N. Barbosa, L. Costa, M. Pinto, P. Rosinha, I. Rosinha et al., Infection: A Systematic Review. Journal of Immunodeficy & Disorders, vol.3, pp.1-11, 2014.

I. Baskara-yhuellou, Effet de l'exposition à la fumée de cigarette sur le profil oxydatif et la senescence des différentes sous-populations lymphocytaires T CD4+. Thèse Health, Institut des Sciences et Industries du Vivant et de l'Environnement, vol.324, 2013.

L. A. Bazydlo, M. Needham, and N. S. Harris, -Calcium, Magnesium, and Phosphate, Laboratory Medicine, vol.45, pp.44-50, 2014.

J. A. Beard, A. Bearden, and R. Striker, Vitamin D and the anti-viral state, Journal of Clinical Virology, vol.50, pp.194-200, 2011.

A. Y. Belorusova and N. Rochel, Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties. Vitamins and Hormones, vol.100, pp.83-116, 2016.

E. Bergereau, Rôle des LT-CD8+ dans l'auto-immunité du SNC : influence des autres effecteurs de l'immunité adaptative, vol.246, 2010.

O. Bernard-poenaru and J. Guéris, Immuno-Analyse et Biologie Specialisée, vol.11, pp.24-27, 1996.

T. Berndt and R. Kumar, Novel mechanisms in the regulation of phosphorus homeostasis, Physiology, vol.24, pp.17-25, 2009.

C. Best, N. Neufingerl, J. M. Del-rosso, C. Transler, T. Van-den-briel et al., Can multi-micronutrient food fortification improve the micronutrient status, growth, health, and cognition of schoolchildren? A systematic review, Nutrition Reviews, vol.69, pp.186-204, 2011.

S. Biadgilign, A. A. Reda, and T. Digaffe, Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: a retrospective cohort study, AIDS Research and Therapy, vol.9, p.15, 2012.

D. D. Bikle, Nonclassic Actions of Vitamin D, The Journal of Clinical Endocrinology and Metabolism, vol.94, pp.26-34, 2009.

D. D. Bikle, Vitamin D Regulation of Immune Function, Vitamins and Hormones, vol.86, pp.1-21, 2011.

A. Chakraborty, A. K. Mishra, A. Soni, T. Regina, R. Mohil et al.,

C. Chintamani, P. C. Sharma, and S. Saxena, Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians, Cancer Detection and Prevention, vol.32, pp.386-394, 2009.

N. Chandel, A. Malhotra, and P. C. Singhal, Vitamin D receptor and epigenetics in HIV infection and drug abuse, Frontiers in Microbiology, vol.6, p.788, 2015.

H. L. Chaves, H. A. Corrêa, W. B. Machado, R. B. Teles, L. R. Nascimento et al.,

M. S. Medeiros and H. P. Moreira, Vitamin D and Secondary Hyperparathyroidism in HIV Infected Patients Taking Antiretroviral Therapy, World Journal of AIDS, vol.4, pp.430-437, 2014.

A. Chawla, J. J. Repa, R. M. Evans, and D. J. Mangelsdorf, Nuclear receptors and lipid physiology: opening the X-files, vol.294, pp.1866-1870, 2001.

C. Chen, Q. Liu, L. Zhu, H. Yang, and W. Wei-lu, Vitamin D Receptor Gene Polymorphisms on the Risk of Tuberculosis, a Meta-Analysis of 29 Case-Control Studies, PLoS ONE, vol.8, pp.1-11, 2013.

K. S. Chen and H. F. Deluca, Cloning of the human 1 alpha, 25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D responsive elements, Biochimica et Biophysica Acta, vol.1263, pp.1-9, 1995.

T. C. Chen, F. Chimeh, Z. Lu, J. Mathieu, K. S. Person et al., Factors that influence the cutaneous synthesis and dietary sources of vitamin D, Archives of Biochemistry and Biophysics, vol.460, pp.213-217, 2007.

R. Cherqaoui, K. M. Shakir, B. Shokrani, S. Madduri, F. Farhat et al., , 2014.

, Histopathological Changes of the Thyroid and Parathyroid Glands in HIV-Infected Patients, Journal of Thyroid Research, p.7

U. C. Chimah, T. O. Lawoyin, C. C. Nnebue, and A. L. Ilika, Survey of Knowledge and Source of Information Relating to Reproduction and Sexually Transmitted Infections among Senior Secondary Schools Students in a Military Barracks in Nigeria, British Journal of Medicine & Medical Research, vol.7, pp.884-894, 2015.

R. Civitelli and K. Ziambaras, Calcium and phosphate homeostasis: concerted interplay of new regulators, Journal of endocrinological investigation, vol.34, pp.3-7, 2011.

A. Conesa-botella, E. Florence, L. Lynen, R. Colebunders, J. Menten et al., Decrease of vitamin D concentration in patients with HIV infection on a non-nucleoside reverse transcriptase inhibitor-containing regimen, AIDS Research and Therapy, vol.7, p.40, 2010.

A. Conesa-botella, C. Mathieu, R. Colebunders, R. Moreno-reyes, E. V. Etten et al.,

L. Kestens, Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?, AIDS Research and Therapy, vol.6, pp.1-5, 2009.

J. Couret and T. L. Chang, Reactive Oxygen Species in HIV Infection, EC Microbiology, vol.3, issue.6, pp.597-604, 2016.

A. K. Coussens, C. E. Naude, R. Goliath, G. Chaplin, R. J. Wilkinson et al., High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1, 2015.

, Southern Africans. Proceedings of the National Academy of Sciences of the United States of America, vol.112, pp.8052-8057

V. Coxam, M. Davicco, and Y. Wittrant, Vitamine D et santé osseuse. Cahiers de Nutrition et de Diététique, vol.49, pp.260-266, 2014.

M. Cozzolino, M. Vidal, M. V. Arcidiacono, P. Tebas, K. E. Yarasheski et al., HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D, AIDS, vol.17, p.513, 2003.

P. D'amour, Acute and chronic regulation of circulating PTH: Significance in health and in disease, Clinical biochemistry, vol.45, pp.964-969, 2012.

T. M. De-la, C. Torres, G. Nieto, S. Vergara, A. J. Carrero et al., -Vitamin D Receptor Gene Haplotypes and Susceptibility to HIV-1 Infection in Injection Drug Users, Journal of Infectious Diseases, vol.197, pp.405-410, 2008.

H. F. Deluca and M. T. Cantorna, -Vitamin D: its role and uses in immunology, The FASEB Journal, vol.15, pp.2579-2585, 2001.

H. F. Deluca, History of the discovery of vitamin D and its active metabolites, BoneKEy Reports, vol.3, p.479, 2014.

D. Vernejoul, M. C. Marie, and P. J. , Cellules osseuses et remodelage osseux. In : Kuntz D, ed. Madadies métaboliques osseuses de l'adulte, pp.3-16, 1996.

A. Falchetti, E. Rossi, R. Cosso1, A. Buffa, S. Corvaglia et al., Food and Nutrition Sciences, vol.7, pp.1033-1051, 2016.

H. Fan and L. G. Margaret, -Methods in Molecular Medicine, Molecular Pathology Protocols, vol.49, p.p, 2001.

J. H. Faraco, N. A. Morrison, A. Baker, J. Shine, and P. M. Frossard, ApaI dimorphism at the human vitamin D receptor gene locus, Nucleic Acids Research, vol.17, p.2150, 1989.

