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Etude du rôle de la kinésine KIF21B au cours du développement cortical

Abstract : The development of the cerebral cortex is a highly regulated process that is crucial for the establishment of functional cortical networks. Disruption of one or several of these steps can lead severe neurodevelopmental disorders that are associated with intellectual disabilities, epilepsies and cognitive impairment. Over the past few years, several genetic mutations in genes encoding either tubulin or microtubule-associated motors such as kinesins, have been found in individuals with neurodevelopmental disorders. Although kinesins have been found to be essential for a proper cortical development, the exact functions of kinesins in these processes are still poorly understood. My work clearly identified Kif21b, a poorly-known kinesin, as a novel key regulator of cortical development both in mouse and human. We show that Kif21b regulates both radial and tangential migration of cortical neurons, and identify four KIF21B variants in individuals presenting neurodevelopmental disorders. We show that ectopic expression of variants recapitulate phenotypes both in mice and zebrafish.
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Submitted on : Monday, December 16, 2019 - 3:47:13 PM
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Laure Asselin. Etude du rôle de la kinésine KIF21B au cours du développement cortical. Biologie du développement. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ032⟩. ⟨tel-02414344⟩

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