A role for direct interactions in the modulation of rhodopsin by -3 polyunsaturated lipids, Proceedings of the National Academy of Sciences, vol.103, pp.4888-4893, 2006. ,
Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials, PLoS ONE, vol.9, p.96905, 2014. ,
Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors, 2016. ,
Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study, Schizophrenia Research, vol.171, pp.225-232, 2016. ,
Modulation of Ca2+ channels ?? G-protein py subunits, Nature, vol.380, pp.258-262, 1996. ,
Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET, Psychopharmacology, vol.197, pp.581-590, 2008. ,
Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D 2/3 receptors in major depressive disorder studied with [ 11 C]raclopride PET, Journal of Psychopharmacology, vol.25, pp.1329-1336, 2011. ,
Red blood cell polyunsaturated fatty acids measured in red blood cells and schizophrenia: A metaanalysis, Psychiatry Research, vol.207, pp.1-12, 2013. ,
Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging, Curr. Pharm. Des, vol.15, pp.2550-2559, 2009. ,
Brain lipid concentrations in bipolar disorder, Journal of Psychiatric Research, vol.44, pp.177-182, 2010. ,
Voltage-dependent modulation of N-type calcium channels by G-protein ? ?subunits, Nature, vol.380, pp.255-258, 1996. ,
Association analyses between brain-expressed fattyacid binding protein ( FABP ) genes and schizophrenia and bipolar disorder, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.153, pp.484-493, 2010. ,
Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models, International Journal of Developmental Neuroscience, vol.64, pp.38-47, 2018. ,
Dopamine D2 receptors in striatal output neurons enable the psychomotor effects of cocaine, Proceedings of the National Academy of Sciences, vol.113, pp.11609-11614, 2016. ,
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions, Nature Neuroscience, vol.14, pp.345-350, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00612705
Fatty acid composition in postmortem brains of people who completed suicide, J Psychiatry Neurosci, vol.32, pp.363-370, 2007. ,
Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxietylike behavior in mice, Journal of Physiology and Biochemistry, vol.68, pp.671-681, 2012. ,
Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resistant major depressive disorder, vol.2, pp.38-46, 2014. ,
Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation, Lipids in Health and Disease, vol.15, 2016. ,
Ala54Thr Fatty Acid-Binding Protein 2 (FABP2) Polymorphism in Recurrent Depression: Associations with Fatty Acid Concentrations and Waist Circumference, PLoS ONE, vol.8, 2013. ,
Extrastriatal D2 and striatal D2 receptors in depressive illness: Pilot PET studies using [11C]FLB 457 and [11C]raclopride, Journal of Affective Disorders, vol.101, pp.113-122, 2007. ,
Disambiguating ventral striatum fMRI-related bold signal during reward prediction in schizophrenia, Molecular Psychiatry, vol.17, pp.280-289, 2012. ,
BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.78, pp.351-360, 2008. ,
Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity, The Journal of Neuroscience, vol.37, pp.2723-2733, 2017. ,
Epigenetic Basis of Mental Illness, The Neuroscientist, vol.22, pp.447-463, 2016. ,
Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n -3 Fatty Acid Deficiency, Journal of Biological Chemistry, vol.279, pp.31098-31104, 2004. ,
Cross-National Comparisons of Seafood Consumption and Rates of Bipolar Disorders, American Journal of Psychiatry, vol.160, pp.2222-2227, 2003. ,
Identification of Pathways for Bipolar Disorder: A Meta-analysis, JAMA Psychiatry, vol.71, p.657, 2014. ,
Crystal structure of rhodopsin: A G protein-coupled receptor, Science, vol.289, pp.739-745, 2000. ,
International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis, Br J Psychiatry, vol.184, pp.404-408, 2004. ,
Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Individuals With Major Depressive Disorder, American Journal of Psychiatry, vol.166, pp.702-710, 2009. ,
Red blood cell fatty acids are associated with depression in a case-control study of adolescents, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.86, pp.161-165, 2012. ,
n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPKdependent mechanism, Molecular Psychiatry, vol.12, pp.36-46, 2007. ,
The Mysterious Motivational Functions of Mesolimbic Dopamine, Neuron, vol.76, pp.470-485, 2012. ,
, REFERENCES BIBLIOGRAPHIQUES, vol.184
A Dual Hit Model for Dopamine in Schizophrenia, Biological Psychiatry, vol.81, 2017. ,
, Actualisation des apports nutritionnels conseillés pour les acides gras: rapport d'expertise collective, 2011.
A review of the possible role of the essential fatty acids and fish oils in the aetiology, prevention or pharmacotherapy of schizophrenia: Essential fatty acids and schizophrenia, Journal of Clinical Pharmacy and Therapeutics, vol.37, pp.132-139, 2012. ,
The vulnerable ventral tegmental area in Parkinson's disease, Basal Ganglia, vol.5, pp.51-55, 2015. ,
Why is depression more prevalent in women, Journal of Psychiatry & Neuroscience, vol.40, pp.219-221, 2015. ,
Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy, Proceedings of the National Academy of Sciences, vol.108, pp.18488-18493, 2011. ,
Dietary intake in population-based adolescents: support for a relationship between eating disorder symptoms, low fatty acid intake and depressive symptoms, Journal of Human Nutrition and Dietetics, vol.26, pp.459-469, 2013. ,
The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods, Biochimica et Biophysica Acta (BBA) -Biomembranes, vol.1808, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00632160
, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, American Psychiatric Association, 2013.
Long-Chain ?-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Placebo-Controlled Trial, Archives of General Psychiatry, vol.67, 2010. ,
Longerterm outcome in the prevention of psychotic disorders by the Vienna omega-3 study, Nature Communications, vol.6, 2015. ,
Striatal dopamine transporter availability in unmedicated bipolar disorder: Striatal DAT in unmedicated bipolar disorder, Bipolar Disorders, vol.13, pp.406-413, 2011. ,
Lesions of the human amygdala impair enhanced perception of emotionally salient events, Nature, vol.411, pp.305-309, 2001. ,
Evaluation of a novel translational task for assessing emotional biases in different species, Cognitive, Affective, & Behavioral Neuroscience, vol.12, pp.373-381, 2012. ,
Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index, PLOS ONE, vol.12, 2017. ,
, Apathy: a neuropsychiatric syndrome, The Journal of Neuropsychiatry and Clinical Neurosciences, vol.3, pp.243-254, 1991.
Omega-3 fatty acids for depression in adults, Cochrane Database of Systematic Reviews, 2015. ,
Effect of a diet supplemented with soybean oil or fish oil on the reversibility of docosahexaenoic acid deficiency (22:6w3) in the brain and erythrocytes of rats, Arch Latinoam Nutr, vol.44, pp.105-111, 1994. ,
Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients, Biol. Psychiatry, vol.53, pp.56-64, 2003. ,
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment, Molecular Psychiatry, vol.22, pp.666-679, 2017. ,
Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women, Lipids, vol.39, pp.527-535, 2004. ,
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort, Journal of Psychiatric Research, vol.44, pp.748-753, 2010. ,
Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy: FRONTOSTRIATAL CONNECTIVITY AND APATHY IN PD, Movement Disorders, vol.30, pp.671-679, 2015. ,
A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task, Behavioral Neuroscience, vol.129, pp.269-280, 2015. ,
Neural substrates underlying effort, time, and risk-based decision making in motivated behavior, Neurobiology of Learning and Memory, vol.133, pp.233-256, 2016. ,
Metabolism and functional effects of plant-derived omega-3 fatty acids in humans, Progress in Lipid Research, vol.64, pp.30-56, 2016. ,
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates, Neuropharmacology, vol.37, pp.407-419, 1998. ,
Dopamine Modulates Release from Corticostriatal Terminals, Journal of Neuroscience, vol.24, pp.9541-9552, 2004. ,
Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors, Neuron, vol.97, pp.494-510, 2018. ,
Association between BanI genotype and increased phospholipase A2 activity in schizophrenia, European Archives of Psychiatry and Clinical Neuroscience, vol.257, pp.340-343, 2007. ,
Goal Representations and Motivational Drive in Schizophrenia: The Role of Prefrontal-Striatal Interactions, Schizophrenia Bulletin, vol.36, pp.919-934, 2010. ,
Behavioral Neuroscience of Motivation, Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia, pp.411-449, 2015. ,
Cognitive Control in Schizophrenia: Psychological and Neural Mechanisms, pp.556-580, 2017. ,
Effort, anhedonia, and function in schizophrenia: Reduced effort allocation predicts amotivation and functional impairment, Journal of Abnormal Psychology, vol.123, pp.387-397, 2014. ,
Dopamine modulates effort-based decision making in rats, Behavioral Neuroscience, vol.123, pp.242-251, 2009. ,
D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement, Neuroscience, vol.135, pp.959-968, 2005. ,
The role of dopamine in alcohol self-administration in humans: Individual differences, European Neuropsychopharmacology, vol.18, pp.439-447, 2008. ,
Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease, Biochimica et Biophysica Acta (BBA) -Molecular and Cell Biology of Lipids, vol.1861, pp.524-537, 2016. ,
Historical Development of the Dopamine Hypothesis of Schizophrenia, Journal of the History of the Neurosciences, vol.11, pp.265-277, 2002. ,
Enhanced food-related motivation after bilateral lesions of the subthalamic nucleus, J. Neurosci, vol.22, pp.562-568, 2002. ,
Polyunsaturated fatty acids and their metabolites in brain function and disease, Nature Reviews Neuroscience, vol.15, pp.771-785, 2014. ,
The Physiology, Signaling, and Pharmacology of Dopamine Receptors, Pharmacological Reviews, vol.63, pp.182-217, 2011. ,
Akt/GSK3 Signaling in the Action of Psychotropic Drugs, Annual Review of Pharmacology and Toxicology, vol.49, pp.327-347, 2009. ,
High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking, Science, vol.320, pp.1352-1355, 2008. ,
Omega-3 fatty acids upregulate adult neurogenesis, Neuroscience Letters, vol.415, pp.154-158, 2007. ,
Dopamine agonists in schizophrenia: a review, European Neuropsychopharmacology, vol.5, p.22, 1995. ,
Modulation of anti-tumor immunity by the brain's reward system, Nature Communications, vol.9, 2018. ,
Chapter I The organization and circuits of mesencephalic dopaminergic neurons and the distribution of dopamine receptors in the brain, in: Handbook of Chemical Neuroanatomy, pp.80005-80008, 2005. ,
Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trial, J Clin Psychiatry, vol.68, pp.1867-1875, 2007. ,
What does dopamine mean?, Nature Neuroscience, vol.21, pp.787-793, 2018. ,
Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects, European Psychiatry, vol.13, pp.303-309, 1998. ,
The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study, J Clin Psychiatry, vol.68, pp.843-853, 2007. ,
Motivation concepts in behavioral neuroscience, Physiology & Behavior, vol.81, pp.179-209, 2004. ,
Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns, Neurosci Biobehav Rev, vol.24, pp.173-198, 2000. ,
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res, Brain Res. Rev, vol.28, pp.309-369, 1998. ,
What is the degree of segregation between striatonigral and striatopallidal projections? Frontiers in Neuroanatomy 4, 2010. ,
Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol, Journal of Neuroscience, vol.28, pp.5671-5685, 2008. ,
Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: A quantitative analysis, Behavioural Brain Research, vol.195, pp.223-230, 2008. ,
Adaptive reward pursuit: How effort requirements affect unconscious reward responses and conscious reward decisions, Journal of Experimental Psychology: General, vol.141, pp.728-742, 2012. ,
The brief negative symptom scale: validation of the German translation and convergent validity with self-rated anhedonia and observer-rated apathy, BMC Psychiatry, vol.16, 2016. ,
Relationship between effortful motivation and neurocognition in schizophrenia, Schizophrenia Research, vol.193, pp.69-76, 2018. ,
Dietary Tyrosine/Phenylalanine Depletion Effects on Behavioral and Brain Signatures of Human Motivational Processing, Neuropsychopharmacology, vol.39, pp.595-604, 2014. ,
EMOTICOM: A Neuropsychological Test Battery to Evaluate Emotion, Motivation, Impulsivity, and Social Cognition, Frontiers in Behavioral Neuroscience, vol.10, 2016. ,
Dopamine agonists can improve pure apathy associated with lesions of the prefrontal-basal ganglia functional system, Neurological Sciences, vol.36, pp.1197-1201, 2015. ,
Double-Blind, Placebo-Controlled, Multicenter Trial of Selegiline Augmentation of Antipsychotic Medication to Treat Negative Symptoms in Outpatients With Schizophrenia, American Journal of Psychiatry, vol.162, pp.388-390, 2005. ,
Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios, Journal of Lipid Research, vol.51, pp.2325-2333, 2010. ,
Adolescent Behavior and Dopamine Availability Are Uniquely Sensitive to Dietary Omega-3 Fatty Acid Deficiency, Biological Psychiatry, vol.75, pp.38-46, 2014. ,
Characterization of reward and effort mechanisms in apathy, Journal of Physiology-Paris, vol.109, pp.16-26, 2015. ,
Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress, Cell Reports, vol.16, pp.1237-1242, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01826144
Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models: Brain arachidonate metabolism in knockout mice, Journal of Neurochemistry, vol.102, pp.577-586, 2007. ,
Effort discounting in human nucleus accumbens, Cognitive, Affective, & Behavioral Neuroscience, vol.9, pp.16-27, 2009. ,
Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice, Neurochemistry International, vol.56, pp.585-589, 2010. ,
The Effects of Dietary ?-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats, The Journal of Nutrition, vol.119, pp.1880-1892, 1989. ,
Maternal DHA Status during Pregnancy Has a Positive Impact on Infant Problem Solving: A Norwegian Prospective Observation Study, Nutrients, vol.10, 2018. ,
Depression, Avolition, and Attention Disorders in Patients with Schizophrenia: Associations with Verbal Memory Efficiency, The Journal of Neuropsychiatry and Clinical Neurosciences, vol.21, pp.206-215, 2009. ,
Lipoprotein lipase and acid lipase activity in rabbit brain microvessels, J. Lipid Res, vol.20, pp.464-471, 1979. ,
The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue, Frontiers in Psychiatry, vol.5, 2014. ,
Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens, Comp. Biochem. Physiol. B, Biochem. Mol. Biol, vol.131, pp.653-673, 2002. ,
, Dopamine in Motivational Control: Rewarding, Aversive, and Alerting, vol.68, pp.815-834, 2010.
