GEANT4: A Simulation toolkit, Nucl.Instrum.Meth, vol.506, pp.250-303, 2003. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00020246
Geant4 developments and applications, IEEE Transactions on Nuclear Science, vol.53, issue.1, pp.270-278, 2006. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00069212
Recent developments in GEANT4, Nuclear Instruments and Methods in Physics Research A, vol.835, pp.186-225, 2016. ,
URL : https://hal.archives-ouvertes.fr/in2p3-01412626
Track structure of protons and other light ions in liquid water: Applications of the LIonTrack code at the nanometer scale, Medical Physics, issue.6Part1, p.64101, 2013. ,
Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit, Physica Medica, issue.8, pp.861-874, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01288764
An atomistic geometrical model of the B-DNA configuration for DNA-radiation interaction simulations, Computer Physics Communications, vol.184, pp.2840-2847, 2013. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00918490
Charged particle tracks in water of different phases. Monte Carlo simulation of electron tracks. Radiation Physics and Chemistry, vol.47, pp.197-207, 1996. ,
Modelling low energy electron and positron tracks in biologically relevant media, The European Physical Journal D, vol.67, issue.9, p.199, 2013. ,
Microdosimetry on nanometric scale with a new low-pressure avalanche-confinement TEPC, Journal of Physics: Conference Series, vol.1154, p.12004, 2019. ,
A computationally convenient parameterisation of experimental angular distributions of low energy electrons elastically scattered off water vapour, Physics in Medicine and Biology, vol.29, issue.4, pp.443-447, 1984. ,
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response, International Journal of Radiation Oncology*Biology*Physics, vol.100, issue.3, pp.776-784, 2018. ,
Theoretical cross sections for electron collisions in water: structure of electron tracks, Physics in Medicine and Biology, vol.48, issue.14, pp.2147-2168, 2003. ,
A free-parameter theoretical model for describing the electron elastic scattering in water in the Geant4 toolkit. Radiation Physics and Chemistry, vol.78, pp.745-750, 2009. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00410416
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
A Monte Carlo Code for the Simulation of Heavy-Ion Tracks in Water, Radiation Research, vol.163, issue.2, pp.222-231, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00021990
EPOTRAN: A full-differential Monte Carlo code for electron and positron transport in liquid and gaseous water, International Journal of Radiation Biology, vol.88, issue.1-2, pp.54-61, 2012. ,
Landolt-Börnstein Numerical Data and Functional Relationships in Science and Technology, Group VII/1b, Nucleic Acids, pp.31-170, 1989. ,
Calculation of initial yields of single-and doublestrand breaks in cell nuclei from electrons, protons and alpha particles, International Journal of Radiation Biology, vol.56, issue.1, pp.1-19, 1989. ,
Computer Simulation of Initial Events in the Biochemical Mechanisms of DNA Damage, Advances in Radiation Biology, vol.17, pp.181-226, 1993. ,
Stochastic models of multi-species kinetics in radiation-induced spurs, Journal of the Chemical Society, Faraday Transactions, vol.1, issue.9, pp.2673-2689, 1986. ,
Analysis of the Debye-Smoluchowski equation. Approximations for high-permittivity solvents, The Journal of Physical Chemistry, vol.88, issue.18, pp.4171-4176, 1984. ,
, , 1998.
, Monte Carlo simulation of fast electron and proton tracks in liquid water --I. physical and physicochemical aspects. Radiation Physics and Chemistry, vol.51, pp.229-243
Accurate transport simulation of electron tracks in the energy range 1 keV-4 MeV, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, vol.215, pp.1782-1790, 2004. ,
Track structure of light ions: experiments and simulations, New Journal of Physics, vol.14, issue.9, p.93010, 2012. ,
Track structure characterization and its link to radiobiology, Radiation Measurements, vol.106, pp.506-511, 2017. ,
Predicting three-dimensional genome structure from transcriptional activity, Nature Genetics, vol.32, issue.3, pp.347-352, 2002. ,
PDB4DNA: Implementation of DNA geometry from the Protein Data Bank (PDB) description for Geant4-DNA Monte-Carlo simulations, Computer Physics Communications, vol.192, pp.282-288, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01197196
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines, International Journal of Radiation Biology, vol.73, issue.3, pp.269-278, 1998. ,
Electron inelastic-scattering cross sections in liquid water. Radiation Physics and Chemistry, vol.53, pp.317-321, 1998. ,
Inelastic-collision cross sections of liquid water for interactions of energetic protons. Radiation Physics and Chemistry, vol.59, pp.255-275, 2000. ,
Modélisation de la topologie des dépôts d'énergie créés par un rayonnement ionisant à l'échelle nanométrique dans les noyaux cellulaires et relation avec les événements précoces radio-induits (Thèse), 2013. ,
Inelastic cross-sections for electron transport in liquid water: a comparison of dielectric models. Radiation Physics and Chemistry, vol.66, pp.373-385, 2003. ,
Monte Carlo simulation of the energy loss of low-energy electrons in liquid water, Physics in Medicine and Biology, vol.48, issue.15, pp.2355-2371, 2003. ,
Higher-order chromatin structure in DSB induction, repair and misrepair, Mutation Research, vol.704, issue.1-3, pp.88-100, 2010. ,
, , 1996.
, Monte Carlo simulation of 0.1-100 keV electron and positron transport in solids using optical data and partial wave methods, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, vol.108, pp.1055-1061
Simulation of DNA Damage after Proton Irradiation, Radiation Research, vol.159, issue.3, pp.401-410, 2003. ,
, , 1998.
, Monte Carlo simulation of the production of short DNA fragments by low-linear energy transfer radiation using higher-order DNA models, Radiation Research, vol.150, issue.2, pp.170-182
Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.756, issue.1, pp.213-223, 2013. ,
First steps towards systems radiation biology studies concerned with DNA and chromosome structure within living cells, Radiation and Environmental Biophysics, vol.47, issue.1, pp.49-61, 2008. ,
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping, Scientific Reports, vol.7, 2017. ,
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
Track-structure simulations of energy deposition patterns to mitochondria and damage to their DNA, International Journal of Radiation Biology, vol.95, issue.1, pp.3-11, 2019. ,
, , 1998.
