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Impact du diabète de type 2 sur la réparation osseuse et vasculaire des défauts osseux craniaux

Abstract : Now that diabetes reaches pandemic proportions, this thesis focuses on the effect of T2DM on bone. Very few studies document the effect of T2DM on maxillo-facial bone and their endomembraneous repair.After a short review on bone, diabetes and animal study models, we will showcase our results of the impact of T2DM on, (i) vascular and bone repair of calvarial defects in ZDF rats; (ii) the vascular and bone microarchitechture of ZDF rat’s femur; (iii) the secretome and angiogenic properties of zdf rat’s bone marrow stromal cells (BMSC). These studies showed an alteration of bone repair in critical size defects, and an impaired vascular repair in critical and subcritical T2DM defects. We also found evidences of bone and vascular microarchitechture impairement in ZDF femur. At a cellular level, T2DM BMSCs have an unique angiogenic profile. These findings may contribute to the better understanding of the adverse vascular healing in T2DM and provide successful bone healing therapies for patients with T2DM.
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Submitted on : Friday, December 13, 2019 - 3:55:16 PM
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Guavri Caliaperoumal. Impact du diabète de type 2 sur la réparation osseuse et vasculaire des défauts osseux craniaux. Médecine humaine et pathologie. Université Sorbonne Paris Cité, 2018. Français. ⟨NNT : 2018USPCC166⟩. ⟨tel-02409918⟩

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