Functional anatomy of the basal ganglia: Limbic aspects, Revue Neurologique, vol.168, pp.569-575, 2012. ,
Dopaminergic Influences on Emotional Decision Making in Euthymic Bipolar Patients, Neuropsychopharmacology, vol.39, pp.274-282, 2014. ,
Striatal Local Circuitry: A New Framework for Lateral Inhibition, Neuron, vol.96, pp.267-284, 2017. ,
From ventral-medial to dorsal-lateral striatum: Neural correlates of reward-guided decision-making, Neurobiology of Learning and Memory, vol.117, pp.51-59, 2015. ,
Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling, Cell Reports, vol.21, pp.246-258, 2017. ,
Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders, Journal of Affective Disorders, vol.168, pp.439-451, 2014. ,
Mechanisms of Action of (n-3) Fatty Acids, Journal of Nutrition, vol.142, pp.592-599, 2012. ,
Docosahexaenoic acid promotes neurite growth in hippocampal neurons, Journal of Neurochemistry, vol.90, pp.979-988, 2004. ,
Imaging studies on dopamine transporter and depression: A review of literature and suggestions for future research, Journal of Psychiatric Research, vol.51, pp.7-18, 2014. ,
Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112, Neuropsychopharmacology, vol.34, pp.1277-1287, 2009. ,
Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration, Archives of General Psychiatry, vol.69, 1044. ,
Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core, Science, vol.292, pp.2499-2501, 2001. ,
Long-Term Feeding of Formulas High in Linolenic Acid and Marine Oil to Very Low Birth Weight Infants: Phospholipid Fatty Acids, Pediatric Research, vol.30, pp.404-412, 1991. ,
Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation, J. Lipid Res, vol.41, pp.465-472, 2000. ,
Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice, Br. J. Nutr, vol.83, pp.439-447, 2000. ,
Apathy in Parkinson's disease is associated with nucleus accumbens atrophy: A magnetic resonance imaging shape analysis: An Mri Shape Analysis, Movement Disorders, vol.29, pp.897-903, 2014. ,
Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action, Journal of Neuroscience, vol.36, pp.5988-6001, 2016. ,
The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects, Brain Res. Bull, vol.56, pp.79-85, 2001. ,
Ventral Striatum Activity in Response to Reward: Differences Between Bipolar I and II Disorders, American Journal of Psychiatry, vol.170, pp.533-541, 2013. ,
Reduced Dopamine Response to Amphetamine in Subjects at Ultra-High Risk for Addiction, Biological Psychiatry, vol.76, pp.23-30, 2014. ,
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder, JAMA, vol.288, pp.1740-1748, 2002. ,
Mood and behavioural effects of subthalamic stimulation in Parkinson's disease, The Lancet Neurology, vol.13, pp.287-305, 2014. ,
Cognitive deficits in docosahexaenoic acid-deficient rats, Behav. Neurosci, vol.116, pp.1022-1031, 2002. ,
Schedule-dependent effects of haloperidol and amphetamine: multiple-schedule task shows within-subject effects, Pharmacol. Biochem. Behav, vol.68, pp.53-63, 2001. ,
D2-Dopamine receptors target regulator of G protein signaling 9-2 to detergent-resistant membrane fractions: D2R targets RGS9-2 to DRM, Journal of Neurochemistry, vol.120, pp.56-69, 2012. ,
Dopamine in the orbitofrontal cortex regulates operant responding under a progressive ratio of reinforcement in rats, Neuroscience Letters, vol.370, pp.114-117, 2004. ,
Omega-3 fatty acids and monoamine neurotransmission, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.75, pp.259-269, 2006. ,
Motivational Responses to Natural and Drug Rewards in Rats with Neonatal Ventral Hippocampal Lesions An Animal Model of Dual Diagnosis Schizophrenia, Neuropsychopharmacology, vol.27, pp.889-905, 2002. ,
The neural circuitry of reward and its relevance to psychiatric disorders, Curr Psychiatry Rep, vol.6, pp.391-399, 2004. ,
Effects of reinforcer sweetness and the D2/D3 antagonist raclopride on progressive ratio operant performance, Behav Pharmacol, vol.6, pp.127-132, 1995. ,
A meta-analysis of placebo-controlled trials of omega-3 fatty acid augmentation in schizophrenia: Possible stage-specific effects, Ann Clin Psychiatry, vol.27, pp.289-296, 2015. ,
Regulation of brain polyunsaturated fatty acid uptake and turnover, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.79, pp.85-91, 2008. ,
Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study: Rapid loss of eicosapentaenoic acid from brain phospholipids, Journal of Neurochemistry, vol.116, pp.363-373, 2011. ,
Rapid ?-oxidation of eicosapentaenoic acid in mouse brain: An in situ study, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.80, pp.157-163, 2009. ,
Brief Report: Selective Social Anhedonia in High Functioning Autism, Journal of Autism and Developmental Disorders, vol.42, pp.1504-1509, 2012. ,
Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression, Journal of Psychiatric Research, vol.75, pp.65-74, 2016. ,
Polyunsaturated fatty acid deficit in patients with bipolar mania, Eur Neuropsychopharmacol, vol.13, pp.99-103, 2003. ,
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase, J. Biol. Chem, vol.274, pp.471-477, 1999. ,
Updating the role of dopamine in human motivation and apathy, Current Opinion in Behavioral Sciences, vol.22, pp.35-41, 2018. ,
Neurocomputational mechanisms underlying subjective valuation of effort costs, PLOS Biology, vol.15, 2017. ,
Quantifying motivation with effort-based decision-making paradigms in health and disease, in: Progress in Brain Research, pp.71-100, 2016. ,
Dopamine enhances willingness to exert effort for reward in Parkinson's disease, Cortex, vol.69, pp.40-46, 2015. ,
The role of dopamine in the pathophysiology and treatment of apathy, Progress in Brain Research, pp.389-426, 2016. ,
Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent familybased samples, Psychiatr. Genet, vol.11, pp.207-212, 2001. ,
Minireview: The Neuroreceptors: One Key for Many Locks, Journal of Receptors and Signal Transduction, vol.15, pp.161-172, 1995. ,
Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements, Early Hum. Dev, vol.4, pp.121-129, 1980. ,
Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements, Early Human Development, vol.4, issue.80, p.90016, 1980. ,
The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo, Transgenic Research, vol.23, pp.489-501, 2014. ,
Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D 2 Receptor Creates an Internalization-defective Receptor, Journal of Biological Chemistry, vol.289, pp.33663-33675, 2014. ,
Reduced mania and depression in juvenile bipolar disorder associated with long-chain ?-3 polyunsaturated fatty acid supplementation, European Journal of Clinical Nutrition, vol.63, pp.1037-1040, 2009. ,
Long-Chain Omega-3 Polyunsaturated Fatty Acids in the Blood of Children and Adolescents with Juvenile Bipolar Disorder, Lipids, vol.43, pp.1031-1038, 2008. ,
Why Don't You Try Harder? An Investigation of Effort Production in Major Depression, PLoS ONE, vol.6, 2011. ,
Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task, Neuropsychopharmacology, vol.37, pp.1825-1837, 2012. ,
Motivation: theory and research, 1967. ,
Surprise! Dopamine signals mix action, value and error, Nature Neuroscience, vol.19, pp.3-5, 2016. ,
Maternal DHA and the Development of Attention in Infancy and Toddlerhood, Child Development, vol.75, pp.1254-1267, 2004. ,
Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults, Neuroscience Letters, vol.421, pp.209-212, 2007. ,
Agerelated changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.82, pp.111-119, 2010. ,
Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys, J. Lipid Res, vol.31, pp.237-247, 1990. ,
Anhedonia in depression: biological mechanisms and computational models, Current Opinion in Behavioral Sciences, vol.22, pp.128-135, 2018. ,
Resolution of sleepiness and fatigue: A comparison of bupropion and selective serotonin reuptake inhibitors in subjects with major depressive disorder achieving remission at doses approved in the European Union, Journal of Psychopharmacology, vol.28, pp.118-124, 2014. ,
Influence of increased membrane cholesterol on membrane fluidity and cell function in human red blood cells, Journal of Supramolecular Structure, vol.8, pp.413-430, 1978. ,
Reward Circuitry in Addiction, Neurotherapeutics, vol.14, pp.687-697, 2017. ,
Origins and evolution of the Western diet: health implications for the 21st century, The American Journal of Clinical Nutrition, vol.81, pp.341-354, 2005. ,
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacininduced dermal erythema, American Journal of Medical Genetics, vol.127, pp.42-47, 2004. ,
Appetites and Aversions as Constituents of Instincts, Proc. Natl. Acad. Sci. U.S.A, vol.3, pp.685-688, 1917. ,
Behavioral changes in Huntington Disease, Neuropsychiatry Neuropsychol Behav Neurol, vol.14, pp.219-226, 2001. ,
Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain, Lipids, vol.34, pp.39-47, 1999. ,
A map of the rat mesencephalon for electrical self-stimulation, Brain Res, vol.36, pp.265-273, 1972. ,
Effort-Based Cost-Benefit Valuation and the Human Brain, Journal of Neuroscience, vol.29, pp.4531-4541, 2009. ,
Concurrent activation of striatal direct and indirect pathways during action initiation, Nature, vol.494, pp.238-242, 2013. ,
Effort-based decision-making in schizophrenia, Current Opinion in Behavioral Sciences, vol.22, pp.1-6, 2018. ,
Effort-cost decision-making in psychosis and depression: could a similar behavioral deficit arise from disparate psychological and neural mechanisms?, Psychological Medicine, vol.48, pp.889-904, 2018. ,
Apathy following subthalamic stimulation in Parkinson disease: A dopamine responsive symptom: Apathy Following Subthalamic Stimulation in PD, Movement Disorders, vol.23, pp.964-969, 2008. ,
Impulsivity, Compulsivity, and Top-Down Cognitive Control, Neuron, vol.69, pp.680-694, 2011. ,
Intact hedonic responses to sweet tastes in autism spectrum disorder, Research in Autism Spectrum Disorders, vol.8, pp.230-236, 2014. ,
Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions, Journal of Neurodevelopmental Disorders, vol.4, 2012. ,
Translational approaches to treatmentinduced symptoms in cancer patients, Nature Reviews Clinical Oncology, vol.9, pp.414-426, 2012. ,
From inflammation to sickness and depression: when the immune system subjugates the brain, Nature Reviews Neuroscience, vol.9, pp.46-56, 2008. ,
Apathy and related executive syndromes in dementia associated with Parkinson's disease and in Alzheimer's disease, Behavioural Neurology, 2013. ,
Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3, Nature, vol.440, pp.813-817, 2006. ,
Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases, Clinical Neurology and Neurosurgery, vol.110, pp.19-24, 2008. ,
Allosteric regulation of G protein-coupled receptor activity by phospholipids, Nature Chemical Biology, vol.12, pp.35-39, 2015. ,
Effect of ?-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome, The American Journal of Clinical Nutrition, vol.79, pp.251-260, 2004. ,
Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization, Journal of Neurochemistry, vol.105, pp.296-307, 2008. ,
Nutritional restriction of omega-3 fatty acids alters topographical fine tuning and leads to a delay in the critical period in the rodent visual system, Experimental Neurology, vol.234, pp.220-229, 2012. ,
A meta-analytic review of experiments examining the effects of extrinsic rewards on intrinsic motivation, Psychological Bulletin, vol.125, pp.627-668, 1999. ,
Intrinsic Motivation and Self-Determination in Human Behavior, 1985. ,
Control of fluid palatability by exteroceptive Pavlovian signals, Journal of Experimental Psychology: Animal Behavior Processes, vol.12, pp.143-152, 1986. ,
Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet, J. Lipid Res, vol.38, pp.680-689, 1997. ,
Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats, J. Nutr, vol.124, pp.2466-2476, 1994. ,
Transgenic Increase in n-3/n-6 Fatty Acid Ratio Protects Against Cognitive Deficits Induced by an Immune Challenge through Decrease of Neuroinflammation, Trends in Neurosciences, vol.13, pp.525-536, 1990. ,
Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment, Neuropsychopharmacology, vol.40, pp.2774-2787, 2015. ,
?-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid: ?-LNA is not significantly converted to DHA in brain, Journal of Neurochemistry, vol.94, pp.1063-1076, 2005. ,
The many faces of fatigue in major depressive disorder, The International Journal of Neuropsychopharmacology, vol.8, pp.93-105, 2005. ,
Apathy in Parkinson's disease: A systematic review and metaanalysis: APATHY IN PARKINSON'S DISEASE, Movement Disorders, vol.30, pp.759-769, 2015. ,
Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort, Psychopharmacology, vol.179, pp.587-596, 2005. ,
Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders, Translational Neuropsychopharmacology, pp.231-262, 2015. ,
The neurobiology of anhedonia and other reward-related deficits, Trends in Neurosciences, vol.35, pp.68-77, 2012. ,
A novel probe for the cannabinoid receptor, J. Med. Chem, vol.35, pp.2065-2069, 1992. ,
, Diagnostic and statistical manual of mental disorders : DSM-5, n.d, 2013.
Unipolar depression does not moderate responses to the Sweet Taste Test, Depression and Anxiety, vol.27, pp.859-863, 2010. ,
Motivational control of goal-directed action, Animal Learning & Behavior, vol.22, pp.1-18, 1994. ,
Is sex important? Gender differences in bipolar disorder, International Review of Psychiatry, vol.22, pp.437-452, 2010. ,
Comparative Biochemical Studies of the Murine Fatty Acid Transport Proteins (FATP) Expressed in Yeast, Journal of Biological Chemistry, vol.280, pp.16829-16837, 2005. ,
Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine, Neuron, vol.90, pp.1100-1113, 2016. ,
Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders: Restructuring of basal ganglia circuitry and associated behaviors, Genes, Brain and Behavior, vol.16, pp.56-70, 2017. ,
Is docosahexaenoic acid synthesis from ?-linolenic acid sufficient to supply the adult brain?, Progress in Lipid Research, vol.59, pp.54-66, 2015. ,
Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation, 2018. ,
Transient Overexpression of Striatal D2 Receptors Impairs Operant Motivation and Interval Timing, Journal of Neuroscience, vol.27, pp.7731-7739, 2007. ,
Influence of Phasic and Tonic Dopamine Release on Receptor Activation, Journal of Neuroscience, vol.30, pp.14273-14283, 2010. ,
The psychological significance of the concept of arousal or activation, Psychol Rev, vol.64, pp.265-275, 1957. ,
Membrane Fluidity and Oxygen Diffusion in Cholesterol-Enriched Erythrocyte Membrane, Archives of Biochemistry and Biophysics, vol.341, pp.34-39, 1997. ,
The Role of Dopamine in the Pathophysiology of Depression, Archives of General Psychiatry, vol.64, 2007. ,
Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair, Lipids, vol.52, pp.885-900, 2017. ,
Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats, Behav. Neurosci, vol.113, pp.718-731, 1999. ,
Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels, Frontiers in Physiology, vol.8, 2017. ,
Randomized, Placebo-Controlled Study of Ethyl-Eicosapentaenoic Acid as Supplemental Treatment in Schizophrenia, American Journal of Psychiatry, vol.159, pp.1596-1598, 2002. ,
Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment, Prostaglandins Leukot. Essent. Fatty Acids, vol.69, pp.393-399, 2003. ,
Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism, Journal of Psychiatric Research, vol.57, pp.58-64, 2014. ,
Gender affects liver desaturase expression in a rat model of n?3 fatty acid repletion?, The Journal of Nutritional Biochemistry, vol.21, pp.180-187, 2010. ,
Phospholipase A?-Generated Lipid Mediators in the Brain: The Good, the Bad, and the Ugly, The Neuroscientist, vol.12, pp.245-260, 2006. ,
Modulation of inflammation in brain: a matter of fat: Neuroinflammation and fatty acids, Journal of Neurochemistry, vol.101, pp.577-599, 2006. ,
Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior, Neuroscience, vol.152, pp.321-330, 2008. ,
Deficit in prepulse inhibition in mice caused by dietary n-3 fatty acid deficiency, Behavioral Neuroscience, vol.123, pp.1218-1225, 2009. ,
An n-3 fatty acid deficient diet affects mouse spatial learning in the Barnes circular maze, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.77, pp.269-277, 2007. ,
Chronic Interferon-? Decreases Dopamine 2 Receptor Binding and Striatal Dopamine Release in Association with Anhedonia-Like Behavior in Nonhuman Primates, Neuropsychopharmacology, vol.38, pp.2179-2187, 2013. ,
Polyunsaturated Fatty Acids in Lipid Bilayers: Intrinsic and Environmental Contributions to Their Unique Physical Properties, Journal of the American Chemical Society, vol.124, pp.318-326, 2002. ,
Red blood cell PUFAs reflect the phospholipid PUFA composition of major organs, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.112, pp.12-23, 2016. ,
Regulation of fat intake in the absence of flavor signaling, The Journal of Physiology, 2012. ,
Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making, Journal of Psychiatric Research, vol.47, pp.1590-1596, 2013. ,
Docosahexaenoic Acid Pretreatment Confers Protection and Functional Improvements after Acute Spinal Cord Injury in Adult Rats, Journal of Neurotrauma, vol.29, pp.551-566, 2012. ,
Shared Motivational Functions of Ventral Striatum D1 and D2 Medium Spiny Neurons, The Journal of Neuroscience, vol.37, pp.6177-6179, 2017. ,
Behavioral Activation System (BAS) differences in bipolar I and II disorder, Journal of Affective Disorders, vol.151, pp.121-128, 2013. ,
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action, Annual Review of Psychology, vol.66, pp.25-52, 2015. ,
Amygdala-Prefrontal Cortical Circuitry Regulates Effort-Based Decision Making, Cerebral Cortex, vol.17, pp.251-260, 2006. ,
Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making, Cognitive, Affective, & Behavioral Neuroscience, vol.8, pp.375-389, 2008. ,
Negative Symptoms in Schizophrenia: Avolition and Occam's Razor, Schizophrenia Bulletin, vol.36, pp.359-369, 2010. ,
Amphetamine-Induced Striatal Dopamine Release Measured With an Agonist Radiotracer in Schizophrenia, Biological Psychiatry, vol.83, pp.707-714, 2018. ,
Omega-3 Fatty Acids and Depression: From Cellular Mechanisms to Clinical Care: (ASCP Corner), The Journal of Clinical Psychiatry, vol.72, pp.258-259, 2011. ,
, Frontal-subcortical circuits and neuropsychiatric disorders, The Journal of Neuropsychiatry and Clinical Neurosciences, vol.6, pp.358-370, 1994.
Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder, Am. J. Med. Genet, vol.105, pp.301-305, 2001. ,
Striatal Circuits as a Common Node for Autism Pathophysiology, Frontiers in Neuroscience, vol.10, 2016. ,
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology, Science, vol.294, pp.1871-1875, 2001. ,
Striatal Presynaptic Dopamine in Schizophrenia, Part II: Meta-Analysis of [18F/11C]-DOPA PET Studies, Schizophrenia Bulletin, vol.39, pp.33-42, 2013. ,
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs, Advances in Nutrition, vol.6, pp.513-540, 2015. ,
Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum, Nature Communications, vol.9, 2018. ,
Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells, J. Neurochem, vol.70, pp.24-30, 1998. ,
Brain Docosahexaenoic Acid Status and Learning in Young Rats Submitted to Dietary Long-Chain Polyunsaturated Fatty Acid Deficiency and Supplementation Limited to Lactation, Pediatric Research, vol.57, pp.719-723, 2005. ,
Motivation and its Relationship to Neurocognition, Social Cognition, and Functional Outcome in Schizophrenia, Schizophrenia Research, vol.115, pp.74-81, 2009. ,
Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure, Schizophrenia Research, vol.93, pp.253-260, 2007. ,
Structure and dynamics of polyunsaturated hydrocarbon chains in lipid bilayers-significance for GPCR function, Chemistry and Physics of Lipids, vol.153, pp.64-75, 2008. ,
Erbb4 Deletion from Medium Spiny Neurons of the Nucleus Accumbens Core Induces Schizophrenia-Like Behaviors via Elevated GABA A Receptor ?1 Subunit Expression, The Journal of Neuroscience, vol.37, pp.7450-7464, 2017. ,
Nutritional influences on brain development, Acta Paediatrica, vol.107, pp.1310-1321, 2018. ,
Gender-specific fatty acid profiles in platelet phosphatidyl-choline and -ethanolamine, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.82, pp.51-56, 2010. ,
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons, Science, vol.250, pp.1429-1432, 1990. ,
Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder, Journal of Clinical Psychopharmacology, vol.32, pp.61-64, 2012. ,
Role of Dopamine D2 Receptors for Antipsychotic Activity, Current Antipsychotics, pp.27-52, 2012. ,
Meta-Analysis of Gray Matter Anomalies in Schizophrenia: Application of Anatomic Likelihood Estimation and Network Analysis, Biological Psychiatry, vol.64, pp.774-781, 2008. ,
Preference for reinforcers under progressive-and fixed-ratio schedules: a comparison of single and concurrent arrangements, J Appl Behav Anal, vol.41, pp.163-176, 2008. ,
Faster onset of antimanic action with haloperidol compared to secondgeneration antipsychotics. A meta-analysis of randomized clinical trials in acute mania, European Neuropsychopharmacology, vol.23, pp.305-316, 2013. ,
Negative Symptoms of Schizophrenia Are Associated with Abnormal Effort-Cost Computations, Biological Psychiatry, vol.74, pp.130-136, 2013. ,
Reward Processing in Schizophrenia: A Deficit in the Representation of Value, Schizophrenia Bulletin, vol.34, pp.835-847, 2008. ,
Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: The role of PET and SPECT studies, International Review of Psychiatry, vol.21, pp.323-335, 2009. ,
Neural Processing of Reward and Loss in Girls at Risk for Major Depression, Archives of General Psychiatry, vol.67, 2010. ,
Dissociable regulation of instrumental action within mouse prefrontal cortex: Prefrontal lesion in the mouse, European Journal of Neuroscience, vol.32, pp.1726-1734, 2010. ,
Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet, Journal of Lipid Research, vol.51, pp.535-543, 2010. ,
The emerging role of group VI calcium-independent phospholipase A 2 in releasing docosahexaenoic acid from brain phospholipids: Fig. 1, Journal of Lipid Research, vol.49, pp.939-944, 2008. ,
Effort-Based Decision Making: A Novel Approach for Assessing Motivation in Schizophrenia, Schizophrenia Bulletin, vol.41, pp.1035-1044, 2015. ,
Developmental changes in rat brain membrane lipids and fatty acids. The preferential prenatal accumulation of docosahexaenoic acid, J. Lipid Res, vol.40, pp.960-966, 1999. ,
Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks, Lipids, vol.34, pp.239-243, 1999. ,
Cognitive control and the dopamine D2-like receptor: a dimensional understanding of addiction: Cognitive Control and Addiction, Depression and Anxiety, vol.29, pp.295-306, 2012. ,
A role for direct interactions in the modulation of rhodopsin by -3 polyunsaturated lipids, Proceedings of the National Academy of Sciences, vol.103, pp.4888-4893, 2006. ,
Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials, PLoS ONE, vol.9, 2014. ,
Inadequate daily intakes of n-3 polyunsaturated fatty acids (PUFA) in the general French population of children (3-10 years) and adolescents (11-17 years): the INCA2 survey, European Journal of Nutrition, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01896168
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization, Nature, vol.411, pp.86-89, 2001. ,
Action controls dopaminergic enhancement of reward representations, Proceedings of the National Academy of Sciences, vol.109, pp.7511-7516, 2012. ,
Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors, Scientific Reports, vol.6, 2016. ,
Corticostriatal circuitry, Dialogues Clin Neurosci, vol.18, pp.7-21, 2016. ,
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum, J. Neurosci, vol.20, pp.2369-2382, 2000. ,
The Reward Circuit: Linking Primate Anatomy and Human Imaging, Neuropsychopharmacology, vol.35, pp.4-26, 2010. ,
DNA Methylation Perturbations in Genes Involved in Polyunsaturated Fatty Acid Biosynthesis Associated with Depression and Suicide Risk, Frontiers in Neurology, vol.6, 2015. ,
Neural response to reward anticipation is modulated by Gray's impulsivity, NeuroImage, vol.46, pp.1148-1153, 2009. ,
An fMRI study of reward circuitry in patients with minimal or extensive history of major depression, European Archives of Psychiatry and Clinical Neuroscience, vol.264, pp.187-198, 2014. ,
Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study, Schizophrenia Research, vol.171, pp.225-232, 2016. ,
Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task, Brain Research, vol.1397, pp.38-45, 2011. ,
Mesolimbic dopamine signals the value of work, Nature Neuroscience, vol.19, pp.117-126, 2016. ,
Nucleus Accumbens Dopamine Depletions and Time-Constrained Progressive Ratio Performance, Pharmacology Biochemistry and Behavior, vol.64, pp.92-93, 1999. ,
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human ?2-Adrenergic Receptor, Structure, vol.16, pp.897-905, 2008. ,
Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on brain development using artificial rearing of delta-6-desaturase knockout mice, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.127, pp.32-39, 2017. ,
FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants, The American Journal of Clinical Nutrition, vol.97, pp.1403-1410, 2013. ,
Apathy in schizophrenia as a deficit in the generation of options for action, Journal of Abnormal Psychology, vol.124, pp.309-318, 2015. ,
Depression in Schizophrenia: Associations With Cognition, Functional Capacity, Everyday Functioning, and Self-Assessment, Schizophrenia Bulletin sbw103, 2016. ,
Functional neural substrates of selfreported physical anhedonia in non-clinical individuals and in patients with schizophrenia, Journal of Psychiatric Research, vol.44, pp.707-716, 2010. ,
Prefrontostriatal Circuitry Regulates Effort-Related Decision Making, Cerebral Cortex, vol.19, pp.2240-2247, 2009. ,
Drives and the C.N.S. (conceptual nervous system), Psychol Rev, vol.62, pp.243-254, 1955. ,
Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior, Journal of Abnormal Psychology, vol.116, pp.268-278, 2007. ,
Diminished effort on a progressive ratio task in both unipolar and bipolar depression, Journal of Affective Disorders, vol.196, pp.97-100, 2016. ,
Fish consumption and major depression, The Lancet, vol.351, pp.79168-79174, 1213. ,
Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study, The Lancet, vol.369, pp.578-585, 2007. ,
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior, Neuron, vol.66, pp.896-907, 2010. ,
Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D 2/3 receptors in major depressive disorder studied with [ 11 C]raclopride PET, Journal of Psychopharmacology, vol.25, pp.1329-1336, 2011. ,
Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET, Psychopharmacology, vol.197, pp.581-590, 2008. ,
, , p.3, 2013.
, Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-?42 by Human Microglia and Decrease Inflammatory Markers, Journal of Alzheimer's Disease, vol.35, pp.697-713
Progressive ratio as a measure of reward strength, Science, vol.134, pp.943-944, 1961. ,
Red blood cell polyunsaturated fatty acids measured in red blood cells and schizophrenia: A meta-analysis, Psychiatry Research, vol.207, pp.1-12, 2013. ,
Anhedonia in Schizophrenia: A Review of Assessment Strategies, Schizophrenia Bulletin, vol.32, pp.259-273, 2006. ,
Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 2-External Validity and Correlates, Schizophrenia Bulletin, vol.41, pp.1055-1065, 2015. ,
Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort, Neuropsychopharmacology, vol.39, pp.1558-1567, 2014. ,
Effort: A Comparison of Two Rodent Cost/Benefit Decision-Making Tasks, Neuropsychopharmacology, vol.40, pp.1005-1015, 2015. ,
Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging, Curr. Pharm. Des, vol.15, pp.2550-2559, 2009. ,
The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia, Biological Psychiatry, vol.81, pp.9-20, 2017. ,
Medium Maximization, Journal of Consumer Research, vol.30, pp.1-14, 2003. ,
Neural substrates of the impaired effort expenditure decision making in schizophrenia, Neuropsychology, vol.30, pp.685-696, 2016. ,
A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury, Brain, vol.130, pp.3004-3019, 2007. ,
Principles of Behavior. An Introduction to Behavior Theory, The Journal of Philosophy, vol.40, 1943. ,
Neuroscience of apathy and anhedonia: a transdiagnostic approach, Nature Reviews Neuroscience, vol.19, pp.470-484, 2018. ,
Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain, Journal of Lipid Research, vol.48, pp.2463-2470, 2007. ,
Brain lipid concentrations in bipolar disorder, Journal of Psychiatric Research, vol.44, pp.177-182, 2010. ,
Intakes of essential n?6 and n?3 polyunsaturated fatty acids among pregnant Canadian women, The American Journal of Clinical Nutrition, vol.77, pp.473-478, 2003. ,
Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways, Biochimica et Biophysica Acta (BBA) -Molecular and Cell Biology of Lipids, vol.1862, pp.552-560, 2017. ,
Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders, American Journal of Psychiatry, vol.167, pp.748-751, 2010. ,
Physical anhedonia in Parkinson's disease, J. Neurol. Neurosurg. Psychiatry, vol.74, pp.1308-1311, 2003. ,
, , 2008.
, Adenosine Receptor Bound to an Antagonist, Science, vol.322, pp.1211-1217
Dextroamphetamine-induced arousal in human subjects as a model for mania, Psychol Med, vol.16, pp.323-329, 1986. ,
Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice, The Journal of Nutritional Biochemistry, vol.26, pp.24-35, 2015. ,
A meta-analysis of the response to chronic l-dopa in patients with schizophrenia: therapeutic and heuristic implications, Psychopharmacology, vol.171, pp.365-374, 2004. ,
Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function, Progress in Lipid Research, vol.50, pp.267-277, 2011. ,
The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL, Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016. ,
,
Comparison of Therapeutic Effects of Omega-3 Fatty Acid Eicosapentaenoic Acid and Fluoxetine, Separately and in Combination, Major Depressive Disorder. Australian & New Zealand Journal of Psychiatry, vol.42, pp.192-198, 2008. ,
The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers?, J. Mol. Neurosci, vol.33, pp.25-31, 2007. ,
Cellular and molecular introduction to brain development, Neurobiology of Disease, vol.92, pp.3-17, 2016. ,
Modulation of brain PUFA content in different experimental models of mice, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.114, pp.1-10, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01430319
Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models, International Journal of Developmental Neuroscience, vol.64, pp.38-47, 2018. ,
Wholeblood fatty acids are associated with executive function in Tanzanian children aged 4-6 years: a cross-sectional study, British Journal of Nutrition, vol.116, pp.1537-1545, 2016. ,
The Neurobiology of Decision: Consensus and Controversy, Neuron, vol.63, pp.733-745, 2009. ,
Individual negative symptoms and domains -Relevance for assessment, pathomechanisms and treatment, Schizophrenia Research, vol.186, pp.39-45, 2017. ,
Efficacy of aripiprazole in psychotic disorders: Comparison with haloperidol and placebo, Schizophrenia Research, vol.41, pp.90383-90392, 2000. ,
Fat-1 mice convert n-6 to n-3 fatty acids: Transgenic mice, Nature, vol.427, pp.504-504, 2004. ,
Maternal DHA Levels and Toddler Free-Play Attention, Developmental Neuropsychology, vol.34, pp.159-174, 2009. ,
Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia, American Journal of Psychiatry, vol.160, pp.13-23, 2003. ,
From dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis, Schizophrenia Research, vol.79, pp.59-68, 2005. ,
Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia, The International Journal of Neuropsychopharmacology, vol.6, pp.325-337, 2003. ,
Grundlagen der Motivation, U & S Psychologie, 1981. ,
Structural Neuroimaging Studies in Major Depressive Disorder: Metaanalysis and Comparison With Bipolar Disorder, Archives of General Psychiatry, vol.68, 2011. ,
Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics, Schizophr. Res, vol.58, pp.1-10, 2002. ,
Dopamine D2 receptors in striatal output neurons enable the psychomotor effects of cocaine, Proceedings of the National Academy of Sciences, vol.113, pp.11609-11614, 2016. ,
The effect of orbital prefrontal cortex lesions on performance on a progressive ratio schedule: implications for models of inter-temporal choice, Behavioural Brain Research, vol.156, pp.145-152, 2005. ,
3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity, J. Pharmacol. Exp. Ther, vol.274, issue.7, pp.329-336, 1995. ,
Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study, PLOS ONE, vol.11, 2016. ,
Developing Concepts in Negative Symptoms: Primary vs Secondary and Apathy vs Expression, The Journal of Clinical Psychiatry, vol.75, pp.3-7, 2014. ,
Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression, Proceedings of the National Academy of Sciences, vol.101, pp.10931-10936, 2004. ,
Endogenomorphic depression. A conceptual and terminological revision, Arch. Gen. Psychiatry, vol.31, pp.447-454, 1974. ,
Neural Signatures of Value Comparison in Human Cingulate Cortex during Decisions Requiring an Effort-Reward Trade-off, Journal of Neuroscience, vol.36, pp.10002-10015, 2016. ,
A categorized list of emotion definitions, with suggestions for a consensual definition, Motivation and Emotion, vol.5, pp.345-379, 1981. ,
Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats: critical role of developmental stage, J. Lipid Res, vol.43, pp.1209-1219, 2002. ,
Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study, The American Journal of Clinical Nutrition, vol.94, pp.1592-1599, 2011. ,
Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children, The American Journal of Clinical Nutrition, vol.93, pp.211-219, 2011. ,
Neural and Behavioral Evidence for an Intrinsic Cost of Self-Control, PLoS ONE, vol.8, 2013. ,
Inside-outside transitions of phospholipids in vesicle membranes, Biochemistry, vol.10, pp.1111-1120, 1971. ,
, DEMENTIA PRAECOX AND PARAPHRENIA: The Journal of Nervous and Mental Disease, vol.54, 1921.
