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Effets antitumoraux des anesthésiques locaux dans le cancer du sein

Abstract : Retrospective clinical studies have suggested a protective effect of regional anesthesia against recurrences after cancer surgery, bringing the management of perioperative pain to a new level. Prospective studies are underway to support these results. The first objective of this work was to show the direct antitumor effect of lidocaine, a local anesthetic commonly used in clinical practice. The impact of lidocaine was measured in vitro on viability, proliferation and migration of several human breast cancer cell lines, as well as in vivo on the metastatic peritoneal progression of triple negative cells. The second objective was to determine by which molecular mechanisms lidocaine exerts this antitumor action. Global approaches by transcriptomic and metabolomic analyses have highlighted new mechanistic hypotheses, notably in relation to the lipid composition of cell membrane. Finally, a candidate gene approach suggested that the mode of action of lidocaine is independent of the voltage-gated sodium channel.
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Submitted on : Wednesday, November 27, 2019 - 4:53:10 PM
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Thiên-Nga Chamaraux-Tran. Effets antitumoraux des anesthésiques locaux dans le cancer du sein. Pharmacologie. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ021⟩. ⟨tel-02383360⟩

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