Y. Feng, L. Li, and X. H. Sun, Monocytes and Alzheimer's disease, Neuroscience Bulletin, vol.27, p.115, 2011.

P. Fener and C. Criton, Manifestations cliniques et biologiques de l'infection `a VIH/sida chez la femme, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01456818

A. Filus, A. Trzmiel, J. Kuliczkowska-plaksej, U. Tworowska, D. Jedrzejuk et al.,

M. M?dra?, Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome, Aging Male, vol.11, pp.134-139, 2008.

H. J. Fleury, , vol.245, 2002.

H. J. Fleury, Virologie Humaine. 5 éd MASSON, vol.265, 2009.

S. Fourati, Contribution des protéines régulatrices Vif et Vpr du VIH-1 dans la résistance aux antirétroviraux chez des patients en échec virologique, p.101, 2012.

J. Fox, B. Peters, M. Prakash, J. Arribas, A. Hill et al., Improvement in vitamin D deficiency following antiretroviral regime change: results from the MONET trial, AIDS Research and Human Retroviruses, vol.27, pp.29-34, 2011.

M. Fukagawa and J. Kazama, With or without the kidney : the role of FGF 23 in CKD, 2005.

, Nephrology Dialysis Transplantation, vol.20, pp.1295-1298

X. H. Gao, P. P. Dwivedi, J. L. Omdahl, H. A. Morris, and B. K. May, , 2004.

H. Huang, B. Caballero, S. Chang, A. J. Alberg, R. D. Semba et al., Multivitamin/Mineral supplements and prevention of chronic disease: executive summary, American Journal of Clinical Nutrition, vol.85, pp.265-268, 2007.

J. M. Huraux, H. Agut, J. C. Nicolas, and H. Peigue-lafeuille, , 2003.

E. Ed and P. , , vol.699

F. G. Hustmyer, H. F. Deluca, and M. Peacock, -Apa I, Bsm I, EcoRV, and Taq I polymorphism at the vitamin D receptor gene locus in Caucasians, Blacks and Asians, Human Molecular Genetics, vol.2, p.487, 1993.

O. N. Iloh, A. C. Ubesie, K. K. Iloh, I. J. Emodi, A. N. Ikefuna et al., Poor Physical Growth among Perinatally HIV-infected Girls despite Anti-retroviral Therapy, 2016.

S. Enugu and . Nigeria, World Journal of Nutrition and Health, vol.4, pp.22-26

O. S. Indridason and L. D. Quarles, Hyperphosphatemia in end-stage renal disease, Advances in Renal Replacement Therapy, vol.9, pp.184-192, 2002.

S. Iordanskiy, R. V. Duyne, G. C. Sampey, C. M. Woodson, K. Fry et al., Therapeutic doses of irradiation activate viral transcription and induce Apoptosis in HIV-1infectedcells. Virology, vol.485, pp.1-15, 2015.

N. Israel, M. A. Gougerot-pocidalo, F. Aillet, and J. L. Virelizier, Redox status of cells influences constitutive or induced NF-kb translocation and HIV long terminal repeat in human R and monocytic cell lines, The Journal of Immunology, vol.149, pp.3386-3393, 1992.

P. Jaeger, S. Otto, R. F. Speck, L. Villiger, F. F. Horber et al., Altered parathyroid gland function in severely immunocompromised patients infected with human immunodeficiency virus, Journal of Clinical Endocrinology and Metabolism, vol.79, pp.1701-1705, 1994.

A. Janoly-dumenil, Optimisation des modalités thérapeutiques de l'infection a cmv en posttransplantation de moelle osseuse pédiatrique par l'étude in vitro des relations PK/PD de l'efficacité antivirale et de la toxicité cellulaire du ganciclovir, vol.221, 2008.

G. R. Ji, M. Yao, C. Y. Sun, Z. H. Li, and Z. Han, BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone, 47 : 681-686. aboriginal populations with high rates of tuberculosis, Journal of Infectious Diseases, vol.198, pp.1175-1179, 2010.

M. J. Larriba, J. M. González-sancho, A. Barbáchano, N. Niell, G. Ferrer-mayorga et al., Vitamin D is a multilevel repressor of Wnt/?-catenin signaling in cancer cells, Cancers, 2013.

S. D. Lawn, A. D. Harries, X. Anglaret, L. Myer, and R. Wood, Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa, AIDS, vol.22, pp.1897-1908, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00266588

G. L. Lensmeyer, D. A. Wiebe, N. Binkley, and M. K. Drezner, , p.25, 2006.

D. Hydroxyvitamin and . Measurement, Comparison with Contemporary Assays, vol.52, pp.1120-1126

E. Lerma, M. E. Molas, M. M. Montero, A. Guelar, A. González et al., Prevalence and Factors Associated with Vitamin D Deficiency and Hyperparathyroidism in HIV-Infected Patients Treated in Barcelona, International Scholarly Research Network AIDS, p.485307, 2012.

J. A. Levy, HIV and the pathogenesis of AIDS, vol.644, 2007.

J. Li, M. Z. Molnar, J. J. Zaritsky, J. J. Sim, E. Streja et al.,

K. Zadeh, Correlates of parathyroid hormone concentration in hemodialysis patients, 2013.

, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association -European Renal Association, vol.28, pp.1516-1525

P. Lindroth and K. Mopper, High performance liquid chromatographic determination of subpicomole amount of amino acids by precolumn fluorescence derivatization with ophtaldialdéhyde, Analytical Chemistry, vol.51, pp.1667-1674, 1979.

D. A. Luis, P. Bachiller, R. Aller, J. De-luis, O. Izaola et al., Relation among Micronutrient Intakes with CD4 Count in HIV Infected Patients, 2002.

, Nutricion Hospitalaria, vol.17, pp.285-289

M. A. Maaty, R. S. Hanafi, H. Y. Aboul-enein, and M. Z. Gad, Design-of-Experiment Approach for HPLC Analysis of 25-Hydroxyvitamin D: A Comparative Assay with ELISA, Journal of Chromatographic Science, vol.53, pp.66-72, 2015.

A. M. Mackawy and M. E. Badawi, Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients, Meta Gene, vol.2, pp.540-556, 2014.

V. J. Madhad and K. P. Sentheil, The Rapid and Non-Enzymatic isolation of DNA from the Human peripheral whole blood suitable for Genotyping, European Journal of Biotechnology and Bioscience, vol.1, pp.1-16, 2014.

A. A. Mahmoud and A. H. Ali, Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis, Egyptian Journal of Chest Diseases and Tuberculosis, vol.63, pp.651-655, 2014.

M. Ma?odobra-mazur, A. Paduch, A. Lebioda, M. Konopacka, J. Rogoli?ski et al.,

J. Wierzgo?, A. Maciejewski, E. Chmielik, A. Jonkisz, S. Pó?torak et al., VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma, Acta Biochimica Polonica, vol.59, pp.627-630, 2012.

M. Mangin, R. Sinha, and K. Fincher, Inflammation and vitamin D: the infection connection, Inflammation Research, vol.63, pp.803-819, 2014.

P. Mansueto, A. Seidita, G. Vitale, S. Gangemi, C. Iaria et al., Vitamin D Deficiency in HIV Infection : Not Only a Bone Disorder, BioMed Research International, 2015.