, Monte Carlo simulation of fast electron and proton tracks in liquid water --II. nonhomogeneous chemistry. Radiation Physics and Chemistry, vol.51, pp.245-254
The performance of a novel ion-counting nanodosimeter, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol.492, issue.1, pp.212-235, 2002. ,
Production of HO2 and O2 by multiple ionization in water radiolysis by swift carbon ions, Chemical Physics Letters, vol.410, issue.4, pp.330-334, 2005. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00409801
Stochastic modeling of fast kinetics in a radiation track, Journal of Physical Chemistry, vol.94, issue.1, 1990. ,
Heterochromatin revisited, Nature Reviews Genetics, vol.8, issue.1, pp.35-46, 2007. ,
Heterochromatin: Dark Matter or Variation on a Theme?, Current Biology, vol.25, issue.11, pp.462-465, 2015. ,
The track structure of ?-particles from the point of view of ionization-cluster formation in nanometric volumes of nitrogen, Radiation and Environmental Biophysics, vol.41, issue.2, pp.91-102, 2002. ,
Cell to Cell Variability of Radiation-Induced Foci: Relation between Observed Damage and Energy Deposition, PLOS ONE, vol.11, issue.1, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02345047
Absorption Spectrum of the Hydrated Electron in Water and in Aqueous Solutions, Journal of the American Chemical Society, vol.84, issue.21, pp.4090-4095, 1962. ,
Optical spectra of liquid water in vacuum uv region by means of inelastic x-ray scattering spectroscopy, The Journal of Chemical Physics, vol.108, issue.3, pp.823-825, 1998. ,
Collective oscillation in liquid water, Journal of Chemical Physics, vol.60, pp.3483-3486, 1974. ,
Calculation of initial and primary yields in the radiolysis of water. Radiation Physics and Chemistry, vol.43, pp.265-280, 1994. ,
Clusters of DNA induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling, Radiation Research, vol.145, issue.2, pp.188-199, 1996. ,
, Journal of the International Commission on Radiation Units and Measurements, vol.19, issue.1, 1983.
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
, Radiation Protection Dosimetry, vol.150, issue.4, pp.550-552, 2012.
The geant4-dna project, International Journal of Modeling, Simulation, and Scientific Computing, issue.02, pp.157-178, 2010. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00468402
Comparison of GEANT4 very low energy cross section models with experimental data in water, Medical Physics, vol.37, issue.9, pp.4692-4708, 2010. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00530147
Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project, Medical Physics, issue.8, pp.722-739, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01885579
Calculation of double strand break probability of DNA for low LET radiations based on track structure analysis. Nuclear and Atomic Data for Radiotherapy and Related Radiobiology, 1987. ,
DNA strand breaks induced by electrons simulated with Nanodosimetry Monte Carlo Simulation Code: NASIC. Radiation Protection Dosimetry, vol.166, pp.38-43, 2015. ,
Biological consequences of radiation-induced DNA damage: relevance to radiotherapy, Clinical Oncology, issue.10, pp.578-585, 2013. ,
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit, Physics in Medicine and Biology, vol.63, issue.17, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01897238
Cross Sections and Interpretation of Dissociative Attachment Reactions Producing OH-, O-, and H-in H2O, Journal of Chemical Physics, vol.57, pp.4218-4225, 1972. ,
Développement d'un outil de simulation multi-échelles adapté au calcul des dommages radio-induits précoces dans des cellules exposées à des irradiations d'ions légers (proton et alpha) (Thèse), 2016. ,
Target Model of Nucleosome Particle for Track Structure Calculations and DNA Damage Modelling, International Journal of Radiation Biology, vol.66, issue.3, pp.267-277, 1994. ,
Computer-Aided Stochastic Modeling of the Radiolysis of Liquid Water, Radiation Research, vol.149, issue.3, pp.224-236, 1998. ,
Cross sections for low-energy (1-100 eV) electron elastic and inelastic scattering in amorphous ice, Radiation Research, vol.159, issue.1, pp.3-22, 2003. ,
Proton Energy Degradation in Water Vapor, Radiation Research, vol.54, issue.3, pp.343-363, 1973. ,
Parameters of the human genome, Proceedings of the National Academy of Sciences, vol.88, issue.17, pp.7474-7476, 1991. ,
A model of the cell nucleus for DNA damage calculations, International Journal of Radiation Biology, vol.88, issue.1-2, pp.87-97, 2012. ,
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
The structure of DNA in the nucleosome core, Nature, vol.423, issue.6936, pp.145-150, 2003. ,
Structure of the '30nm' chromatin fibre: A key role for the linker histone, Current Opinion in Structural Biology, vol.16, issue.3, pp.336-343, 2006. ,
Spatial distribution of energy deposition by ionizing radiation, Radiation Research, vol.2, 1960. ,
Electron production in proton collisions: total cross sections, Reviews of Modern Physics, vol.57, pp.965-994, 1985. ,
Principles of Nucleic Acid Structure, 1984. ,
Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA, Physica Medica, vol.62, pp.152-157, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02166564
Modelling low energy electron and positron tracks for biomedical applications, International Journal of Radiation Biology, vol.88, issue.1-2, pp.71-76, 2012. ,
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice, Nucleic Acids Research, vol.41, issue.16, pp.7589-7605, 2013. ,
A New Standard DNA Damage (SDD) Data Format, Radiation Research, vol.191, issue.1, pp.76-92, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-01999036
NOREC, a Monte Carlo code for simulating electron tracks in liquid water, Radiation and Environmental Biophysics, vol.42, issue.3, pp.213-217, 2003. ,
Theoretical modelling of radiolytic damage of free DNA bases and within DNA macromolecule, Radiation Protection Dosimetry, vol.122, issue.1-4, pp.110-112, 2006. ,
The Non-homologous End-Joining (NHEJ) Mathematical Model for the Repair of Double-Strand Breaks: II. Application to Damage Induced by Ultrasoft X Rays and Low-Energy Electrons, Radiation Research, vol.179, issue.5, pp.540-548, 2013. ,
Simulation of Space and Time Evolution of Radiolytic Species Induced by Electrons in Water, Radiation Protection Dosimetry, vol.31, issue.1-4, pp.175-177, 1990. ,
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
, , 1997.