Distinct roles for direct and indirect pathway striatal neurons in reinforcement, Nature Neuroscience, vol.15, pp.816-818, 2012. ,
Contributions of the prefrontal cortex to the neural basis of human decision making, Neuroscience & Biobehavioral Reviews, vol.26, pp.631-664, 2002. ,
Emotional Response Deficits in Schizophrenia: Insights From Affective Science, Schizophrenia Bulletin, vol.34, pp.819-834, 2008. ,
To work or not to work, Progress in Brain Research, pp.125-157, 2016. ,
The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think, Neuropsychopharmacology, vol.42, pp.369-370, 2017. ,
Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary deficiency, Journal of Neurochemistry, vol.106, pp.662-671, 2008. ,
Overexpression of dopamine receptor genes and their products in the postnatal rat brain following maternal n-3 fatty acid dietary deficiency, Journal of Neurochemistry, vol.95, pp.1550-1562, 2005. ,
Biomarkers of DHA status, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.81, pp.111-118, 2009. ,
Choosing to Make an Effort: The Role of Striatum in Signaling Physical Effort of a Chosen Action, Journal of Neurophysiology, vol.104, pp.313-321, 2010. ,
Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation, Brain, Behavior, and Immunity, vol.73, pp.427-440, 2018. ,
Compoundspecific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain, Journal of Lipid Research, vol.58, pp.2071-2081, 2017. ,
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions, Nature Neuroscience, vol.14, pp.345-350, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00612705
Lysophosphatidylcholine as a Preferred Carrier Form of Docosahexaenoic Acid to the Brain, Journal of Molecular Neuroscience, vol.16, pp.201-204, 2001. ,
Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Response and Development of Postischemic Neuronal Damage, Stroke, vol.42, pp.2903-2909, 2011. ,
Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers, Journal of Affective Disorders, vol.120, pp.24-31, 2010. ,
Fatty acid composition in postmortem brains of people who completed suicide, J Psychiatry Neurosci, vol.32, pp.363-370, 2007. ,
Apathy associated with neurocognitive disorders: Recent progress and future directions, Alzheimer's & Dementia, vol.13, pp.84-100, 2017. ,
Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice, Journal of Physiology and Biochemistry, vol.68, pp.671-681, 2012. ,
Omega-3 fatty acids deficiency aggravates glutamatergic synapse and astroglial aging in the rat hippocampal CA1, Aging Cell, vol.12, pp.76-84, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-02325139
DHA Effects in Brain Development and Function, Nutrients, vol.8, 2016. ,
Membrane Lipids in Presynaptic Function and Disease, Neuron, vol.90, pp.11-25, 2016. ,
Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology, Pharmacological Reviews, vol.70, pp.12-38, 2018. ,
The anatomy of apathy: A neurocognitive framework for amotivated behaviour, 2017. ,
D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAS in distinct neuronal populations of the dorsal and ventral striatum, The Journal of Comparative Neurology, vol.355, pp.418-426, 1995. ,
Hippocampus and nucleus accumbens activity during neutral word recognition related to trait physical anhedonia in patients with schizophrenia: An fMRI study, Psychiatry Research: Neuroimaging, vol.203, pp.46-53, 2012. ,
Researching the pathophysiology of pediatric bipolar disorder, Biol. Psychiatry, vol.53, pp.1009-1020, 2003. ,
Anhedonia, Depression, and Motor Functioning in Parkinson's Disease During Treatment With Pramipexole, The Journal of Neuropsychiatry and Clinical Neurosciences, vol.17, pp.214-220, 2005. ,
Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling, Neuron, vol.90, pp.824-838, 2016. ,
N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence, CNS Neurol Disord Drug Targets, vol.12, pp.450-459, 2013. ,
Developmental effects of dietary n?3 fatty acids on activity and response to novelty, Physiology & Behavior, vol.101, pp.176-183, 2010. ,
Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order, Biophysical Journal, vol.110, pp.1800-1810, 2016. ,
Apathy: A pathology of goal-directed behaviour. A new concept of the clinic and pathophysiology of apathy, Revue Neurologique, vol.168, pp.585-597, 2012. ,
Conditioned and sensitized responses to stimulant drugs in humans, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.31, pp.1601-1613, 2007. ,
Selective modulation of GABAergic tonic current by dopamine in the nucleus accumbens of alcohol-dependent rats, Journal of Neurophysiology, vol.112, pp.51-60, 2014. ,
Provocative tests with psychostimulant drugs in schizophrenia, Psychopharmacology, vol.91, pp.415-433, 1987. ,
An Open Randomized Pilot Trial on the Differential Effects of Aripiprazole versus Risperidone on Anhedonia and Subjective Well-Being, Pharmacopsychiatry, vol.44, pp.109-113, 2011. ,
A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression, Biological Psychiatry, vol.68, pp.140-147, 2010. ,
Cocaine modifies brain lipidome in mice, Molecular and Cellular Neuroscience, vol.85, pp.29-44, 2017. ,
Differences in long chain polyunsaturates composition and metabolism in male and female rats, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.113, pp.19-27, 2016. ,
A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: Challenges and therapeutic opportunities, Schizophrenia Research, vol.147, pp.241-252, 2013. ,
Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: A lipidomic analysis, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.77, pp.155-162, 2007. ,
Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease, Brain Research, vol.1597, pp.220-246, 2015. ,
Regulation of monoamine transporters and receptors by lipid microdomains: implications for depression, 2018. ,
Maternal Long-Chain Polyunsaturated Fatty Acid Status during Early Pregnancy and Children's Risk of Problem Behavior at Age 5-6 Years, The Journal of Pediatrics, vol.164, pp.762-768, 2014. ,
Dietary intake of essential and longchain polyunsaturated fatty acids in pregnancy, Lipids, vol.39, pp.421-424, 2004. ,
Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease, The Journal of Neuropsychiatry and Clinical Neurosciences, vol.15, pp.346-353, 2003. ,
Synaptic transmission and modulation in the neostriatum, Int. Rev. Neurobiol, vol.39, pp.77-111, 1996. ,
The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism, Psychiatr. Genet, vol.11, pp.41-43, 2001. ,
Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice. The Journal of Nutrition jn254607, 2017. ,
Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes, Brain, Behavior, and Immunity, vol.41, pp.22-31, 2014. ,
Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects, Journal of Human Genetics, vol.55, pp.127-130, 2010. ,
Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes, Translational Psychiatry, vol.7, 2017. ,
Lowered ?3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients, Psychiatry Research, vol.85, pp.14-15, 1999. ,
Fatty acid composition of brain, retina, and erythrocytes in breast-and formula-fed infants, The American Journal of Clinical Nutrition, vol.60, pp.189-194, 1994. ,
Arkypallidal Cells Send a Stop Signal to Striatum, Neuron, vol.89, pp.308-316, 2016. ,
Depression and adipose essential polyunsaturated fatty acids, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.67, pp.311-318, 2002. ,
Amplification of mGlu 5 -Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance, The Journal of Neuroscience, vol.37, pp.6851-6868, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01602593
The nucleus accumbens as a nexus between values and goals in goal-directed behavior: a review and a new hypothesis, Frontiers in Behavioral Neuroscience, 2013. ,
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats, Neuropsychopharmacology, vol.41, pp.402-409, 2016. ,
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens, Neuron, vol.98, pp.575-587, 2018. ,
The Efficacy and Safety of Aripiprazole as Adjunctive Therapy in Major Depressive Disorder: A Second Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, Journal of Clinical Psychopharmacology, vol.28, pp.156-165, 2008. ,
The sources of convergence between measures of apathy and depression, J Affect Disord, vol.28, pp.117-124, 1993. ,
Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis, Neuropsychopharmacology, vol.18, pp.113-122, 1998. ,
Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia, Neuroscience & Biobehavioral Reviews, vol.37, pp.2149-2165, 2013. ,
Polyunsaturated fatty acids and neurotransmission in Caenorhabditis elegans, Biochemical Society Transactions, vol.34, pp.77-80, 2006. ,
Polyunsaturated Fatty Acids Influence Synaptojanin Localization to Regulate Synaptic Vesicle Recycling, Molecular Biology of the Cell, vol.19, pp.833-842, 2008. ,
Long-chain acyl-CoA synthetases and fatty acid channeling, Future Lipidology, vol.2, pp.465-476, 2007. ,
Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation, Brain, vol.137, pp.2346-2355, 2014. ,
FADS genetic variants and ?-6 polyunsaturated fatty acid metabolism in a homogeneous island population, Journal of Lipid Research, vol.51, pp.2766-2774, 2010. ,
Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum, Journal of Neuroscience, vol.29, pp.444-453, 2009. ,
Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats, Behavioural Brain Research, vol.109, pp.59-68, 2000. ,
Effect of aripiprazole on self-reported anhedonia in bipolar depressed patients, Psychiatry Research, vol.165, pp.193-196, 2009. ,
Why Don't We Move Faster? Parkinson's Disease, Movement Vigor, and Implicit Motivation, Journal of Neuroscience, vol.27, pp.7105-7116, 2007. ,
Inefficient effort allocation and negative symptoms in individuals with schizophrenia, Schizophrenia Research, vol.170, pp.278-284, 2016. ,
A randomized, double-blind, placebo-controlled, study of the efficacy and safety of aripiprazole 10, 15 or 20mg/day for the treatment of patients with acute exacerbations of schizophrenia, Journal of Psychiatric Research, vol.41, pp.895-905, 2007. ,
Effect of ?-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial, JAMA Psychiatry, vol.74, 2017. ,
Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: Role of ovarian hormones and dietary omega-3 fatty acid composition, Psychoneuroendocrinology, vol.34, pp.532-539, 2009. ,
Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study, The American Journal of Clinical Nutrition, vol.91, pp.1060-1067, 2010. ,
Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: Dissociation from estrogenic effects, Journal of Psychiatric Research, vol.43, pp.656-663, 2009. ,
Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.75, pp.329-349, 2006. ,
Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder, Biological Psychiatry, vol.62, pp.17-24, 2007. ,
Investigation of postmortem brain polyunsaturated fatty acid composition in psychiatric disorders: Limitations, challenges, and future directions, Journal of Psychiatric Research, vol.45, pp.44-46, 2011. ,
Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder, Journal of Affective Disorders, vol.126, pp.303-311, 2010. ,
Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: Gender differences and partial normalization with antipsychotic medications, Schizophrenia Research, vol.91, pp.37-50, 2007. ,
Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder, Psychiatry Research, vol.160, pp.285-299, 2008. ,
First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine, Psychiatry Research, vol.230, pp.447-453, 2015. ,
Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease, Journal of Psychiatric Research, vol.47, pp.1187-1191, 2013. ,
Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: A 1 H MRS Study, Nutritional Neuroscience, vol.16, pp.183-190, 2013. ,
Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder, Journal of Affective Disorders, vol.129, pp.359-363, 2011. ,
Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resistant major depressive disorder, vol.2, pp.38-46, 2014. ,
Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: Prevention by chronic lithium treatment, Journal of Psychiatric Research, vol.42, pp.458-468, 2008. ,
Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: Relationship with ventral striatum dopamine concentrations, Synapse, vol.62, pp.725-735, 2008. ,
Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence, Neuroscience, vol.343, pp.423-433, 2017. ,
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem. Pharmacol, vol.50, pp.83-90, 1995. ,
Schizotaxia, schizotypy, schizophrenia, American Psychologist, vol.17, pp.827-838, 1962. ,
Schizophrenic symptoms and dietary intake of n-3 fatty acids, Schizophr. Res, vol.18, pp.85-86, 1995. ,
Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity, Cell Reports, vol.19, pp.1045-1055, 2017. ,
Sex/gender differences in the brain and cognition in schizophrenia, Neuroscience & Biobehavioral Reviews, vol.67, pp.57-78, 2016. ,
Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation, Lipids in Health and Disease, vol.15, 2016. ,
Avolition and expressive deficits capture negative symptom phenomenology: Implications for DSM-5 and schizophrenia research, Clinical Psychology Review, vol.31, pp.161-168, 2011. ,
Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model, Journal of Lipid Research, vol.59, pp.357-367, 2018. ,
Predictive Values of Neurocognition and Negative Symptoms on Functional Outcome in Schizophrenia: A Longitudinal First-Episode Study With 7-Year Follow-Up, American Journal of Psychiatry, vol.162, pp.495-506, 2005. ,
Mechanisms of cytokine-induced behavioral changes: Psychoneuroimmunology at the translational interface, Brain, Behavior, and Immunity, vol.23, pp.149-158, 2009. ,
Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice, European Journal of Neuroscience, vol.28, pp.1877-1886, 2008. ,
Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway, Journal of Neuroscience, vol.28, pp.9037-9046, 2008. ,
Modulation of amyloid-?-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid, Journal of Neurochemistry, vol.103, pp.914-926, 2007. ,
Enhancement of G protein-coupled signaling by DHA phospholipids, Lipids, vol.38, pp.437-443, 2003. ,
The Role of Dopamine in Symptoms and Treatment of Apathy in Alzheimer's Disease: Apathy in the Treatment of Alzheimer's Disease, CNS Neuroscience & Therapeutics, vol.17, pp.411-427, 2011. ,
Motivation: New Directions for Theory, Research, and Practice, Management Review, vol.7, pp.80-88, 1982. ,
Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.78, pp.1-11, 2017. ,
Ala54Thr Fatty Acid-Binding Protein 2 (FABP2) Polymorphism in Recurrent Depression: Associations with Fatty Acid Concentrations and Waist Circumference, PLoS ONE, vol.8, 2013. ,
Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression, Psychoneuroendocrinology, vol.38, pp.1607-1617, 2013. ,
From motivation to action: functional interface between the limbic system and the motor system, Prog. Neurobiol, vol.14, pp.69-97, 1980. ,
Extrastriatal D2 and striatal D2 receptors in depressive illness: Pilot PET studies using [11C]FLB 457 and [11C]raclopride, Journal of Affective Disorders, vol.101, pp.113-122, 2007. ,
Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia, International Immunopharmacology, vol.7, pp.222-229, 2007. ,
Ecological momentary assessment of negative symptoms in schizophrenia: Relationships to effort-based decision making and reinforcement learning, Journal of Abnormal Psychology, vol.126, pp.96-105, 2017. ,
Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice, Brain, Behavior, and Immunity, vol.26, pp.721-731, 2012. ,
Neural response to reward as a predictor of increases in depressive symptoms in adolescence, Neurobiology of Disease, vol.52, pp.66-74, 2013. ,
Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration, J. Neurochem, vol.75, pp.2563-2573, 2000. ,
Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum, J. Lipid Res, vol.42, pp.419-427, 2001. ,
Enhancement of membrane fluidity in cholesterolpoor endothelial cells pre-treated with simvastatin, Endothelium, vol.5, pp.107-113, 1997. ,
Advances and challenges in the search for D 2 and D 3 dopamine receptor-selective compounds, Cellular Signalling, vol.41, pp.75-81, 2018. ,
The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases, Molecular Neurobiology, vol.53, pp.1195-1219, 2016. ,
Disambiguating ventral striatum fMRI-related bold signal during reward prediction in schizophrenia, Molecular Psychiatry, vol.17, pp.280-289, 2012. ,
Neural Correlates of Impaired Reward-Effort Integration in Remitted Bulimia Nervosa, Neuropsychopharmacology, vol.43, pp.868-876, 2018. ,
, , 2010.
, Polyunsaturated Fatty Acid Intake and Depressive Symptoms: Ryukyus Child Health Study, PEDIATRICS, vol.126, pp.623-630
BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.78, pp.351-360, 2008. ,
Pharmacological insights into impulsive-compulsive spectrum disorders associated with dopaminergic therapy, European Journal of Neuroscience, 2018. ,
, , 2017.
, Goal-Directed Behavior Independently of D1 and D2 Selectivity, Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, vol.37, pp.2723-2733
Omega-3 Treatment of Childhood Depression: A Controlled, Double-Blind Pilot Study, American Journal of Psychiatry, vol.163, pp.1098-1100, 2006. ,
The Dopamine Receptors, 2010. ,
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid, Nature, vol.509, pp.503-506, 2014. ,
Reassessing wanting and liking in the study of mesolimbic influence on food intake, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.311, pp.811-840, 2016. ,
Dopaminergic Modulation of Neuronal Excitability in the Striatum and Nucleus Accumbens, Annual Review of Neuroscience, vol.23, pp.185-215, 2000. ,
Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n -3 Fatty Acid Deficiency, Journal of Biological Chemistry, vol.279, pp.31098-31104, 2004. ,
Tonic dopamine: opportunity costs and the control of response vigor, Psychopharmacology, vol.191, pp.507-520, 2007. ,
New treatment guidelines for acute bipolar depression: A systematic review, Journal of Affective Disorders, vol.129, pp.14-26, 2011. ,
Treatment strategies according to clinical features in a naturalistic cohort study of bipolar patients: A principal component analysis of lifetime pharmacological and biophysic treatment options, European Neuropsychopharmacology, vol.23, pp.263-275, 2013. ,
Cross-National Comparisons of Seafood Consumption and Rates of Bipolar Disorders, American Journal of Psychiatry, vol.160, pp.2222-2227, 2003. ,
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption, Pharmacol. Biochem. Behav, vol.69, pp.373-382, 2001. ,
Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression, Journal of Neuroscience, vol.33, 2013. ,
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors, Neuroscience & Biobehavioral Reviews, vol.37, 2013. ,
Pleasure, Reward, Preference, 1973. ,
The bloodbrain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport, Journal of Neurochemistry, vol.141, pp.400-412, 2017. ,
Dietary intake of omega-3 fatty acids and risk of depressive symptoms in adolescents, Depression and Anxiety, vol.28, pp.582-588, 2011. ,
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning, Science, vol.304, pp.452-454, 2004. ,
Efficacy of Pramipexole for Treatment of Apathy in Parkinson's Disease, International Journal of Clinical Medicine, vol.05, pp.885-889, 2014. ,
Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort, The American Journal of Clinical Nutrition, vol.88, pp.789-796, 2008. ,
Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR), 2013. ,
, Psychopharmacology, vol.230, pp.617-630
Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study, Developmental Cognitive Neuroscience, vol.8, pp.55-64, 2014. ,
Current perspectives on incentive salience and applications to clinical disorders, Current Opinion in Behavioral Sciences, vol.22, pp.59-69, 2018. ,
The role of financial compensation in industrial motivation, Psychol Bull, vol.66, pp.94-118, 1966. ,
The emerging role of docosahexaenoic acid in neuroinflammation, Curr Opin Investig Drugs, vol.9, pp.735-743, 2008. ,
The Fat-1 Mouse has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding, Neurochemical Research, vol.35, pp.811-819, 2010. ,
Effect of relevance on amygdala activation and association with the ventral striatum, NeuroImage, vol.62, pp.95-101, 2012. ,
, The Lancet, vol.388, pp.1121-1127, 2016.
