, Les sarcomes à amplification : une altération spécifique dans un génome remanié
,
,
, Acquisition et héritage de propriétés phénotypiques par les hybrides
Creation of human tumour cells with defined genetic elements, Nature, vol.400, pp.464-468, 1999. ,
Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011. ,
Pan-cancer patterns of somatic copy-number alteration, Nature genetics, vol.45, p.1134, 2013. ,
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome, Cell, vol.155, pp.948-962, 2013. ,
The causes and consequences of polyploidy in normal development and cancer, Annu. Rev. Cell Dev. Biol, vol.27, pp.585-610, 2011. ,
Genome doubling shapes the evolution and prognosis of advanced cancers, Nature Genetics, p.1, 2018. ,
Tetraploidy and tumor development, Cancer Cell, vol.8, pp.353-354, 2005. ,
,
, , vol.17, pp.157-162, 2007.
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes, Genes Dev, vol.22, pp.2189-2203, 2008. ,
Mitotic catastrophe: a mechanism for avoiding genomic instability, Nat. Rev. Mol. Cell Biol, vol.12, pp.385-392, 2011. ,
Illicit survival of cancer cells during polyploidization and depolyploidization, Cell Death Differ, vol.18, pp.1403-1413, 2011. ,
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells, Nature, vol.437, pp.1043-1047, 2005. ,
Short-and long-term effects of chromosome mis-segregation and aneuploidy, Nat. Rev. Mol. Cell Biol, vol.16, pp.473-485, 2015. ,
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy, Science, vol.355, 2017. ,
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal, Cell, vol.173, pp.581-594, 2018. ,
Chromosomal instability drives metastasis through a cytosolic DNA response, Nature, vol.553, pp.467-472, 2018. ,
Persistent telomere damage induces bypass of mitosis and tetraploidy, Cell, vol.141, pp.81-93, 2010. ,
Cancer: a CINful evolution, Curr. Opin. Cell Biol, vol.52, pp.136-144, 2018. ,
Cell fusion: a hidden enemy?, Cancer Cell, vol.3, pp.445-448, 2003. ,
Cell-to-cell fusion as a link between viruses and cancer, Nat. Rev. Cancer, vol.7, pp.968-976, 2007. ,
A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion, Current Biology, vol.17, pp.431-437, 2007. ,
Muscle regeneration by bone marrow-derived myogenic progenitors, Science, vol.279, pp.1528-1530, 1998. ,
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion, Nature, vol.416, pp.542-545, 2002. ,
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant, Nat. Cell Biol, vol.5, pp.959-966, 2003. ,
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells, Proc Natl Acad Sci U S A, vol.103, pp.6321-6325, 2006. ,
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes, Nature, vol.425, pp.968-973, 2003. ,
Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates, Nat. Med, vol.9, pp.1520-1527, 2003. ,
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation, Nat. Cell Biol, vol.10, pp.575-583, 2008. ,
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion, Nat. Cell Biol, vol.10, pp.584-592, 2008. ,
Cell Fusion Connects Oncogenesis with Tumor Evolution, Am J Pathol, vol.185, pp.2049-2060, 2015. ,
, Vorträge und Aufsätze über Entvickelungsmechanik Der Organismen, pp.92-111, 1911.
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis, Nat. Rev. Cancer, vol.8, pp.377-386, 2008. ,
Tumour-cell fusion as a source of myeloid traits in cancer, Lancet Oncol, vol.6, pp.988-993, 2005. ,
Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming, Cancer Res, vol.71, pp.1497-1505, 2011. ,
Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival, Sci Adv, vol.4, 2018. ,
Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient, Bone Marrow Transplant, vol.34, pp.183-186, 2004. ,
Circulating tumor cells in melanoma patients, PLoS One, vol.7, p.41052, 2012. ,
Cancer. Fusion for moving, Science, vol.342, pp.699-700, 2013. ,
Macrophage-Tumor Cell Fusions from Peripheral Blood of Melanoma Patients, PLOS ONE, vol.10, p.134320, 2015. ,
The shock of being united and symphiliosis. Another lesson from plants? Cell Cycle, vol.13, pp.2323-2329, 2014. ,
Biological implications of cell fusion, Nat. Rev. Mol ,
, Cell Biol, vol.6, pp.567-575, 2005.
Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei, Nature, vol.226, pp.717-722, 1970. ,
Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis, Nature, vol.225, pp.159-164, 1970. ,
Macrophage fusion, J Exp Med, vol.202, pp.337-340, 2005. ,
Unveiling the mechanisms of cell-cell fusion, Science, vol.308, pp.369-373, 2005. ,
Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells, Int J Mol Sci, vol.16, pp.30362-30381, 2015. ,
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants, Proc Natl Acad Sci U S A, vol.106, pp.9385-9390, 2009. ,
Tumor associated macrophage x cancer cell hybrids may acquire cancer stem cell properties in breast cancer, PLoS One, vol.7, p.41942, 2012. ,
Metaplasia: tissue injury adaptation and a precursor to the dysplasiacancer sequence, Nat. Rev. Cancer, vol.17, pp.594-604, 2017. ,
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms, Nat. Rev. Cancer, vol.13, pp.759-771, 2013. ,
Myogenic Reprogramming of Bone Marrow Derived Cells in a W41Dmdmdx Deficient Mouse Model, PLoS One, vol.6, 2011. ,
Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours, Int J Cancer, vol.36, pp.637-641, 1985. ,
Spontaneous cell fusion in human malignancies: possible mechanism leading to heterogeneity, Lancet, vol.1, p.350, 1985. ,
Silencing of endogenous envelope genes in human choriocarcinoma cells shows that envPb1 is involved in heterotypic cell fusions, The Journal of General Virology, vol.93, pp.1696-1699, 2012. ,
Genomic Instability in Cancer, Cold Spring Harbor Perspectives in Biology, vol.5, pp.12914-012914, 2013. ,
Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas, Genes, Chromosomes and Cancer, vol.45, pp.829-838, 2006. ,
ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion, Cell Death and Differentiation, vol.22, pp.1970-1984, 2015. ,
Genetic basis of cell-cell fusion mechanisms, Trends in genetics: TIG, vol.29, pp.427-437, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00847175
Über zellverschmelzung mit quantitativ abnormer chromosomenverteilung als ursache der geschwulstbildung, Vorträge und aufsätze über entwicklungsmechanik der organismen, pp.1-115, 1911. ,
Transcription-mediated gene fusion in the human genome, Genome Research, vol.16, pp.30-36, 2005. ,
Annotating non-coding regions of the genome, Nature Reviews Genetics, vol.11, pp.559-571, 2010. ,
Deciphering signatures of mutational processes operative in human cancer, Cell Reports, vol.3, pp.246-259, 2013. ,
Signatures of mutational processes in human cancer, Nature, vol.500, pp.415-421, 2013. ,
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes, Nature, vol.425, pp.968-973, 2003. ,
Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership?, The Journal of Pathology, vol.211, pp.10-17, 2007. ,
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors, Science, vol.361, p.8419, 2018. ,
The age distribution of cancer and a multi-stage theory of carcinogenesis, British Journal of Cancer, vol.8, pp.1-12, 1954. ,
Comptes rendus des seances de l'Academie des sciences, Sciences de la vie, vol.296, pp.1105-1107, 1983. ,
STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III, The Journal of Experimental Medicine, vol.79, pp.137-158, 1944. ,
Eukaryotic Cell-Cell Fusion Families, Current Topics in Membranes, pp.209-234, 2011. ,
Punctuated evolution of prostate cancer genomes, Cell, vol.153, pp.666-677, 2013. ,
Comprehensive Characterization of Cancer Driver Genes and Mutations, Cell, vol.173, pp.371-385, 2018. ,
Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach, BMC genomics, vol.7, p.246, 2006. ,
