Experimental gingivitis in man, J Periodontol, vol.36, pp.177-87, 1965. ,
Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation, J Periodontal Res, vol.1, pp.1-13, 1966. ,
Principles of aetiology and pathogenesis governing the treatment of periodontal disease, Int Dent J, vol.33, issue.2, pp.119-145, 1983. ,
Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age, J Clin Periodontol, vol.13, issue.5, pp.431-476, 1986. ,
Measurement of prostaglandin E in crevicular fluid, J Clin Periodontol, vol.8, issue.4, pp.359-67, 1981. ,
Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts, Periodontol, vol.62, issue.1, pp.203-220, 2000. ,
Host modulation therapy with anti-inflammatory agents, Periodontol, vol.76, issue.1, pp.131-180, 2000. ,
Development and general structure of the periodontium, Periodontol, vol.24, pp.9-27, 2000. ,
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions, J Clin Periodontol, vol.45, pp.68-77, 2018. ,
Periodontal diseases, Lancet Lond Engl, vol.19, issue.9499, pp.1809-1829, 2005. ,
New concepts of destructive periodontal disease, J Clin Periodontol, vol.1, issue.1, pp.21-32, 1984. ,
Periodontitis epidemiology: is periodontitis under-recognized, over-diagnosed, or both? Periodontol, vol.75, pp.45-51, 2000. ,
A new classification scheme for periodontal and peri-implant diseases and conditions -Introduction and key changes from the 1999 classification, J Periodontol, vol.89, issue.1, pp.1-8, 2018. ,
Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action, J Clin Periodontol, vol.44, issue.5, pp.456-62, 2017. ,
Disabilityadjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study, Lancet Lond Engl, vol.380, issue.9859, pp.2197-223, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00827610
Global burden of oral conditions in 1990-2010: a systematic analysis, J Dent Res, vol.92, issue.7, pp.592-599, 2013. ,
Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression, J Dent Res, vol.93, issue.11, pp.1045-53, 2014. ,
Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis, J Dent Res, vol.93, issue.7, pp.20-28, 2014. ,
Global Economic Impact of Dental Diseases, J Dent Res, vol.94, issue.10, pp.1355-61, 2015. ,
Global oral health inequalities: task group--periodontal disease, Adv Dent Res, vol.23, issue.2, pp.221-227, 2011. ,
Epidemiology of periodontal status in dentate adults in France, J Periodontal Res, vol.42, issue.3, pp.219-246, 2002. ,
Periodontal diseases in Europe, Periodontol, vol.29, pp.104-125, 2000. ,
Roy Page (University of Washin. Prevalence of periodontitis in adults in the United States, American Academy of Periodontology), vol.91, issue.10, pp.914-934, 2009. ,
Clinical research activity in periodontal medicine: a systematic mapping of trial registers, J Clin Periodontol, vol.43, issue.5, pp.390-400, 2016. ,
working group 2 of the joint EFP/AAP workshop. Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases, J Periodontol, vol.84, issue.4, pp.106-112, 2013. ,
Prevention: Reducing the risk of CVD in patients with periodontitis, Nat Rev Cardiol, vol.7, issue.9, pp.479-80, 2010. ,
Bioactive Polymeric Nanoparticles for Periodontal Therapy, Disponible sur, vol.7, 2016. ,
Antiinflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes, Nanomed, vol.12, issue.23, pp.2651-74, 2017. ,
In situ forming parenteral drug delivery systems: an overview, Eur J Pharm Biopharm Off J Arbeitsgemeinschaft Pharm Verfahrenstechnik EV, vol.58, issue.2, pp.445-55, 2004. ,
Intragingival delivery systems for treatment of periodontal disease ,
, US5324520A, 1994.