M. Masiá, S. Padilla, M. Fernández, C. Rodríguez, A. Moreno et al., Oxidative Stress Predicts All-Cause Mortality in HIV-Infected Patients, PLoS ONE, vol.11, pp.1-12, 2016.

H. Masuyama and P. N. Macdonald, Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR, Journal of Cellular Biochemistry, vol.71, pp.429-440, 1998.

H. Masuyama, S. C. Jefcoat, and P. N. Macdonald, The N-terminal domain of transcription factor IIB is required for direct interaction with the vitamin D receptor and participates in vitamin D-mediated transcription, Molecular Endocrinology, vol.11, pp.218-228, 1997.

R. Maurya, B. Kumar, and S. Sundar, Evaluation of salt-out method for the isolation of DNA from whole blood: a pathological approach of DNA based diagnosis, International Journal of Life Sciences Biotechnology Pharma Research, vol.2, pp.53-57, 2013.

J. J. Mcgrath, S. Saha, T. H. Burne, and D. W. Eyles, A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations, The Journal of Steroid Biochemistry and Molecular Biology, vol.121, pp.471-477, 2010.

L. Mcnamara, S. Takuva, T. Chirwa, and P. Macphail, Prevalence of common vitamin D receptor genepolymorphisms in HIV-infected and uninfected South Africans, International Journal of Molecular Epidemiology and Genetics, vol.7, pp.74-80, 2016.

K. Menck, D. Behme, M. Pantke, N. Reiling, C. Binder et al., Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags, Journal of Visualized Experiments, vol.91, pp.1-10, 2014.

P. Mezquita-raya, M. Muñoz-torres, J. D. Luna, V. Luna, F. Lopez-rodriguez et al., Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women, Journal of bone and mineral research, vol.16, pp.1408-1415, 2001.

T. C. Michels and K. M. Kelly, Parathyroid Disorders, vol.88, pp.249-257, 2013.

L. Milovanova, Y. Milovanov, and A. Plotnikova, Phosphorus and Calcium Metabolism Disorders Associated with Chronic Kidney Disease Stage III-IV (Systematic Review and Meta-Analysis), Chronic Kidney Disease and Renal Transplantation, Prof. Manisha Sahay, pp.95-119, 2012.

D. K. Mishra, Y. Wu, M. Sarkissyan, S. Sarkissyan, Z. Chen et al.,

H. P. Koeffler and J. V. Vadgama, Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women, PLoS ONE, vol.8, p.57967, 2013.

R. Mitsuyasu, Oncological Complications of Human Immunodeficiency Virus Disease and Hematologic Consequences of Their Treatment, Clinical Infectious Diseases, vol.29, pp.35-43, 1999.

K. Miyamoto, R. A. Kesterson, H. Yamamoto, Y. Taketani, E. Nishiwaki et al.,

K. Morita, E. Takeda, and J. W. Pike, Structural organization of the human vitamin D receptor chromosomal gene and its promoter, Molecular Endocrinology, vol.11, pp.1165-1179, 1997.

S. M. Moe, Disorders Involving Calcium, Phosphorus, and Magnesium. Primary Care -Clinics in Office Practice, vol.35, pp.215-237, 2008.

B. Moges, B. Amare, T. Yabutani, and A. Kassu, HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study, BMC Public Health, vol.14, pp.679-686, 2014.

S. Mohapatra, A. Saxena, G. Gandhi, B. C. Koner, and P. C. Ray, Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population, Journal of Ovarian Research, vol.6, pp.1-6, 2013.

M. Monsigny, E. Duverger, and S. Bourgerie, Dictionnaire de biochimie moderne, vol.346, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00088423

L. Montagnier, SIDA et infection par le VIH, vol.63, 1998.

A. Moodley, M. Qin, K. K. Singh, and S. A. Spector, Vitamin D Related Host Genetic Variants Alter HIV Disease Progression in Children, Pediatric Infectious Disease Journal, vol.32, pp.1230-1236, 2013.

J. R. Mora, M. Iwata, and U. H. Von-andrian, Vitamin effects on the immune system: vitamins A and D take centre stage, Nature Reviews Immunology, vol.8, pp.685-698, 2008.

L. D. Moreira-pfrimer, M. A. Pedrosa, L. Teixeira, and M. Lazaretti-castro, Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: A randomized double-blind controlled trial, Annals of nutrition & metabolism, vol.54, pp.291-300, 2009.

H. Mori, Y. Okada, and Y. Tanaka, Incidence of Vitamin D Deficiency and Its Relevance to Bone Metabolism in Japanese Postmenopausal Women with Type 2 Diabetes Mellitus, Internal medicine, vol.54, pp.1599-1604, 2015.

M. A. Morrison, A. C. Silveira, N. Huynh, G. Jun, S. E. Smith et al.,

W. Farrer, L. A. Hageman, G. S. Kim, I. K. Schaumberg, D. A. Deangelis et al., Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration, Human Genomics, vol.5, pp.538-568, 2011.

S. Muller and B. Kappes, Vitamin and co-factor biosynthesis pathways in Plasmodium and other apicomplexan parasites, Trends in Parasitology, vol.23, pp.112-121, 2007.

K. L. Munger, L. I. Levin, B. W. Hollis, N. S. Howard, and A. Ascherio, Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis, JAMA, vol.296, pp.2832-2838, 2006.

L. Nagy and J. W. Schwabe, Mechanism of the nuclear receptor molecular switch, Trends in Biochemical Sciences, vol.29, pp.317-324, 2004.

R. Nair and A. Maseeh, Vitamin D : The sunshine vitamin, Journal of Pharmacology & Pharmacotherapeutics, vol.3, pp.118-126, 2012.

K. Nakai, H. Fujii, K. Kono, S. Goto, R. Kitazawa et al.,

M. Fukagawa and S. Nishi, -Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats, American Journal of Hypertension, vol.27, pp.586-595, 2014.

V. S. Neela, N. C. Suryadevara, V. G. Shinde, S. S. Pydi, S. Jain et al., Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with leprosy, Human immunology, vol.76, pp.402-405, 2015.

I. Nemere, N. Garbi, G. J. Hämmerling, and R. C. Khanal, , vol.1, pp.25-28, 2010.

/. Erp57, The Journal of biological chemistry, vol.285, pp.31859-31866

N. R. Ngwa and A. E. Ambe, Assessment of serum calcium in relation to dietary calcium intake in a rural population in Cameroon, Open Journal of Epidemiology, vol.3, pp.209-212, 2013.

M. H. Nielsen, F. S. Pedersen, and J. Kjems, Molecular strategies to inhibit HIV-1 replication, 2005.

, Retrovirology, vol.2, p.10

G. Nieto, Y. Barber, M. C. Rubio, M. Rubio, and J. Fibla, Association between AIDS disease progression rates and the Fok-I polymorphism of the VDR gene in a cohort of HIV-1 seropositive patients, Journal of Steroid Biochemistry and Molecular Biology, pp.199-207, 2004.

V. O'neill, F. F. Asani, T. J. Jeffery, D. S. Saccone, and L. Bornman, Vitamin D Receptor Gene Expression and Function in a South African Population: Ethnicity, Vitamin D and FokI, PLoS ONE, vol.8, p.67663, 2013.