Gene expression profiling of human sarcomas: insights into sarcoma biology, Cancer Research, vol.65, pp.9226-9235, 2005. ,
Chromosomal instability drives metastasis through a cytosolic DNA response, Nature, vol.553, pp.467-472, 2018. ,
Monogenic and polygenic determinants of sarcoma risk: an international genetic study, The Lancet Oncology, vol.17, pp.1261-1271, 2016. ,
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer, Nature Genetics, vol.44, pp.685-689, 2012. ,
The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA, Nature Communications, vol.9, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02346642
Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus, Cancer Research, vol.63, pp.4211-4217, 2003. ,
The Dark Side of Cell Fusion, International Journal of Molecular Sciences, vol.17, p.638, 2016. ,
Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells, Nature Communications, vol.5, p.4825, 2014. ,
Acute lymphoblastic leukemia and chromosome 21, Cancer Genetics and Cytogenetics, vol.94, pp.8-12, 1997. ,
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT, International Journal of Cancer, vol.122, pp.1483-1495, 2007. ,
Control of muscle formation by the fusogenic micropeptide myomixer, Science, vol.356, pp.323-327, 2017. ,
Nonrandom duplication of the chromosome bearing a mutated Haras-1 allele in mouse skin tumors, Proceedings of the National Academy of Sciences of the United States of America, vol.87, pp.6902-6906, 1990. ,
Juno is the egg Izumo receptor and is essential for mammalian fertilization, Nature, vol.508, pp.483-487, 2014. ,
Paradoxical relationship between chromosomal instability and survival outcome in cancer, Cancer Research, vol.71, pp.3447-3452, 2011. ,
Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice, Anatomy and Embryology, vol.199, pp.391-396, 1999. ,
The origin of the cancer stem cell: current controversies and new insights, Nature Reviews Cancer, vol.5, p.899, 2005. ,
Syncytin is involved in breast cancer-endothelial cell fusions, Cellular and molecular life sciences: CMLS, vol.63, pp.1906-1911, 2006. ,
Syncytin-1 in differentiating human myoblasts: relationship to caveolin-3 and myogenin, Cell and Tissue Research, vol.357, pp.355-362, 2014. ,
Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution, Proceedings of the National Academy of Sciences of the United States of America, vol.100, pp.13013-13018, 2003. ,
Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes, Retrovirology, vol.2, p.19, 2005. ,
Cytoplasmic activation of human nuclear genes in stable heterocaryons, Cell, vol.32, pp.1171-1180, 1983. ,
Plasticity of the differentiated state, Science, vol.230, pp.758-766, 1985. ,
How fixed is the differentiated state?: Lessons from heterokaryons, Trends in Genetics, vol.5, pp.268-272, 1989. ,
Plasticity of cell fate: Insights from heterokaryons, Seminars in Cell & Developmental Biology, vol.10, pp.267-272, 1999. ,
Gastrointestinal stromal tumors (GIST): a rare entity, a tumor model for personalized therapy, and yet ten different molecular subtypes, Discovery Medicine, vol.13, pp.357-367, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00861776
& Mallet F. 1999. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family, Journal of Virology, vol.73, pp.1175-1185 ,
An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor, Journal of Virology, vol.74, pp.3321-3329, 2000. ,
17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy, Cancer Research, vol.54, pp.2292-2295, 1994. ,
The reovirus fusion-associated small transmembrane (FAST) proteins: virusencoded cellular fusogens, Current Topics in Membranes, vol.68, pp.107-140, 2011. ,
Zur Frage der Entstehung maligner Tumoren, Science, vol.40, pp.857-859, 1914. ,
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint, Current biology: CB, vol.16, pp.1194-1200, 2006. ,
Integrin alpha3 subunit participates in myoblast adhesion and fusion in vitro. Differentiation, Research in Biological Diversity, vol.74, pp.105-118, 2006. ,
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks, Cell, vol.141, pp.243-254, 2010. ,
Cellular mechanisms of tumour suppression by the retinoblastoma gene, Nature Reviews Cancer, vol.8, pp.671-682, 2008. ,
Re-Evaluating Clonal Dominance in Cancer Evolution, Trends in Cancer, vol.2, pp.263-276, 2016. ,
Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates, Nature Medicine, vol.9, pp.1520-1527, 2003. ,
Sarcoma developing in a burn scar: case report and review of the literature, Burns: Journal of the International Society for Burn Injuries, vol.24, pp.68-71, 1998. ,
, Comprehensive molecular characterization of human colon and rectal cancer, Nature, vol.487, pp.330-337, 2012.
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia, The New England Journal of Medicine, vol.368, pp.2059-2074, 2013. ,
Integrated genomic characterization of endometrial carcinoma, Nature, vol.497, pp.67-73, 2013. ,
, Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas, Cell, vol.171, pp.950-965, 2017.
Absolute quantification of somatic DNA alterations in human cancer, Nature Biotechnology, vol.30, pp.413-421, 2012. ,
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up ?, Annals of Oncology, vol.29, pp.51-67, 2018. ,
Overexpression of Eg5 causes genomic instability and tumor formation in mice, Cancer Research, vol.67, pp.10138-10147, 2007. ,
The mini-driver model of polygenic cancer evolution, Nature Reviews Cancer, vol.15, p.680, 2015. ,
Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient, Bone Marrow Transplantation, vol.34, pp.183-186, 2004. ,
Human monocyte$\times$ mouse melanoma fusion hybrids express human gene, Gene, vol.275, pp.103-106, 2001. ,
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science, vol.266, pp.1865-1869, 1994. ,
Fusion competence of myoblasts rendered genetically null for N-cadherin in culture, The Journal of Cell Biology, vol.138, pp.331-336, 1997. ,
Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p, Cell, vol.111, pp.163-172, 2002. ,
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore, Cell, vol.127, pp.983-997, 2006. ,
Unveiling the Mechanisms of Cell-Cell Fusion, Science, vol.308, pp.369-373, 2005. ,
The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma, Cancer research, vol.60, pp.6339-6345, 2000. ,
A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of welldifferentiated liposarcomas, Cancer genetics and cytogenetics, vol.139, pp.24-29, 2002. ,
ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications, Genes, Chromosomes & Cancer, vol.40, pp.32-37, 2004. ,
Biologie moléculaire des sarcomes des tissus mous, Oncologie, vol.9, pp.88-96, 2007. ,
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity, Nature Medicine, vol.16, pp.781-787, 2010. ,
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors, Nature Genetics, vol.45, pp.131-132, 2013. ,
Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data, British Journal of Cancer, vol.85, pp.14-22, 2001. ,
Integrative genomic and transcriptomic analysis of leiomyosarcoma, Nature Communications, vol.9, 2018. ,
Reovirus FAST proteins: virus-encoded cellular fusogens, Trends in Microbiology, vol.22, pp.715-724, 2014. ,
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells, The Journal of Cell Biology, vol.153, pp.517-527, 2001. ,
Anaphase spindle mechanics prevent mis-segregation of merotelically oriented chromosomes, Current biology: CB, vol.14, pp.2149-2155, 2004. ,
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors, Current biology: CB, vol.16, pp.1711-1718, 2006. ,
Emerging landscape of oncogenic signatures across human cancers, Nature Genetics, vol.45, pp.1127-1133, 2013. ,