BanI Polymorphism of the Cytosolic Phospholipase A 2 Gene and Mood Disorders in the Korean Population, Neuropsychobiology, vol.49, pp.185-188, 2004. ,
Dopamine signaling as a neural correlate of consciousness, Neuroscience, vol.198, pp.213-220, 2011. ,
Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3? Signalling Pathways in Rats, PLOS ONE, vol.10, 2015. ,
Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function, The Journal of Neuroscience, vol.36, pp.11755-11767, 2016. ,
Dopamine Is Required for the Neural Representation and Control of Movement Vigor, Cell, vol.162, pp.1418-1430, 2015. ,
Altered cingulo-striatal function underlies reward drive deficits in schizophrenia, Schizophrenia Research, vol.161, pp.229-236, 2015. ,
Effort-Based Reinforcement Processing and Functional Connectivity Underlying Amotivation in Medicated Patients with Depression and Schizophrenia, The Journal of Neuroscience, vol.37, pp.4370-4380, 2017. ,
Aripiprazole treatment for patients with schizophrenia: from acute treatment to maintenance treatment, Expert Review of Neurotherapeutics, vol.11, pp.1541-1552, 2011. ,
Limited Encoding of Effort by Dopamine Neurons in a Cost-Benefit Trade-off Task, Journal of Neuroscience, vol.33, pp.8288-8300, 2013. ,
The association between polyunsaturated fatty acid consumption and the transition to psychosis in ultra-high risk individuals, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.108, pp.30-37, 2016. ,
Blunted reward responsiveness in remitted depression, Journal of Psychiatric Research, vol.47, pp.1864-1869, 2013. ,
Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response, European Neuropsychopharmacology, vol.27, pp.977-986, 2017. ,
Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study, Neurosurgery & Psychiatry, vol.80, pp.1279-1282, 2009. ,
International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis, Br J Psychiatry, vol.184, pp.404-408, 2004. ,
A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs, Arch. Gen. Psychiatry, vol.59, pp.913-919, 2002. ,
A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms, J Psychiatr Res, vol.36, pp.7-18, 2002. ,
Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients, Biological Psychiatry, vol.43, pp.315-319, 1998. ,
Assessing potency of high-and low-preference reinforcers with respect to response rate and response patterns, J Appl Behav Anal, vol.41, pp.177-188, 2008. ,
Polyunsaturated fatty acids and brain white matter anisotropy in recent-onset schizophrenia: A preliminary study, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.81, pp.61-63, 2009. ,
Polyunsaturated Fatty Acid Concentration Predicts Myelin Integrity in Early-Phase Psychosis, Schizophrenia Bulletin, vol.39, pp.830-838, 2013. ,
Brain White Matter Development Is Associated with a Human-Specific Haplotype Increasing the Synthesis of Long Chain Fatty Acids, Journal of Neuroscience, vol.34, pp.6367-6376, 2014. ,
Elucidation of G-protein and ?-arrestin functional selectivity at the dopamine D2 receptor, Proceedings of the National Academy of Sciences, vol.112, pp.7097-7102, 2015. ,
P.2.114 Aripiprazole, a new typical antipsychotic: Phase 2 clinical trial result, European Neuropsychopharmacology, vol.7, pp.88746-88755, 1997. ,
Intentional action: from anticipation to goal-directed behavior, Psychological Research Psychologische Forschung, vol.73, pp.437-440, 2009. ,
Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures, Current Opinion in Behavioral Sciences, vol.22, pp.21-27, 2018. ,
Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins, Science, vol.345, pp.693-697, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01141794
A neuroscientist's guide to lipidomics, Nature Reviews Neuroscience, vol.8, pp.743-754, 2007. ,
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model, Annual Review of Clinical Psychology, vol.10, pp.393-423, 2014. ,
Toward an objective characterization of an anhedonic phenotype: A signal-detection approach, Biological Psychiatry, vol.57, pp.319-327, 2005. ,
Dopaminergic Neurotransmission in Patients with Schizophrenia in Relation to Positive and Negative Symptoms, Pharmacopsychiatry, vol.45, pp.36-41, 2012. ,
Cholesterol-dependent Separation of the ? 2 -Adrenergic Receptor from Its Partners Determines Signaling Efficacy: INSIGHT INTO NANOSCALE ORGANIZATION OF SIGNAL TRANSDUCTION, Journal of Biological Chemistry, vol.283, pp.24659-24672, 2008. ,
Asymmetric dopamine loss differentially affects effort to maximize gain or minimize loss, Cortex, vol.51, pp.82-91, 2014. ,
Aripiprazole, an Antipsychotic With a Novel Mechanism of Action, and Risperidone vs Placebo in Patients With Schizophrenia and Schizoaffective Disorder, Archives of General Psychiatry, vol.60, p.681, 2003. ,
Red blood cell fatty acids are associated with depression in a case-control study of adolescents, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.86, pp.161-165, 2012. ,
Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI Study, Neurology, vol.82, pp.435-442, 2014. ,
No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat, J. Lipid Res, vol.38, pp.526-530, 1997. ,
Packing and Viscoelasticity of Polyunsaturated ?-3 and ?-6 Lipid Bilayers as Seen by 2 H NMR and X-ray Diffraction, Journal of the American Chemical Society, vol.127, pp.1576-1588, 2005. ,
The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs, PLoS ONE, vol.9, 2014. ,
Bupropion Increases Selection of High Effort Activity in Rats Tested on a Progressive Ratio/Chow Feeding Choice Procedure: Implications for Treatment of Effort-Related Motivational Symptoms, International Journal of Neuropsychopharmacology, vol.18, pp.17-017, 2015. ,
Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences, PLoS ONE, vol.7, 2012. ,
Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients, Psychiatry Res, vol.121, pp.109-122, 2003. ,
n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism, Molecular Psychiatry, vol.12, pp.36-46, 2007. ,
Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.88, pp.79-85, 2013. ,
Delivery and turnover of plasma-derived essential PUFAs in mammalian brain, J. Lipid Res, vol.42, pp.678-685, 2001. ,
Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.77, pp.251-261, 2007. ,
Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression, The Journal of Nutritional Biochemistry, vol.24, pp.505-515, 2013. ,
Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1-Psychometric Characteristics of 5 Paradigms, Schizophrenia Bulletin, vol.41, pp.1045-1054, 2015. ,
Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline, Schizophr Bull, vol.30, pp.901-911, 2004. ,
Visual attention in infant monkeys: effects of dietary fatty acids and age, Dev Psychol, vol.33, pp.387-395, 1997. ,
Effects of Ropinirole on Nonmotor Symptoms of Parkinson Disease: A Prospective Multicenter Study, Clinical Neuropharmacology, vol.31, pp.261-266, 2008. ,
Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system, Brain, vol.128, pp.1314-1322, 2005. ,
Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain, Brain, Behavior, and Immunity, 2018. ,
Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro, Brain, Behavior, and Immunity, vol.55, pp.249-259, 2016. ,
La Psychologie des Sentiments. Par Th. Ribot. Paris: Alcan, 1896. Pp. 443. Price 7frs. 50, Journal of Mental Science, vol.43, pp.164-168, 1897. ,
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy, Journal of Neuroscience Methods, vol.66, pp.1-11, 1996. ,
Assessing reinforcers under progressive schedule requirements, Journal of Applied Behavior Analysis, vol.34, pp.145-166, 2001. ,
A role for mesencephalic dopamine in activation: commentary on Berridge, Psychopharmacology, vol.191, pp.433-437, 2006. ,
Disruptions in effort-based decision-making and consummatory behavior following antagonism of the dopamine D2 receptor, Behavioural Brain Research, vol.320, pp.431-439, 2017. ,
The Subjective and Cognitive Effects of Acute Phenylalanine and Tyrosine Depletion in Patients Recovered from Depression, Neuropsychopharmacology, vol.30, pp.775-785, 2005. ,
The ventral pallidum: Subregionspecific functional anatomy and roles in motivated behaviors, Progress in Neurobiology, vol.130, pp.29-70, 2015. ,
Brainstem pathways of reward, J Comp Physiol Psychol, vol.68, pp.22-30, 1969. ,
Effects of n-3 polyunsaturated fatty acid supplementation on cognitive functions, electrocortical activity and neurogenesis in a non-human primate, the grey mouse lemur ( Microcebus murinus ), Behavioural Brain Research, vol.347, pp.394-407, 2018. ,
URL : https://hal.archives-ouvertes.fr/mnhn-02291418
, Fatty Acids: Structures and Properties, 2005.
Dopaminergic Modulation of Decision Making and Subjective Well-Being, Journal of Neuroscience, vol.35, pp.9811-9822, 2015. ,
Are there common core features of apathy in different neuropsychiatric samples as assessed by the Apathy Evaluation Scale?, Nordic Journal of Psychiatry, vol.64, pp.49-57, 2010. ,
Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, doubleblind, placebo-controlled clinical trial, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.84, pp.267-271, 2018. ,
Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine, Current Opinion in Pharmacology, vol.5, pp.34-41, 2005. ,
Nucleus Accumbens Dopamine and the Forebrain Circuitry Involved in Behavioral Activation and Effort-Related Decision Making: Implications for Understanding Anergia and Psychomotor Slowing in Depression, Current Psychiatry Reviews, vol.2, pp.267-280, 2006. ,
Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes, Psychopharmacology (Berl.), vol.107, pp.160-174, 1992. ,
Neurobiology and pharmacology of activational and effortrelated aspects of motivation: rodent studies, Current Opinion in Behavioral Sciences, vol.22, pp.114-120, 2018. ,
The Mysterious Motivational Functions of Mesolimbic Dopamine, Neuron, vol.76, pp.470-485, 2012. ,
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine, Behav. Brain Res, vol.137, pp.3-25, 2002. ,
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits, Psychopharmacology, vol.191, pp.461-482, 2007. ,
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research, Frontiers in Behavioral Neuroscience, vol.12, 2018. ,
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure, Psychopharmacology (Berl.), vol.104, pp.515-521, 1991. ,
Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe, Neurology, vol.79, pp.642-650, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01164730
Improved Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin by Specific Interaction with Docosahexaenoic Acid Phospholipid, ChemBioChem, vol.14, pp.639-644, 2013. ,
The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina, Progress in Retinal and Eye Research, vol.24, pp.87-138, 2005. ,
Apathy and striatal dopamine transporter levels in de-novo, untreated Parkinson's disease patients, Parkinsonism & Related Disorders, vol.21, pp.489-493, 2015. ,
Dopamine transporter binding in depressed patients with anhedonia, Psychiatry Research: Neuroimaging, vol.147, pp.243-248, 2006. ,
Omega-3 for Bipolar Disorder: Meta-Analyses of Use in Mania and Bipolar Depression, The Journal of Clinical Psychiatry, vol.73, pp.81-86, 2012. ,
Lipids of nervous tissue: composition and metabolism, Prog. Lipid Res, vol.24, pp.69-176, 1985. ,
Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids, Human Molecular Genetics, vol.15, pp.1745-1756, 2006. ,
Disconnecting force from money: effects of basal ganglia damage on incentive motivation, Brain, vol.131, pp.1303-1310, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00333398
Neural Mechanisms Underlying Motivation of Mental Versus Physical Effort, PLoS Biology, vol.10, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00706782
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release, Journal of Neuroscience, vol.28, pp.14311-14319, 2008. ,
Dissociating behavioral disorders in early dementia-An FDG-PET study, Psychiatry Research: Neuroimaging, vol.194, pp.235-244, 2011. ,
Neuronal Reward and Decision Signals: From Theories to Data, Physiological Reviews, vol.95, pp.853-951, 2015. ,
A Neural Substrate of Prediction and Reward, Science, vol.275, pp.1593-1599, 1997. ,
Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making, Learning & Memory, vol.13, pp.777-782, 2006. ,
Pro-resolving lipid mediators are leads for resolution physiology, Nature, vol.510, pp.92-101, 2014. ,
Allocating effort and anticipating pleasure in schizophrenia: Relationship with real world functioning, European Psychiatry, vol.46, pp.57-64, 2017. ,
Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts, The Journal of Nutritional Biochemistry, vol.23, pp.101-105, 2012. ,
Microinjections of SCH 23390 in the ventral tegmental area reduce operant responding under a progressive ratio schedule of food reinforcement in rats, Brain Research, vol.1033, pp.179-185, 2005. ,
Anticipatory pleasure predicts motivation for reward in major depression, Journal of Abnormal Psychology, vol.121, pp.51-60, 2012. ,
Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies, Human Molecular Genetics, vol.23, pp.6495-6511, 2014. ,
Frequency and subgroups of neuropsychiatric symptoms in mild cognitive impairment and different stages of dementia in Alzheimer's disease, International Psychogeriatrics, vol.30, pp.103-113, 2018. ,
Automatic effort mobilization and the principle of resource conservation: One can only prime the possible and justified, Journal of Personality and Social Psychology, vol.104, pp.803-816, 2013. ,
Functional interaction between the basolateral amygdala and the nucleus accumbens underlies incentive motivation for food reward on a fixed ratio schedule, Neuroscience, vol.159, pp.1264-1273, 2009. ,
Functional rafts in cell membranes, Nature, vol.387, pp.569-572, 1997. ,
Lipid sorting in epithelial cells, Biochemistry, vol.27, pp.6197-6202, 1988. ,
Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain, Molecular Neurobiology, vol.44, pp.203-215, 2011. ,
Pharmacologic Rescue of Motivational Deficit in an Animal Model of the Negative Symptoms of Schizophrenia, Biological Psychiatry, vol.69, pp.928-935, 2011. ,
Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents, Schizophrenia Bulletin, vol.38, pp.1111-1117, 2012. ,
Selective Overexpression of Dopamine D3 Receptors in the Striatum Disrupts Motivation but not Cognition, Biological Psychiatry, vol.76, pp.823-831, 2014. ,
Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior, Psychopharmacology, vol.196, pp.565-574, 2008. ,
The behavior of organisms: an experimental analysis, Science Education, vol.38, pp.436-436, 1954. ,
Rat models of reward deficits in psychiatric disorders, Current Opinion in Behavioral Sciences, vol.22, pp.136-142, 2018. ,
Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis, Molecular Psychiatry, vol.19, pp.317-324, 2014. ,
Reappraising striatal D1-and D2-neurons in reward and aversion, Neuroscience & Biobehavioral Reviews, vol.68, pp.370-386, 2016. ,
The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders, CNS Neurol Disord Drug Targets, vol.5, pp.25-43, 2006. ,
The Role of Accumbens Dopamine in Lever Pressing and Response Allocation: Effects of 6-OHDA Injected into Core and Dorsomedial Shell, Pharmacology Biochemistry and Behavior, vol.59, pp.557-566, 1998. ,
Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study, BMC Psychiatry, vol.16, 2016. ,
The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats, The International Journal of Neuropsychopharmacology, vol.17, pp.2045-2056, 2014. ,
Membrane domains and the "lipid raft" concept, Curr. Med. Chem, vol.20, pp.4-21, 2013. ,
Longitudinal Neuropsychiatric Predictors of Death in Alzheimer's Disease, Journal of Alzheimer's Disease, vol.48, pp.627-636, 2015. ,
Reconstitution of affinity-purified dopamine D2 receptor binding activities by specific lipids, Biochim. Biophys. Acta, vol.900, pp.175-182, 1987. ,
Prefrontal Cortical Contribution to Risk-Based Decision Making, Cerebral Cortex, vol.20, pp.1816-1828, 2010. ,
The psychopharmacology of energy and fatigue, J Clin Psychiatry, vol.63, pp.7-8, 2002. ,
The Construct of Minor and Major Depression in Alzheimer's Disease, American Journal of Psychiatry, vol.162, pp.2086-2093, 2005. ,
The nosological position of apathy in clinical practice, Neurosurgery & Psychiatry, vol.79, pp.1088-1092, 2008. ,
Neurobiological Correlates of Apathy in Alzheimer's Disease and Mild Cognitive Impairment: A Critical Review, Journal of Alzheimer's Disease, vol.39, pp.633-648, 2014. ,
Effect of symptom severity on efficacy and safety of aripiprazole adjunctive to antidepressant monotherapy in major depressive disorder: A pooled analysis, Journal of Affective Disorders, vol.162, pp.20-25, 2014. ,
Relation of obesity to consummatory and anticipatory food reward, Physiology & Behavior, vol.97, pp.551-560, 2009. ,
Omega 3 fatty acids in bipolar disorder: a preliminary doubleblind, placebo-controlled trial, Arch. Gen. Psychiatry, vol.56, pp.407-412, 1999. ,
Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making, Cognitive, Affective, & Behavioral Neuroscience, vol.11, pp.97-112, 2011. ,
A New Perspective on Anhedonia in Schizophrenia, American Journal of Psychiatry, vol.169, pp.364-373, 2012. ,
Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a Progressive Ratio task, Schizophrenia Research, vol.170, pp.198-204, 2016. ,
The Brain's Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample, American Journal of Psychiatry, vol.172, pp.1215-1223, 2015. ,
URL : https://hal.archives-ouvertes.fr/cea-01221894
Common and distinctive approaches to motivation in different disciplines, Progress in Brain Research, pp.3-23, 2016. ,
A benefit-cost framework of motivation for a specific activity, Progress in Brain Research, pp.25-47, 2016. ,
Phospholipase A2 and Cyclooxygenase 2 Genes Influence the Risk of Interferon-?-Induced Depression by Regulating Polyunsaturated Fatty Acids Levels, Biological Psychiatry, vol.67, pp.550-557, 2010. ,
Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis, JAMA Network Open, vol.1, 2018. ,
Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression, The Journal of Clinical Psychiatry, vol.72, pp.1577-1584, 2011. ,
Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice, Scientific Reports, vol.7, 2017. ,
Distribution, biochemistry and function of striatal adenosine A2A receptors, Prog. Neurobiol, vol.59, pp.355-396, 1999. ,
Omega-3 polyunsaturated essential fatty acids are associated with depression in adolescents with eating disorders and weight loss: Essential fatty acids in depression and eating disorders, Acta Paediatrica, vol.100, pp.1610-1615, 2011. ,
A family based study of the genetic association between the PLA2G4D gene and schizophrenia, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.73, pp.419-422, 2005. ,
Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders, Translational Psychiatry, vol.2, pp.204-204, 2012. ,
