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Theses

Isotopes radioactifs produits par voies non conventionnelles

Abstract : Nuclear medicine uses radionuclides for diagnosis and therapy. Nowadays, the nuclear medicine tends to adapt more efficiently to each patient. To achieve this goal, a wide range of radionuclides must be available for the physician’s requirements. A theranostic approach (therapy and diagnosis) can be implemented from drug’s design in order to guide medicine towards a personalised medicine. In this sense, studies on the production of innovative radionuclides using unconventional pathways (deuteron beams, non-standard target materials: enriched targets or fission products) were conducted during this thesis. Reaction pathways 197Au(d,2n)197mHg and 70Zn(d,x)67Cu were identified as relevant and their cross section were measured. The production parameters limiting the production of contaminants were proposed and yields were calculated for the highlighted reactions. For the measurements of these cross sections, a new experimental device has been designed to directly measure the particle flow. An intensive study on the optimal operational conditions was performed by defining an uncertainty of measurements of 2%. This device allows obtaining cross-section values with diminished uncertainties in comparison with the commonly used method of monitor reactions which have uncertainties of the order of 10%. The possibility of recovering light fission products from spent nuclear fuel was also explored. These fission products can be considered as a target to produce radionuclides of medical interest. Some nuclei, which can be created from these fission products, have been identified and their production pathways, based on their cross sections, have been studied in detail. The yield curves were calculated for the reaction paths were recognised as potentially interesting/feasible for this mean.
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Submitted on : Wednesday, January 8, 2020 - 7:00:10 PM
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Etienne Nigron. Isotopes radioactifs produits par voies non conventionnelles. Physique Nucléaire Expérimentale [nucl-ex]. Université de Nantes - Faculté des Sciences et Techniques, 2019. Français. ⟨tel-02433056⟩

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