2) translocation found in human synovial sarcoma, Nature Genetics, vol.7, pp.502-508, 1994. ,
Diversity of TMPRSS2-ERG fusion transcripts in the human prostate, Oncogene, vol.26, pp.2667-2673, 2007. ,
Fusion from without directed by human immunodeficiency virus particles, Journal of Virology, vol.68, pp.1179-1185, 1994. ,
Circulating tumor cells in melanoma patients, PloS One, vol.7, p.41052, 2012. ,
Macrophage-tumor cell fusions from peripheral blood of melanoma patients, PloS One, vol.10, p.134320, 2015. ,
The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement, The Journal of Membrane Biology, vol.199, pp.1-14, 2004. ,
Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group, Cancer: Interdisciplinary International Journal of the American Cancer Society, vol.91, pp.1914-1926, 2001. ,
Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.16, pp.256-262, 2003. ,
Grading of soft tissue sarcomas: review and update, Archives of Pathology & Laboratory Medicine, vol.130, pp.1448-1453, 2006. ,
Well-differentiated and dedifferentiated liposarcomas, Virchows Archiv, vol.456, pp.167-179, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00437654
Contribution of hematopoietic stem cells to skeletal muscle, Nature Medicine, vol.9, pp.1528-1532, 2003. ,
E-cadherin expression during the differentiation of human trophoblasts, Development, vol.113, pp.767-777, 1991. ,
Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study, Blood, vol.115, pp.3089-3097, 2010. ,
DNA breaks and chromosome pulverization from errors in mitosis, Nature, vol.482, pp.53-58, 2012. ,
Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppelassociated box in human synovial sarcoma, The EMBO journal, vol.14, pp.2333-2340, 1995. ,
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.28, pp.1001-1010, 2015. ,
Genome profiling is an efficient tool to avoid the STUMP classification of uterine smooth muscle lesions: a comprehensive array-genomic hybridization analysis of 77 tumors, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.31, pp.816-828, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01926566
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency, Cancer Research, vol.64, pp.440-445, 2004. ,
Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features, The Journal of Pathology, vol.182, pp.437-441, 1997. ,
Inflammation and proliferation act together to mediate intestinal cell fusion, PloS One, vol.4, p.6530, 2009. ,
Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy, Cell, vol.141, pp.81-93, 2010. ,
Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome, Cell, vol.155, pp.948-962, 2013. ,
Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells, Cancer Metastasis Reviews, vol.3, pp.5-24, 1984. ,
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains, Proceedings of the National Academy of Sciences, vol.93, pp.5466-5471, 1996. ,
Liposarcoma: New entities and evolving concepts, Annals of Diagnostic Pathology, vol.4, pp.252-266, 2000. ,
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours, Nature, vol.359, pp.162-165, 1992. ,
The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts, The New England Journal of Medicine, vol.331, pp.294-299, 1994. ,
, Recurrent TRIO Fusion in Nontranslocation-Related Sarcomas, vol.23, pp.857-867, 2017.
Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber, Seminars in Cell & Developmental Biology, vol.72, pp.45-55, 2017. ,
Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas, Laboratory investigation, vol.81, p.211, 2001. ,
Identification of a functional envelope protein from the HERV-K family of human endogenous retroviruses, Journal of Virology, vol.79, pp.15573-15577, 2005. ,
Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution, Cancer Discovery, vol.4, pp.175-185, 2014. ,
RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis, Journal of Cellular Physiology, vol.228, pp.1676-1687, 2013. ,
The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations, EMBO Molecular Medicine, vol.8, pp.442-457, 2016. ,
Soft tissue sarcomas of the head and neck associated with surgical trauma, The Journal of Laryngology and Otology, vol.109, pp.126-129, 1995. ,
Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells, International Journal of Molecular Sciences, vol.16, pp.30362-30381, 2015. ,
Methods to generate genetically engineered mouse models of soft tissue sarcoma, Methods in Molecular Biology, vol.1267, pp.283-295, 2015. ,
Breast cancer statistics and markers, Journal of Cancer Research and Therapeutics, vol.10, pp.506-511, 2014. ,
Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing, PLoS ONE, vol.6, p.20294, 2011. ,
Cell fusion: a hidden enemy, Cancer Cell, vol.3, pp.445-448, 2003. ,
Cell-to-cell fusion as a link between viruses and cancer, Nature Reviews Cancer, vol.7, p.968, 2007. ,
A primate virus generates transformed human cells by fusion, The Journal of Cell Biology, vol.171, pp.493-503, 2005. ,
A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion, Current Biology, vol.17, pp.431-437, 2007. ,
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs), Oncogene, vol.23, pp.3999-4006, 2004. ,
Aneuploidy, the somatic mutation that makes cancer a species of its own, Cell Motility and the Cytoskeleton, vol.47, pp.81-107, 2000. ,
Is carcinogenesis a form of speciation?, Cell Cycle, vol.10, pp.2100-2114, 2011. ,
Ploidy reductions in murine fusion-derived hepatocytes, PLoS genetics, vol.5, p.1000385, 2009. ,
The ploidy conveyor of mature hepatocytes as a source of genetic variation, Nature, vol.467, pp.707-710, 2010. ,
Inactivation of the P16INK4/MTS1 gene by a chromosome translocation t(9;14)(p21-22;q11) in an acute lymphoblastic leukemia of B-cell type, Cancer Research, vol.56, pp.848-854, 1996. ,
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements, Cell Cycle, vol.17, pp.605-615, 2018. ,
Breast cancer genetic evolution: I. Data from cytogenetics and DNA content, Breast Cancer Research and Treatment, vol.19, pp.245-255, 1991. ,
Xeroderma pigmentosum: a glimpse into nucleotide excision repair, genetic instability, and cancer, Critical Reviews in Oncogenesis, vol.13, pp.159-177, 2007. ,
RB1 : a prototype tumor suppressor and an enigma, Genes & Development, vol.30, pp.1492-1502, 2016. ,
Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR, Oncogene, vol.26, pp.7267-7281, 2007. ,
Identification and characterization of cell lines with a defect in a post-adsorption stage of Sendai virusmediated membrane fusion, The Journal of Biological Chemistry, vol.275, pp.17549-17555, 2000. ,
Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation, Journal of Cell Science, vol.114, pp.3631-3642, 2001. ,
DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance, Cancer Research, vol.60, pp.3899-3903, 2000. ,
Hypoxia and inflammation, The New England Journal of Medicine, vol.364, pp.656-665, 2011. ,
Malignancy of Somatic Cell Hybrids, Nature, vol.224, pp.1314-1315, 1969. ,
Soft-tissue sarcomas and exposure to chemical substances: a case-referent study, British Journal of Industrial Medicine, vol.38, pp.27-33, 1981. ,
Exposure to dioxins as a risk factor for soft tissue sarcoma: a population-based case-control study, Journal of the National Cancer Institute, vol.82, pp.486-490, 1990. ,
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells, Nature Cell Biology, vol.16, pp.779-791, 2014. ,
The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization, Human Reproduction Update, vol.8, pp.297-311, 2002. ,
A genetic model for colorectal tumorigenesis, Cell, vol.61, pp.759-767, 1990. ,
, Human Bone Marrow-Derived Stem Cells Acquire Epithelial Characteristics through Fusion with Gastrointestinal Epithelial Cells Ludgate M, vol.6, p.19569, 2011.
