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Development of dynamic MRI to study the musculoskeletal system during motion

Abstract : Cerebral Palsy (CP) is a common birth pathology in children leading to ankle joint deformity, also known as the Spastic Equinus (SE) deformity, which causes abnormal function of the joint. While the management of ankle disorders focuses on restoring the joint functions, the underlying pathomechanics is not clearly understood yet. To better understand the biomechanics of the pediatric ankle joint, it is crucial to establish in vivo normative joint biomechanics before focusing on pathomechanics studies. Dynamic MRI has made it possible to non-invasively capture the ankle joint during a complete motion cycle. However, dynamic MRI comes with its own set of unique challenges such as low resolution, anisotropy, and motion artifacts. This motivates our choice for combining spatial information of conventional static MRI with temporal information of dynamic MRI sequences. The global aim of this research work is to build computational frameworks and to develop robust intensity-based approaches for estimating the joint motion and deformations from 3D+t MRI data, and thus for deriving the joint kinematics and the joint contact mechanics during a single cycle of dorsiplantarflexion. Due to a lack of sufficient Imaging data in the pediatric cohort, the proposed algorithms are applied on dynamic MRI data (portraying both passive and active ankle motions) from 6 healthy children.
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Submitted on : Monday, December 16, 2019 - 5:15:09 PM
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  • HAL Id : tel-02414706, version 1


Karim Makki. Development of dynamic MRI to study the musculoskeletal system during motion. Image Processing [eess.IV]. Ecole nationale supérieure Mines-Télécom Atlantique, 2019. English. ⟨NNT : 2019IMTA0151⟩. ⟨tel-02414706⟩



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