Separate circuitries encode the hedonic and nutritional values of sugar, Nature Neuroscience, vol.19, pp.465-470, 2016. ,
Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations, Translational Psychiatry, vol.6, pp.906-906, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01380206
A review of neuroimaging findings of apathy in Alzheimer's disease, International Psychogeriatrics, vol.26, pp.195-207, 2014. ,
Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil, Brain, vol.136, pp.1568-1577, 2013. ,
Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation, Cerebral Cortex, vol.052, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01826142
Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats, Psychopharmacology, vol.234, pp.2697-2705, 2017. ,
Dopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons, Frontiers in Systems Neuroscience, vol.5, 2011. ,
Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons, Neuron, vol.75, pp.58-64, 2012. ,
Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recentonset schizophrenia patients, Brain, Behavior, and Immunity, vol.52, pp.178-186, 2016. ,
Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice, Proceedings of the National Academy of Sciences, vol.99, pp.8986-8991, 2002. ,
Effort-based decisionmaking in major depressive disorder: A translational model of motivational anhedonia, Journal of Abnormal Psychology, vol.121, pp.553-558, 2012. ,
Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making, Journal of Neuroscience, vol.32, pp.6170-6176, 2012. ,
Worth the 'EEfRT'? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia, PLoS ONE, vol.4, 2009. ,
Impaired effort allocation in patients with schizophrenia, Schizophrenia Research, vol.161, pp.382-385, 2015. ,
Reconsidering anhedonia in depression: Lessons from translational neuroscience, Neuroscience & Biobehavioral Reviews, vol.35, pp.537-555, 2011. ,
Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine, Arch. Gen. Psychiatry, vol.59, pp.409-416, 2002. ,
Fatty acid dietary intake in the general French population: are the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) national recommendations met?, British Journal of Nutrition, vol.116, pp.1966-1973, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01494337
Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior, Seminars in Nuclear Medicine, vol.47, pp.64-74, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01603845
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation, Molecular Psychiatry, vol.18, pp.1025-1033, 2013. ,
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity, Neuropharmacology, vol.76, pp.498-509, 2014. ,
Dopaminergic neurons inhibit striatal output through non-canonical release of GABA, Nature, vol.490, pp.262-266, 2012. ,
Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum, Neuron, vol.76, pp.33-50, 2012. ,
Reinforcement magnitude: an evaluation of preference and reinforcer efficacy, J Appl Behav Anal, vol.41, pp.203-220, 2008. ,
Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder, Neuropsychopharmacology, vol.39, pp.1914-1923, 2014. ,
Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder, Mol. Psychiatry, vol.3, pp.534-538, 1998. ,
6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway: the turning syndrome, Pharmacol Ther B, vol.2, pp.37-40, 1976. ,
Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system, Acta Physiol Scand Suppl, vol.367, pp.95-122, 1971. ,
Aripiprazole has Functionally Selective Actions at Dopamine D2 Receptor-Mediated Signaling Pathways, Neuropsychopharmacology, vol.32, pp.67-77, 2007. ,
Distinct cortical and striatal actions of a ?-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties, Proceedings of the National Academy of Sciences, vol.113, pp.8178-8186, 2016. ,
New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy, Biological Psychiatry, vol.81, pp.78-85, 2017. ,
Lipid polarity and sorting in epithelial cells, Journal of Cellular Biochemistry, vol.36, pp.51-58, 1988. ,
Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia, Metabolic Brain Disease, vol.24, pp.659-672, 2009. ,
Noradrenaline and Dopamine Neurons in the Reward/Effort Trade-Off: A Direct Electrophysiological Comparison in Behaving Monkeys, Journal of Neuroscience, vol.35, pp.7866-7877, 2015. ,
Acute Phenylalanine/Tyrosine Depletion Reduces Motivation to Smoke Cigarettes Across Stages of Addiction, Neuropsychopharmacology, vol.36, pp.2469-2476, 2011. ,
A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states, Nature Communications, vol.9, 2018. ,
Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine, J. Neurosci, vol.22, pp.4654-4662, 2002. ,
Inflammation-induced motivational changes: perspective gained by evaluating positive and negative valence systems, Current Opinion in Behavioral Sciences, vol.22, pp.90-95, 2018. ,
Pharmacological Management of Bipolar Depression: Acute Treatment, Maintenance, and Prophylaxis, CNS Drugs, vol.27, pp.515-529, 2013. ,
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids, BMC Psychiatry, vol.16, 2016. ,
Localization and signaling of GPCRs in lipid rafts, Methods in Cell Biology, pp.3-23, 2016. ,
Drug Abuse and Mental Illness: Progress in Understanding Comorbidity, American Journal of Psychiatry, vol.158, pp.1181-1183, 2001. ,
NOW vs LATER brain circuits: implications for obesity and addiction, Trends in Neurosciences, vol.38, pp.345-352, 2015. ,
Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders, The Lancet Neurology, vol.8, pp.1140-1149, 2009. ,
Putting a spin on the dorsal-ventral divide of the striatum, Trends in Neurosciences, vol.27, pp.468-474, 2004. ,
Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging, Neurobiology of Aging, vol.35, pp.1055-1064, 2014. ,
Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making, European Journal of Neuroscience, vol.29, pp.1678-1691, 2009. ,
Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity, Schizophrenia Research, vol.168, pp.465-474, 2015. ,
Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference, Neuropsychopharmacology, vol.43, pp.953-963, 2018. ,
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases, Journal of Lipid Research, vol.46, pp.706-715, 2005. ,
Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia, Neuropsychopharmacology, vol.37, pp.1699-1707, 2012. ,
Amping Up Effort: Effects of d-Amphetamine on Human Effort-Based Decision-Making, Journal of Neuroscience, vol.31, pp.16597-16602, 2011. ,
Brain arachidonic acid incorporation and precursor pool specific activity during intravenous infusion of unesterified [3H]arachidonate in the anesthetized rat, J. Neurochem, vol.63, pp.727-736, 1994. ,
A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.70, pp.413-415, 2004. ,
Functioning outcomes with adjunctive treatments for major depressive disorder: a systematic review of randomized placebo-controlled studies, Neuropsychiatric Disease and Treatment, vol.14, pp.103-115, 2017. ,
Pathway-Specific Dopamine Abnormalities in Schizophrenia, Biological Psychiatry, vol.81, pp.31-42, 2017. ,
Quantifying motivational deficits and apathy: A review of the literature, European Neuropsychopharmacology, vol.25, pp.1060-1081, 2015. ,
Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina, Invest. Ophthalmol. Vis. Sci, vol.40, pp.327-338, 1999. ,
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia: Current Opinion in Psychiatry, vol.28, pp.7-12, 2015. ,
Dopamine and reward: The anhedonia hypothesis 30 years on, Neurotoxicity Research, vol.14, pp.169-183, 2008. ,
Neuroleptics and operant behavior: The anhedonia hypothesis, Behavioral and Brain Sciences, vol.5, p.39, 1982. ,
Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food, Science, vol.201, pp.262-264, 1978. ,
Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning, Science, vol.330, pp.1677-1681, 2010. ,
Amotivation in Schizophrenia: Integrated Assessment With Behavioral, Clinical, and Imaging Measures, Schizophrenia Bulletin, vol.40, pp.1328-1337, 2014. ,
Aripiprazole acts as a selective dopamine D 2 receptor partial agonist, Expert Opinion on Investigational Drugs, vol.16, pp.771-775, 2007. ,
The dopamine motor system, Mov. Disord, vol.4, pp.38-47, 1989. ,
, The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, 1992.
Omega-3 fatty acid monotherapy for pediatric bipolar disorder: A prospective open-label trial, European Neuropsychopharmacology, vol.17, pp.440-447, 2007. ,
Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain, Br. J. Nutr, vol.94, pp.544-550, 2005. ,
DHA depletion in rat brain is associated with impairment on spatial learning and memory, Biomed. Environ. Sci, vol.19, pp.474-480, 2006. ,
Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n-6) and (n-3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation, The Journal of Nutrition, vol.138, pp.2222-2228, 2008. ,
Association of the iPLA2? gene with bipolar disorder and assessment of its interaction with TRPM2 gene polymorphisms, Psychiatric Genetics, vol.23, pp.86-89, 2013. ,
CD36 Enhances Fatty Acid Uptake by Increasing the Rate of Intracellular Esterification but Not Transport across the Plasma Membrane, Biochemistry, vol.52, pp.7254-7261, 2013. ,
Dynamics of the dopaminergic system as a key component to the understanding of depression, Progress in Brain Research, pp.265-286, 2008. ,
Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome, Cell, vol.160, pp.62-73, 2015. ,
Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.64, pp.52-59, 2016. ,
Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients, Psychiatry Research, vol.220, pp.874-882, 2014. ,
Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients, Schizophr. Res, vol.42, pp.7-17, 2000. ,
PET Study of [ 18 F]6-Fluoro-L -Dopa Uptake in Neurolepticand Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium, American Journal of Psychiatry, vol.159, pp.768-774, 2002. ,
Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency, Neuroscience, vol.162, pp.1011-1022, 2009. ,
L'apathie dans la schizophrénie : une revue clinique et critique de la question, L'Encéphale, vol.40, pp.231-239, 2014. ,
Omega-6/omega-3 ratio and brain-related functions, World Rev Nutr Diet, vol.92, pp.37-56, 2003. ,
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization, Psychopharmacology, vol.233, pp.3575-3586, 2016. ,
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists, Pharmacology Biochemistry and Behavior, vol.135, pp.217-226, 2015. ,
A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.73, pp.351-354, 2005. ,
Apathy in Late-Life Depression: Common, Persistent, and Disabling, The American Journal of Geriatric Psychiatry, vol.23, pp.488-494, 2015. ,
Dopamine Manipulation Affects Response Vigor Independently of Opportunity Cost, Journal of Neuroscience, vol.36, pp.9516-9525, 2016. ,
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis, Brain Imaging and Behavior, vol.10, pp.920-939, 2016. ,
Fatty acid transporting proteins: Roles in brain development, aging, and stroke, Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017. ,
,
The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis, Journal of Affective Disorders, vol.190, pp.264-271, 2016. ,
The relevance of reward pathways for schizophrenia: Current Opinion in Psychiatry, vol.23, pp.91-96, 2010. ,
Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n-3 polyunsaturated fatty acids, J. Lipid Res, vol.41, pp.32-40, 2000. ,
Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex, Neurosci. Lett, vol.284, pp.25-28, 2000. ,
Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study, Neurosci. Lett, vol.240, pp.177-181, 1998. ,
The dopamine mesocorticolimbic pathway is affected by deficiency in n?3 polyunsaturated fatty acids, The American Journal of Clinical Nutrition, vol.75, pp.662-667, 2002. ,
Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo, 2018. ,
,
Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior, Semin Nucl Med, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01603845
, , vol.47, pp.64-74, 2016.
Decrease in operant responding under obesogenic diet exposure is not related to deficits in incentive or hedonic processes ,
The atypical antipsychotic aripiprazole acts as an antagonist on dopamine-dependent components of reward processing ,
Causal link between developmental n-3 PUFA deficiency and motivation deficits ,
, Unique sensitivity of medium spiny neurons to lipid manipulation: consequences on nucleus accumbens network and reward processing, Liste des communications: Communications orales locales ?, 2018.
, , 2018.
, , 2017.
, Popular scientific event "Pint of science, 2016.
, , 2016.
, , 2015.
, International Dopamine meeting 2016, Symposium "Novel mouse models in the service of dopamine-linked brain disorders: insights into pathophysiology and treatments, Communications orales internationnales et nationales ?, 2016.
, Impact of dietary lipids on dopaminergic transmission and motivation in mice, Basal Ganglia Club, 2015.
,
, Fabien Ducrocq F, vol.1
,
, International Associated Laboratory
,
, *These authors share senior authorship Keywords: dopamine, high-fat diet, motivation, hedonic response
, HFD, high-fat diet
,
, RR, random ratio Running title : reward processing and obesogenic diet exposure Contact information : Sylvie Vancassel INRA, UMR 1286, Laboratory of Nutrition and Integrative Neurobiology
, 4207 Funding : This study was supported by INRA and University of Bordeaux "Investissements d'avenir Initiative d'excellence" (Idex) (LIA OptiNutriBrain, SL). HF is the recipient of INRA and Idex
, NARSAD Young Investigator Grant from the Brain and Behavior Foundation (PT), ANR "SynLip, PT)
, GF
Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior, Curr Opin Behav Sci, vol.9, pp.97-105, 2016. ,
The dopamine motive system: implications for drug and food addiction, Nat Rev Neurosci, vol.18, pp.741-752, 2017. ,
Effort-Based Choice, and Behavioral Economics: Basic and Translational Research, Front Behav Neurosci, vol.12, p.52, 2018. ,
Reward, dopamine and the control of food intake: implications for obesity, Trends Cogn Sci, vol.15, pp.37-46, 2011. ,
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats, Nat Neurosci, vol.13, pp.635-641, 2010. ,
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat, Behav Neurosci, vol.122, pp.1257-1263, 2008. ,
Why obese children cannot resist food: the role of impulsivity, Eat Behav, vol.7, pp.315-322, 2006. ,
Neural substrates underlying effort, time, and risk-based decision making in motivated behavior, Neurobiol Learn Mem, vol.133, pp.233-256, 2016. ,
Effects of diet-induced obesity on motivation and pain behavior in an operant assay, Neuroscience, vol.235, pp.87-95, 2013. ,
Food quality and motivation: A refined lowfat diet induces obesity and impairs performance on a progressive ratio schedule of instrumental lever pressing in rats, Physiol Behav, vol.128, pp.220-225, 2014. ,
Altered motivation masks appetitive learning potential of obese mice, Front Behav Neurosci, vol.8, p.377, 2014. ,
The effect of high-fat diet consumption on appetitive instrumental behavior in rats, Appetite, vol.108, pp.203-211, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01604971
Characterization of attenuated food motivation in high-fat diet-induced obesity: Critical roles for time on diet and reinforcer familiarity, Physiol Behav, vol.141, pp.69-77, 2015. ,
Decreased rates of operant food selfadministration are associated with reward deficits in high-fat feeding mice, Eur J Nutr, vol.55, pp.1615-1622, 2016. ,
Reward mechanisms in obesity: new insights and future directions, Neuron, vol.69, pp.664-679, 2011. ,
Dopamine signalling adaptations by prolonged high-fat feeding, Curr Opin Behav Sci, vol.9, pp.136-143, 2016. ,
Obesity Is Associated with Decreased -Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain, J Neurosci, vol.35, pp.3959-3965, 2015. ,
Aberrant mesolimbic dopamine-opiate interaction in obesity, NeuroImage, vol.122, pp.80-86, 2015. ,
Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO, Neuropsychopharmacology, vol.41, pp.3042-3050, 2016. ,
Associations between dopamine D2 receptor availability and BMI depend on age, NeuroImage, vol.138, pp.176-183, 2016. ,
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity, Cell Metab, vol.25, pp.312-321, 2017. ,
A reciprocal interaction between food-motivated behavior and diet-induced obesity, Front Hum Neurosci, vol.10, pp.1286-1294, 2007. ,
Diet-induced obesity: dopamine transporter function, impulsivity and motivation, Int J Obes, vol.37, pp.1095-1103, 2013. ,
Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity, Neuropsychopharmacology, vol.40, pp.2113-2123, 2015. ,
The impact of a junk-food diet during development on "wanting" and "liking, Behav Brain Res, vol.317, pp.163-178, 2017. ,
Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models, Int J Dev Neurosci, vol.64, pp.38-47, 2018. ,
Impact of early consumption of High-Fat Diet on the mesolimbic dopaminergic system, vol.1, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01582969
Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia, Neuropsychopharmacology, vol.37, pp.1699-1707, 2012. ,
Within-session decrement of the emission of licking bursts following reward devaluation in rats licking for, PLOS ONE, vol.12, p.177705, 2017. ,
Liking" and "wanting" food rewards: Brain substrates and roles in eating disorders, Physiol Behav, vol.97, pp.537-550, 2009. ,
Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity, Neuroscience, vol.159, pp.1193-1199, 2009. ,
Neural vulnerability factors that increase risk for future weight gain, Psychol Bull, vol.142, pp.447-471, 2016. ,
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation, Mol Psychiatry, vol.18, pp.1025-1033, 2013. ,
Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum, Nat Commun, vol.9, 2018. ,
Dietary manipulations influence sucrose acceptance in diet induced obese mice, Appetite, vol.58, pp.215-221, 2012. ,
Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition, AJP Regul Integr Comp Physiol, vol.301, pp.1267-1280, 2011. ,
A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function, Chem Senses, vol.27, pp.461-474, 2002. ,
Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese, PLoS ONE, vol.7, p.32967, 2012. ,
Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice, Hippocampus, vol.22, issue.11, pp.2095-100, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-02326398
Reversal of dopamine system dysfunction in response to high-fat diet, Obesity, vol.21, issue.12, pp.2513-2534, 2013. ,
Regulation of fat intake in the absence of flavor signaling, J Physiol, vol.590, pp.953-972, 2012. ,
Separate circuitries encode the hedonic and nutritional values of sugar, Nat Neurosci, vol.19, pp.465-470, 2016. ,
The Addictive Dimensionality of Obesity ,
, Biol Psychiatry, vol.73, pp.811-818, 2013.