Muscle regeneration by bone marrow-derived myogenic progenitors, Science, vol.279, pp.1528-1530, 1998. ,
E-cadherin is important for cell differentiation during osteoclastogenesis, Bone, vol.86, pp.106-118, 2016. ,
Weltgesundheitsorganisation & International Agency for Research on Cancer, Internat. Agency for Research on Cancer, 2013. ,
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors, Science, vol.347, pp.273-277, 2015. ,
Cell fusion in tumor development and progression: occurrence of cell fusion in primary methylcholanthrene-induced tumorigenesis, International Journal of Cancer, vol.44, pp.731-737, 1989. ,
Chromosomal abnormalities in cancer, New England Journal of Medicine, vol.359, pp.722-734, 2008. ,
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells, Nature, vol.437, pp.1043-1047, 2005. ,
Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal musclespecific markers, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.14, pp.595-603, 2001. ,
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma, Nature Genetics, vol.5, pp.230-235, 1993. ,
17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus, Proceedings of the National Academy of Sciences of the United States of America, vol.93, pp.7081-7084, 1996. ,
, Tetraploidy, aneuploidy and cancer. Current Opinion in Genetics & Development, vol.17, pp.157-162, 2007.
A mechanism linking extra centrosomes to chromosomal instability, Nature, vol.460, pp.278-282, 2009. ,
Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation, Cell, vol.158, pp.833-848, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01085073
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers, Cell Reports, vol.23, pp.227-238, 2018. ,
Lessons from the Cancer Genome, Cell, vol.153, pp.17-37, 2013. ,
The Architecture and Evolution of Cancer Neochromosomes, Cancer Cell, vol.26, pp.653-667, 2014. ,
Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group, The American Journal of Surgical Pathology, vol.26, pp.601-616, 2002. ,
The molecular basis of fertilization (Review), International Journal of Molecular Medicine, vol.38, pp.979-986, 2016. ,
Review: An overview of molecular events occurring in human trophoblast fusion, Placenta, vol.36, issue.1, pp.35-42, 2015. ,
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing, The New England Journal of Medicine, vol.366, pp.883-892, 2012. ,
Cancer: Evolution Within a Lifetime, Annual Review of Genetics, vol.48, pp.215-236, 2014. ,
Centrosome-kinetochore interaction in multinucleate cells, Chromosoma, vol.95, pp.136-143, 1987. ,
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos, Cell Division, vol.10, 2015. ,
New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics, The Journal of Pathology, vol.223, pp.64-71, 2011. ,
Dermal fibroblasts convert to a myogenic lineage in mdx mouse muscle, Journal of Cell Science, vol.108, pp.207-214, 1995. ,
Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas, Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, vol.28, pp.2064-2069, 2010. ,
Causes and consequences of centrosome abnormalities in cancer, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.369, pp.20130467-20130467, 2014. ,
In vivo hybridisation of human tumour and normal hamster cells, Nature, vol.250, pp.649-651, 1974. ,
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo, International Journal of Cancer, vol.131, pp.49-58, 2012. ,
Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W, Biochemical and Biophysical Research Communications, vol.331, pp.1193-1200, 2005. ,
Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case, Cancer Genetics and Cytogenetics, vol.140, pp.73-77, 2003. ,
Antigenic characterization of a heterotransplanted human tumour, GW-127, Experientia, vol.24, pp.957-958, 1968. ,
Measles virus-induced suppression of immune responses: Measles virus-induced immunosuppression, Immunological Reviews, vol.236, pp.176-189, 2010. ,
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22, Cell, vol.36, pp.93-99, 1984. ,
Exploiting DNA mismatch repair deficiency as a therapeutic strategy, Experimental Cell Research, vol.329, pp.110-115, 2014. ,
Soft tissue sarcomas with complex genomic profiles, Virchows Archiv, vol.456, pp.201-217, 2010. ,
Dystrophin expression in the mdx mouse restored by stem cell transplantation, Nature, vol.401, pp.390-394, 1999. ,
Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation, The Journal of Clinical Investigation, vol.110, pp.807-814, 2002. ,
Creation of human tumour cells with defined genetic elements, Nature, vol.400, pp.464-468, 1999. ,
Enumeration of the simian virus 40 early region elements necessary for human cell transformation, Molecular and Cellular Biology, vol.22, pp.2111-2123, 2002. ,
A conditional mouse model of synovial sarcoma: insights into a myogenic origin, Cancer Cell, vol.11, pp.375-388, 2007. ,
Rho GTPases and the actin cytoskeleton, Science, vol.279, pp.509-514, 1998. ,
The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation, Nature Communications, vol.7, p.10421, 2016. ,
Hallmarks of Cancer: The Next Generation, Cell, vol.144, pp.646-674, 2011. ,
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B, Nature Genetics, vol.36, pp.1159-1161, 2004. ,
Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung. Archiv für Pathologische Anatomie und, Physiologie und für Klinische Medicin, vol.119, pp.299-326, 1890. ,
, HYBRID CELLS DERIVED FROM MOUSE AND MAN: ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES, vol.205, pp.640-646, 1965.
Suppression of Malignancy by Cell Fusion, Nature, vol.223, pp.363-368, 1969. ,
The Croonian Lecture, 1971: Cell Fusion and the Analysis of Malignancy, Proceedings of the Royal Society B: Biological Sciences, vol.179, pp.1-20, 1971. ,
How tumour suppressor genes were discovered, FASEB journal: official publication of the Federation of American Societies for Experimental Biology, vol.7, pp.978-979, 1993. ,
Risks of leukaemia and solid tumours in individuals with Down's syndrome, Lancet, vol.355, pp.165-169, 2000. ,
Mechanisms of change in gene copy number, Nature Reviews. Genetics, vol.10, pp.551-564, 2009. ,
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation, Proceedings of the National Academy of Sciences of the United States of America, vol.107, pp.4176-4181, 2010. ,
Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations, Human Pathology, vol.33, pp.484-495, 2002. ,
PDGFRA activating mutations in gastrointestinal stromal tumors, Science, vol.299, pp.708-710, 2003. ,
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor, Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, vol.21, pp.4342-4349, 2003. ,
Mechanisms underlying mutational signatures in human cancers, Nature Reviews Genetics, vol.15, pp.585-598, 2014. ,
The hallmarks of cell-cell fusion, Development, vol.144, pp.4481-4495, 2017. ,
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas, Nature Medicine, vol.13, pp.748-753, 2007. ,
Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes, Genome Research, vol.21, pp.665-675, 2011. ,
Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors, Science, vol.279, pp.577-580, 1998. ,
Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma, Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol.21, pp.864-869, 2015. ,
Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements, Nature Medicine, vol.18, pp.1630-1638, 2012. ,
Soft tissue sarcoma in France in 2015: Epidemiology, classification and organization of clinical care, Journal of Visceral Surgery, vol.152, pp.223-230, 2015. ,
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases, The American Journal of Surgical Pathology, vol.28, pp.1257-1267, 2004. ,
CD19 is linked to the integrinassociated tetraspans CD9, CD81, and CD82, The Journal of Biological Chemistry, vol.273, pp.30537-30543, 1998. ,
Sendai virion structure and its interaction with cellular membranes, Electron Microscopy Reviews, vol.1, pp.17-38, 1988. ,
Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1, JAMA oncology, vol.1, pp.1319-1323, 2015. ,
Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion, Virology, vol.384, pp.125-134, 2009. ,
Inner acrosomal membrane of mammalian spermatozoa: its properties and possible functions in fertilization, The American Journal of Anatomy, vol.174, pp.249-268, 1985. ,
The mechanisms of UV mutagenesis, Journal of Radiation Research, vol.52, pp.115-125, 2011. ,
Structural mutations in cancer: mechanistic and functional insights, Trends in Genetics, vol.28, pp.550-559, 2012. ,
The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs, Nature, vol.434, pp.234-238, 2005. ,
Cancer-mutation network and the number and specificity of driver mutations, Proceedings of the National Academy of Sciences, vol.115, pp.6010-6019, 2018. ,