B. W. Ogunkolade, B. J. Boucher, J. M. Prah, S. A. Bustin, J. M. Burrin et al.,

V. Mannan, N. Mcdermott, M. F. Deluca, H. F. Hitman, and G. A. , Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians, Diabetes, vol.51, pp.2294-2312, 2002.

R. Okazaki, T. Sugimoto, H. Kaji, Y. Fujii, M. Shiraki et al.,

I. Kurahashi and T. Matsumoto, Infection à VIH : Aspects virologiques. Module de cours "Santé et environnement-Maladies transmissibles, 2007.

J. W. Pike, M. B. Meyer, and K. A. Bishop, Regulation of target gene expression by the vitamin D receptor -an update on mechanisms, Reviews in Endocrine and Metabolic Disorders, vol.13, pp.45-55, 2012.

B. F. Pirotte, M. Rassenfosse, R. Collin, A. Devoeght, M. Moutschen et al., , vol.68, pp.25-31, 2013.

E. Poitras and A. Houde, La PCR en temps réel : principe et application. Review in Biology and Biotechnology, vol.2, pp.2-11, 2002.

H. A. Pols, J. P. Van-leeuwen, J. P. Schilte, T. J. Visser, and J. C. Birkenhager, Heterologous upregulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone (PTH) and PTH like peptide in osteoblast-like cells, Biochemical and Biophysical Research Communications, vol.156, pp.588-594, 1988.

S. M. Post, H. Duez, P. P. Gervois, B. Staels, F. Kuipers et al., -Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alphahydroxylase and sterol 27-hydroxylase expression, 2001.

T. Arteriosclerosis and V. Biology, , vol.21, pp.1840-1845

A. Prentice, I. Schoenmakers, K. S. Jones, L. M. Jarjou, and G. R. Goldberg, Vitamin D Deficiency and Its Health Consequences in Africa, Clinical Reviews in Bone and Mineral Metabolism, vol.7, pp.94-106, 2009.

J. M. Quinn, J. Elliott, M. T. Gillespie, and T. J. Martin, A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro, Endocrinology, vol.139, pp.4424-4427, 1998.

R. Raina, G. Garg, S. K. Sethi, M. J. Schreiber, J. F. Simon et al., Phosphorus Metabolism, p.8, 2012.

G. J. Randolph, C. Jakubzick, and C. Qu, Antigen Presentation by Monocytes and Monocytederived Cells, Current Opinion in Immunology, vol.20, pp.52-60, 2008.

J. Rashedi, M. Asgharzadeh, S. R. Moaddab, L. Sahebi, M. Khalili et al., Vitamin D Receptor Gene Polymorphism and Vitamin D Plasma Concentration: Correlation with Susceptibility to Tuberculosis, vol.5, pp.607-611, 2014.

H. Rasmussen and L. C. Craig, Purification of parathormone by use of countercurrent distribution, Journal of the American chemical society, vol.81, pp.5003-5004, 1959.

E. M. Reiche and A. N. Simão, The Role of Human Immunodeficiency Virus Type 1 (HIV-1) Proteins and Antiretroviral Drug Therapy in HIV-1-Induced Oxidative Stress, Immunology, Epidemiology and Treatment Strategies, pp.41-69, 2011.

T. A. Reinhardt, R. L. Horst, and J. P. Goff, Calcium, phosphorus, and magnesium homeostasis in ruminants. The Veterinary clinics of North America, Food animal practice, vol.4, pp.331-350, 1988.

A. G. Richetta, V. Silvestri, S. Giancristoforo, P. Rizzolo, S. D'epiro et al., A-1012G promoter polymorphism of vitamin D receptor gene is associated with psoriasis risk and lower allelespecific expression, DNA and Cell Biology, vol.33, pp.102-109, 2014.

M. M. Rizk, N. H. Zakaria, and W. G. Elshazely, Study of Vitamin D Receptor (VDR) Gene Polymorphisms among Egyptian Cohort Patients with Different Stages of Colorectal Cancer, Journal of Cancer Therapy, vol.5, pp.253-263, 2014.

M. M. Rosenvinge, K. Gedela, A. J. Copas, A. Wilkinson, C. A. Sheehy et al.,

M. R. Pakianathan and S. T. Sadiq, Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency, Journal of acquired immune deficiency syndromes, vol.54, pp.496-499, 2010.

A. Ross, S. Judd, M. Kumari, C. Hileman, N. Storer et al., Vitamin D Linked to Carotid Intima-Media Thickness and Immune Reconstitution in HIV-Positive Individuals, Antiviral Therapy, vol.16, pp.555-563, 2011.

M. Rothe, N. Israël, and F. Barré-sanoussi, Mécanismes de la réplication virale des VIH, 1996.

, Medecine Therapeutique, vol.2, pp.12-18

I. Ru?evi?, V. Bari?i?-dru?ko, L. Glava?-obrovac, and M. ?tefani?, Vitamin D Endocrine System and Psoriasis Vulgaris, Acta dermatovenerologica Croatica, vol.17, pp.187-192, 2009.

R. D. Semba, B. Bartali, J. Zhou, C. Blaum, C. W. Ko et al., Low Serum Micronutrient Concentrations Predict Frailty Among Older Women Living in the Community, Biological sciences and medical sciences, vol.61, pp.594-599, 2006.

S. C. Serrano, D. G. Villareal, M. Aguilar-medina, J. G. Romero-navarro, and J. G. Quintana,

E. A. Meraz, I. O. Ramírez, V. Picos-cárdenas, J. Granados, I. Estrada-garcía et al., Genetic Polymorphisms of Interleukin-1 Alpha and the, 2014.

, Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration, International Journal of Genomics, 2014.

D. H. Shin, S. S. Martinez, M. Parsons, D. T. Jayaweera, A. Campa et al., Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami, International journal of bioscience, vol.2, pp.217-223, 2012.

D. Shoback, Clinical practice, Hypoparathyroidism. New England journal of medicine, vol.359, pp.391-403, 2008.

J. C. Souberbielle, J. J. Body, J. M. Lappe, M. Plebani, Y. Shoenfeld et al.,

L. Heickendorff, B. W. Hollis, S. Ish-shalom, G. Jean, P. Von-landenberg et al., -Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice, Autoimmun Review, vol.9, pp.709-715, 2010.

J. C. Souberbielle, E. Lawson-body, and C. Cormier, Updating about PTH: our immunoassays are not specific of the sole intact PTH. Immune-analyze & specialized, Biology, vol.17, pp.48-53, 2002.

J. C. Souberbielle, E. Lawson-body, B. Hammadi, E. Sarfati, A. Kahan et al., The use in clinical practice of parathyroid hormone normative values established in vitamin Dsufficient subjects, Journal of Clinical Endocrinology and Metabolism, vol.88, pp.3501-3504, 2003.

J. C. Souberbielle, D. Prié, M. Courbebaisse, G. Friedlander, P. Houillier et al., Update on vitamin D and evaluation of vitamin D status, Annales d'Endocrinologie, vol.69, pp.501-510, 2008.

B. C. Stack and G. Randolph, Parathyroid disease : Investigations, pp.164-173, 2010.

M. Stearns and J. Cox, -Parathyroid disease : Symptoms, differential diagnosis, and management. In : A Practical Manual of Thyroid and Parathyroid Disease, pp.145-163, 2010.