, Monte Carlo simulation of physicochemical processes of liquid water radiolysis, Radiation and Environmental Biophysics, vol.36, issue.2, pp.105-116
Facultative Heterochromatin: Is There a Distinctive Molecular Signature?, Molecular Cell, vol.28, issue.1, pp.1-13, 2007. ,
Secondary exposure for 73 and 200 MeV proton therapy, Radiation Protection Dosimetry, vol.125, issue.1-4, pp.349-354, 2007. ,
Chemical and Biological Effects of Radiation, Atoms, Radiation, and Radiation Protection, pp.399-447, 2007. ,
Cross-sections for water vapour for the Monte Carlo electron track structure code from 10 eV to the MeV region, Physics in Medicine and Biology, vol.38, issue.12, pp.1841-1858, 1993. ,
, , 2002.
, Monte Carlo Track Structure Code for Low-Energy Alpha-Particles in Water, The Journal of Physical Chemistry B, vol.106, issue.42, pp.11051-11063
Development of a Monte Carlo track structure code for low-energy protons in water, International Journal of Radiation Biology, vol.77, issue.2, pp.139-154, 2001. ,
A knowledge-based model of DNA hydration, International Journal of Radiation Biology, vol.67, issue.2, pp.145-152, 1995. ,
DNA Structure: A-, B-and Z-DNA Helix Families, eLS, 2002. ,
Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up, Radiotherapy and Oncology, vol.108, issue.3, pp.362-369, 2013. ,
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid, Nature, vol.171, issue.4356, pp.737-738, 1953. ,
A Monte Carlo program for the analysis of low-energy electron tracks in liquid water, Physics in Medicine and Biology, vol.56, issue.7, pp.1985-2003, 2011. ,
Analysis of Low-Energy Electron Track Structure in Liquid Water, Radiation Research, vol.161, issue.5, pp.591-596, 2004. ,
A Monte Carlo code for positive ion track simulation, Radiation and Environmental Biophysics, vol.38, issue.2, pp.97-104, 1999. ,
Crystal structure analysis of a complete turn of B-DNA, Nature, vol.287, issue.5784, pp.755-758, 1980. ,
, Chapitre 1 -Etat de l'art de la simulation des dommages à l'ADN
Radical and molecular yields in water irradiated by .gamma.-rays and heavy ions, The Journal of Physical Chemistry, vol.73, issue.6, pp.1937-1941, 1969. ,
DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone, Proceedings of the National Academy of Sciences of the United States of America, vol.95, pp.9738-9743, 1998. ,
An atomistic geometrical model of the B-DNA configuration for DNA-radiation interaction simulations, Computer Physics Communications, vol.184, pp.2840-2847, 2013. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00918490
Effect of radiation type in water radiolysis, Journal of the Chemical Society, Faraday Transactions, vol.1, issue.11, pp.2803-2813, 1981. ,
Critical Review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (?OH/?O? in Aqueous Solution, Journal of Physical and Chemical Reference Data, vol.17, issue.2, pp.513-886, 1988. ,
A free-parameter theoretical model for describing the electron elastic scattering in water in the Geant4 toolkit. Radiation Physics and Chemistry, vol.78, pp.745-750, 2009. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00410416
Chromosome territories, nuclear architecture and gene regulation in mammalian cells, Nature Reviews. Genetics, vol.2, issue.4, pp.292-301, 2001. ,
Mechanisms of free radical-induced damage to DNA, Free Radical Research, vol.46, issue.4, pp.382-419, 2012. ,
Influence of Chromatin Structure on the Induction of DNA Double Strand Breaks by Ionizing Radiation, Cancer Research, vol.52, issue.6, pp.1580-1586, 1992. ,
A Density-based Algorithm for Discovering Clusters a Density-based Algorithm for Discovering Clusters in Large Spatial Databases with Noise, Proceedings of the Second International Conference on Knowledge Discovery and Data Mining, pp.226-231, 1996. ,
Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC, Mutation Research, vol.711, issue.1-2, pp.28-40, 2011. ,
Simulation of DNA Damage after Proton Irradiation, Radiation Research, vol.159, issue.3, pp.401-410, 2003. ,
Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.756, issue.1, pp.213-223, 2013. ,
Comparison of GEANT4 very low energy cross section models with experimental data in water, Medical Physics, vol.37, issue.9, pp.4692-4708, 2010. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00530147
Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project, Medical Physics, issue.8, pp.722-739, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01885579
Diffusion-controlled reactions modeling in Geant4-DNA, Journal of Computational Physics, vol.274, pp.841-882, 2014. ,
URL : https://hal.archives-ouvertes.fr/cea-01296702
Time-and space-resolved Monte Carlo study of water radiolysis for photon, electron and ion irradiation, Radiation and Environmental Biophysics, vol.48, issue.1, p.11, 2009. ,
Radial arrangement of chromosome territories in human cell nuclei: a computer model approach based on gene density indicates a probabilistic global positioning code, Biophysical Journal, vol.86, issue.5, pp.74333-74340, 2004. ,
Mechanistic DNA damage simulations in Geant4-DNA Part 2: Electron and proton damage in a bacterial cell, Physica Medica: PM: An International Journal Devoted to the Applications of Physics to Medicine and Biology: Official Journal of the Italian Association of Biomedical Physics, vol.48, pp.146-155, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01815184
,
DNA strand breakage by 125I-decay in a synthetic oligodeoxynucleotide--2. Quantitative analysis of fragment distribution, Acta Oncologica, issue.7, pp.809-815, 1996. ,
Développement d'un outil de simulation multi-échelles adapté au calcul des dommages radio-induits précoces dans des cellules exposées à des irradiations d'ions légers (proton et alpha) (Thèse), 2016. ,
Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA, Scientific Reports, vol.7, issue.1, p.11923, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01703528
Molecular biology. A sting in the tail of electron tracks, Science, issue.5458, pp.1603-1604, 2000. ,
Theoretical Analysis of the LET Dependence of Transient Yields Observed in Pulse Radiolysis with Ion Beams, Radiation Research, vol.77, issue.1, pp.47-61, 1979. ,
Computational approach for determining the spectrum of DNA damage induced by ionizing radiation, Radiation Research, vol.156, issue.5, pp.577-583, 2001. ,
Critical energies for SSB and DSB induction in plasmid DNA by low-energy photons: action spectra for strand-break induction in plasmid DNA irradiated in vacuum, International Journal of Radiation Biology, vol.76, issue.7, pp.881-890, 2000. ,
Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA, Physica Medica, vol.62, pp.152-157, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02166564
A New Standard DNA Damage (SDD) Data Format, Radiation Research, vol.191, issue.1, pp.76-92, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-01999036
Evaluation of the influence of physical and chemical parameters on water radiolysis simulations under MeV electron irradiation using Geant4-DNA, Journal of Applied Physics, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02327748
Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA, Medical Physics, vol.46, issue.3, pp.1501-1511, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Effect of Chromatin Structure on the Extent and Distribution of DNA Double Strand Breaks Produced by Ionizing Radiation; Comparative Study of hESC and Differentiated Cells Lines, International Journal of Molecular Sciences, vol.17, issue.1, 2016. ,
Assessing the contribution of cross-sections to the uncertainty of Monte Carlo calculations in micro-and nanodosimetry, Radiation Protection Dosimetry, vol.183, issue.1-2, pp.11-16, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02355461
A molecular dynamics simulation of DNA damage induction by ionizing radiation, Chapitre 3 -Influence du rapport du volume de l'ADN nucléaire sur le volume du noyau cellulaire et du niveau de compaction de la chromatine sur les dommages radio-induits précoces à l'ADN Références Abolfath, vol.58, pp.7143-7157, 2013. ,
Modeling of DNA fragmentation induced in human fibroblasts by 56Fe ions, Advances in Space Research, vol.40, issue.9, pp.1401-1407, 2007. ,
,
, , 2011.
, Monte Carlo evaluation of DNA fragmentation spectra induced by different radiation qualities, Radiation Protection Dosimetry, vol.143, issue.2-4, pp.226-231
Heterochromatin and the DNA damage response: the need to relaxThis paper is one of a selection of papers in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal's usual peer review process, Biochemistry and Cell Biology, vol.89, issue.1, pp.45-60, 2010. ,
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization, Mutation Research, vol.704, issue.1-3, pp.78-87, 2010. ,
Modélisation de la topologie des dépôts d'énergie créés par un rayonnement ionisant à l'échelle nanométrique dans les noyaux cellulaires et relation avec les événements précoces radio-induits (Thèse), 2013. ,
Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation, Cancer Research, vol.52, issue.6, pp.1580-1586, 1992. ,
Higher-order chromatin structure in DSB induction, repair and misrepair, Mutation Research, vol.704, issue.1-3, pp.88-100, 2010. ,
Induction of DNA Double-Strand Breaks by 1 H and 4 He Ions in Primary Human Skin Fibroblasts in the LET Range of 8 to 124 keV/?m, Radiation Research, vol.151, issue.5, pp.540-549, 1999. ,
Simulation of DNA Damage after Proton Irradiation, Radiation Research, vol.159, issue.3, pp.401-410, 2003. ,
Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.756, issue.1, pp.213-223, 2013. ,
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping, Scientific Reports, vol.7, 2017. ,
A stochastic model of DNA fragments rejoining, PloS One, vol.7, issue.9, 2012. ,
Clustered DNA Damage in Irradiated Human Diploid Fibroblasts: Influence of Chromatin Organization, Radiation Research, vol.173, issue.3, pp.272-282, 2009. ,
Développement d'un outil de simulation multi-échelles adapté au calcul des dommages radio-induits précoces dans des cellules exposées à des irradiations d'ions légers (proton et alpha) (Thèse), 2016. ,
Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA, Scientific Reports, vol.7, issue.1, p.11923, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01703528
Chromatin Organization Contributes to Nonrandomly Distributed Double-Strand Breaks after Exposure to High-LET Radiation, Radiation Research, vol.161, issue.1, pp.1-8, 2004. ,
Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks of killing of mammalian cells, Radiation Research, vol.64, issue.2, pp.306-320, 1975. ,
Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA, Physica Medica, vol.62, pp.152-157, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02166564
Sub-micrometer 20MeV protons or 45MeV lithium spot irradiation enhances yields of dicentric chromosomes due to clustering of DNA double-strand breaks, Mutation Research. Genetic Toxicology and Environmental Mutagenesis, vol.793, pp.30-40, 2015. ,
Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness, Physics in Medicine and Biology, vol.57, issue.19, pp.5889-5907, 2012. ,
A New Standard DNA Damage (SDD) Data Format, Radiation Research, vol.191, issue.1, pp.76-92, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01999036
Induction of DNA Damage by Light Ions Relative to 60Co ?-rays, International Journal of Particle Therapy, vol.5, issue.1, pp.25-39, 2018. ,
Chromatin compaction protects genomic DNA from radiation damage, PloS One, vol.8, issue.10, 2013. ,
Simulation of early radiation-induced DNA damage on different types of cell nuclei, Radiation Protection Dosimetry, vol.183, issue.1-2, pp.26-31, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02144332
Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA, Medical Physics, vol.46, issue.3, pp.1501-1511, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Micro-irradiation ciblée par faisceau d'ions pour la radiobiologie in vitro et in vivo. (Thèse), 2014. ,
Geant4-DNA simulation of DNA damage caused by direct and indirect radiation effects and comparison with biological data, EPJ Web Conf, vol.153, p.4019, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01645304
The complexity of DNA damage: relevance to biological consequences, International Journal of Radiation Biology, vol.66, issue.5, pp.427-432, 1994. ,
Chromosome aberrations and cell death by ionizing radiation: Evolution of a biophysical model. Radiation Physics and Chemistry, vol.128, pp.18-25, 2016. ,
DNA damage by charged and neutral radiation at different spatial and temporal scales: integrating Monte Carlo simulations with in vitro experiments (Thèse), 2019. ,
Meiotic Recombination at the Ends of Chromosomes in Saccharomyces cerevisiae, Genetics, vol.179, issue.3, pp.1221-1235, 2008. ,
An empirical method for deriving RBE values associated with electrons, photons and radionuclides, Radiation Protection Dosimetry, vol.167, issue.4, pp.664-670, 2015. ,