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon, International Journal of Cancer, vol.122, pp.2233-2241, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00320104
Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice, Cancer Research, vol.67, pp.160-166, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-02137886
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis, The Journal of Cell Biology, vol.179, pp.255-267, 2007. ,
Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells, Oncotarget, vol.8, pp.16669-16689, 2017. ,
Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes, Biochemical and Biophysical Research Communications, vol.414, pp.9-13, 2011. ,
Amplification of FRS2 in atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma: a clinicopathological and genetic study of 146 cases, Histopathology, vol.72, pp.1145-1155, 2018. ,
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation, Nature Cell Biology, vol.10, pp.575-583, 2008. ,
Mosaicism in organisation concanavalin A receptors on surface membrane of mouse egg, Nature, vol.257, pp.321-322, 1975. ,
Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei, Nature, vol.226, pp.717-722, 1970. ,
The mechanism of sperm-oocyte fusion in mammals, Reproduction, vol.127, pp.423-429, 2004. ,
Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice, Genes, Chromosomes & Cancer, vol.44, pp.29-36, 2005. ,
CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family, The Journal of Cell Biology, vol.138, pp.203-213, 1997. ,
CDO, a robo-related cell surface protein that mediates myogenic differentiation, The Journal of Cell Biology, vol.143, pp.403-413, 1998. ,
Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation, Proceedings of the National Academy of Sciences of the United States of America, vol.100, pp.3989-3994, 2003. ,
Putting p53 in Context, Cell, vol.170, pp.1062-1078, 2017. ,
Dominant-negative mechanism of leukemogenic PAX5 fusions, Oncogene, vol.31, pp.966-977, 2012. ,
Regulation of NFATc1 in Osteoclast Differentiation, Journal of Bone Metabolism, vol.21, p.233, 2014. ,
Putative chromosomal deletions on 9p, 9q and 22q occur preferentially in malignant gastrointestinal stromal tumors, International Journal of Cancer, vol.85, pp.633-638, 2000. ,
Systematic analysis of short internal indels and their impact on protein folding, BMC structural biology, vol.10, p.24, 2010. ,
A spatially and temporally restricted mouse model of soft tissue sarcoma, Nature Medicine, vol.13, pp.992-997, 2007. ,
STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments, Journal of Cell Science, vol.127, pp.4225-4233, 2014. ,
K-ras mutations in pancreatic ductal proliferative lesions, The American Journal of Pathology, vol.145, pp.1547-1550, 1994. ,
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma, Nature Genetics, vol.18, pp.184-187, 1998. ,
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues, Proceedings of the National Academy of Sciences of the United States of America, vol.111, pp.13409-13414, 2014. ,
Mutation and cancer: statistical study of retinoblastoma, Proceedings of the National Academy of Sciences of the United States of America, vol.68, pp.820-823, 1971. ,
Studies of membrane fusion. III. Fusion of erythrocytes with polyethylene glycol, Journal of Cell Science, vol.36, pp.61-72, 1979. ,
Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates, The Journal of Infectious Diseases, vol.176, pp.94-102, 1997. ,
Differential nuclear ATRX expression in sarcomas, Histopathology, vol.68, pp.738-745, 2016. ,
Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours, International journal of cancer, vol.36, pp.637-641, 1985. ,
Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis, Cold Spring Harbor Perspectives in Biology, vol.9, p.29298, 2017. ,
Transforming activity of human tumor DNAs, Proceedings of the National Academy of Sciences of the United States of America, vol.78, pp.1181-1184, 1981. ,
Circos: an information aesthetic for comparative genomics, Genome Research, vol.19, pp.1639-1645, 2009. ,
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens, 2018. ,
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells, Cell Cycle, vol.14, pp.2810-2820, 2015. ,
The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation, The American Journal of Pathology, vol.165, pp.2157-2166, 2004. ,
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation, Molecular Biology of the Cell, vol.16, pp.861-870, 2005. ,
Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors, Clinical Cancer Research, vol.18, pp.826-838, 2012. ,
Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas, Journal of Clinical Oncology, vol.31, pp.608-615, 2013. ,
Stable Instability of Sarcoma Cell Lines Genome Despite Intra-Tumoral Heterogeneity: A Genomic and Transcriptomic Study of Sarcoma Cell Lines, Austin J Genet Genomic Res, 2015. ,
Genomic index predicts clinical outcome of intermediate-risk gastrointestinal stromal tumours, providing a new inclusion criterion for imatinib adjuvant therapy, European Journal of Cancer, vol.51, pp.75-83, 2015. ,
A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential, Laboratory Investigation; a Journal of Technical Methods and Pathology, vol.84, pp.874-883, 2004. ,
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo, Proceedings of the National Academy of Sciences of the United States of America, vol.105, pp.15446-15451, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02385094
The shock of being united and symphiliosis: Another lesson from plants?, Cell Cycle, vol.13, pp.2323-2329, 2014. ,
A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer, PLoS ONE, vol.8, p.66731, 2013. ,
Polymer-induced membrane fusion: potential mechanism and relation to cell fusion events, Chemistry and Physics of Lipids, vol.73, pp.91-106, 1994. ,
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts, Cancer Cell, vol.1, pp.393-401, 2002. ,
Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer, Gastroenterology, vol.101, pp.1198-1210, 1991. ,
Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?, Annals of Internal Medicine, vol.71, pp.747-752, 1969. ,
Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas, Modern Pathology, vol.28, pp.1545-1554, 2015. ,
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations, DNA repair, vol.5, pp.1234-1245, 2006. ,
Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice, Carcinogenesis, vol.30, pp.1789-1795, 2009. ,
Cell-fusion-mediated somatic-cell reprogramming: a mechanism for tissue regeneration, Journal of Cellular Physiology, vol.223, pp.6-13, 2010. ,
Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium, Current Biology, vol.23, pp.2224-2232, 2013. ,
N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts, Proceedings of the National Academy of Sciences of the United States of America, vol.107, pp.4212-4217, 2010. ,
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants, Proceedings of the National Academy of Sciences, vol.106, pp.9385-9390, 2009. ,
Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis, Trends in Cell Biology, vol.27, pp.917-930, 2017. ,
Modulation of phosphatidylserine epitope expression by BeWo cells during forskolin treatment, Placenta, vol.14, pp.177-186, 1993. ,
Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain, British Journal of Cancer, vol.108, pp.2455-2463, 1951. ,
Chromothripsis and Kataegis Induced by Telomere Crisis, Cell, vol.163, pp.1641-1654, 2015. ,
Telomeres in cancer: tumour suppression and genome instability, Nature Reviews. Molecular Cell Biology, vol.18, pp.175-186, 2017. ,
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, The Journal of Biological Chemistry, vol.273, pp.13375-13378, 1998. ,
Establishment of a human malignant fibrous histiocytoma cell line, COMA. Characterization By conventional cytogenetics, comparative genomic hybridization, and multiplex fluorescence In situ hybridization, Cancer Genetics and Cytogenetics, vol.121, pp.117-123, 2000. ,
Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells, Placenta, vol.28, pp.185-191, 2007. ,
Induced chromosomal proximity and gene fusions in prostate cancer, Science, vol.326, p.1230, 2009. ,
Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer, American Journal of Cancer Research, vol.1, pp.604-617, 2011. ,
, & Aurias A. 2007. JUN Oncogene Amplification and Overexpression Block Adipocytic Differentiation in Highly Aggressive Sarcomas, vol.11, pp.361-374
RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays, Genome Research, vol.18, pp.1509-1517, 2008. ,
Universal Patterns of Selection in Cancer and Somatic Tissues, Cell, vol.171, pp.1029-1041, 2017. ,
Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers, Cell, vol.160, pp.913-927, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01126597
The Arf/p53 pathway in cancer and aging, Cancer Research, vol.68, pp.6031-6034, 2008. ,
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation, Proceedings of the National Academy of Sciences of the United States of America, vol.90, pp.5752-5756, 1993. ,
Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS, The New England Journal of Medicine, vol.332, pp.12-18, 1995. ,
Chromosome organization and genic expression, Cold Spring Harbor Symposia on Quantitative Biology, vol.16, pp.13-47, 1951. ,
The significance of responses of the genome to challenge, Science, vol.226, pp.792-801, 1984. ,
Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution, Cancer Cell, vol.27, pp.15-26, 2015. ,
Mice lacking ?3 integrins are osteosclerotic because of dysfunctional osteoclasts, Journal of Clinical Investigation, vol.105, pp.433-440, 2000. ,
Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells, Journal of Experimental Medicine, vol.167, pp.598-611, 1988. ,
?1 and ?2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell Formation, The American Journal of Pathology, vol.160, pp.621-630, 2002. ,
deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data, PLoS computational biology, vol.7, p.1001138, 2011. ,
Analysis of chromosomal imbalances in sporadic and NF1-associated peripheral nerve sheath tumors by comparative genomic hybridization, Genes, Chromosomes & Cancer, vol.25, pp.362-369, 1999. ,
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair, Cold Spring Harbor Perspectives in Biology, vol.6, pp.16428-016428, 2014. ,
Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant, The American Journal of Surgical Pathology, vol.20, pp.391-405, 1996. ,
Aurora kinases link chromosome segregation and cell division to cancer susceptibility, Current Opinion in Genetics & Development, vol.14, pp.29-36, 2004. ,
Genomic characteristics of soft tissue sarcomas, Virchows Archiv, vol.456, pp.129-139, 2010. ,
The emerging complexity of gene fusions in cancer, Nature Reviews Cancer, vol.15, pp.371-381, 2015. ,
Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes, Genes, Chromosomes & Cancer, vol.55, pp.291-310, 2016. ,
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis, Nature, vol.403, pp.785-789, 2000. ,
Induction of early mitotic events in a cell-free system, Cell, vol.41, pp.165-175, 1985. ,
Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL, Leukemia, vol.23, pp.2242-2247, 2009. ,
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells, Nature, vol.409, pp.355-359, 2001. ,
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis, Archives of Pathology & Laboratory Medicine, vol.130, pp.1466-1478, 2006. ,
Myomaker is a membrane activator of myoblast fusion and muscle formation, Nature, vol.499, pp.301-305, 2013. ,
Spontaneous fusion between metastatic mammary tumor subpopulations, Journal of Cellular Biochemistry, vol.36, pp.129-136, 1988. ,
Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations, Cancer Research, vol.49, pp.4316-4321, 1989. ,
The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1, Progress in Tumor Research, S. Karger AG, pp.273-301, 1968. ,
Metabolic activation and reactivity of chemical carcinogens, Mutation Research, vol.33, pp.25-26, 1975. ,
Carcinogens occurring naturally in foods, Federation Proceedings, vol.35, pp.1316-1321, 1976. ,
Some historical aspects of N-aryl carcinogens and their metabolic activation, Environmental Health Perspectives, vol.49, pp.3-12, 1983. ,
The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole, British Journal of Cancer, vol.48, pp.1-15, 1983. ,
The impact of translocations and gene fusions on cancer causation, Nature Reviews Cancer, vol.7, pp.233-245, 2007. ,
An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion, Journal of Biological Chemistry, vol.287, pp.32479-32484, 2012. ,
, Fusion in Cancer: An Explanatory Model for Aneuploidy, Metastasis Formation, and Drug Resistance, pp.21-40, 2015.
IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin, Journal of Leukocyte Biology, vol.82, pp.1542-1553, 2007. ,
Complete sequence of the Sendai virus NP gene from a cloned insert, Virology, vol.135, pp.279-287, 1984. ,
Mapping and quantifying mammalian transcriptomes by RNA-Seq, Nature Methods, vol.5, pp.621-628, 2008. ,
Virus cell-to-cell transmission, Journal of Virology, vol.84, pp.8360-8368, 2010. ,
Terminal phase of cytokinesis in D-98s cells, The Journal of Cell Biology, vol.73, pp.672-684, 1977. ,
Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.20, pp.749-759, 2007. ,
Chromosomal translocations in cancer, Biochimica et Biophysica Acta (BBA) -Reviews on Cancer, vol.1786, pp.139-152, 2008. ,
Aneuploidy in Cancer and Aging, Annual Review of Genetics, vol.50, pp.45-66, 2016. ,
Sarcomas, example of a pathologist network organization, Bulletin du Cancer, pp.1275-1281, 2013. ,
Grading of soft tissue sarcomas: from histological to molecular assessment, Pathology, vol.46, pp.113-120, 2014. ,
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries, Nature Cell Biology, vol.13, pp.1154-1160, 2011. ,
Mutational processes molding the genomes of 21 breast cancers, Cell, vol.149, pp.979-993, 2012. ,
Apoptosis-induced cancer cell fusion: a mechanism of breast cancer metastasis, FASEB journal: official publication of the Federation of American Societies for Experimental Biology, vol.29, pp.4036-4045, 2015. ,
, Chromosome Studies on Normal and Leukemic Human Leukocytes. JNCI: Journal of the National Cancer Institute, 1960.
The clonal evolution of tumor cell populations, Science, vol.194, pp.23-28, 1976. ,
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation, Nature Medicine, vol.10, pp.494-501, 2004. ,
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion, Nature Cell Biology, vol.10, pp.584-592, 2008. ,
Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas, Genes, Chromosomes and Cancer, vol.23, pp.187-193, 1998. ,
Biological implications of cell fusion, Nature Reviews Molecular Cell Biology, vol.6, pp.567-575, 2005. ,
Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database, Cancer, vol.118, pp.1387-1396, 2012. ,
Integrated genetic and epigenetic analysis of myxofibrosarcoma, Nature Communications, vol.9, p.2765, 2018. ,
Tetraploidy and chromosomal instability are early events during cervical carcinogenesis, Carcinogenesis, vol.27, pp.337-343, 2006. ,
Loss of heterozygosity at 1p36 predicts poor prognosis in gastrointestinal stromal/smooth muscle tumors, Laboratory Investigation; a Journal of Technical Methods and Pathology, vol.79, pp.1461-1467, 1999. ,
Mechanisms of transcription factor deregulation in lymphoid cell transformation, Oncogene, vol.26, pp.6838-6849, 2007. ,
Genomic complexity in pediatric synovial sarcomas (Synobio study): the European pediatric soft tissue sarcoma group (EpSSG) experience, Cancer Medicine, vol.7, pp.1384-1393, 2018. ,
Detection of chromosomal imbalances in leiomyosarcoma by comparative genomic hybridization and interphase cytogenetics, Cytogenetics and Cell Genetics, vol.90, pp.86-92, 2000. ,
E-cadherin cytoplasmic domain inhibits cell surface localization of endogenous cadherins and fusion of C2C12 myoblasts, Biology Open, vol.4, pp.1427-1435, 2015. ,
Malignant fibrous histiocytoma and squamous carcinoma derived from a burn scar, Acta Chirurgica Belgica, vol.104, pp.745-747, 2004. ,
Myoblasts and macrophages share molecular components that contribute to cell-cell fusion, The Journal of Cell Biology, vol.180, pp.1005-1019, 2008. ,
Rhabdomyosarcomas in adults and children: an update, Archives of Pathology & Laboratory Medicine, vol.130, pp.1454-1465, 2006. ,
Involvement of Brca2 in DNA Repair, Molecular Cell, vol.1, pp.347-357, 1998. ,
Altered Nglycosylation in macrophage x melanoma fusion hybrids, Cellular and Molecular Biology, vol.45, pp.1011-1027, 1999. ,
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis, Nature Reviews Cancer, vol.8, p.377, 2008. ,
Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma, Genes, Chromosomes & Cancer, vol.10, pp.85-94, 1994. ,
Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement, Cytogenetics and Cell Genetics, vol.72, pp.171-174, 1996. ,
Common signalling pathways in macrophage and osteoclast multinucleation, Journal of Cell Science, vol.131, p.216267, 2018. ,
Structural Basis of Eukaryotic Cell-Cell Fusion, Cell, vol.157, pp.407-419, 2014. ,
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas, Cancer Research, vol.69, pp.2269-2278, 2009. ,
, Constant p53 Pathway Inactivation in a Large Series of Soft Tissue Sarcomas with Complex Genetics, vol.177, pp.2080-2090, 2010.