J. P. Viard, Vitamine D et pathologies infectieuses, vol.39, pp.430-434, 2015.

K. Waki and E. O. Freed, Macrophages and Cell-Cell Spread of HIV-1. Viruses, vol.2, p.1603, 2010.

J. D. Wall and J. K. Pritchard, Assessing the performance of the haplotype block model of linkage disequilibrium, American Journal of Human Genetics, vol.73, pp.502-515, 2003.

D. G. Wang, J. B. Fan, C. J. Siao, A. Berno, P. Young et al., Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome, Science, vol.280, pp.1077-1082, 1998.

T. J. Wang, F. Zhang, J. B. Richards, B. Kestenbaum, J. B. Van-meurs et al.,

K. Glazer, N. L. Vandenput, L. Peacock, M. Shi, J. Rivadeneira et al.,

N. J. Wareham, L. J. Hocking, D. Hart, N. K. Arden, C. Cooper et al.,

S. B. Kritchevsky, J. C. Florez, J. A. Todd, J. Dupuis, E. Hyppönen et al., Common genetic determinants of vitamin D insufficiency: a genome wide association study, Lancet, vol.376, pp.180-188, 2010.

J. C. Waterhouse, T. H. Perez, and P. J. Albert, Reversing bacteria-induced 25-hydroxyvitamin D receptor dysfunction is key to autoimmune disease, Annals of the New York Academy of Sciences, vol.1173, pp.757-765, 2009.

R. Welch and R. D. Graham, Breeding for micronutrients in staple food crops from a human nutrition perspective, Journal of Experimental Botany, vol.55, pp.353-364, 2004.

T. Welz, K. Childs, F. Ibrahim, M. Poulton, C. B. Taylor et al., Efavirenz is associated with severe Vitamin D deficiency and increased alkaline phosphatase, AIDS, vol.24, pp.1923-1928, 2010.

J. H. White, Vitamin D Signaling, Infectious Diseases and Regulation of Innate Immunity, 2008.

J. H. White, Regulation of intracrine production of 1,25-dihydroxyvitamin D and its role in innate immune defense against infection, Archives of Biochemistry and Biophysics, vol.523, pp.58-63, 2012.

G. K. Whitfield, L. S. Remus, P. W. Jurutka, H. Zitzer, A. K. Oza et al.,

M. A. Galligan, M. L. Thatcher, E. C. Dominguez, and M. R. Haussler, Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene, Molecular and Cellular Endocrinology, vol.177, pp.145-159, 2001.

, Determine HIV Rapid Test (For use with whole blood, serum, or plasma Store kit : 2 -30° C), WHO, vol.1, 2005.

, Revised Surveillance Case Definitions for HIV Infection among Adults, Adolescents, and Children Aged < 18 Months and for HIV Infection and AIDS Among Children Aged 18 Months to < 13 Years -United States, WHO, vol.16, 2008.

, World Health Organization: Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach, WHO, vol.273, 2013.

, Global Report UNAIDS, report on the global AIDS epidemic, vol.27, 2016.

, Global Report UNAIDS, report on the global AIDS, vol.27, p.16, 2016.

U. Who/unaids-;-unaids, La riposte mondiale au VIH/sida : le point sur l'épidémie et sur les progrès du secteur de santé vers un accès universel: 2011 rapport de situation. Genève : Organisation mondiale de la Santé. viii, vol.225, p.p, 2011.

E. M. Wilson and I. Sereti, Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs, Immunological Reviews, vol.254, pp.343-354, 2013.

E. S. Wintergerst, S. Maggini, and D. H. Hornig, Contribution of selected vitamins and trace elements to immune function, Annals of Nutrition and Metabolism, vol.51, pp.301-323, 2007.

M. D. Witham, M. A. Nadir, and A. D. Struthers, Effect of vitamin D on blood pressure: A systematic review and meta-analysis, Journal of Hypertension, vol.27, pp.1948-1954, 2009.

D. A. Wohl, C. Orkin, M. Doroana, J. H. Pilotto, S. Sungkanuparph et al., Change in vitamin D levels and risk of severe vitamin D deficiency over 48 weeks among HIV-1-infected, treatment-naive adults receiving rilpivirine or efavirenz in a Phase III trial (ECHO), Antiviral Therapy, vol.19, pp.191-200, 2014.

M. N. Woods, A. M. Tang, J. Forester, C. Jones, K. Hendricks et al., Effect of dietary intake and protease inhibitors on serum vitamin B12 levels in a cohort of human immunodeficiency virus-positive patients, Clinical Infectious Diseases, vol.37, pp.124-131, 2003.

G. M. Wuerzner and B. Waeber, Hypertension and vitamin D: not again. Revue Médicale Suisse, vol.7, pp.121-124, 2011.

N. Yamamoto, N. Ushijima, and Y. Koga, Immunotherapy of HIV-infected patients with GC Protein-derived Macrophage Activating Factor (GcMAF), Journal of medical Virology, vol.81, pp.16-26, 2009.

A. E. Yapo, M. Assayi, N. B. Aka, R. Bonetto, L. Comoe et al., Les valeurs de référence de 21 constituants biochimiques sanguins de l'ivoirien adulte présumé sain, Publications Médicales Africaines, vol.110, pp.49-57, 1990.

H. Yasuda, N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki et al.,

N. Takahashi and T. Suda, Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL, Proceedings of the National Academy of Sciences of the United States of America, vol.95, pp.3597-3602, 1998.

D. Yilma, P. Kaestel, M. F. Olsen, A. Abdissa, M. Tesfaye et al.,

K. F. Michaelsen, C. Ritz, O. Kirk, Å. B. Andersen, and H. Friis, Change in serum 25-hydroxyvitamin D with antiretroviral treatment initiation and nutritional intervention in HIV-positive adults, British Journal of Nutrition, vol.116, pp.1720-1727, 2016.

A. Yilmaz, Antiretroviral treatment of HIV-1 in the central nervous system, Vasastadens Bokbinderi AB, vol.60, 2007.

M. Yin and E. Stein, The Effect of Antiretrovirals on Vitamin D. Clinical Infectious Diseases, vol.52, pp.406-408, 2011.

A. Younus, M. Faiz, and A. Yasmeen, Association of Vitamin D Receptor FokI and TaqI Gene Polymorphisms in Pakistani Women with 25(OH)D Levels, Journal of Food and Nutrition Research, vol.5, pp.475-480, 2017.

B. U. Zabel, H. M. Kronenberg, G. I. Bell, and T. B. Shows, Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-ras 1, and beta hemoglobin, Cytogenetic and Genome Research, vol.39, pp.200-205, 1985.

Z. Zaman, P. Fielden, and P. G. Frost, Simultaneous determination of vitamins A and E and carotenoids in plasma by reversed-phase HPLC in elderly and younger subjects, Clinical Chemistry, vol.39, pp.2229-2234, 1993.

H. S. Zhang, -Nrf2 is involved in inhibiting Tat-induced HIV-1 long terminal repeat transactivation, Free Radical Biology & Medicine, vol.47, pp.261-268, 2009.

R. Zhang and D. P. Naughton, Vitamin D in health and disease: Current perspectives, Nutrition Journal, vol.9, pp.1-13, 2010.

