Skip to Main content Skip to Navigation
Theses

Embryogenèse de la moelle épinière : de la dynamique collective observable à une proposition de modèle comportemental à l'échelle cellulaire

Abstract : We consider the developing spinal cord as a dynamical system made of behavioral units (cells). For the adult spinal cord to be functional, different neurons must be of the right kind at the right place. They are issued from a dynamical process of proliferative and differenciating neural progenitors, with a fine control of the balance between proliferation and differentiation. Some experimental data are available for the evolution of progenitors and neurons population and for how the balance progresses with time. Based on these data, we propose a first model at the collective scale to account for these dynamics all along the process. A second model is proposed at the cell scale which includes a loss of proliferative capacity that progressively concerns more and more progenitors. This behavioural switch at cell scale is reflected by a continous progression of the balance proliferation / differentiation at population scale, as it is experimentally observed. Finally, we introduce a feedback control process so that this progression is under the control of the progenitors and neurons populations. Among the multiple possibilities for this feedback, we point out to the most relevant process. We discuss these findings, and how they can be extended to spatialized dynamics and neocortex development.
Complete list of metadatas

Cited literature [140 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02417559
Contributor : Abes Star :  Contact
Submitted on : Wednesday, December 18, 2019 - 11:46:15 AM
Last modification on : Thursday, September 10, 2020 - 3:08:10 PM
Long-term archiving on: : Thursday, March 19, 2020 - 4:21:20 PM

File

2018TOU30283a.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02417559, version 1

Collections

Citation

Manon Azaïs. Embryogenèse de la moelle épinière : de la dynamique collective observable à une proposition de modèle comportemental à l'échelle cellulaire. Embryologie et organogenèse. Université Paul Sabatier - Toulouse III, 2018. Français. ⟨NNT : 2018TOU30283⟩. ⟨tel-02417559⟩

Share

Metrics

Record views

62

Files downloads

79