A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion, Nature Genetics, vol.44, pp.461-466, 2012. ,
Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22, The Journal of Pathology, vol.185, pp.188-190, 1998. ,
Cell fusion contributes to pericyte formation after stroke, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, vol.29, pp.480-485, 2009. ,
Virus and Cell Fusion Mechanisms, Annual Review of Cell and Developmental Biology, vol.30, pp.111-139, 2014. ,
Cutaneous leiomyosarcoma arising in a smallpox scar, World Journal of Surgical Oncology, vol.10, p.148, 2012. ,
Driver and Passenger Mutations in Cancer, Annual Review of Pathology: Mechanisms of Disease, vol.10, pp.25-50, 2015. ,
Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation, Cancer Research, vol.72, pp.5454-5462, 2012. ,
Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action, Human Reproduction Update, vol.10, pp.487-496, 2004. ,
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development, Nature Communications, vol.8, p.15665, 2017. ,
Melanoma x macrophage hybrids with enhanced metastatic potential, Clinical & Experimental Metastasis, vol.16, pp.299-312, 1998. ,
Developmental defects in mouse embryos lacking N-cadherin, Developmental Biology, vol.181, pp.64-78, 1997. ,
Mammalian cell fusion in an electroporation device, Journal of Immunological Methods, vol.188, pp.209-217, 1995. ,
Spatio-temporal coordination of cell cycle exit, fusion and differentiation of adult muscle precursors by Drosophila Erect wing (Ewg), Mechanisms of Development, vol.141, pp.109-118, 2016. ,
Fusion-derived epithelial cancer cells express hematopoietic markers and contribute to stem cell and migratory phenotype in ovarian carcinoma, Cancer Research, vol.73, pp.5360-5370, 2013. ,
Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis, Nature, vol.225, pp.159-164, 1970. ,
Premature chromosome condensation: a mechanism for the elimination of chromosomes in virus-fused cells, Journal of Cell Science, vol.10, pp.495-513, 1972. ,
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity, The American Journal of Pathology, vol.180, pp.2504-2515, 2012. ,
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene, Nature, vol.300, pp.149-152, 1982. ,
Exogenous genes are expressed in mdx muscle fibres following implantation of primary mouse skin cells, Basic App. Myol, pp.211-219, 1997. ,
Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas, Oncology Letters, vol.15, pp.7489-7496, 2018. ,
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates, Journal of Molecular Biology, vol.352, pp.1029-1034, 2005. ,
Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors, Genes, Chromosomes & Cancer, vol.15, pp.234-245, 1996. ,
DNA copy number losses in chromosome 14: an early change in gastrointestinal stromal tumors, Cancer Research, vol.56, pp.3230-3233, 1996. ,
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53, Molecular Cell, vol.62, pp.890-902, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01886397
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells, Proceedings of the National Academy of Sciences of the United States of America, vol.103, pp.6321-6325, 2006. ,
Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase, Annual Review of Pathology, vol.8, pp.79-103, 2013. ,
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing, Nature Genetics, vol.45, pp.180-185, 2013. ,
Sperm phospholipases and acrosomal exocytosis, Frontiers in Bioscience: A Journal and Virtual Library, vol.12, pp.89-104, 2007. ,
Spatial dynamics of chromosome translocations in living cells, Science, vol.341, pp.660-664, 2013. ,
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth, Cell Reports, vol.15, pp.2679-2691, 2016. ,
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors, Cancer Research, vol.61, pp.8118-8121, 2001. ,
, Gastrointestinal stromal tumour. The Lancet, vol.369, pp.1731-1741, 2007.
Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes, Journal of Molecular Medicine, vol.88, pp.1143-1156, 2010. ,
Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution, Developmental Biology, vol.304, pp.317-325, 2007. ,
Selective advantage of trisomic human cells cultured in non-standard conditions, 2016. ,
Simulated coevolution in a mutating ecology, Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, vol.61, pp.2212-2215, 2000. ,
A virus-encoded cell-cell fusion machine dependent on surrogate adhesins, PLoS pathogens, vol.4, p.1000016, 2008. ,
Myoblast fusion confusion: the resolution begins, Skeletal Muscle, vol.8, p.3, 2018. ,
Wnt/?-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina, Cell Reports, vol.4, pp.271-286, 2013. ,
The Role of Aneuploidy in Cancer Evolution, Cold Spring Harbor Perspectives in Medicine, vol.7, p.28373, 2017. ,
Determinants and clinical implications of chromosomal instability in cancer, Nature Reviews Clinical Oncology, vol.15, pp.139-150, 2018. ,
Aneuploidy-induced cellular stresses limit autophagic degradation, Genes & Development, vol.29, pp.2010-2021, 2015. ,
MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation, Nature Communications, vol.8, p.14674, 2017. ,
, CIN and Aneuploidy: Different Concepts, Different Consequences, vol.40, p.1700147, 2018.
