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Rôle des cellules B régulatrices dans l’immunodépression induite par le choc septique

Abstract : Sepsis in a major health problem associated with rising incidence and high mortality rate. In septic patients, an initial proinflammatory response causing life-threatening organ failures is followed by the development of a deep immunosuppression, associated with increased risk of secondary infections and death. In this context, immunostimulating therapies are currently tested. However, success of this strategy requires identification of relevant therapeutical targets and biomarkers allowing individualisation of treatments. B lymphocytes have been poorly studied in sepsis. Moreover, existence of regulatory B cells was recently revealed in several clinical contexts. Thus, we made the assumption that regulatory B lymphocytes or plasma cells could be implied in sepsis-induced immunosuppression establishment.In septic shock patients, we showed that B cells present with decreased proliferation capacity and exhausted-like profile, and are able to produce immunosuppressive IL-10 (Journal of Immunology 2018). We also observed blood plasmacytosis in patients, confirmed by mass cytometry analysis (Scientific Reports 2018). In a murine model of sepsis, the ability of plasma cells to inhibit T cell proliferation ex vivo, and their phenotypic profile suggest for the first time the existence of regulatory plasma cells in sepsis.The role of regulatory plasma cells within sepsis-induced immunosuppression has to be further explored in patients (underlying regulatory mechanisms, associations with clinical outcomes and viral reactivations…). It could highlight novel biomarkers for patients’ monitoring and innovative therapeutical approaches
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https://tel.archives-ouvertes.fr/tel-02422224
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Submitted on : Saturday, December 21, 2019 - 1:04:05 AM
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Morgane Gossez. Rôle des cellules B régulatrices dans l’immunodépression induite par le choc septique. Immunologie. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1017⟩. ⟨tel-02422224⟩

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