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, Fabien Ducrocq F, vol.1

N. Inra and I. Neurobiology,

. Optinutribrain, International Associated Laboratory

F. Bordeaux,

, *These authors share senior authorship Keywords: dopamine, high-fat diet, motivation, hedonic response

, HFD, high-fat diet

. Pr and . Fr,

, RR, random ratio Running title : reward processing and obesogenic diet exposure Contact information : Sylvie Vancassel INRA, UMR 1286, Laboratory of Nutrition and Integrative Neurobiology

, 4207 Funding : This study was supported by INRA and University of Bordeaux "Investissements d'avenir Initiative d'excellence" (Idex) (LIA OptiNutriBrain, SL). HF is the recipient of INRA and Idex

, NARSAD Young Investigator Grant from the Brain and Behavior Foundation (PT), ANR "SynLip, PT)

. Anr-"obeteen, GF

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, 2: HFD consumption induced a decrease in lever pressing in random ratio (RR) and progressive ratio (PR) schedules

, Operant conditioning in ad libitum (A, C, E and G) or food deprived conditions (15% of initial weight

B. , D. , F. , and H. ). , Lever presses during fixed ratio (FR1) and RR tasks (Ctrl: n=13 and HF: n=24

A. and C. , , p.21

B. ). , PRx2 task: Levels are presented for cumulative lever presses during a progressive ratio times 2 task (PRx2) (Ctrl: n=13 and HF: n=24 ; C and D), and for total lever presses during the 1h-session (Ctrl: n=13 and HF: n=24 ; E and F), Number of reward earned during fixed ratio (FR1) and RR schedules (Ctrl: n=13 and HF, p.24

G. and C. , , p.21

, Ctrl: control group; HF: high-fat diet group. in RR5 non-concurrent task (1 session) performed before the concurrent task, and in one session of the RR5 concurrent task (B). Results for concurrent/non-concurrent ratio of lever pressing (C), caloric intake for both rewards earned by lever pressing and freely available food (D) and total caloric intake (E) (Ctrl: n=21 and HF: n=21). Data are means ± sem, Data are means ± sem. *p<0.05, **p<0.01, ***p<0.001 significant differences between dietary groups (ANOVA)

, 4: HFD consumption induced alterations in licking microstructures revealing altered post-ingestive negative feedback without change in hedonic response

, Measures of parameters linked to postingestive negative feedback (consumption, number of licks and number of burts

, B-D) and palatability of the ingested tastant (delay to first lick, licks/burst, bursts duration, inter-licks interval and lick frequency in bursts

E. , Representation of the number of licks and number of bursts during the first 10 minutes of the task (5-minute bins) (left graphs) and expressed as a percentage relative to the first 5 minutes (right graphs) (J-K), Ctrl: n=21 and HF: n=21)

, HF: high-fat diet group

, 1 Nutrition and Integrative Neurobiology, INRA UMR 1286, vol.1

, France 3 Correspondence: Fabien.ducrocq@inra.fr or pierre

, Keywords: Aripiprazole, motivation, hedonic response, D 2 -receptor, antipsychotic, schizophrenia Running title: Aripiprazole blocks reward-processing in mice INRA, Batiment UFR Pharmacie -2eme Tranche -2eme Etage -CC34, 146 rue Leo Saignat, vol.33076

, Word count: Abstract: 248, p.3999

, Responding on the left lever (active lever) was followed by a brief tone (65 db, 3000 Hz, 200 ms), illumination of a cue light located at 8,5 cm above the lever, activation of the syringe pump, and the delivery of a 15µL drop of reward

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