L. Zhang, X. Yin, J. Wang, D. Xu, Y. Wang et al., Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women : A systematic review and MetaAnalysis Scientific Reports, vol.8, p.981, 2018.

R. Zineb, B. Zhor, W. Odile, and R. R. Marthe, Distinct, tissue-specific regulation of vitamin D receptor in the intestine, kidney, and skin by dietary calcium and vitamin D, Endocrinology, vol.139, pp.1844-1852, 1998.

A. Zittermann and J. F. Gummert, Nonclassical vitamin D action, Nutrients, vol.2, pp.408-425, 2010.

J. M. Zmuda, J. A. Cauley, and R. E. Ferrel, Molecular Epidemiology of Vitamin D Receptor Gene Variants, Epidemiologic Reviews, vol.22, pp.203-217, 2000.

, Editor(s)

. Dr and . Gabriella-gd-d'ettorre, Sapienza" and Azienda Policlinico

F. Edzeamey, Ashanti Bekwai Municipal Hospital

. Tabe-franklin-nyenty,

A. Iorhen-ephraim,

, Programme Commun des Nations Unies sur le VIH et le sida. Fiche D'information 2016, UNAIDS, pp.1-9, 2016.

P. Mansueto, A. Seidita, G. Vitale, S. Gangemi, C. Iaria et al., Vitamin D deficiency in HIV infection: Not only a bone disorder, Biomed Res Int, 2015.

S. Biadgilign, A. A. Reda, and T. Digaffe, Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: A retrospective cohort study, AIDS Res Ther, vol.9, pp.1-7, 2012.

D. J. Nolan, R. Rose, P. H. Rodriguez, M. Salemi, E. J. Singer et al., The spleen is an HIV-1 sanctuary during combined antiretroviral therapy, AIDS Res Hum Retroviruses, vol.34, issue.1, pp.123-125, 2018.

S. D. Lawn, A. D. Harries, X. Anglaret, L. Myer, and R. Wood, Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa, AIDS, vol.22, issue.15, pp.1897-1908, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00266588

M. F. Holick, Vitamin D deficiency, N Engl J Med, vol.357, issue.3, pp.266-281, 2007.

N. J. Schuch, V. C. Garcia, S. R. Vivolo, and L. A. Martini, Relationship between Vitamin D Receptor gene polymorphisms and the components of metabolic syndrome, Nutr J, vol.12, p.96, 2013.

K. Akesson, Bone and joint diseases around the world. Sweden: A brief update on burden and priority, J Rheumatol Suppl, vol.67, pp.38-40, 2003.

M. F. Holick and . Mf-h, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease, Am J Clin Nutr, vol.80, issue.6, pp.1678-1688, 2004.

F. P. Havers, B. Detrick, S. W. Cardoso, S. Berendes, J. R. Lama et al., Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings, PLoS One, vol.9, issue.4, 2014.

A. Conesa-botella, F. E. Lynen, L. Colebunders, R. Menten, J. Moreno-reyes et al., Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitorcontaining regimen, AIDS Res Ther, vol.7, issue.1, p.40, 2010.

C. Allavena, C. Delpierre, L. Cuzin, D. Rey, N. Viget et al., High frequency of vitamin D deficiency in HIV-infected patients: Effects of HIV-related factors and antiretroviral drugs, J Antimicrob Chemother, vol.67, issue.9, pp.2222-2230, 2012.

L. Boyvin, J. A. Aké, K. L. Séri, M. Boh, G. M. Yapo et al., 25 (OH) vitamin D level and calcium/phosphorus metabolism disorders in patients living with HIV in Abidjan, Int J Biochem Res Rev, vol.17, issue.4, pp.1-7, 2017.

T. Crucitti, D. Taylor, G. Beelaert, K. Fransen, and L. Van-damme, Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trial, Sagar NA, Sen M, Yadav VK, vol.18, pp.623-629, 2011.

M. G. Ormerod and P. R. Imrie, Flow cytometry. Human Pres. USA, vol.558, 1990.

J. Nicholson, M. Hubbard, and B. M. Jones, Use of CD45 fluorescence and side-scatter characteristics for gating lymphocytes when using the whole blood lysis procedure and flow cytometry, Commun Clin Cytom, vol.26, issue.1, pp.16-21, 1996.

Z. Zaman, P. Fielden, and P. G. Frost, Simultaneous determination of vitamins A and E and carotenoids in plasma by reversed-phase HPLC in elderly and younger subjects, Clin Chem, vol.39, issue.11I, pp.2229-2234, 1993.

P. L. Havens, C. B. Stephensen, R. Hazra, P. M. Flynn, C. M. Wilson et al., A randomized, vol.54, pp.1013-1025, 2012.

J. C. Souberbielle, F. Brazier, M. L. Piketty, C. Cormier, S. Minisola et al., How the reference values for serum parathyroid hormone concentration are (or should be) established?, J Endocrinol Invest, 2017.

C. W. Gichuhi, D. Kariuki, A. Nyerere, M. Riyat, and C. W. Gichuhi, Studies on vitamin D levels in serum of HIV infected patients: Their effect on progression towards, AIDS. World J AIDS, vol.4, issue.4, pp.422-429, 2013.

M. Yin and E. Stein, The effect of antiretrovirals on vitamin D, Clinical Infectious Diseases, vol.52, issue.3, pp.406-408, 2011.

K. Yin and D. K. Agrawal, Vitamin D and inflammatory diseases, J Inflamm Res, vol.7, pp.69-87, 2014.

J. E. Lake and J. S. Adams, Vitamin D in HIVinfected patients, Curr HIV/AIDS Rep, vol.8, issue.3, pp.133-141, 2011.

J. C. Waterhouse, T. H. Perez, and P. J. Albert, Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease, Ann N Y Acad Sci, vol.1173, pp.757-765, 2009.

M. Theodorou, T. Serste, M. Van-gossum, and S. Dewit, Factors associated with vitamin D deficiency in a population of 2044 HIVinfected patients, Clin Nutr, vol.33, issue.2, pp.274-279, 2014.

J. Fox, B. Peters, M. Prakash, J. Arribas, A. Hill et al., Improvement in vitamin D deficiency following antiretroviral regime change: Results from the MONET trial, AIDS Res Hum Retroviruses, vol.27, issue.1, pp.29-34, 2011.

T. Welz, K. Childs, F. Ibrahim, M. Poulton, C. B. Taylor et al., Efavirenz is associated with severe vitamin D deficiency and increased alkaline phosphatase, AIDS, vol.24, issue.12, pp.1923-1928, 2010.

C. N. Dao, P. Patel, E. T. Overton, F. Rhame, S. L. Pals et al., Low vitamin D among HIV-infected adults: Prevalence of and risk factors for low vitamin D levels in a cohort of HIV-infected adults and comparison to prevalence among adults in the US general population, Clin Infect Dis, vol.52, issue.3, pp.396-405, 2011.

C. A. Fux, S. Baumann, H. Furrer, and N. J. Mueller, Is lower serum 25-hydroxy vitamin D associated with efavirenz or the nonnucleoside reverse transcriptase inhibitor class?, AIDS, vol.25, issue.6, pp.876-878, 2011.

M. F. Holick, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers and cardiovascular disease, Am J Clin Nutr, 2004.

M. A. Abbas, Physiological functions of vitamin D in adipose tissue, J Steroid Biochem Mol Biol, vol.165, pp.369-381, 2017.

