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Effet protecteur des produits laitiers sur le risque de syndrome métabolique : quel est l'impact nutritionnel de l'acide trans-palmitoléique (C16∶1 n-7 trans) ?

Abstract : Trans-palmitoleic acid (trans-C16:1 n-7, TPA) is usually considered as a biomarker of dairy fat consumption. On the one hand, dairy product consumption is associated with lower risk of metabolic syndrome. On the other hand, high circulating levels of TPA in humans are epidemiologically associated with lower risk of type 2 diabetes. Could benefits of dairy products consumption rely in part on TPA? So far, there is no nutritional study involving TPA to confirm such observational associations, and doubts remain as regards to the formal origin of TPA. In this work, we demonstrate (1) that TPA arises from the endogenous retro-conversion of dietary trans-vaccenic acid (trans-C18:1 n-7, TVA) in humans, (2) that both TPA and TVA intakes are exclusively ensured by ruminant products (milk and meat) consumption, (3) the ability to get pure TPA in enough amounts to carry out reliable nutritional studies and (4) that pure TPA supplementation on mice fed an obesogenic diet prevents from several metabolic dysfunctions. Taken together, our results demonstrate that the dairy fatty acid TPA may explain part of the epidemiological association between high consumption of dairy products and lower risk of metabolic syndrome.
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https://tel.archives-ouvertes.fr/tel-02372027
Contributor : Abes Star :  Contact
Submitted on : Wednesday, November 20, 2019 - 11:07:04 AM
Last modification on : Tuesday, October 20, 2020 - 10:28:38 AM

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GUILLOCHEAU_Etienne.pdf
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  • HAL Id : tel-02372027, version 1

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Etienne Guillocheau. Effet protecteur des produits laitiers sur le risque de syndrome métabolique : quel est l'impact nutritionnel de l'acide trans-palmitoléique (C16∶1 n-7 trans) ?. Médecine humaine et pathologie. Université Rennes 1, 2019. Français. ⟨NNT : 2019REN1B026⟩. ⟨tel-02372027⟩

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