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Alcohol consumption and lifestyle factors in association with pancreatic cancer in the EPIC study

Abstract : Commonly diagnosed at late stage, pancreatic cancer (PC) is a highly fatal cancer with limited opportunities for early detection and effective treatment. The identification of modifiable risk factors may offer relevant scientific evidence for PC prevention. This doctoral research program investigated PC etiology through a comprehensive examination of the role of alcohol consumption and other lifestyle determinants in the occurrence of PC within the European Prospective Investigation into Cancer and nutrition (EPIC) study, a multi-center cohort involving more than 500,000 participants from 10 European countries. Alcohol intake was evaluated with respect to the risk of PC. The role of different alcoholic beverages and potential effect modification by smoking habits on PC risk were also examined. Findings from this evaluation provided epidemiological evidence that large intakes of alcohol were associated with an increased risk of PC.The association between the healthy lifestyle index, a score combining information on smoking history, alcohol intake, diet, obesity, and physical activity and the risk of PC was examined. To quantify the impact of modifying several lifestyle factors, population attributable fractions were estimated assuming counterfactual scenarios whereby study participants hypothetically moved towards healthier behaviors. Adherence to healthy lifestyle habits was strongly inversely related to PC. This comprehensive evaluation provides informative insights on the etiology of PC and supports the development and implementation of public health guidelines to promote individuals’ adoption of healthy lifestyle habits for PC prevention
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Sabine Naudin. Alcohol consumption and lifestyle factors in association with pancreatic cancer in the EPIC study. Health. Université de Lyon, 2019. English. ⟨NNT : 2019LYSE1133⟩. ⟨tel-02434882⟩

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