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REPONSES DES ANTICORPS ANTI-PLASMODIAUX DIRIGEES CONTRE UN PANEL D'ANTIGENES ET LEUR EFFET A L'ISSUE DU TRAITEMENT CONTRE LE PALUDISME SIMPLE EN CÔTE D'IVOIRE

Abstract : The emergence and extension of artemisinin derivative resistance observed in Southeast Asia is a public health problem.The efficacy of antimalarial drugs is influenced by several factors besides the patient’s immune status. This study consisted on the one hand to determine the contribution of the immune response in the outcome of treatment with the associations Artesunate + Amodiaquine (AS + AQ) and Artemether + Lumefantrine (AL) to man and on the other hand the effect of the epidemiological facies (man and Bouaké) On the immune response in Cote d’Ivoire. The study was conducted in two clinical trials evaluating the efficacy of the two antimalarial drugs AS + AQ and AL. These clinical trials were conducted in Man (West) and the other in Bouaké (Center) of Côte d'Ivoire. Serum samples collected at the time of malaria diagnosis and on day 7 after treatment were used to quantify the level of specific response to 5 Plasmodium falciparum antigens and the total extract of Sch 07/03. The ELISA method was used. In total 55 and 56 serum samples respectively in AL and AS + AQ treatment arm available at D0 and D7 were used for the determination of the specific response level of each antigen. The comparison of the mean level of antibodies specific to each antigen in two different epidemiological facies (Man and Bouaké), respectively 111 and 40 serum samples at D0 and D7 were used. On completion of this study, it appears that the mean levels of response directed against the antigens CSP, GLURP and SALSA increase significantly with age (p ˂ 0.05). The levels of antibody responses specific to all the antigens decreased significantly at day 7 with the exception of levels of specific responses to SALSA antigens and the total extract of Sch 07/03. The level of response specific to GLURP antigen was the largest decline at D7 (P = 0.0013). The appropriate parasitological clinical response after PCR correction was 98.3% (AS + AQ) and 100% (AL). GLURP and CSP antigenspecific response levels were significantly (p ˂ 0.001) high in patients with APCR respectively in the AS + AQ arm and AL arm. The comparison of specific responses against Plasmodium antigens between the patients of Man and Bouaké suffering from malaria showed that the proportion of responders and the mean levels of antibodies specific to GLURP antigens and The total extract of Sch 07/03 was significantly (P ˂ 0.05) higher in Bouaké than in Man. The results indicate that in Man the level of antibodies specific to SALSA antigen was higher in women than in men. The women of Bouaké responded more to the GLURP antigens and total extract than those of Man (P ˂ 0.05). The study showed that the acquisition of the humoral immune response may be different in people of the same age living in different areas especially in younger children and by gender.
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Serge Stéphane Yao. REPONSES DES ANTICORPS ANTI-PLASMODIAUX DIRIGEES CONTRE UN PANEL D'ANTIGENES ET LEUR EFFET A L'ISSUE DU TRAITEMENT CONTRE LE PALUDISME SIMPLE EN CÔTE D'IVOIRE. Immunologie. Université Félix Houphouêt-Boigny (Abidjan,Côte d'Ivoire), 2018. Français. ⟨tel-02396377⟩

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