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, Annexe 4 : Publication complémentaire

, Les MSCs BRCA1 +/-utilisées dans ce travail ont été différenciées à partir d'iPSCs. Les iPSCs BRCA1 +/-ont été générées par une méthode de transduction virale non-intégrative (virus de Sendaï) comprenant les facteurs Oct3/4, Sox2, Klf4 et c-Myc à partir de cellules mononuclées du sang cryopréservées d'une patiente de, p.56

, Cette lignée (PB38) ainsi obtenue a été caractérisée quant à l'expression des marqueurs de pluripotence, de son caryotype, de sa capacité à former des tératomes in vivo et de la présence d'une mutation sur le gène BRCA1. La lignée PB38 a fait l'objet d'une publication dans la revue Stem Cell

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