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Étude de la réactivité des uréthanes et polyuréthanes : application aux dispositifs médicaux

Abstract : Many implantable medical devices (stents, catheters, cardiac valves…) are used everyday in many domains. The control of the interface between the medical device and the surrounding tissue is still to be improved. Many implanted devices are facing serious complications following implantation such as infections or thrombosis. These problematics are especially present for intravenous catheters used to administrate drugs. In this context, we investigated a way to strongly limit the problematics associated with their implantation, by covalently binding polymers at the surface, to reduce protein adsorption and cell adhesion on the materials used in implantation (polyurethane). The reactivity of urethanes was first studied, it allowed identifying the transcarbamoylation reaction as an efficient tool to modify urethanes and polyurethanes in soft reaction conditions. The reaction of poly (ethylene glycol) and the polyurethane surface, catalyzed by bases, allowed us to get hydrophilic polyurethane surfaces. Modification conditions were optimized to obtain a good covering of the surface with PEG. Surfaces were analyzed: contact angle, profilometry, infrared spectroscopy, XPS and TOF-SIMS. Modified surfaces showed excellent antiadhesive properties with a strong reduction of protein adsorption, cell and bacterial adhesion. The properties of modified surfaces were evaluated and compared to other systems. This strategy of modification is promising to allow one step modification of polyurethane surfaces. In vitro tests show the potential of this surface modification technique to obtain a polyurethane with enhance biocompatibility.
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  • HAL Id : tel-02401862, version 1

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Benoît Rhoné. Étude de la réactivité des uréthanes et polyuréthanes : application aux dispositifs médicaux. Chimie thérapeutique. Université Pierre et Marie Curie - Paris VI, 2016. Français. ⟨NNT : 2016PA066602⟩. ⟨tel-02401862⟩

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