,
In situ forming implants -an attractive formulation principle for parenteral depot formulations, J Control Release Off J Control Release Soc, vol.20, issue.2, pp.668-79, 2012. ,
In situ forming implants for periodontitis treatment with improved adhesive properties, Eur J Pharm Biopharm Off J Arbeitsgemeinschaft Pharm Verfahrenstechnik EV, vol.88, issue.2, pp.342-50, 2014. ,
Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment, Eur J Pharm Biopharm Off J Arbeitsgemeinschaft Pharm Verfahrenstechnik EV, vol.94, pp.273-83, 2015. ,
In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance, Int J Pharm, vol.486, issue.1-2, pp.38-51, 2015. ,
Properties of lactic acid based polymers and their correlation with composition, Prog Polym Sci, vol.1, issue.6, pp.1123-63, 2002. ,
Biodegradable polymers as biomaterials, Prog Polym Sci, vol.1, issue.8, pp.762-98, 2007. ,
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review, Int J Pharm, vol.30, issue.1-2, pp.34-52, 2011. ,
An investigation of bioadhesion for periodontal and oral mucosal drug delivery, J Clin Periodontol, vol.24, issue.6, pp.394-400, 1997. ,
Characterisation of bioadhesives for periodontal and oral mucosal drug delivery, J Clin Periodontol, vol.25, issue.1, pp.74-82, 1998. ,
Prevalence of periodontitis in adults in the United States: 2009 and 2010, J. Dent. Res, vol.91, pp.914-920, 2012. ,
Periodontal status, sociodemographic, and behavioral indicators in subjects attending a public dental school in Brazil: analysis of clinical attachment loss, J. Periodontol, vol.80, pp.1945-1954, 2009. ,
Suppurationassociated bacteria in patients with chronic and aggressive periodontitis ,
, J. Periodontol, vol.84, pp.9-16, 2013.
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex, Periodontol, vol.38, pp.72-122, 2000. ,
, Lancet, 2005.
The bacteria of periodontal diseases, Periodontol, vol.5, pp.66-77, 1994. ,
Local delivery system of doxycycline hyclate based on ?-caprolactone copolymers for periodontitis treatment, Int. J. Pharm, vol.491, pp.335-344, 2015. ,
El-zamarany, E.A. Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol, Int. J. Pharm, 2015. ,
Optimization of metronidazole sustained-release films using D-optimal design, Int. J. Pharm, 2015. ,
Local delivery of resveratrol using polycaprolactone nanofibers for treatment of periodontal disease, JDDST, vol.30, pp.408-416, 2015. ,
Bioactive glass combined with bisphosphonates provides protection against biofilms formed by the periodontal pathogen Aggregatibacter actinomycetemcomitans, Int. J. Pharm, vol.501, pp.211-220, 2016. ,
Local delivery of antimicrobial agents for the treatment of periodontal diseases, Eur. J. Pharm. Biopharm, vol.50, pp.83-99, 2000. ,
Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases, J. Clin. Pharm. Ther, vol.25, pp.21-42, 2000. ,
,
, J. Pharm. Biopharm, vol.88, pp.342-350, 2014.
The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review, J. Periodontol, vol.84, pp.332-351, 2013. ,
A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis, J. Clin. Periodontol, vol.40, pp.227-241, 2013. ,
Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone, J. Periodontol, vol.69, pp.989-997, 1998. ,
Local delivery of chlorhexidine gluconate (PerioChip) in periodontal maintenance patients, J. Clin ,
, Periodontol, vol.28, pp.90-95, 2001.
Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial, J. Periodontol, vol.80, pp.1479-1492, 2009. ,
In situ forming implants -an attractive formulation principle for parenteral depot formulations, J. Control. Release, vol.161, pp.668-679, 2012. ,
, , 0931.
,
, , 0931.
, 1+02+8!816D!10.-3!N0M!*04+!-7
,
,
,
,
,
*+! /65=! 956-8! ,02! ,
, , vol.810
,
Periodontal diseases, Lancet, vol.19, issue.9499, pp.1809-1829, 2005. ,
Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action, J Clin Periodontol, vol.44, issue.5, pp.456-62, 2017. ,
Prevalence of periodontitis in adults in the United States: 2009 and 2010, J. Dent. Res, vol.91, pp.914-920, 2012. ,
Global burden of severe periodontitis in 1990-2010: a systematic review and metaregression, J Dent Res, vol.93, issue.11, pp.1045-53, 2014. ,
Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis, J Dent Res, vol.93, issue.7, pp.20-28, 2014. ,
Global Economic Impact of Dental Diseases, J Dent Res, vol.94, issue.10, pp.1355-61, 2015. ,
Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology ,
, Mol Oral Microbiol, vol.27, issue.6, pp.409-428, 2012.
