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Amélioration de la préservation du pancréas lors de l’ischémie froide pour l’optimisation de la transplantation d’îlots pancréatiques

Abstract : Ischemia is one of the major problems of transplantation, it occurs at the time of disconnection of an organ of the vascular system and lasts until its reconnection in the recipient. It causes a decrease in graft quality and only one-third of the eligible pancreases results in a transplant. This work aimed to improve the quality of the grafts in preparing the pancreas to undergo ischemia preconditioning and improve their preservation after identifying the pathways involved in ischemia. Major metabolic changes in the organ have been demonstrated that appeared to ischemia time dependent enhancing damages to the endocrine part of the pancreas, the islets. This was prevented by the preconditioning of the pancreas to ischemia activating the antioxidant defenses and by the use of the marine worm M101 hemoglobin providing oxygen during the preservation of rat pancreas and humans. Thus, it is possible to improve the quality of the grafts by acting upstream of the sample and during the preservation, this allowing a better function.
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Submitted on : Tuesday, December 17, 2019 - 11:50:15 AM
Last modification on : Friday, October 23, 2020 - 4:40:53 PM
Long-term archiving on: : Wednesday, March 18, 2020 - 5:57:52 PM

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  • HAL Id : tel-02415773, version 1

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Florent Lemaire. Amélioration de la préservation du pancréas lors de l’ischémie froide pour l’optimisation de la transplantation d’îlots pancréatiques. Endocrinologie et métabolisme. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ037⟩. ⟨tel-02415773⟩

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