DNA double-strand breaks induced by low energy protons in V79 cells, International Journal of Radiation Biology, vol.65, issue.5, pp.529-536, 1994. ,
RBE of 20 kV and 70 kV X-rays determined for survival of V 79 cells, Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, vol.7, issue.2, pp.175-180, 1986. ,
Tbf1 and Vid22 promote resection and nonhomologous end joining of DNA double-strand break ends, The EMBO Journal, vol.32, issue.2, pp.275-289, 2013. ,
Spectral modeling and compilation of quantum fluence in radiography and mammography, International Society for Optics and Photonics, vol.3336, pp.592-601, 1998. ,
New challenges in high-energy particle radiobiology, The British Journal of Radiology, vol.87, 1035. ,
Cluster effects within the local effect model, Radiation Research, vol.167, issue.3, pp.319-329, 2007. ,
Higher-order chromatin structure in DSB induction, repair and misrepair, Mutation Research, vol.704, issue.1-3, pp.88-100, 2010. ,
Induction of DNA double-strand breaks in mammalian cells and yeast, Advances in Space Research, vol.25, issue.10, pp.2085-2094, 2000. ,
Enhanced Neoplastic Transformation by Mammography X Rays Relative to 200 kVp X Rays: Indication for a Strong Dependence on Photon Energy of the RBEM for Various End Points, Radiation Research, vol.157, issue.1, pp.99-105, 2002. ,
Repair of DNA Double-Strand Breaks in Irradiated Yeast Cells under Nongrowth Conditions, Radiation Research, vol.82, issue.3, pp.498-510, 1980. ,
Relation between DNA double-strand breaks and energy spectra of secondary electrons produced by different X-ray energies, International Journal of Radiation Biology, pp.1-10, 2018. ,
Simulation of DNA Damage after Proton and Low LET Irradiation, Radiation Protection Dosimetry, vol.99, issue.1-4, pp.99-102, 2002. ,
Simulation of DNA fragment distributions after irradiation with photons, Radiation and Environmental Biophysics, vol.38, issue.1, pp.39-47, 1999. ,
Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.756, issue.1, pp.213-223, 2013. ,
Simulation of DSB yield for high LET radiation, Radiation Protection Dosimetry, vol.166, issue.1-4, pp.61-65, 2015. ,
The non-homologous end-joining pathway of S. cerevisiae works effectively in G1-phase cells, and religates cognate ends correctly and nonrandomly, DNA repair, vol.42, pp.1-10, 2016. ,
Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells, Radiation and Environmental Biophysics, vol.42, issue.3, pp.175-182, 2003. ,
From Energy Deposition of Ionizing Radiation to Cell Damage Signaling: Benchmarking Simulations by Measured Yields of Initial DNA Damage after Ion Microbeam Irradiation, Radiation Research, vol.191, issue.6, pp.566-584, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02318865
Cell to Cell Variability of Radiation-Induced Foci: Relation between Observed Damage and Energy Deposition, PLOS ONE, vol.11, issue.1, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02345047
A high-resolution voxel phantom of the breast for dose calculations in mammography, Radiation Protection Dosimetry, vol.114, issue.1-3, pp.406-409, 2005. ,
Soft X-ray dosimetry and RBE for survival of Chinese hamster V79 cells, International Journal of Radiation Biology, vol.54, issue.4, pp.577-591, 1988. ,
Electron Spectra and the RBE of X Rays, Radiation Research, vol.158, issue.1, pp.13-23, 2002. ,
RBE of kV CBCT radiation determined by Monte Carlo DNA damage simulations, Physics in Medicine and Biology, vol.58, issue.16, pp.5693-5704, 2013. ,
, Chapitre 4 -Mise en place de la simulation micro et nanodosimétrique pour des irradiations photon : comparaison à des données expérimentales
DNA Double-Strand Break Misrejoining after Exposure of Primary Human Fibroblasts to CK Characteristic X Rays, 29 kVp X Rays and 60Co ? Rays, Radiation Research, vol.164, issue.5, pp.669-677, 2005. ,
RBE of 10 kV X rays determined for the human mammary epithelial cell line MCF-12A, Radiation Research, vol.169, issue.3, pp.330-336, 2008. ,
Relative biological effectiveness for photons: implication of complex DNA double-strand breaks as critical lesions, Physics in Medicine and Biology, vol.62, issue.6, pp.2153-2175, 2017. ,
DNA Double-strand Break Induction in Yeast by X-rays and ?-particles Measured by Pulsed-field Gel Electrophoresis, International Journal of Radiation Biology, vol.64, issue.5, pp.539-546, 1993. ,
The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining, DNA Repair, vol.14, pp.9-16, 2014. ,
Cell cycle regulation of homologous recombination in Saccharomyces cerevisiae, FEMS Microbiology Reviews, vol.38, issue.2, pp.172-184, 2014. ,
Induction of Incomplete and Complex Chromosome Aberrations by 30 kVp X Rays, Radiation Research, vol.175, issue.2, pp.201-208, 2010. ,
Saccharomyces cerevisiae-based system for studying clustered DNA damages, Radiation and Environmental Biophysics, vol.49, issue.3, pp.447-456, 2010. ,
Detection of gamma-irradiation induced DNA damage and radioprotection of compounds in yeast using comet assay, Journal of Radiation Research, vol.45, issue.2, pp.169-174, 2004. ,
RBE of low energy electrons and photons, Physics in Medicine and Biology, vol.55, issue.10, pp.65-109, 2010. ,
HDF1 and RAD17 genes are involved in DNA double-strand break repair in stationary phase Saccharomyces cerevisiae, Journal of Biological Physics, vol.34, issue.1-2, pp.63-71, 2008. ,
Calculation of x-ray spectra emerging from an x-ray tube. Part II. X-ray production and filtration in x-ray targets, Medical Physics, vol.34, issue.6Part1, pp.2175-2186, 2007. ,
Calculation of x-ray spectra emerging from an x-ray tube. Part I. Electron penetration characteristics in x-ray targets, Medical Physics, vol.34, issue.6Part1, pp.2164-2174, 2007. ,
SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes, Physics in Medicine and Biology, vol.54, issue.19, pp.433-438, 2009. ,
, Chapitre 4 -Mise en place de la simulation micro et nanodosimétrique pour des irradiations photon : comparaison à des données expérimentales
A Review of Studies of Ionizing Radiation-Induced Double-Strand Break Clustering, Radiation Research, vol.156, issue.5, pp.572-577, 2001. ,
gamma-H2AX as protein biomarker for radiation exposure, Annali Dell'Istituto Superiore Di Sanita, vol.45, issue.3, pp.265-271, 2009. ,
The Effect of 29 kV X Rays on the Dose Response of Chromosome Aberrations in Human Lymphocytes, Radiation Research, vol.158, issue.6, pp.771-777, 2002. ,
, , 2002.