experimental gingivitis in man, j periodontol, vol.36, pp.177-87, 1965. ,
Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis, Science, vol.1, issue.4835, pp.55-62, 1988. ,
Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque, Oral Microbiol Immunol, vol.24, issue.6, pp.469-77, 2009. ,
Microbial complexes in subgingival plaque, J Clin Periodontol, vol.25, issue.2, pp.134-178, 1998. ,
Microbial interactions in building of communities, Mol Oral Microbiol, vol.28, issue.2, pp.83-101, 2013. ,
Nonsurgical periodontal therapy, Periodontol, vol.25, pp.77-88, 2000. ,
Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontol, vol.75, pp.152-88, 2000. ,
Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone, J. Periodontol, vol.69, pp.989-997, 1998. ,
Local delivery of chlorhexidine gluconate (PerioChip) in periodontal maintenance patients, J. Clin ,
, Periodontol, vol.28, pp.90-95, 2001.
Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial, J. Periodontol, vol.80, pp.1479-1492, 2009. ,
Host modulation: controlling the inflammation to control the infection, Periodontol, vol.75, issue.1, pp.317-346, 2000. ,
Host modulation therapy with anti-inflammatory agents, Periodontol, vol.76, issue.1, pp.131-180, 2000. ,
Working Group 3 of Seventh European Workshop on Periodontology. Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on Periodontology, J Clin Periodontol, vol.38, issue.11, pp.114-122, 2011. ,
Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis, Clin Oral Investig, vol.22, issue.7, pp.2413-2443, 2018. ,
Novel host response therapeutic approaches to treat periodontal diseases, Periodontol, vol.43, pp.294-315, 2000. ,
The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease, Periodontol, vol.43, pp.85-101, 2000. ,
Systemic Application of Anti-inflammatory Agents in Periodontal Treatment, Clin Anti-Inflamm Anti-Allergy Drugs, vol.2, issue.1, pp.3-13, 2015. ,
In situ forming implants for periodontitis treatment with improved adhesive properties, Eur J Pharm Biopharm, vol.88, issue.2, pp.342-50, 2014. ,
Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment, Eur J Pharm Biopharm, vol.94, pp.273-83, 2015. ,
Insitu forming composite implants for periodontitis treatment: How the formulation determines system performance, Int. J. Pharm, vol.486, pp.38-51, 2015. ,
Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment, Int J Pharm, vol.15, issue.1-2, pp.282-93, 2017. ,
Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae). Evid Based, Complement Alternat Med, p.604536, 2013. ,
Chlorhexidine-protein interactions, J Periodontal Res Suppl, vol.12, pp.11-17, 1973. ,
,
*-?+@!'52!.212.+!-4!8,80572?,!A/622?!.*?2!B!2>*,52.*8.!8,80572?,! .212.C!:2..-3!B!4*D6-E+!0, 20,*12!,*++E2!8,80572?,F!8?<!8.12-.86!D-?2!062+,!AD.E2!.*?2F!3262!728+E62<!46-7!,52!")G!A62<!.*?2F!8?<!0-7>862<!*?!,52!<*44262?,! /6-E>+!&HI&!AJ!"59K&DE=!LC!L@MC!NF@!'52 ,
*-?+@!'52 .212.+!-4!8,80572?,!A/622? .*?2 B!2>*,52.*8.!8,80572?,! .212.C!:2..-3!B!4*D6-E+!0, 80572?,F!8?<!8.12-.86!D-?2!062+,!AD.E2!.*?2F!3262!728+E62<!46-7!,52!")G!A62<!.*?2F!8?<!0-7>862<!*?!,52!<*44262?, /6-E>+!&HI&!AJ!"59K&DE=!LC!L@MC!NF@!'52!E?,628,2<!+*,2+!3262!E+2<!8+!0-?,6-.+@! References, vol.1, pp.1809-1829, 2005. ,
Nonsurgical periodontal therapy, Periodontol, vol.25, pp.77-88, 2000. ,
Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontol, vol.75, pp.152-88, 2000. ,
Immuno-microbial pathogenesis of periodontitis: Keystones, pathobionts, and the host response, Trends Immunol, vol.35, issue.1, pp.3-11, 2014. ,
Periodontitis: from microbial immune subversion to systemic inflammation, Nat Rev Immunol, vol.15, issue.1, pp.30-44, 2015. ,
Host modulation: controlling the inflammation to control the infection, Periodontol, vol.75, issue.1, pp.317-346, 2000. ,
