations as follows. First, instead of considering a unique behavioral pattern for each cognitive profile, we relax this heavy constraint by allowing the emergence of multimodal behavioral patterns. We achieve this by performing semi-supervised learning to uncover homogeneous clusters of subjects, and then we analyze how much information these clusters carry on the cognitive profiles. Second, instead of relying on global kinematic parameters, mostly consisting of their average, we refine the encoding either by a semi-global parameterization, or by modeling the full dynamics of each parameter, harnessing thereby the rich temporal information inherently characterizing online HW. Thanks to our modeling, we obtain new findings that are the first of their kind on this research field. A striking finding is revealed: two major clusters are unveiled, one dominated by HC and MCI subjects, and one by MCI and ES-AD, thus revealing that MCI patients have fine motor skills leaning towards either HC’s or ES-AD’s. This thesis introduces also a new finding from HW trajectories that uncovers a rich set of features simultaneously like the full velocity profile, size and slant, fluidity, and shakiness, and reveals, in a naturally explainable way, how these HW features conjointly characterize, with fine and subtle details, the cognitive profiles.
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Submitted on : Monday, January 13, 2020 - 4:40:09 PM
Last modification on : Monday, August 24, 2020 - 4:16:12 PM
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  • HAL Id : tel-02437269, version 1


Christian Kahindo Senge Muvingi. Analyse automatique de l’écriture manuscrite sur tablette pour la détection et le suivi thérapeutique de personnes présentant des pathologies. Traitement du signal et de l'image [eess.SP]. Université Paris-Saclay, 2019. Français. ⟨NNT : 2019SACLL016⟩. ⟨tel-02437269⟩



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