Neoantigens encoded in the cancer genome, Current Opinion in Immunology, vol.41, pp.98-103, 2016. ,
Beta1 integrins regulate myoblast fusion and sarcomere assembly, Developmental Cell, vol.4, pp.673-685, 2003. ,
Cell-cell fusion as a mechanism of DNA exchange in cancer, Oncotarget, vol.9, p.6156, 2018. ,
Classification and Subtype Prediction of Adult Soft Tissue Sarcoma by Functional Genomics, The American Journal of Pathology, vol.163, pp.691-700, 2003. ,
Reprogramming Mediated by Cell Fusion Technology, International Review of Cell and Molecular Biology, pp.155-190, 2011. ,
On the origin of cancer metastasis, Critical Reviews in Oncogenesis, vol.18, pp.43-73, 2013. ,
Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival, International Journal of Cancer, vol.123, pp.780-786, 2008. ,
Single-chromosome Gains Commonly Function as Tumor Suppressors, Cancer Cell, vol.31, pp.240-255, 2017. ,
Development of a sarcoma in a surgical scar, Postgraduate Medical Journal, vol.63, pp.1097-1098, 1987. ,
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines, Nature, vol.437, pp.1038-1042, 2005. ,
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts, Nature, vol.290, pp.261-264, 1981. ,
Sequence of 3,687 nucleotides from the 3' end of Sendai virus genome RNA and the predicted amino acid sequences of viral NP, P and C proteins, Nucleic Acids Research, vol.11, pp.7317-7330, 1983. ,
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors, Proceedings of the National Academy of Sciences, vol.110, pp.4134-4141, 2013. ,
The hidden duplication past of Arabidopsis thaliana, Proceedings of the National Academy of Sciences of the United States of America, vol.99, pp.13627-13632, 2002. ,
Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism, Pigment Cell Research, vol.11, pp.299-309, 1998. ,
Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion, Bone, vol.48, pp.837-846, 2011. ,
A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion, Proceedings of the National Academy of Sciences, vol.106, pp.9274-9279, 2009. ,
Mutational inactivation of STAG2 causes aneuploidy in human cancer, Science, vol.333, pp.1039-1043, 2011. ,
Tumor necrosis factor-? enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway, Experimental Cell Research, vol.318, pp.1707-1715, 2012. ,
Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms, The New England Journal of Medicine, vol.314, pp.1010-1015, 1986. ,
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice, Cancer Cell, vol.11, pp.9-23, 2007. ,
p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies, Cell Reports, vol.19, pp.2423-2431, 2017. ,
Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis, Scientific Reports, vol.6, 2016. ,
Prostate cancer as a model system for genetic diversity in tumors, Advances in Cancer Research, vol.112, pp.183-216, 2011. ,
Suppression of malignancy in human cells, Nature, vol.260, pp.17-20, 1976. ,
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development, Cell, vol.144, pp.27-40, 2011. ,
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells, Molecular Systems Biology, vol.8, 2012. ,
Genome-wide genetic analysis of polyploidy in yeast, Nature, vol.443, pp.541-547, 2006. ,
Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma, International Journal of Cancer, vol.117, pp.1055-1057, 2005. ,
The cancer genome, Nature, vol.458, pp.719-724, 2009. ,
Mechanism of activation of a human oncogene, Nature, vol.300, pp.143-149, 1982. ,
Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo, The Journal of Cell Biology, vol.175, pp.383-388, 2006. ,
Tetraploidy in cancer and its possible link to aging, Cancer Science, 2018. ,
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors, Journal of Clinical Investigation, vol.91, pp.257-263, 1993. ,
Identification of Aneuploidy-Selective Antiproliferation Compounds, Cell, vol.144, pp.499-512, 2011. ,
Advances in sarcoma genomics and new therapeutic targets, Nature Reviews Cancer, vol.11, pp.541-557, 2011. ,
Examining the link between chromosomal instability and aneuploidy in human cells, The Journal of Cell Biology, vol.180, pp.665-672, 2008. ,
Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors, Proceedings of the National Academy of Sciences, vol.108, pp.17974-17978, 2011. ,
Mesenchymal stem cell features of Ewing tumors, Cancer Cell, vol.11, pp.421-429, 2007. ,
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations, Cancer Discovery, vol.4, pp.1342-1353, 2014. ,
TGF-?-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway, The Journal of Biological Chemistry, vol.287, pp.11602-11615, 2012. ,
Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system, International Journal of Cancer, vol.33, pp.37-42, 1984. ,
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice, Oncogene, vol.25, pp.7673-7679, 2006. ,
Metastasis as an evolutionary process, Science, vol.352, pp.169-175, 2016. ,
, , 1983.
, Comptes rendus des seances de l'Academie des sciences, Sciences de la vie, vol.296, pp.1101-1103
Consistent chromosomal translocation in alveolar rhabdomyosarcoma, Cancer Genetics and Cytogenetics, vol.19, pp.361-362, 1986. ,
Insertional polymorphisms of full-length endogenous retroviruses in humans, Current biology: CB, vol.11, pp.1531-1535, 2001. ,
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens, The Journal of Cell Biology, vol.216, pp.571-581, 2017. ,
Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway, Cancer Research, vol.75, pp.605-614, 2015. ,
Transplanted bone marrow regenerates liver by cell fusion, Nature, vol.422, pp.901-904, 2003. ,
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.8935-8940, 2009. ,
Tumor Evolutionary Principles: How Intratumor Heterogeneity Influences Cancer Treatment and Outcome, Annual Meeting, vol.35, pp.141-149, 2016. ,
Macrophage fusion: the making of osteoclasts and giant cells, The Journal of Experimental Medicine, vol.202, pp.337-340, 2005. ,
Cancer genome landscapes, Science, vol.339, pp.1546-1558, 2013. ,
Efficient spontaneous fusion between some co-cultured cells, especially murine melanoma cells, Cell Biology International, vol.18, pp.207-210, 1994. ,
Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells, Science, vol.190, pp.784-785, 1975. ,
Spleen cells transmit osteopetrosis in mice, Science, vol.190, pp.785-787, 1975. ,
Domains involved in ETO and human N-CoR interaction and ETO transcription repression, Leukemia Research, vol.28, pp.409-414, 2004. ,
The NF-?B subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells, International Journal of Oncology, vol.49, pp.381-392, 2016. ,
Cell fusion is the principal source of bone-marrow-derived hepatocytes, Nature, vol.422, pp.897-901, 2003. ,
Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors, International Journal of Cancer, vol.106, pp.887-895, 2003. ,
Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid, Nature, vol.171, pp.737-738, 1953. ,
Transcriptomic definition of molecular subgroups of small round cell sarcomas, The Journal of Pathology, vol.245, pp.29-40, 2018. ,
Aneuploidy acts both oncogenically and as a tumor suppressor, Cancer Cell, vol.11, pp.25-36, 2007. ,
Characterizing the cancer genome in lung adenocarcinoma, Nature, vol.450, pp.893-898, 2007. ,
Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer, vol.32, pp.1-5, 2018. ,
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme, Critical Reviews in Biochemistry and Molecular Biology, vol.43, pp.189-219, 2008. ,
Sarcoma and trauma, British Journal of Surgery, vol.18, pp.321-325, 1930. ,
Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model, Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol.19, pp.407-416, 2006. ,
Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells, Science, vol.322, pp.703-709, 2008. ,
State of the art in cell-cell fusion, Cell Fusion, pp.1-19, 2015. ,
Polarised cell migration: intrinsic and extrinsic drivers, Current Opinion in Cell Biology, vol.30, pp.25-32, 2014. ,
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps, Molecular and Cellular Biology, vol.20, pp.3951-3964, 2000. ,
Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells, Journal of Bone and Mineral Metabolism, vol.24, pp.355-358, 2006. ,
Chemotherapy promotes tumour cell hybridization in vivo, Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine, vol.37, pp.5025-5030, 2016. ,
APOBEC: From mutator to editor, Journal of Genetics and Genomics, vol.44, pp.423-437, 2017. ,
Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma, American Journal of Translational Research, vol.7, pp.2072-2081, 2015. ,
Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT-tumor hybrids by FISH, Bone Marrow Transplantation, vol.35, pp.1021-1024, 2005. ,
Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors, Cancer, vol.117, pp.380-389, 2011. ,
The landscape and therapeutic relevance of cancer-associated transcript fusions, Oncogene, vol.34, pp.4845-4854, 2015. ,
Myogenesis and muscle regeneration, Histochemistry and Cell Biology, vol.138, pp.187-199, 2012. ,
Pan-cancer patterns of somatic copy number alteration, Nature Genetics, vol.45, pp.1134-1140, 2013. ,
Evolving concepts of tumor heterogeneity, Cell & Bioscience, vol.4, p.69, 2014. ,
The microprotein Minion controls cell fusion and muscle formation, Nature Communications, vol.8, p.15664, 2017. ,
Comparison of stranded and non-stranded RNA-seq transcriptome profiling and investigation of gene overlap, BMC Genomics, vol.16, 2015. ,
Cell-to-cell transmission of viruses, Current Opinion in Virology, vol.3, pp.44-50, 2013. ,
Cell Fusion Connects Oncogenesis with Tumor Evolution, The American Journal of Pathology, vol.185, pp.2049-2060, 2015. ,
Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population, Cancer, vol.79, pp.2125-2131, 1997. ,
, L'ensemble des profils génomiques de la partie « Implication du cycle cellulaire dans la formation d'altérations dans les hybrides » sont présentés ci-dessous. Pour chaque profil, l'axe des abscisses représentent les chromosomes de 1 à Y