Á. H. Borges, J. L. O'connor, A. N. Phillips, F. F. Rönsholt, S. Pett et al., Factors associated with plasma IL-6 levels during HIV infection, J Infect Dis, vol.212, issue.4, pp.585-595, 2015.

D. Yilma, P. Kaestel, M. F. Olsen, A. Abdissa, M. Tesfaye et al., Change in serum 25-hydroxyvitamin D with antiretroviral treatment initiation and nutritional intervention in HIV-positive adults, Br J Nutr

K. Klassen, A. R. Martineau, R. J. Wilkinson, G. Cooke, A. P. Courtney et al., The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicity, PLoS One, vol.7, issue.9, 2012.

L. Hamzah, J. M. Tiraboschi, H. Iveson, M. Toby, C. Mant et al., Effects on vitamin D, bone and the kidney of switching from fixed-dose tenofovir disoproxil fumarate/emtricitabine/efavirenz to darunavir/ritonavir monotherapy: A randomized

, Antivir Ther, vol.21, issue.4, pp.287-296, 2016.

M. M. Rosenvinge, K. Gedela, A. J. Copas, A. Wilkinson, C. A. Sheehy et al., Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency, Geneva. World Health Organization, vol.27, issue.5, p.54, 2010.

D. H. Shin, S. S. Martinez, M. Parsons, D. T. Jayaweera, A. Campa et al., Relationship of oxidative stress with HIV disease progression in HIV/HCV Coinfected and HIV mono-infected adults in Miami, Intern J Biosci Biochem Bioinform, vol.2, pp.217-240, 2012.

B. Marco, D. G. , F. V. , E. D. Laura, C. Carlo et al., Metabolic bone disease in HIV infection, Editorial Review, vol.23, pp.1297-1310, 2009.

L. Boyvin, J. A. Aké, K. L. Séri, M. Boh, G. M. Yapo et al., 25 (OH) Vitamin D level and calcium/phosphorus metabolism disorders in patients living with HIV in Abidjan, Int J Biochem Res Rev, vol.17, issue.4, pp.1-7, 2017.

L. Milovanova, Y. Milovanov, and A. Plotnikova, Phosphorus and calcium metabolism disorders associated with chronic kidney disease stage III-IV (Systematic review and meta-analysis), In Tech, pp.95-119, 2012.

T. C. Michels and K. M. Kelly, Parathyroid disorders, American Family Physician, vol.88, issue.4, pp.249-57, 2013.

C. Carlberg, S. Seuter, D. Mello, V. Schwab, U. Voutilainen et al., Primary vitamin D target genes allow a categorization of possible benefits of vitamin D3 supplementation, Plos One, vol.8, pp.1-7, 2013.

N. J. Schuch, V. C. Garcia, S. Vívolo, and L. A. Martini, Relationship between Vitamin D receptor gene polymorphisms and the components of metabolic syndrome, J Nutr, vol.12, pp.1-96, 2013.

H. L. Chaves, H. P. Moreira, H. Corrêa, W. Machado, R. B. Teles et al., Vitamin D and secondary hyperparathyroidism in HIV infected patients taking antiretroviral therapy, World Journal of AIDS, vol.4, pp.430-467, 2014.

D. J. Nolan, R. Rose, P. H. Rodriguez, M. Salemi, E. J. Singer et al., The spleen is an HIV-1 sanctuary during combined antiretroviral therapy, AIDS Research and Human Retroviruses, vol.34, issue.1, pp.123-148, 2018.

P. Mansueto, A. Seidita, G. Vitale, S. Gangemi, C. Iaria et al., Vitamin D deficiency in HIV infection: Not only a bone disorder, Biomed Res Int, 2015.

T. Crucitti, D. Taylor, G. Beelaert, K. Fransen, and L. V. Damme, Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trial, Clin. Vaccine Immunol, vol.18, issue.9, pp.1480-1485, 2011.

N. A. Sagar, M. Sen, and V. K. Yadav, Serodiagnosis of HIV by rapid test and ELISA test assay in a tertiary care centre in Northern India, Int J Curr Microbiol App Sci, vol.4, issue.10, pp.623-652, 2015.

M. G. Ormerod and P. R. Imrie, Flow cytometry, USA, 1990.

F. Deyhimi, M. Arabieh, and P. , Optimization of the Emerson-trinder enzymatic reaction by response surface methodology, Biocatalysisand Bio Transformation, vol.24, pp.263-71, 2006.

L. Boyvin, M. Boh, G. Ake-edjeme, A. Soumahoro-agbo, M. K. Séri et al., Serum level of two antioxidant vitamins (A and E) in Ivorian (Côte d'Ivoire) people living with human immunodeficiency virus, Annals of Biological Research, vol.4, issue.11, pp.48-52, 2013.

D. A. Luis, P. Bachiller, R. Aller, J. De-luis, O. Izaola et al., Relation among micronutrient intakes with CD4 count in HIV infected patients, Nutricion Hospitalaria, vol.17, pp.285-89, 2002.

A. Ademasu, B. Kerisew, E. Nibret, A. Munshea, and M. Adal, Serum Zinc Deficiency and associated factors among preart and on-ART adults at Felegehiwot referral hospital, Int J Nutr Food Sci, vol.3, pp.311-328, 2014.

C. J. Haug, P. Aukrust, E. Haug, L. Mørkrid, F. Müller et al., Severe deficiency of 1,25-dihydroxyvitamin D3 in human immunodeficiency virus infection: Association with immunological hyperactivity and only minor changes in calcium homeostasis, J Clin Endocrinol Metab, vol.83, issue.11, pp.3832-3838, 1998.

B. Moges, B. Amare, T. Yabutani, and A. Kassu, HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: A cross sectional study, Adv Ren Replace Ther, vol.14, p.679, 2002.

T. T. Brown and R. B. Qaqish, Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: A meta-analytic review, AIDS, vol.20, pp.2165-2174, 2006.

A. J. Sai, R. W. Walters, X. Fang, and J. C. Gallagher, Relationship between vitamin D, parathyroid hormone and bone health, J Clin Endocrinol Metab, vol.96, issue.3, pp.1-11, 2011.

C. O. Hileman, E. T. Overton, M. Comsey, and G. A. , Vitamin D and bone loss in HIV, Curr Opin HIV AIDS, vol.11, issue.3, pp.277-84, 2016.

T. Ansemant, S. Mahy, C. Piroth, P. Ornetti, S. Ewing et al.,

J. H. Kim, V. Gandhi, G. Psevdos, F. Espinoza, J. Park et al., Evaluation of vitamin D levels among HIV-infected patients in New York City, AIDS Res Hum Retroviruses, vol.28, pp.235-241, 2012.

M. Norval, A. K. Coussens, R. J. Wilkinson, L. Bornman, R. M. Lucas et al., Vitamin D status and its consequences for health in 32. South Africa, Int J Environ Res Public Health, vol.13, issue.10, p.1019, 2016.

K. A. Dougherty, J. I. Schall, B. S. Zemel, F. Tuluc, X. Hou et al., Safety and efficacy of high-dose daily vitamin D3 supplementation in children and young adults infected with human immunodeficiency virus, J Pediatric Infect Dis Soc, vol.3, issue.4, pp.294-303, 2014.