, Monte Carlo calculation of nine megavoltage photon beam spectra using the BEAM code, Medical Physics, vol.29, issue.3, pp.391-402
The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination, Genetics, vol.142, issue.1, pp.91-102, 1996. ,
The relative biological effectiveness of 22-Mevp x-rays, cobalt-60 gamma rays, and 200-Kvcp x-rays. VII. Summary of studies for five criteria of effect, Radiation Research, vol.16, pp.394-398, 1962. ,
Induction of micronuclei in human fibroblasts and keratinocytes by 25 kV x-rays, Radiation and Environmental Biophysics, vol.42, issue.1, 2003. ,
Comparison between 4-MV and 6-MV radiotherapy in T1N0 glottic cancer, The Laryngoscope, vol.127, issue.5, pp.1061-1067, 2017. ,
The relative biological effectiveness of 60Co gamma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses, International Journal of Radiation Biology, vol.61, issue.3, pp.345-353, 1992. ,
Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study, PLOS ONE, vol.10, issue.6, 2015. ,
167 5.1.1 Jonction d'extrémités non-homologues (NHEJ), Les voies de réparation des dommages à l ,
, 2.2.1 Le « Two-lesion kinetic model » (TLK), Les modèles d'extension vers les effets tardifs
3 BIANCA (Biophysical analysis of cell death and chromosome aberrations) ,
3.2 Application du modèle TLK pour le calcul des courbes de survie cellulaire, Choix des modèles paramétriques : application ,
,
,
et ne peut donc prédire à elle seule, un effet biologique. Un modèle radiobiologique intégrant en plus de la mort cellulaire, l'état (phénotype) des cellules survivantes permettrait de dépasser les limites actuelles de l'EBR. Dans le programme ROSIRIS, les effets tardifs additionnels à la mort cellulaire sont considérés comme par exemple, le nombre de foyers ?-H2AX persistants, le phénomène de sénescence (arrêt irréversible du cycle cellulaire) etc. Cela mènerait donc à l'apparition d'une EBR « multiparamétrique » dont les données expérimentales devront être reliées aux données simulées afin d'établir leurs éventuelles relations. L'utilisation conjointe des simulations Monte-Carlo pour le calcul des dommages et de modèles paramétriques intégrant les différentes finalités biologiques et leurs mesures expérimentales, Chapitre 5 -Extension de la simulation vers les effets biologiques tardifs Geant4-DNA comme données d'entrée de ces différents modèles afin de pouvoir évaluer leur compatibilité, 2018. ,
, ce stade, c'est-à-dire, que l'algorithme de clusterisation DBScan n'est pas utilisé
, ADN) et lorsqu'un SB se trouve à moins de 10 bp de ce DSB, il n'est pas pris en compte dans celui-ci. Egalement, notons que contrairement au LEM IV, nous avons utilisé tardifs et permettra notamment, d'établir d'autres modèles paramétriques pour d'autres finalités biologiques. Ces outils seront utilisés afin de pouvoir établir la chaîne de causalité entre les dommages à l'ADN obtenus par simulation et l'évolution du nombre de foyers ?-H2AX, de foyers persistants, la sénescence, la mort cellulaire. Tout cela sera pris en compte dans une EBR « multiparamétrique » (Cf. Section 5.3) afin de mieux étudier les effets d, Les DSBs sont alors tous « simples » (deux SB séparés par moins de 10 bp et situés sur des brins opposés de l'
, Chapitre 5 -Extension de la simulation vers les effets biologiques tardifs
Chromosome aberrations and cell death by ionizing radiation: Evolution of a biophysical model. Radiation Physics and Chemistry, vol.128, pp.18-25, 2016. ,
Chromosome aberrations induced by light ions: Monte Carlo simulations based on a mechanistic model, International Journal of Radiation Biology, vol.75, issue.1, pp.35-46, 1999. ,
Inactivation of human normal and tumour cells irradiated with low energy protons, International Journal of Radiation Biology, vol.76, issue.6, pp.831-839, 2000. ,
Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review, Journal of Theoretical Biology, vol.394, pp.93-101, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01382777
Pathway choice in DNA double strand break repair: observations of a balancing act, Genome Integrity, vol.3, issue.9, 2012. ,
BIANCA, a biophysical model of cell survival and chromosome damage by protons, C-ions and He-ions at energies and doses used in hadrontherapy, Physics in Medicine & Biology, vol.63, issue.7, p.75007, 2018. ,
A modified microdosimetric kinetic model for relative biological effectiveness calculation, Physics in Medicine and Biology, vol.63, issue.1, 2017. ,
Lethal and Potentially Lethal Lesions Induced by Radiation ---A Unified Repair Model, Radiation Research, vol.106, issue.2, pp.252-270, 1986. ,
Development of a radiation track structure clustering algorithm for the prediction of DNA DSB yields and radiation induced cell death in Eukaryotic cells, Physics in Medicine and Biology, vol.60, issue.8, pp.3217-3236, 2015. ,
The radiobiology of cultured mammalian cells, 1967. ,
Impact of track structure calculations on biological treatment planning in ion radiotherapy, New Journal of Physics, vol.10, issue.7, p.75005, 2008. ,
Cluster effects within the local effect model, Radiation Research, vol.167, issue.3, pp.319-329, 2007. ,
Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning, International Journal of Radiation Oncology, vol.78, issue.4, pp.1177-1183, 2010. ,
Higher-order chromatin structure in DSB induction, repair and misrepair, Mutation Research, vol.704, issue.1-3, pp.88-100, 2010. ,
Modeling studies on dicentrics induction after sub-micrometer focused ion beam grid irradiation, Radiation Protection Dosimetry, vol.183, issue.1-2, pp.40-44, 2019. ,
Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.756, issue.1, pp.213-223, 2013. ,
Stochastic Simulation of DNA Double-Strand Break Repair by Non-homologous End Joining Based on Track Structure Calculations, Radiation Research, vol.173, issue.5, pp.677-688, 2010. ,
Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern, International Journal of Radiation Biology, vol.88, issue.1-2, pp.103-107, 2012. ,
Temporal lobe reactions after carbon ion radiation therapy: comparison of relative biological effectiveness-weighted tolerance doses predicted by local effect models I and IV, International Journal of Radiation Oncology, vol.88, issue.5, pp.1136-1141, 2014. ,
Saturable repair models of radiation action in mammalian cells, Radiation Research. Supplement, vol.8, pp.58-67, 1985. ,
LET-Dependent Survival of Irradiated Normal Human Fibroblasts and Their Descendents, Radiation Research, vol.166, issue.1, pp.24-30, 2006. ,
A microdosimetric-kinetic model for the effect of non-Poisson distribution of lethal lesions on the variation of RBE with LET, Radiation Research, vol.160, issue.1, pp.61-69, 2003. ,
Modeling of time-dose-LET effects in the cellular response to radiation (Thèse), 2015. ,
Regulation of Homologous Recombination in Eukaryotes, Annual Review of Genetics, vol.44, issue.1, pp.113-139, 2010. ,
Mechanisms of DNA double strand break repair and chromosome aberration formation, Cytogenetic and Genome Research, vol.104, issue.1-4, pp.14-20, 2004. ,
DNA double-strand breaks: their cellular and clinical impact?, Oncogene, vol.26, issue.56, pp.7717-7719, 2007. ,
Rôle des facteurs de la réparation de l'ADN dans la dynamique du génome au sein du système immunitaire (Thèse), 2015. ,
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase, Molecular Cell, vol.47, issue.2, pp.320-329, 2012. ,
Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams, Radiation Research, vol.166, issue.4, pp.629-638, 2006. ,
, Actions of radiations on living cells, 1946.
Joining of Correct and Incorrect DNA Ends at Double-Strand Breaks Produced by High-Linear Energy Transfer Radiation in Human Fibroblasts, Radiation Research, vol.150, issue.6, pp.619-626, 1998. ,
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis, Trends in Biochemical Sciences, vol.42, issue.9, pp.690-701, 2017. ,
A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation, Scientific Reports, vol.7, issue.1, p.10790, 2017. ,
MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings, Trends in genetics, vol.24, issue.11, pp.529-538, 2008. ,
DNA double-strand break repair within heterochromatic regions, Biochemical Society Transactions, vol.40, issue.1, pp.173-178, 2012. ,
A Multi-port Low-Fluence Alpha-Particle Irradiator: Fabrication, Testing and Benchmark Radiobiological Studies, Radiation Research, vol.161, issue.6, pp.732-738, 2004. ,
Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review, Critical Reviews in Oncology/Hematology, vol.129, pp.13-26, 2018. ,
Radiation Carcinogenesis at Low Doses, Science, vol.175, issue.4018, pp.200-202, 1972. ,
Pathways of DNA double-strand break repair during the mammalian cell cycle, Molecular and Cellular Biology, vol.23, issue.16, pp.5706-5715, 2003. ,
Template Switching During Break-Induced Replication Is Promoted by the Mph1 Helicase in Saccharomyces cerevisiae, Genetics, vol.196, issue.4, pp.1017-1028, 2014. ,
Rejoining of DNA fragments produced by radiations of different linear energy transfer, International Journal of Radiation Biology, vol.76, issue.4, pp.549-557, 2000. ,
Two-Lesion Kinetic Model of Double-Strand Break Rejoining and Cell Killing, Radiation Research, vol.156, issue.4, pp.365-378, 2001. ,
DSB repair model for mammalian cells in early S and G1 phases of the cell cycle: application to damage induced by ionizing radiation of different Chapitre 5 -Extension de la simulation vers les effets biologiques tardifs quality, Mutation Research. Genetic Toxicology and Environmental Mutagenesis, vol.779, pp.5-14, 2015. ,
Biochemical DSB-repair model for mammalian cells in G1 and early S phases of the cell cycle, Mutation Research, vol.756, issue.1-2, pp.206-212, 2013. ,
The Repair-Misrepair Model in Radiobiology: Comparison to Other Models, Radiation Research, vol.104, issue.2, pp.77-95, 1985. ,
A DNA double-strand break kinetic rejoining model based on the local effect model, Radiation Research, vol.180, issue.5, pp.524-538, 2013. ,
Application of the local effect model to predict DNA double-strand break rejoining after photon and high-LET irradiation, Radiation Protection Dosimetry, vol.166, issue.1-4, pp.66-70, 2015. ,
Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair, Cancer Research, vol.79, issue.10, pp.2526-2535, 2019. ,
Lorsque l'on s'intéresse en particulier à l'étude des dommages à l'ADN, il devient nécessaire de connaitre avec précision la topologie des dépôts d'énergie le cadre du programme ROSIRIS, plusieurs travaux ont été menés à l'IRSN depuis 2010 afin de contribuer au développement du code Monte-Carlo Geant4 et son extension Geant4-DNA qui permet de réaliser des simulations de ce type, Journal of Radiation Research, vol.43, pp.181-185, 2002. ,
une chaîne de calcul des dommages à l'ADN Geant4-DNA a été développée permettant les simulations des étapes physique, physico-chimique et chimique dans des noyaux cellulaires humains en phase G0/G1 du cycle cellulaire. Egalement, un logiciel a été développé (DnaFabric) permettant la modélisation multi-échelles de l'ADN allant de la paire de nucléotides aux différents territoires chromosomiques au sein d'une cellule en phase G0/G1 du cycle cellulaire ainsi que son intégration et son, Plus récemment, lors de la thèse de Sylvain Meylan au LDRI, 2013. ,
ainsi que dans la poursuite de la contribution de l'IRSN aux collaborations Geant4 et Geant4-DNA. La première partie de ce travail de thèse a consisté tout d'abord, à modifier la partie chimique de la chaîne de simulation au niveau des réactions chimiques considérées. De nouvelles réactions ont été prises en compte entre les différents radicaux libres et l'ADN en suivant l'approche adoptée par, Le travail de thèse présenté dans ce manuscrit s'encadre donc dans la continuité de ce sujet à l'IRSN (projet ROSIRIS), 2018. ,
