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Plant virus-derived nanoparticles for the imaging and treatment of cancer

Abstract : Nanoparticles play an ever increase role in carrying therapeutic compounds in the cancer field. In this research project, the coat protein of Tobacco mosaic virus (TMV) was used as nanocarrier to solubilize a hydrophobic peptide interfering with the transmembrane domain of neuropilin-1. The nanoparticles created have conserved the antiangiogenic and antimigratory effect of the therapeutic peptide. This strategy was also used to create nanoparticles carrying a peptide targeting the ectodomain of neuropilin-1. The two types of nanoparticles were then assembled through auto-assembling ability of the coat protein. These nanoparticles also exhibit antiangiogenic ability thus, confirming the validity of this approach to combine therapeutic peptides.
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Submitted on : Tuesday, December 17, 2019 - 2:50:14 PM
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  • HAL Id : tel-02416025, version 1

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Coralie Gamper. Plant virus-derived nanoparticles for the imaging and treatment of cancer. Biotechnology. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAJ038⟩. ⟨tel-02416025⟩

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