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Conception et synthèse d’auto-assemblages d’amphiphiles diacétyléniques pour les applications en nanomédecine et en catalyse

Abstract : The work described in this manuscript focuses on the study of nanostructures obtained by self-assembly of polymerizable diacetylenic amphiphiles. Two families of compounds have been studied (spherical micelles and bilayer ribbons) and used for biomedical applications on the one hand and for catalysis on the other. At first, polymerized cationic micelles assembled from diacetylenic amphiphiles are synthesized. These micelles were valorized for the transfection of small interfering RNAs in vitro. Then a "biocompatible" micellar catalyst incorporating copper was developed to promote in vitro chemical transformations. Our studies focused on the Huisgen 1,3-dipolar cycloaddition that we implemented in the intracellular compartment. Finally, we are interested in the synthesis and formulation of supramolecular architectures from diacetylenic amphiphiles. These systems have been used for the asymmetric and semi-heterogeneous catalysis of the aldol reaction.
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  • HAL Id : tel-02420650, version 1

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Minh Duc Hoang. Conception et synthèse d’auto-assemblages d’amphiphiles diacétyléniques pour les applications en nanomédecine et en catalyse. Chimie organique. Université Paris-Saclay, 2019. Français. ⟨NNT : 2019SACLS371⟩. ⟨tel-02420650⟩

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