Host modulation therapy with anti-inflammatory agents, Periodontol, vol.76, issue.1, pp.131-180, 2000. ,
Measurement of prostaglandin E in crevicular fluid, J Clin Periodontol, vol.8, issue.4, pp.359-67, 1981. ,
Modulation of host PGE2 secretion as a determinant of periodontal disease expression, J Periodontol, vol.64, issue.5, 1993. ,
The overexpression of cyclo-oxygenase-2 in chronic periodontitis, J Am Dent Assoc, vol.134, issue.7, pp.861-868, 2003. ,
Systemic Application of Anti-inflammatory Agents in Periodontal Treatment, Clin Anti-Inflamm Anti-Allergy Drugs, vol.2, issue.1, pp.3-13, 2015. ,
Novel host response therapeutic approaches to treat periodontal diseases, Periodontol, vol.43, pp.294-315, 2000. ,
The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease, Periodontol, vol.43, pp.85-101, 2000. ,
A novel in situ forming drug delivery system for controlled parenteral drug delivery, Int. J. Pharm, vol.332, pp.107-114, 2007. ,
In situ forming implants -an attractive formulation principle for parenteral depot formulations, J. Control. Release, vol.161, pp.668-679, 2012. ,
In situ forming implants for periodontitis treatment with improved adhesive properties, Eur J Pharm Biopharm, vol.88, issue.2, pp.342-50, 2014. ,
Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment, Eur J Pharm Biopharm, vol.94, pp.273-83, 2015. ,
Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment, Int J Pharm, vol.15, issue.1-2, pp.282-93, 2017. ,
Wound models for periodontal and bone regeneration: the role of biologic research, Periodontol, vol.68, issue.1, pp.7-20, 2000. ,
Periodontal and systemic responses in various mice models of experimental periodontitis: respective roles of inflammation duration and Porphyromonas gingivalis infection, J Periodontol, vol.84, issue.3, pp.396-406, 2013. ,
Synthesis of a Novel Electrospun Polycaprolactone Scaffold Functionalized with Ibuprofen for Periodontal Regeneration: An In Vitro andIn Vivo Study, Materials (Basel), vol.10, issue.4, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01905785
Role of systemic and local administration of selective inhibitors of cyclooxygenase 1 and 2 in an experimental model of periodontal disease in rats, J Periodontal Res, vol.44, issue.2, pp.153-60, 2009. ,
The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis, J Periodontol, vol.79, issue.10, pp.1934-1975, 2008. ,
Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats, J Periodontol, vol.77, issue.4, pp.657-63, 2006. ,
Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats, J Periodontol, vol.76, issue.1, pp.99-106, 2005. ,
Mucoadhesive drug delivery systems, J Pharm Bioallied Sci, vol.3, issue.1, pp.89-100, 2011. ,
Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment, Clinical Anti-inflammatory & Anti-Allergy Drugs, vol.2, issue.1, pp.282-293, 2015. ,
Novel in-situ forming implants with a dual antimicrobial and anti-inflammatory effect for local periodontitis treatment. (en attente pour soumission ,
Mise au point d'un modèle d'évaluation de l'adhésion d'un implant formé in situ pour le traitement des poches parodontales, Congrès national de la Société Française de Parodontologie et d'Implantologie Orale (SFPIO), 2016. ,
Textural properties and bioadhesion of an in-situ implant for the treatment of periodontal pocket. 4th Congress on Innovation in Drug Delivery Site-Specific Drug Delivery, 2016. ,
Antimicrobial activity of novel in situ forming implants for periodontitis treatment. CED-IADR/NOF Oral Health Research, p.2017 ,
In-situ forming implants for periodontitis treatment: How the drug loading & form affect the mechanical properties, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2018. ,