A. Arabi, R. El-rassi, and F. G. El-hajj, Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes, Nat Rev Endocrinol, vol.6, pp.550-61, 2010.

M. F. Holick, Vitamin D deficiency, N Engl J Med, vol.357, pp.266-81, 2007.

M. Mangin, R. Sinha, and K. Fincher, Inflammation and vitamin D: The infection connection, Inflamm. Res. Inflammation Research, vol.63, pp.803-822, 2014.

A. K. Coussens, C. E. Naude, R. Goliath, G. Chaplin, R. J. Wilkinson et al., High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans, Proc Natl Acad Sci, vol.112, issue.26, pp.8052-8057, 2015.

C. W. Gichuhi, D. Kariuki, A. Nyerere, and R. , Studies on Vitamin D levels in serum of HIV infected patients: Their effect on progression towards, AIDS. World Journal of AIDS, vol.4, pp.422-451, 2014.

, Biochem Biophys, vol.523, pp.58-61, 2012.

A. Conesa-botella, C. Mathieu, R. Colebunders, R. Moreno-reyes, E. Van-etten et al., Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?, AIDS Res Ther, 2009.

E. M. Stein, M. T. Yin, D. J. Mcmahon, A. Shu, C. A. Zhang et al., Vitamin D deficiency in HIV-infected postmenopausal Hispanic and African-American women, Osteoporos Int, vol.22, issue.2, pp.477-87, 2011.

J. H. Kim, V. Gandhi, P. G. Espinoza, F. Park, J. Sharp et al., Evaluation of vitamin D levels among HIV-infected patients in New York City, AIDS Research and Human Retroviruses, vol.28, pp.235-276, 2011.

G. Nieto, Y. Barber, M. C. Rubio, M. Rubio, and J. Fibla, Association between AIDS disease progression rates and the Fok-I polymorphism of the VDR gene in a cohort of HIV-1 seropositive patients, J Steroid Biochem, vol.89, issue.90, pp.199-206, 2004.

J. C. Waterhouse, T. H. Perez, and P. J. Albert, Reversing bacteria-induced 25-hydroxyvitamin D receptor dysfunction is key to autoimmune disease, Ann NY Acad Sci, vol.1173, pp.757-65, 2009.

M. Sánchez-de-la-torre, C. Torres, G. Nieto, S. Vergara, A. J. Carrero et al., Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users, J Infect Dis, vol.197, pp.405-415, 2008.

R. Cherqaoui, K. Shakir, B. Shokrani, S. Madduri, F. Farhat et al., histopathological changes of the thyroid and parathyroid glands in HIV-infected patients, Journal of Thyroid Research, vol.7, 2014.

P. Hellman, A. Karlsson-parra, L. Klareskog, P. Ridefelt, G. Bjerneroth et al., Expression and function of a CD4-like molecule in parathyroid tissue, Surgery, vol.120, pp.985-92, 1996.

J. S. Adams and M. Hewison, Update in vitamin D, J Clin Endocrinol Metab, vol.95, pp.471-78, 2010.

R. Okazaki, T. Sugimoto, and H. Kaji, Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects, J Bone Miner Metab, vol.29, pp.103-113, 2011.

H. Mori, Y. Okada, and Y. Tanaka, Incidence of Vitamin D deficiency and its relevance to bone metabolism in Japanese postmenopausal women with type 2 diabetes mellitus, Intern Med, vol.54, pp.1599-1604, 2015.

, RESUME L'objectif général de cette étude était d'analyser le polymorphisme allélique du récepteur de la vitamine D (VDR)

, OH) D3 pour le déficit en vitamine D3 afin d'une meilleure prise en charge des personnes vivant avec le VIH (PVVIH) en Côte d'Ivoire. Pour y arriver, un des volets importants de cette recherche a consisté à déterminer le statut en 25 (OH) D3 et en parathormone

, Cette étude a porté sur 326 échantillons de sang d'individus adultes, D3 et le degré de l'immunodépression, pp.163-163

, Les produits de PCR obtenus après amplification des extraits d'ADN génomique des cellules mononucléaires du sang périphérique (CMSP) ont été purifiés et séquencés. Les concentrations moyennes de parathormone étaient normales dans l'ensemble. Par contre, un déficit en 25 (OH) D3 a été observé chez les patients traités, âgés de 35 à 49 ans ayant des taux de CD4+ inférieurs à 200 cellules/mm 3 sous AZT-3TC-EFV ou AZT-3TC-NVP et ceux âgés de 18 à 25 ans sous AZT-3TC-NVP. De plus, des niveaux suffisants de 25 (OH) D3 ont été observés, témoins VIH-) âgés de 18 à 49 ans dont 50 (32 patients VIH positif et 18 témoins VIH négatif) ont été utilisés pour l'étude du polymorphisme du gène du récepteur de la vitamine D

, Les polymorphismes affectant les fragments Fok-1, Bsm-1 et Apa-1 étaient associés aux concentrations de la 25 (OH) D3 et également à l'activité du VDR. En conclusion, les patients infectés par le VIH, et sous traitement antirétroviral constituent une population à haut risque de déficience ou d'insuffisance de vitamine D3. Cette perturbation de la concentration de 25 (OH) D3 pourrait être due à un apport nutritionnel insuffisant en aliments riches en vitamine D, au traitement antirétroviral et aux polymorphismes affectant les fragments Fok-1, montré que les polymorphismes affectant les fragments Fok-1, Bsm-1 et Apa-1 étaient plus rencontrés parmi les infectés VIH positif

C. D3, . Ivoire, P. Parathormone, and . Vdr, ABSTRACT The main goal of this study is to contribute to better care for people living with HIV (PLHIV) in Côte d'Ivoire through the analysis of the allelic polymorphism of the vitamin D3 receptor (VDR) in relationship with 25 (OH) D3 concentrations. To achieve this, an important component of this research is to determine the 25 (OH) D3 and parathyroid hormone status, to describe the polymorphism of 4 portions of the vitamin D3 receptor gene and to analyse the association between the polymorphism of the VDR gene of vitamin D, the concentrations of 25 (OH) D3 and the degree of immunosuppression, This study included 326 blood samples from adult individuals (163 PLHIV and 163 HIV-controls)

, The PCR products obtained after amplification of genomic DNA extracts from peripheral blood mononuclear cells (PBMC) have been purified and sequenced. Mean concentrations of parathyroid hormone were normal in the whole thing, The CD4+ lymphocyte count was done by flow cytometry (FacsCalibur)

, VDR) gene has shown that polymorphisms affecting the Fok-1, Bsm-1 and Apa-1 fragments were more common among HIV-positive infected people. The polymorphisms affecting the Fok-1, Bsm-1 and Apa-1 fragments were associated with 25 (OH) D3 concentrations and also with VDR activity. In conclusion, HIV-infected patients on antiretroviral treatment constitute a population at high risk of deficiency or insufficiency of vitamin D3. This disruption of the 25 (OH) D3 concentration could be due to insufficient nutritional intake by foods rich in vitamin D, antiretroviral treatment and polymorphisms affecting the Fok-1, Bsm-1 and Apa-1 fragments and not a defect related to the parathyroid hormone, addition, sufficient levels of 25 (OH) D3 were observed in patients treated with TDF-3TC-LPV/r. The study of the vitamin D3 receptor, p.25