The Neurobiology of "Food Addiction" and Its Implications for Obesity Treatment and Policy, Annu Rev Nutr, vol.36, pp.105-128, 2016. ,
, 2: HFD consumption induced a decrease in lever pressing in random ratio (RR) and progressive ratio (PR) schedules
, Operant conditioning in ad libitum (A, C, E and G) or food deprived conditions (15% of initial weight
Lever presses during fixed ratio (FR1) and RR tasks (Ctrl: n=13 and HF: n=24 ,
, , p.21
PRx2 task: Levels are presented for cumulative lever presses during a progressive ratio times 2 task (PRx2) (Ctrl: n=13 and HF: n=24 ; C and D), and for total lever presses during the 1h-session (Ctrl: n=13 and HF: n=24 ; E and F), Number of reward earned during fixed ratio (FR1) and RR schedules (Ctrl: n=13 and HF, p.24 ,
, , p.21
, Ctrl: control group; HF: high-fat diet group. in RR5 non-concurrent task (1 session) performed before the concurrent task, and in one session of the RR5 concurrent task (B). Results for concurrent/non-concurrent ratio of lever pressing (C), caloric intake for both rewards earned by lever pressing and freely available food (D) and total caloric intake (E) (Ctrl: n=21 and HF: n=21). Data are means ± sem, Data are means ± sem. *p<0.05, **p<0.01, ***p<0.001 significant differences between dietary groups (ANOVA)
, 4: HFD consumption induced alterations in licking microstructures revealing altered post-ingestive negative feedback without change in hedonic response
, Measures of parameters linked to postingestive negative feedback (consumption, number of licks and number of burts
, B-D) and palatability of the ingested tastant (delay to first lick, licks/burst, bursts duration, inter-licks interval and lick frequency in bursts
Representation of the number of licks and number of bursts during the first 10 minutes of the task (5-minute bins) (left graphs) and expressed as a percentage relative to the first 5 minutes (right graphs) (J-K), Ctrl: n=21 and HF: n=21) ,
, HF: high-fat diet group
, 1 Nutrition and Integrative Neurobiology, INRA UMR 1286, vol.1
, France 3 Correspondence: Fabien.ducrocq@inra.fr or pierre
, Keywords: Aripiprazole, motivation, hedonic response, D 2 -receptor, antipsychotic, schizophrenia Running title: Aripiprazole blocks reward-processing in mice INRA, Batiment UFR Pharmacie -2eme Tranche -2eme Etage -CC34, 146 rue Leo Saignat, vol.33076
, Word count: Abstract: 248, p.3999
, Responding on the left lever (active lever) was followed by a brief tone (65 db, 3000 Hz, 200 ms), illumination of a cue light located at 8,5 cm above the lever, activation of the syringe pump, and the delivery of a 15µL drop of reward
) allowed the measurement of the total distance traveled (cm) and the distance traveled in 10-min intervals, Smart V3.0, Panlab ,
Update on Typical and Atypical Antipsychotic Drugs, Annu Rev Med, vol.64, issue.1, pp.393-406, 2013. ,
In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems, Progress in Brain Research, vol.172, pp.177-197, 2008. ,
Treatment for Negative Symptoms in Schizophrenia: A Comprehensive Review, Drugs, vol.77, issue.13, pp.1423-1459, 2017. ,
Aripiprazole treatment for patients with schizophrenia: from acute treatment to maintenance treatment, Expert Rev Neurother, vol.11, issue.11, pp.1541-1552, 2011. ,
Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, doubleblind, placebo-controlled clinical trial, Prog Neuropsychopharmacol Biol Psychiatry, vol.84, pp.267-271, 2018. ,
Antipsychotic With a Novel Mechanism of Action, and Risperidone vs Placebo in Patients With Schizophrenia and Schizoaffective Disorder, Arch Gen Psychiatry, vol.60, issue.7, pp.681-690, 2003. ,
Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophrenia, Int J Neuropsychopharmacol, vol.6, issue.4, pp.325-337, 2003. ,
P.2.114 Aripiprazole, a new typical antipsychotic: Phase 2 clinical trial result, Eur Neuropsychopharmacol, vol.7, p.227, 1997. ,
Efficacy of aripiprazole in psychotic disorders: Comparison with haloperidol and placebo, Schizophr Res, vol.41, issue.1, p.39, 2000. ,
A randomized, double-blind, placebo-controlled, study of the efficacy and safety of aripiprazole 10, 15 or 20 mg/day for the treatment of patients with acute exacerbations of schizophrenia, J Psychiatr Res, vol.41, issue.11, pp.895-905, 2007. ,
An open randomized pilot trial on the differential effects of aripiprazole versus risperidone on anhedonia and subjective well-being, Pharmacopsychiatry, vol.44, issue.3, pp.109-113, 2011. ,
Effect of aripiprazole on selfreported anhedonia in bipolar depressed patients, Psychiatry Res, vol.165, issue.1, pp.193-196, 2009. ,
Functioning outcomes with adjunctive treatments for major depressive disorder: a systematic review of randomized placebocontrolled studies, Neuropsychiatr Dis Treat, vol.14, pp.103-115, 2017. ,
The Efficacy and Safety of Aripiprazole as Adjunctive Therapy in Major Depressive Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, J Clin Psychiatry, vol.68, issue.6, pp.843-853, 2007. ,
The Efficacy and Safety of Aripiprazole as Adjunctive Therapy in Major Depressive Disorder: A Second Multicenter, Randomized, Double-Blind, Placebo-Controlled Study, J Clin Psychopharmacol, vol.28, issue.2, pp.156-165, 2008. ,
Effect of symptom severity on efficacy and safety of aripiprazole adjunctive to antidepressant monotherapy in major depressive disorder: A pooled analysis, J Affect Disord, vol.162, pp.20-25, 2014. ,
The Mysterious Motivational Functions of Mesolimbic Dopamine, Neuron, vol.76, issue.3, pp.470-485, 2012. ,
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation, Mol Psychiatry, vol.18, issue.9, pp.1025-1033, 2013. ,
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia, Curr Opin Psychiatry, vol.28, issue.1, pp.7-12, 2015. ,
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics, Science, vol.234, issue.4783, pp.1558-1563, 1986. ,
Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia, Int J Neuropsychopharmacol, vol.20, issue.11, pp.928-935, 2017. ,
Dopamine receptors in the brains of schizophrenia patients: a meta-analysis of the findings, Behav Pharmacol, vol.12, issue.5, p.355, 2001. ,
Effects of novel antipsychotics with mixed D2 antagonist/5-HT1A agonist properties on PCP-induced social interaction deficits in the rat, Neuropharmacology, vol.49, issue.7, pp.996-1006, 2005. ,
MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol, Behav Pharmacol, vol.26, pp.748-765, 2015. ,
Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice, Psychopharmacology (Berl), vol.191, issue.2, pp.623-630, 2007. ,
Inhibition of the dopamine transporter as an animal model of bipolar disorder mania: Locomotor response, neuroimmunological profile and pharmacological modulation, J Psychiatr Res, vol.102, pp.142-149, 2018. ,
Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity, Neuropharmacology, vol.64, pp.371-379, 2013. ,
The influence of aripiprazole, olanzapine and enriched environment on depressant-like behavior, spatial memory dysfunction and hippocampal level of BDNF in prenatally stressed rats, Pharmacol Rep, vol.66, issue.3, pp.404-411, 2014. ,
Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice, J Basic Clin Pharm, vol.7, issue.4, p.97, 2016. ,
The antipsychotic aripiprazole selectively prevents the stimulant and rewarding effects of morphine in mice, Eur J Pharmacol, vol.742, pp.139-144, 2014. ,
Aripiprazole blocks acute selfadministration of cocaine and is not self-administered in mice, Psychopharmacology (Berl), vol.199, issue.1, pp.37-46, 2008. ,
The influence of aripiprazole and venlafaxine on the antidepressant-like effect observed in prenatally stressed rats (animal model of depression), Hum Exp Toxicol, p.096032711774702, 2017. ,
Decrease in operant responding under obesogenic diet exposure is not related to deficits in incentive or hedonic processes, Obesity, 2018. ,
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure, Psychopharmacology (Berl), vol.104, issue.4, pp.515-521, 1991. ,
, Tetrabenazine: Spotlight on Drug Review. Ann Neurosci, vol.23, issue.3, pp.176-185, 2016.
Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models, Int J Dev Neurosci, vol.64, pp.38-47, 2018. ,
Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia, Neuropsychopharmacology, vol.37, issue.7, pp.1699-1707, 2012. ,
Within-session decrement of the emission of licking bursts following reward devaluation in rats licking for sucrose, PloS One, vol.12, issue.5, p.177705, 2017. ,
Brain dopamine and serotonin differ in regulation and its consequences, Proc Natl Acad Sci, vol.109, issue.29, pp.11510-11515, 2012. ,
Aripiprazole in schizophrenia and schizoaffective disorder: A review, Clin Ther, vol.32, 2010. ,
Aripiprazole acts as a selective dopamine D 2 receptor partial agonist, Expert Opin Investig Drugs, vol.16, issue.6, pp.771-775, 2007. ,
Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic, Expert Opin Investig Drugs, vol.12, issue.4, pp.655-662, 2003. ,
Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants, Eur J Pharmacol, vol.102, issue.3-4, pp.425-430, 1984. ,
Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways, Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol, vol.32, issue.1, pp.67-77, 2007. ,
3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity, J Pharmacol Exp Ther, vol.274, issue.4, pp.329-336, 1995. ,
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine, Behav Brain Res, vol.137, issue.1, pp.3-25, 2002. ,
Skilled motor deficits in rats induced by ventrolateral striatal dopamine depletions: behavioral and pharmacological characterization, Brain Res, vol.732, issue.1, pp.186-194, 1996. ,
Dopamine modulates neural networks involved in effort-based decision-making, Neurosci Biobehav Rev, vol.33, issue.3, pp.383-393, 2009. ,
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure, Psychopharmacology (Berl) ,
Dopaminergic and Glutamatergic Regulation of Effort-and Delay-Based Decision Making, Neuropsychopharmacology, vol.204, issue.1, pp.1966-1979, 2008. ,
Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum, Nat Commun, vol.9, issue.1, 2018. ,
Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism, CNS Drugs, vol.29, issue.9, pp.773-799, 2015. ,
Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour, J Psychopharmacol (Oxf), vol.23, issue.2, pp.177-189, 2009. ,
State-dependent effects of the D2 partial agonist aripiprazole on dopamine neuron activity in the MAM neurodevelopmental model of schizophrenia, Neuropsychopharmacology, 2018. ,
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors, Psychopharmacology (Berl), vol.202, issue.1-3, pp.315-328, 2009. ,
Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex, 58. van den Boss R, Cools AR, Ogren SO. Differential effects of the selective D2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous and damphetamine-induced activity, vol.387, pp.447-451, 1988. ,
Intraaccumbens Raclopride Attenuates Amphetamine-Induced Locomotion, But Fails to Prevent the Response-Reinstating Properties of Food Reinforcement, Pharmacol Biochem Behav, vol.62, issue.2, pp.165-173, 1999. ,
The role of D2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice, Psychopharmacology (Berl), vol.155, issue.1, pp.69-77, 2001. ,
Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats, Brain Res, vol.487, issue.2, pp.267-277, 1989. ,
Dopamine receptor agonists, partial agonists and psychostimulant addiction, Trends Pharmacol Sci, vol.15, issue.10, pp.374-379, 1994. ,
Dynamic dopamine receptor interactions in the core and shell of nucleus accumbens differentially coordinate the expression of unconditioned motor behaviors, Behav Brain Res, vol.36, issue.4, pp.165-177, 2000. ,
Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption, Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol, vol.40, issue.7, pp.1609-1618, 2015. ,
Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study, Eur Neuropsychopharmacol, vol.25, issue.12, pp.2252-2261, 2015. ,
Neural Ensemble Coding of Satiety States, Neuron, vol.51, issue.4, pp.483-494, 2006. ,
A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function, Chem Senses, vol.27, issue.5, pp.461-474, 2002. ,
Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models, Int J Dev Neurosci, vol.64, pp.38-47, 2018. ,
Disruptions in effort-based decision-making and consummatory behavior following antagonism of the dopamine D2 receptor, Behav Brain Res, vol.320, pp.431-439, 2017. ,
Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression, Neuropsychiatr Dis Treat, vol.33, issue.49, pp.19120-19130, 2013. ,
Dissecting components of reward: "liking", "wanting", and learning, Curr Opin Pharmacol, vol.9, issue.1, pp.65-73, 2009. ,
Insulin and Ventral Tegmental Dopamine: What"s Impaired and What"s Intact?, Cell Metab, vol.17, issue.4, pp.469-470, 2013. ,
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor, Neuroscience, vol.250, pp.507-519, 2013. ,
The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs, PLoS ONE, vol.9, issue.6, p.99320, 2014. ,
Influence of palatability on motivation to operate for caloric and non-caloric food in non fooddeprived and food-deprived rats, Neuroscience, vol.236, pp.320-331, 2013. ,
Effects of aripiprazole on operant responding for a natural reward after psychostimulant withdrawal in rats, Psychopharmacology (Berl) ,
, , vol.191, pp.759-765
, Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior References, Annexe, vol.3
Neural systems of reinforcement for drug addiction: From actions to habits to compulsion, Nat Neurosci, vol.8, pp.1481-1489, 2005. ,
Neurobiological mechanisms for opponent motivational processes in addiction, Philos Trans R Soc Lond B Biol Sci, vol.363, pp.3113-3123, 2008. ,
Parallel and interactive learning processes within the basal ganglia: Relevance for the understanding of addiction, Behav Brain Res, vol.199, pp.89-102, 2009. ,
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction, Philos Trans R Soc Lond B Biol Sci, vol.363, pp.3125-3135, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02276476
Neurocircuitry of addiction, Neuropsychopharmacology, vol.35, pp.217-238, 2010. ,
Mesolimbic dopamine and the regulation of motivated behavior, Curr Top Behav Neurosci, vol.27, pp.231-257, 2016. ,
The debate over dopamine's role in reward: The case for incentive salience, Psychopharmacology (Berl), vol.191, pp.391-431, 2007. ,
, Salamone JD: Dopamine, effort, and decision making: Theoretical comment on Bardgett et, vol.123, pp.463-467, 2009.
What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?, Brain Res Brain Res Rev, vol.28, pp.309-369, 1998. ,
Dopamine signals for reward value and risk: Basic and recent data, Behav Brain Funct, vol.6, p.24, 2010. ,
Dopamine reward prediction-error signalling: A twocomponent response, Nat Rev Neurosci, vol.17, pp.183-195, 2016. ,
Imaging neurotransmitter release by drugs of abuse, Curr Top Behav Neurosci, vol.3, pp.219-245, 2010. ,
PET radioligands for in vivo visualization of neuroinflammation, Curr Pharm Des, vol.20, pp.5897-5913, 2014. ,
Consensus nomenclature for in vivo imaging of reversibly binding radioligands, J Cereb Blood Flow Metab, vol.27, pp.1533-1539, 2007. ,
Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review, J Cereb Blood Flow Metab, vol.20, pp.423-451, 2000. ,
Amphetamine-induced dopamine release: Duration of action as assessed with the D2/3 receptor agonist radiotracer (À)-N-[(11)C]propyl-norapomorphine ([11C]NPA) in an anesthetized nonhuman primate, Synapse, vol.61, pp.106-109, 2007. ,
Imaging the high-affinity state of the dopamine D2 receptor in vivo: Fact or fiction, Biochem Pharmacol, vol.83, pp.193-198, 2012. ,
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method, Proc Natl Acad Sci U S A, vol.94, pp.2569-2574, 1997. ,
Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates, Synapse, vol.25, pp.1-14, 1997. ,
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity, Neuropharmacology, vol.76, pp.498-509, 2014. ,
Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior, Neuropsychopharmacology, vol.29, pp.1190-1202, 2004. ,
Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment, Am J Psychiatry, vol.168, pp.634-641, 2011. ,
Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion, Am J Psychiatry, vol.166, pp.1170-1177, 2009. ,
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers, Synapse, vol.14, pp.169-177, 1993. ,
Effects of chronic cocaine abuse on postsynaptic dopamine receptors, Am J Psychiatry, vol.147, pp.719-724, 1990. ,
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects, Nature, vol.386, pp.830-833, 1997. ,
Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence, Psychopharmacology (Berl), vol.116, pp.285-290, 1994. ,
Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients, Am J Psychiatry, vol.162, pp.1515-1520, 2005. ,
Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving, Am J Psychiatry, vol.161, pp.1783-1789, 2004. ,
Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum, Biol Psychiatry, vol.58, pp.779-786, 2005. ,
Decreases in dopamine receptors but not in dopamine transporters in alcoholics, Alcohol Clin Exp Res, vol.20, pp.1594-1598, 1996. ,
Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: A preliminary study, Psychiatry Res, vol.116, pp.163-172, 2002. ,
Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement, J Neurosci, vol.27, pp.12700-12706, 2007. ,
Higher binding of the dopamine D3 receptor-preferring ligand [11 C]-(þ)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: A positron emission tomography study, J Neurosci, vol.32, pp.1353-1359, 2012. ,
Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity, J Neurosci, vol.29, pp.14734-14740, 2009. ,
Low level of brain dopamine D2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex, Am J Psychiatry, vol.158, pp.2015-2021, 2001. ,
Decreased dopamine activity predicts relapse in methamphetamine abusers, Mol Psychiatry, vol.17, pp.918-925, 2012. ,
Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction, Biol Psychiatry, vol.71, pp.192-198, 2012. ,
Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxoneprecipitated withdrawal, Neuropsychopharmacology, vol.16, pp.174-182, 1997. ,
Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males, Eur Neuropsychopharmacol, vol.18, pp.262-270, 2008. ,
Effects of smoking on D(2)/ D(3) striatal receptor availability in alcoholics and social drinkers, Brain Imaging Behav, vol.7, pp.326-334, 2013. ,
Smoking-induced ventral striatum dopamine release, Am J Psychiatry, vol.161, pp.1211-1218, 2004. ,
Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers, Int J Neuropsychopharmacol, vol.15, pp.989-994, 2012. ,
Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse, Am J Psychiatry, vol.165, pp.507-514, 2008. ,
History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability, J Psychopharmacol, vol.26, pp.144-149, 2012. ,
Imaging dopamine transmission parameters in cannabis dependence, Prog Neuropsychopharmacol Biol Psychiatry, vol.52, pp.28-32, 2014. ,
Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users, Drug Alcohol Depend, vol.128, pp.52-57, 2013. ,
Balanced modulation of striatal activation from D2/D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers, Hum Brain Mapp, vol.36, pp.3154-3166, 2015. ,
Dopamine D(3) receptor alterations in cocaine-dependent humans imaged with, Drug Alcohol Depend, vol.139, issue.1, pp.100-105, 2014. ,
Heightened D3 dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [11 C]-þ-PHNO, Neuropsychopharmacology, vol.39, pp.311-318, 2014. ,
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11 C]-(þ)-PHNO is a D3 receptor preferring agonist in vivo, Synapse, vol.60, pp.485-495, 2006. ,
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine, Am J Psychiatry, vol.164, pp.622-629, 2007. ,
Dopaminergic activity in depressed smokers: A positron emission tomography study, Synapse, vol.63, pp.681-689, 2009. ,
In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers, Am J Psychiatry, vol.169, pp.55-63, 2012. ,
Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (þ) ,
, dihydrotetrabenazine and positron emission tomography, Ann Neurol, vol.44, pp.326-333, 1998.