Pour cela, des simulations d'irradiations avec des ions (protons et alphas) ont été effectuées sur trois modèles de noyaux de cellules humaines développés avec DnaFabric lors de la thèse précédente [MEYLAN, Ces modèles correspondent à des noyaux de fibroblastes, de lymphocytes et de cellules endothéliales présentant des caractéristiques morphologiques différentes. Il a été montré Conclusions et perspectives, 2016. ,
Chromosome aberrations and cell death by ionizing radiation: Evolution of a biophysical model. Radiation Physics and Chemistry, vol.128, pp.18-25, 2016. ,
DNA damage by charged and neutral radiation at different spatial and temporal scales: integrating Monte Carlo simulations with in vitro experiments (Thèse), 2019. ,
Modélisation de la topologie des dépôts d'énergie créés par un rayonnement ionisant à l'échelle nanométrique dans les noyaux cellulaires et relation avec les événements précoces radio-induits (Thèse), 2013. ,
Higher-order chromatin structure in DSB induction, repair and misrepair, Mutation Research, vol.704, issue.1-3, pp.88-100, 2010. ,
Relation between DNA double-strand breaks and energy spectra of secondary electrons produced by different X-ray energies, International Journal of Radiation Biology, pp.1-10, 2018. ,
Mechanistic DNA damage simulations in Geant4-DNA Part 2: Electron and proton damage in a bacterial cell, Physica Medica: PM: An International Journal Devoted to the Applications of Physics to Medicine and Biology: Official Journal of the Italian Association of Biomedical Physics (AIFB), vol.48, pp.146-155, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01815184
Développement d'un outil de simulation multi-échelles adapté au calcul des dommages radio-induits précoces dans des cellules exposées à des irradiations d'ions légers (proton et alpha) (Thèse), 2016. ,
Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks of killing of mammalian cells, Radiation Research, vol.64, issue.2, pp.306-320, 1975. ,
Two-Lesion Kinetic Model of Double-Strand Break Rejoining and Cell Killing, Radiation Research, vol.156, issue.4, pp.365-378, 2001. ,
Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA, Medical Physics, vol.46, issue.3, pp.1501-1511, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Simulation of early radiation-induced DNA damage on different types of cell nuclei, Radiation Protection Dosimetry, vol.183, issue.1-2, pp.26-31, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02144332
Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study, PLOS ONE, vol.10, issue.6, 2015. ,
Application of the local effect model to predict DNA double-strand break rejoining after photon and high-LET irradiation, Radiation Protection Dosimetry, vol.166, issue.1-4, pp.66-70, 2015. ,
Physical models implemented in the GEANT4-DNA extension of the GEANT-4 toolkit for calculating initial radiation damage at the molecular level, Radiation Protection Dosimetry, vol.143, issue.2-4, pp.214-218, 2011. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00586587
Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA, Phys Med, vol.62, pp.152-157, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02166564
From Energy Deposition of Ionizing Radiation to Cell Damage Signaling: Benchmarking Simulations by Measured Yields of Initial DNA Damage after Ion Microbeam Irradiation, Radiation Research, vol.191, issue.6, pp.566-584, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02318865
Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA, Med Phys, vol.46, issue.3, pp.1501-1511, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Simulation of early radiationinduced DNA damage on different types of cell nuclei, Radiat Prot Dosimetry, vol.183, issue.1-2, pp.26-31, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02144332
Relation between DNA double-strand breaks and energy spectra of secondary electrons produced by different X-ray energies, Int J Radiat Biol, pp.1-10, 2018. ,
Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project, Medical Physics, vol.45, issue.8, pp.722-739, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01885579
Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA, Scientific Reports, vol.7, issue.1, p.11923, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01703528
Assessment of the biological response of endothelial cells irradiated with 40 kVp, 220 kVp and 4 MV X-rays by means of micro and nanodosimetric calculations, International Journal of Molecular Sciences ,
, Communications internationales
Influence of chromatin compaction on simulated early radiation-induced DNA damage using Geant4-DNA, Physics-Medicine-Biology frontier, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Influence of chromatin compaction on early radiation-induced DNA damage. Oral au 15 th International Workshop on Radiation damage to DNA, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02097397
Simulation of early radiation-induced DNA damage on different types of cell nuclei, th International Symposium on Microdosimetry, Venise, Italie, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02144332
Simulation of early radiation-induced DNA damage on different types of cell nuclei. Oral au 11 th Cancéropôle Grand-Ouest Workshop on Prediction and Modeling of response to Molecular and External Radiotherapies, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02144332
Early DNA damage in a CHO cell nucleus after proton irradiation, Poster au 13 th Symposium on Neutron and Ion Dosimetry, Cracovie, Pologne. Prix : N. Tang, Novembre 2017, Young Investigator Award, 17 th International Symposium on Microdosimetry, 2017. ,
Travel Grant Award, 11 th Cancéropôle Grand-Ouest Workshop on Prediction and Modeling of response to Molecular and External Radiotherapies, EURADOS support for conference fees, 13 th Symposium on Neutron and Ion Dosimetry, 2017. ,