Striatal dopaminergic abnormalities in human cocaine users, Am J Psychiatry, vol.156, pp.238-245, 1999. ,
Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users, Am J Psychiatry, vol.160, pp.47-55, 2003. ,
Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users, Ann Neurol, vol.40, pp.428-439, 1996. ,
Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: Amphetamine-induced dopamine release in the functional subdivisions of the striatum, J Cereb Blood Flow Metab, vol.23, pp.285-300, 2003. ,
Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory, J Neurosci, vol.29, pp.4690-4696, 2009. ,
Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans, Neuropsychopharmacology, vol.31, pp.1016-1026, 2006. ,
Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride, Synapse, vol.64, pp.350-362, 2010. ,
Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use, J Neurosci, vol.20, pp.7109-7115, 2000. ,
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats, Proc Natl Acad Sci U S A, vol.85, pp.5274-5278, 1988. ,
The D-2 agonist quinpirole releases striatal dopamine in vivo, Eur J Pharmacol, vol.142, pp.187-188, 1987. ,
Defining the caudal ventral striatum in primates: Cellular and histochemical features, J Neurosci, vol.22, pp.10078-10082, 2002. ,
Amygdaloid inputs define a caudal component of the ventral striatum in primates, J Comp Neurol, vol.476, pp.330-347, 2004. ,
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving, Neuropsychopharmacology, vol.31, pp.2716-2727, 2006. ,
Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction, J Neurosci, vol.26, pp.6583-6588, 2006. ,
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys, Nat Neurosci, vol.9, pp.1050-1056, 2006. ,
Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release, NeuroImage, vol.121, pp.20-28, 2015. ,
Blunted dopamine release as a biomarker for vulnerability for substance use disorders, Biol Psychiatry, vol.76, pp.4-5, 2014. ,
Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine release in rhesus monkeys exposed to subchronic amphetamine, Neuropsychopharmacology, vol.22, pp.4-13, 2000. ,
Effects of cocaine selfadministration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys, Psychopharmacology (Berl), vol.205, pp.237-247, 2009. ,
Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour, Neuroscience, vol.174, pp.143-150, 2011. ,
Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: An in vivo microdialysis study, J Pharmacol Exp Ther, vol.272, pp.652-657, 1995. ,
Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: Brain neurotoxicity and behavioral profiles, Neuropsychopharmacology, vol.33, pp.1441-1452, 2008. ,
In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment, Brain Res, vol.571, pp.330-337, 1992. ,
Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex, J Pharmacol Exp Ther, vol.281, pp.54-61, 1997. ,
Excessive cocaine use results from decreased phasic dopamine signaling in the striatum, Nat Neurosci, vol.17, pp.704-709, 2014. ,
Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats, Neuropsychopharmacology, vol.38, pp.1963-1973, 2013. ,
Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey, Brain Res, vol.578, pp.235-243, 1992. ,
Effect of cocaine selfadministration on dopamine D2 receptors in rhesus monkeys, Synapse, vol.30, pp.88-96, 1998. ,
Effects of cocaine selfadministration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure, Neuropsychopharmacology, vol.27, pp.35-46, 2002. ,
Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: Reversal by increasing synaptic dopamine, J Pharmacol Exp Ther, vol.273, pp.373-379, 1995. ,
Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high-and low-alcohol drinking lines of rats, Alcohol, vol.6, pp.317-320, 1989. ,
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol, Eur J Pharmacol, vol.573, pp.84-92, 2007. ,
Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine, Psychopharmacology (Berl), vol.174, pp.381-388, 2004. ,
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement, Science, vol.315, pp.1267-1270, 2007. ,
Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats, Alcohol, vol.10, pp.387-390, 1993. ,
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration, Nat Neurosci, vol.5, pp.169-174, 2002. ,
Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system, Alcohol Alcohol, vol.27, pp.127-130, 1992. ,
Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model, Proc Natl Acad Sci U S A, vol.113, pp.2861-2870, 2016. ,
DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking, Alcohol Clin Exp Res, vol.28, pp.720-728, 2004. ,
Overexpression of dopamine D2 receptors reduces alcohol self-administration, J Neurochem, vol.78, pp.1094-1103, 2001. ,
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats, Synapse, vol.62, pp.481-486, 2008. ,
Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking, Life Sci, vol.77, pp.130-139, 2005. ,
Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction, Biol Psychiatry, vol.76, pp.23-30, 2014. ,
Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels, Am J Psychiatry, vol.156, pp.1440-1443, 1999. ,
Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study, Synapse, vol.46, pp.79-82, 2002. ,
High levels of dopamine D2 receptors in unaffected members of alcoholic families: Possible protective factors, Arch Gen Psychiatry, vol.63, pp.999-1008, 2006. ,
Risk taking and the adolescent reward system: A potential common link to substance abuse, Am J Psychiatry, vol.169, pp.39-46, 2012. ,
Linking nucleus accumbens dopamine and blood oxygenation, Psychopharmacology (Berl), vol.191, pp.813-822, 2007. ,
Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release, J Neurosci, vol.28, pp.14311-14319, 2008. ,
Lower ventral striatal activation during reward anticipation in adolescent smokers, Am J Psychiatry, vol.168, pp.540-549, 2011. ,
Behavioral theories and the neurophysiology of reward, Annu Rev Psychol, vol.57, pp.87-115, 2006. ,
Dopamine and reward: The anhedonia hypothesis 30 years on, Neurotox Res, vol.14, pp.169-183, 2008. ,
Impulsivity as a determinant and consequence of drug use: A review of underlying processes, Addict Biol, vol.14, pp.22-31, 2009. ,
, Varieties of impulsivity, vol.146, pp.348-361, 1999.
Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders, Alcohol Clin Exp Res, vol.34, pp.1334-1345, 2010. ,
Are executive function and impulsivity antipodes? A conceptual reconstruction with special reference to addiction, Psychopharmacology (Berl), vol.221, pp.361-387, 2012. ,
Impulsivity, compulsivity, and topdown cognitive control, Neuron, vol.69, pp.680-694, 2011. ,
Similarities and differences between pathological gambling and substance use disorders: A focus on impulsivity and compulsivity, Psychopharmacology (Berl), vol.219, pp.469-490, 2012. ,
Decision-making and addiction (part II): Myopia for the future or hypersensitivity to reward?, Neuropsychologia, vol.40, pp.1690-1705, 2002. ,
Behavioral and neuroeconomics of drug addiction: competing neural systems and temporal discounting processes, Drug Alcohol Depend, vol.90, issue.1, pp.85-91, 2007. ,
Neurodevelopment, impulsivity, and adolescent gambling, J Gambl Stud, vol.19, pp.53-84, 2003. ,
Reversal learning as a measure of impulsive and compulsive behavior in addictions, Psychopharmacology (Berl), vol.219, pp.607-620, 2012. ,
Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats, Psychopharmacology (Berl), vol.146, pp.432-439, 1999. ,
Effects of acute and chronic nicotine on impulsive choice in rats, Behav Pharmacol, vol.16, pp.15-23, 2005. ,
In search of predictive endophenotypes in addiction: Insights from preclinical research, Genes Brain Behav, vol.15, pp.74-88, 2016. ,
Impulsivity predicts individual susceptibility to high levels of alcohol self-administration, Behav Pharmacol, vol.6, pp.810-814, 1995. ,
The role of impulsive behavior in drug abuse, Psychopharmacology (Berl), vol.200, pp.1-26, 2008. ,
Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats, Psychopharmacology (Berl), vol.178, pp.193-201, 2005. ,
High impulsivity predicts the switch to compulsive cocaine-taking, Science, vol.320, pp.1352-1355, 2008. ,
Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats, Biol Psychiatry, vol.63, pp.301-308, 2008. ,
Monetary discounting and ventral striatal dopamine receptor availability in nontreatment-seeking alcoholics and social drinkers, Psychopharmacology (Berl), vol.232, pp.2207-2216, 2015. ,
Dopaminergic network differences in human impulsivity, Science, vol.329, p.532, 2010. ,
Dopamine D(2/3) receptor availability and human cognitive impulsivity: A high-resolution positron emission tomography imaging study with, Acta Neuropsychiatrica, vol.26, issue.1, pp.35-42, 2014. ,
Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release, Neuro-Image, vol.36, pp.153-166, 2007. ,
Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators, Psychiatry Res, vol.202, pp.60-64, 2012. ,
Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder, NeuroImage, vol.25, pp.868-876, 2005. ,
Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance, Psychiatry Res, vol.223, pp.244-252, 2014. ,
Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans, Eur Neuropsychopharmacol, vol.26, pp.644-652, 2016. ,
Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: Possible relevance to the attention-deficit hyperactivity syndrome, Neuropsychopharmacology, vol.38, pp.1460-1471, 2013. ,
Dopaminergic and GABA-ergic markers of impulsivity in rats: Evidence for anatomical localisation in ventral striatum and prefrontal cortex, Eur J Neurosci, vol.37, pp.1519-1528, 2013. ,
Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine, Psychopharmacology (Berl), vol.208, pp.585-592, 2010. ,
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation, Mol Psychiatry, vol.18, pp.1025-1033, 2013. ,
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits, Psychopharmacology (Berl), vol.191, pp.461-482, 2007. ,
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption, Pharmacol Biochem Behav, vol.69, pp.373-382, 2001. ,
Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat, Behav Neurosci, vol.117, pp.202-211, 2003. ,
Dopamine and conditioned reinforcement. I. Differential effects of amphetamine microinjections into striatal subregions, Psychopharmacology (Berl), vol.103, pp.187-196, 1991. ,
Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell, Pharmacol Biochem Behav, vol.96, pp.342-346, 2010. ,
Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward, Neuropsychopharmacology, vol.31, pp.1362-1370, 2006. ,
Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors, Nat Neurosci, vol.14, pp.1033-1038, 2011. ,
Dopaminergic mechanisms of individual differences in human effort-based decision-making, J Neurosci, vol.32, pp.6170-6176, 2012. ,
Incentive motivation is associated with striatal dopamine asymmetry, Biol Psychol, vol.77, pp.98-101, 2008. ,
Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway, Mol Psychiatry, vol.16, pp.1147-1154, 2011. ,
Community reinforcement therapy for cocaine-dependent outpatients, Arch Gen Psychiatry, vol.60, pp.1043-1052, 2003. ,
Genetics of dopamine receptors and drug addiction, Hum Genet, vol.131, pp.803-822, 2012. ,
Reward deficiency syndrome: Genetic aspects of behavioral disorders, Prog Brain Res, vol.126, pp.325-341, 2000. ,
The 3 0 region of the DRD2 gene is involved in genetic susceptibility to schizophrenia, Schizophr Res, vol.67, pp.75-85, 2004. ,
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers, Mol Psychiatry, vol.4, pp.290-296, 1999. ,
D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: Reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele, Pharmacogenetics, vol.7, pp.479-484, 1997. ,
The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers, Mol Psychiatry, vol.3, pp.256-260, 1998. ,
The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction, Ann Hum Genet, vol.78, pp.33-39, 2014. ,
Dopaminergic pathway polymorphisms and heroin addiction: Further support for association of CSNK1E variants, Pharmacogenomics, vol.15, pp.2001-2009, 2014. ,
A DRD2 and ANKK1 haplotype is associated with nicotine dependence, Psychiatry Res, vol.196, pp.285-289, 2012. ,
Genome-wide association study of alcohol dependence, Arch Gen Psychiatry, vol.66, pp.773-784, 2009. ,
A genome-wide association study of alcohol dependence, Proc Natl Acad Sci U S A, vol.107, pp.5082-5087, 2010. ,
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence, J Psychiatr Res, vol.45, pp.1419-1425, 2011. ,
Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction, Psychiatr Genet, vol.20, pp.207-214, 2010. ,
Replicated" genome wide association for dependence on illegal substances: Genomic regions identified by overlapping clusters of nominally positive SNPs, Am J Med Genet Part B Neuropsychiatr Genet, vol.156, pp.125-138, 2011. ,
Genome wide association for addiction: replicated results and comparisons of two analytic approaches, PloS One, vol.5, p.8832, 2010. ,
A genome-wide association study of DSM-IV cannabis dependence, Addict Biol, vol.16, pp.514-518, 2011. ,
Alcohol dependence genetics: Lessons learned from genome-wide association studies (GWAS) and post-GWAS analyses, Alcohol Clin Exp Res, vol.39, pp.1312-1327, 2015. ,
Epigenetic mechanisms in drug addiction, Trends Mol Med, vol.14, pp.341-350, 2008. ,
Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior, Prog Brain Res, vol.223, pp.3-18, 2016. ,
Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring, J Neurosci Res, vol.92, pp.658-670, 2014. ,
Multigenerational effects of adolescent morphine exposure on dopamine D2 receptor function, Psychopharmacology (Berl), vol.227, pp.263-272, 2013. ,
Increased locomotor response to novelty and propensity to intravenous amphetamine selfadministration in adult offspring of stressed mothers, Brain Res, vol.586, pp.135-139, 1992. ,
Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens, Brain Res, vol.685, pp.179-186, 1995. ,
Prenatal stress enhances responsiveness to cocaine, Neuropsychopharmacology, vol.33, pp.769-782, 2008. ,
Response to stress of mesocorticofrontal dopaminergic neurones in rats after long-term isolation, Nature, vol.284, pp.265-267, 1980. ,
Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats, Eur J Neurosci, vol.19, pp.1863-1874, 2004. ,
Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C] raclopride, J Neurosci, vol.24, pp.2825-2831, 2004. ,
Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers, Biol Psychiatry, vol.67, pp.275-278, 2010. ,
Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers, Neurosci Lett, vol.617, pp.27-31, 2016. ,
Social dominance in rats: Effects on cocaine self-administration, novelty reactivity and dopamine receptor binding and content in the striatum, Psychopharmacology (Berl), vol.233, pp.579-589, 2016. ,
Neuroplasticity of dopamine circuits after exercise: Implications for central fatigue, Neuromolecular Med, vol.10, pp.67-80, 2008. ,
Effect of exercise training on striatal dopamine D2/D3 receptors in methamphetamine users during behavioral treatment, Neuropsychopharmacology, vol.41, pp.1629-1636, 2016. ,
Voluntary exercise decreases ethanol preference and consumption in C57BL/6 adolescent mice: Sex differences and hippocampal BDNF expression, Physiol Behav, vol.138, pp.28-36, 2015. ,
Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex, Biol Psychiatry, vol.68, pp.774-777, 2010. ,
Access to a running wheel inhibits the acquisition of cocaine self-administration, Pharmacol Biochem Behav, vol.100, pp.237-243, 2011. ,
Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats, Psychopharmacology, vol.224, pp.387-400, 2012. ,
Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model, Transl Psychiatry, vol.6, p.792, 2016. ,
Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons, Brain Struct Funct, vol.221, pp.261-276, 2016. ,
Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis, Neurosci Biobehav Rev, vol.37, pp.1622-1644, 2013. ,
Associations of physical activity and sport and exercise with at-risk substance use in young men: a longitudinal study, Prev Med, vol.64, pp.27-31, 2014. ,
The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behaviour: A systematic review, Addiction, vol.102, pp.534-543, 2007. ,
The effects of acute exercise on attentional bias towards smoking-related stimuli during temporary abstinence from smoking, Addiction, vol.104, pp.1910-1917, 2009. ,
High-fat diet alters the dopamine and opioid systems: Effects across development, Int J Obes Suppl, vol.2, pp.25-28, 2012. ,
Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling-Two markers of addiction vulnerability, Eur J Neurosci, vol.42, pp.3095-3104, 2015. ,
Omega-3 fatty acids and monoamine neurotransmission, Prostaglandins Leukot Essent Fatty Acids, vol.75, pp.259-269, 2006. ,
Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency, Biol Psychiatry, vol.75, pp.38-46, 2014. ,
Preventative strategies for early-onset bipolar disorder: Towards a clinical staging model, CNS Drugs, vol.24, pp.983-996, 2010. ,
Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder, J Affect Disord, vol.126, pp.303-311, 2010. ,
Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism, Transl Psychiatry, vol.1, p.4, 2011. ,